Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes
Leitung: Prof. Dr. med. Michael D. Menger
Publikationen 2023

Al-Fityan S, Diesel B, Fischer T, Ampofo E, Schomisch A, Mashayekhi V, Schneider M, Kiemer AK.
Nanostructured Microparticles Repolarize Macrophages and Induce Cell Death in an In Vitro Model of Tumour-Associated Macrophages.

Pharmaceutics. 2023 Jul 5;15(7):1895.

Becker V, Yuan X, Boewe AS, Ampofo E, Ebert E, Hohneck J, Bohle RM, Meese E, Zhao Y, Menger MD, Laschke MW, Gu Y.
Hypoxia-induced downregulation of microRNA-186-5p in endothelial cells promotes non-small cell lung cancer angiogenesis by upregulating protein kinase C alpha.

Mol Ther Nucleic Acids. 2023 Jan 27;31:421-436.

Gao L, Beninatto R, Oláh T, Goebel L, Tao K, Roels R, Schrenker S, Glomm J, Venkatesan JK, Schmitt G, Sahin E, Dahhan O, Pavan M, Barbera C, Lucia AD, Menger MD, Laschke MW, Cucchiarini M, Galesso D, Madry H.
A Photopolymerizable Biocompatible Hyaluronic Acid Hydrogel Promotes Early Articular Cartilage Repair in a Minipig Model In Vivo.

Adv Healthc Mater. 2023 Aug 11:e2300931.

Gu Y, Becker MA, Müller L, Reuss K, Umlauf F, Tang T, Menger MD, Laschke MW.

MicroRNAs in Tumor Endothelial Cells: Regulation, Function and Therapeutic Applications.

Cells. 2023 Jun 22;12(13):1692.

Hertz L, Flormann D, Birnbaumer L, Wagner C, Laschke MW, Kaestner L.

Evidence of in vivo exogen protein uptake by red blood cells: a putative therapeutic concept.

Blood Adv. 2023 Mar 28;7(6):1033-1039.

Kern F, Kuhn T, Ludwig N, Simon M, Gröger L, Fabis N, Aparicio-Puerta E, Salhab A, Fehlmann T, Hahn O, Engel A, Wagner V, Koch M, Winek K, Soreq H, Nazarenko I, Fuhrmann G, Wyss-Coray T, Meese E, Keller V, Laschke MW, Keller A.
Ageing-associated small RNA cargo of extracellular vesicles.

RNA Biol. 2023 Jan;20(1):482-494.

Knowles LM, Wolter C, Menger MD, Laschke MW, Beyer L, Grün U, Eichler H, Pilch J.

Activation of the Acute-Phase Response in Hemophilia.

Thromb Haemost. 2023 Sep;123(9):867-879.

Leyendecker G, Wildt L, Laschke MW, Mall G.

Archimetrosis: the evolution of a disease and its extant presentation : Pathogenesis and pathophysiology of archimetrosis (uterine adenomyosis and endometriosis).

Arch Gynecol Obstet. 2023 Jan;307(1):93-112.

Limido E, Weinzierl A, Harder Y, Menger MD, Laschke MW.

Fatter Is Better: Boosting the Vascularization of Adipose Tissue Grafts.

Tissue Eng Part B Rev. 2023 Jun 7 online ahead of print

Menger MM, Manuschewski R, Ehnert S, Rollmann MF, Maisenbacher TC, Tobias AL, Menger MD, Laschke MW, Histing T.

Radiographic, Biomechanical and Histological Characterization of Femoral Fracture Healing in Aged CD-1 Mice.

Bioengineering (Basel). 2023 Feb 20;10(2):275.

Menger MM, Stief M, Scheuer C, Rollmann MF, Herath SC, Braun BJ, Ehnert S, Nussler AK, Menger MD, Laschke MW, Histing T.

Diclofenac, a NSAID, delays fracture healing in aged mice.

Exp Gerontol. 2023 Jul;178:112201

Nordmeier F, Doerr AA, Potente S, Walle N, Laschke MW, Menger MD, Schmidt PH, Meyer MR, Schaefer N.

