Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes
Leitung: Prof. Dr. med. Michael D. Menger
Publikationen 2021

Backes TM, Langfermann DS, Lesch A, Rössler OG, Laschke MW, Vinson C, Thiel G .

Regulation and function of AP-1 in insulinoma cells and pancreatic β-cells.

Biochem Pharmacol. 2021:114748. Online ahead of print.


Becker V, Hui X, Nalbach L, Ampofo E, Lipp P, Menger MD, Laschke MW, Gu Y.

Linalool inhibits the angiogenic activity of endothelial cells by downregulating intracellular ATP levels and activating TRPM8.

Angiogenesis. 2021;24(3):613-630.


Decker Y, Németh E, Schomburg R, Chemla A, Fülöp L, Menger MD, Liu Y, Fassbender K.

Decreased pH in the aging brain and Alzheimer's disease.

Neurobiol Aging. 2021;101:40-49.


Doerr AA, Nordmeier F, Walle N, Laschke MW, Menger MD, Schmidt PH, Schaefer N, Meyer MR.

Can a Recently Developed Pig Model Be Used for In Vivo Metabolism Studies of 7-Azaindole-Derived Synthetic Cannabinoids? A Study Using 5F-MDMB-P7AICA.

J Anal Toxicol. 2021;45(6):593-604.


Federspiel JM, Schnabel PA, Tschernig T, Balint B, Schwab T, Laschke MW, Schäfers HJ.

Aortic aneurysms with tricuspid aortic valve have more degeneration than unicuspid aortic valve aneurysms.

Eur J Cardiothorac Surg. 2021;60(2):333-340.


Gargano EM, Mohamed A, Abdelsamie AS, Mangiatordi GF, Drzewiecka H, Jagodziński PP, Mazzini A, van Koppen CJ, Laschke MW, Nicolotti O, Carotti A, Marchais-Oberwinkler S, Hartmann RW, Frotscher M.

17β-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer.

ACS Med Chem Lett. 2021;12(12):1920-1924.


Gries M, Christmann A, Schulte S, Weyland M, Rommel S, Martin M, Baller M, Röth R, Schmitteckert S, Unger M, Liu Y, Sommer F, Mühlhaus T, Schroda M, Timmermans JP, Pintelon I, Rappold GA, Britschgi M, Lashuel H, Menger MD, Laschke MW, Niesler B, Schäfer KH.

Parkinson mice show functional and molecular changes in the gut long before motoric disease onset.

Mol Neurodegener. 2021;16(1):34.


Gu Y, Pais G, Becker V, Körbel C, Ampofo E, Ebert E, Hohneck J, Ludwig N, Meese E, Bohle RM, Zhao Y, Menger MD, Laschke MW.

Suppression of endothelial miR-22 mediates non-small cell lung cancer cell-induced angiogenesis.

Mol Ther Nucleic Acids. 2021;8;26:849-864.


Hao W, Luo Q, Menger MD, Fassbender K, Liu Y.

Treatment With CD52 Antibody Protects Neurons in Experimental Autoimmune Encephalomyelitis Mice During the Recovering Phase.

Front Immunol. 2021;16;12:792465.


Kihm A, Quint S, Laschke MW, Menger MD, John T, Kaestner L, Wagner C.

Lingering Dynamics in Microvascular Blood Flow.

Biophys J. 2021;120(3):432-439.


Klingele M, Carstens M, Baerens L, Laschke MW, Metzger W, Fliser D, Meier CM.

A material stress test study on occurrence of leakage and material failure of peritoneal dialysis (PD) catheters.

Sci Rep. 2021;11(1):10212.


Lange C, Madry H, Venkatesan JK, Schmitt G, Speicher-Mentges S, Zurakowski D, Menger MD, Laschke MW, Cucchiarini M.

rAAV-Mediated sox9 Overexpression Improves the Repair of Osteochondral Defects in a Clinically Relevant Large Animal Model Over Time In Vivo and Reduces Perifocal Osteoarthritic Changes.

Am J Sports Med. 2021;49(13):3696-3707.


Laschke MW, Menger MD.

The simpler, the better: tissue vascularization using the body's own resources.

Trends Biotechnol. 2021;14:S0167-7799(21)00169-4. Online ahead of print.


Laschke MW, Später T, Menger MD.

Microvascular Fragments: More Than Just Natural Vascularization Units.

Trends Biotechnol. 2021;39(1):24-33.


Maihöfer J, Madry H, Rey-Rico A, Venkatesan JK, Goebel L, Schmitt G, Speicher-Mentges S, Cai X, Meng W, Zurakowski D, Menger MD, Laschke MW, Cucchiarini M.

Hydrogel-Guided, rAAV-Mediated IGF-I Overexpression Enables Long-Term Cartilage Repair and Protection against Perifocal Osteoarthritis in a Large-Animal Full-Thickness Chondral Defect Model at One Year In Vivo.

Adv Mater. 2021;33(16):e2008451.


Menger MM, Nalbach L, Roma LP, Laschke MW, Menger MD, Ampofo E.

Erythropoietin exposure of isolated pancreatic islets accelerates their revascularization after transplantation.

Acta Diabetol. 2021;Online ahead of print.


Menger MM, Merscher B, Scheuer C, Braun BJ, Herath SC, Rollmann MF, Stenger D, Später T, Pohlemann T, Menger MD, Histing T.

Amlodipine accelerates bone healing in a stable closed femoral fracture model in mice.

Eur Cell Mater. 2021;41:592-602.


Menger MM, Nalbach L, Wrublewsky S, Glanemann M, Gu Y, Laschke MW, Menger MD, Ampofo E.

Correction to: Darbepoetin-α increases the blood volume flow in transplanted pancreatic islets in mice.

Acta Diabetol. 2021; Online ahead of print.


Menger MM, Laschke MW, Orth M, Pohlemann T, Menger MD, Histing T.

Vascularization Strategies in the Prevention of Nonunion Formation.

Tissue Eng Part B Rev. 2021;27(2):107-132.


Menger MM, Laschke MW, Scheuer C, Bauer D, Bleimehl M, Später T, Rollmann MF, Braun BJ, Herath SC, Raza A, Menger MD, Histing T.

Establishment of a reliable model to study the failure of fracture healing in aged mice.

J Gerontol A Biol Sci Med Sci. 2021;9:glab304.


Nalbach L, Müller D, Wrublewsky S, Metzger W, Menger MD, Laschke MW, Ampofo E.

Microvascular fragment spheroids: Three-dimensional vascularization units for tissue engineering and regeneration.

J Tissue Eng. 2021;12:20417314211035593.


Meresman GF, Götte M, Laschke MW.

Plants as source of new therapies for endometriosis: a review of preclinical and clinical studies.

Hum Reprod Update. 2021;27(2):367-392.


Morscheid YP, Venkatesan JK, Schmitt G, Orth P, Zurakowski D, Speicher-Mentges S, Menger MD, Laschke MW, Cucchiarini M, Madry H.

rAAV-Mediated Human FGF-2 Gene Therapy Enhances Osteochondral Repair in a Clinically Relevant Large Animal Model Over Time In Vivo.

Am J Sports Med. 2021;49(4):958-969.


Nalbach L, Roma LP, Schmitt BM, Becker V, Körbel C, Wrublewsky S, Pack M, Später T, Metzger W, Menger MM, Frueh FS, Götz C, Lin H, Manning Fox JE, MacDonald PE, Menger MD, Laschke MW, Ampofo E.

Improvement of islet transplantation by the fusion of islet cells with functional blood vessels.

EMBO Mol Med. 2021;13(1):e12616.


Nalbach L, Müller D, Wrublewsky S, Metzger W, Menger MD, Laschke MW, Ampofo E.