Are the (New) Synthetic Opioids U-47700, Tramadol and Their Main Metabolites Prone to Time-Dependent Postmortem Redistribution?-A Systematic Study Using an In Vivo Pig Model.

J Anal Toxicol. 2023 Mar 24;47(3):236-244.

Nouaman M, Darras A, John T, Simionato G, Rab MAE, van Wijk R, Laschke MW, Kaestner L, Wagner C, Recktenwald SM.

Effect of Cell Age and Membrane Rigidity on Red Blood Cell Shape in Capillary Flow.

Cells. 2023 Jun 1;12(11):1529.

Rashidi Y, Simionato G, Zhou Q, John T, Kihm A, Bendaoud M, Krüger T, Bernabeu MO, Kaestner L, Laschke MW, Menger MD, Wagner C, Darras A.

Red blood cell lingering modulates hematocrit distribution in the microcirculation.

Biophys J. 2023 Apr 18;122(8):1526-1537

Salah M, Tahoun M, Rudzitis-Auth J, Stotz L, van Koppen CJ, Laschke MW, Abdelsamie AS, Frotscher M.

Potent Dual Inhibitors of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for In Vivo Proof-of-Principle Studies in an Endometriosis Mouse Model.

J Med Chem. 2023 Jul 13;66(13):8975-8992.

Saul D, Menger MM, Ehnert S, Nüssler AK, Histing T, Laschke MW.

Bone Healing Gone Wrong: Pathological Fracture Healing and Non-Unions-Overview of Basic and Clinical Aspects and Systematic Review of Risk Factors.

Bioengineering (Basel).2023 Jan 9;10(1):85

Schrenker S, Cucchiarini M, Goebel L, Oláh T, Venkatesan JK, Schmitt G, Speicher-Mentges S, Maihöfer J, Gao L, Zurakowski D, Menger MD, Laschke MW, Madry H.

In vivo rAAV-mediated human TGF-β overexpression reduces perifocal osteoarthritis and improves osteochondral repair in a large animal model at one year.

Osteoarthritis Cartilage. 2023 Apr;31(4):467-481.

Spiliotis AE, Holländer S, Rudzitis-Auth J, Wagenpfeil G, Eisele R, Nika S, Mallis Kyriakides O, Laschke MW, Menger MD, Glanemann M, Gäbelein G.

Evaluation of Electrochemotherapy with Bleomycin in the Treatment of Colorectal Hepatic Metastases in a Rat Model.

Cancers (Basel). 2023 Mar 4;15(5):1598.

Stratos I, Rinas I, Schröpfer K, Hink K, Herlyn P, Bäumler M, Histing T, Bruhn S, Müller-Hilke B, Menger MD, Vollmar B, Mittlmeier T.

Effects on Bone and Muscle upon Treadmill Interval Training in Hypogonadal Male Rats.

Biomedicines. 2023 May 5;11(5):1370.

Weinzierl A, Harder Y, Menger MD, Laschke MW.

Perioperative Intermittent Fasting Protects Ischemic Musculocutaneous Flap Tissue from Necrosis.

Plast Reconstr Surg. 2023 May 1;151(5):1030-104.

Weinzierl A, Harder Y, Schmauss D, Menger MD, Laschke MW.

Microvascular Fragments Protect Ischemic Musculocutaneous Flap Tissue from Necrosis by Improving Nutritive Tissue Perfusion and Suppressing Apoptosis.

Biomedicines. 2023 May 16;11(5):1454.

Zewinger S, Reiser J, Jankowski V, Alansary D, Hahm E, Triem S, Klug M, Schunk SJ, Schmit D, Kramann R, Körbel C, Ampofo E, Laschke MW, Selejan SR, Paschen A, Herter T, Gaul S, Silbernagel G, Sester M, Sester U, Aßmann G, Bals R, Kostner G, Jahnen-Dechent W, Menger MD, Rohrer L, März W, Böhm M, Jankowski J, Kopf M, Latz E, Niemeyer BA, Fliser D, Laufs U, Speer T.

Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form.

Nat Immunol. 2023 Mar;24(3):412-413.