Microvascular fragment spheroids: Three-dimensional vascularization units for tissue engineering and regeneration.

J Tissue Eng. 2021;27;12:20417314211035593


Nenicu A, Yordanova K, Gu Y, Menger MD, Laschke MW.

Differences in growth and vascularization of ectopic menstrual and non-menstrual endometrial tissue in mouse models of endometriosis.

Hum Reprod. 2021;36(8):2202-2214


Nordmeier F, Doerr AA, Potente S, Walle N, Laschke MW, Menger MD, Schmidt PH, Meyer MR, Schaefer N.

Perimortem Distribution of U-47700, Tramadol and their Main Metabolites in pigs Following Intravenous Administration.

J Anal Toxicol. 2021:bkab044. Online ahead of print.


Nordmeier F, Sihinevich I, Doerr AA, Walle N, Laschke MW, Lehr T, Menger MD, Schmidt PH, Meyer MR, Schaefer N.

Toxicokinetics of U-47700, tramadol, and their main metabolites in pigs following intravenous administration: is a multiple species allometric scaling approach useful for the extrapolation of toxicokinetic parameters to humans?

Arch Toxicol. 2021;95(12):3681-3693.


Rudzitis-Auth J, Christoffel A, Menger MD, Laschke MW.

Targeting sphingosine kinase-1 with the low MW inhibitor SKI-5C suppresses the development of endometriotic lesions in mice.

Br J Pharmacol. 2021;15601. Online ahead of print.


Ritzmann F, Borchardt K, Vella G, Chitirala P, Angenendt A, Herr C, Menger MD, Hoth M, Lis A, Bohle RM, Bals R, Beisswenger C.

Blockade of PD-1 decreases neutrophilic inflammation and lung damage in experimental COPD.

Am J Physiol Lung Cell Mol Physiol. 2021;320(5):L958-L968.


Schlachtenberger G, Doerr F, Brezina A, Menghesha H, Heldwein MB, Bennink G, Menger MD, Moussavian M, Hekmat K, Wahlers T.

Perigraft reaction and incorporation of porcine and bovine pericardial patches.

Interact Cardiovasc Thorac Surg. 2021;32(4):638-647.


Schmitt BM, Boewe AS, Götz C, Philipp SE, Urbschat S, Oertel J, Menger MD, Laschke MW, Ampofo E.

CK2 Activity Mediates the Aggressive Molecular Signature of Glioblastoma Multiforme by Inducing Nerve/Glial Antigen (NG)2 Expression.

Cancers (Basel). 2021;13(7):1678.


Schunk SJ, Triem S, Schmit D, Zewinger S, Sarakpi T, Becker E, Hütter G, Wrublewsky S, Küting F, Hohl M, Alansary D, Prates Roma L, Lipp P, Möllmann J, Lehrke M, Laschke MW, Menger MD, Kramann R, Boor P, Jahnen-Dechent W, März W, Böhm M, Laufs U, Niemeyer BA, Fliser D, Ampofo E, Speer T.

Interleukin-1α (IL-1α) is a Central Regulator of Leukocyte-Endothelial Adhesion in Myocardial Infarction and in Chronic Kidney Disease.

Circulation. 2021; Online ahead of print.


Schunk SJ, Kleber ME, März W, Pang S, Zewinger S, Triem S, Ege P, Reichert MC, Krawczyk M, Weber SN, Jaumann I, Schmit D, Sarakpi T, Wagenpfeil S, Kramann R, Boerwinkle E, Ballantyne CM, Grove ML, Tragante V, Pilbrow AP, Richards AM, Cameron VA, Doughty RN, Dubé MP, Tardif JC, Feroz-Zada Y, Sun M, Liu C, Ko YA, Quyyumi AA, Hartiala JA, Tang WHW, Hazen SL, Allayee H, McDonough CW, Gong Y, Cooper-DeHoff RM, Johnson JA, Scholz M, Teren A, Burkhardt R, Martinsson A, Smith JG, Wallentin L, James SK, Eriksson N, White H, Held C, Waterworth D, Trompet S, Jukema JW, Ford I, Stott DJ, Sattar N, Cresci S, Spertus JA, Campbell H, Tierling S, Walter J, Ampofo E, Niemeyer BA, Lipp P, Schunkert H, Böhm M, Koenig W, Fliser D, Laufs U, Speer T; eQTLGen consortium; BIOS consortium.

Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality.

Eur Heart J. 2021;42(18):1742-1756.


Simgen A, Kettner M, Webelsiep FJ, Tomori T, Mühl-Benninghaus R, Yilmaz U, Bhogal P, Laschke MW, Menger MD, Reith W, Dietrich P.

Solitaire Stentectomy Using a Stent-Retriever Technique in a Porcine Model.

Clin Neuroradiol. 2021;31(2):475-482.


Simgen A, Kettner M, Dietrich P, Tomori T, Mühl-Benninghaus R, Bhogal P, Laschke MW, Menger MD, Reith W, Yilmaz U.

Different Rescue Approaches of Migrated Woven Endobridge (WEB) Devices: an Animal Study.

Clin Neuroradiol. 2021 Jun;31(2):431-438


Später T, Marschall JE, Brücker LK, Nickels RM, Metzger W, Mai AS, Menger MD, Laschke MW.

Adipose Tissue-Derived Microvascular Fragments From Male and Female Fat Donors Exhibit a Comparable Vascularization Capacity.

Front Bioeng Biotechnol. 2021;27;9:777687.


Später T, Menger MD, Laschke MW.

Vascularization Strategies for Porous Polyethylene Implants.

Tissue Eng Part B Rev 2021; 27(1):29-3.


Später T, Worringer DM, Menger MM, Menger MD, Laschke MW.

Systemic low-dose erythropoietin administration improves the vascularization of collagen-glycosaminoglycan matrices seeded with adipose tissue-derived microvascular fragments.

J Tissue Eng. 2021;12:20417314211000304.


Steiner C, Karl M, Laschke MW, Schupbach P, Venturato A, Gasser A.

Comparison of extraction sites versus artificial defects with xenogenic bone substitute in minipigs.

Clin Exp Dent Res. 2021;7(4):490-501.


Quan W, Luo Q, Hao W, Tomic I, Furihata T, Schulz-Schäffer W, Menger MD, Fassbender K, Liu Y.

Haploinsufficiency of microglial MyD88 ameliorates Alzheimer's pathology and vascular disorders in APP/PS1-transgenic mice.

Glia. 2021;69(8):1987-2005.


Thurner L, Hartmann S, Bewarder M, Fadle N, Regitz E, Schormann C, Quiroga N, Kemele M, Klapper W, Rosenwald A, Trümper L, Bohle RM, Nimmesgern A, Körbel C, Lascke MW, Menger MD, Barth S, Kubuschok B, Mottok A, Kaddu-Mulindwa D, Hansmann ML, Pöschel V, Held G, Murawski N, Stilgenbauer S, Neumann F, Preuss KD, Pfreundschuh M.

Identification of the atypically modified autoantigen Ars2 as the target of B-cell receptors from activated B-cell-type diffuse large B-cell lymphoma.

Haematologica. 2021;106(8):2224-2232.


Vilas-Boas EA, Carlein C, Nalbach L, Almeida DC, Ampofo E, Carpinelli AR, Roma LP, Ortis F.

Early Cytokine-Induced Transient NOX2 Activity Is ER Stress-Dependent and Impacts β-Cell Function and Survival.

Antioxidants (Basel). 2021;10(8):1305.


Vilas-Boas EA, Nalbach L, Ampofo E, Lucena CF, Naudet L, Ortis F, Carpinelli AR, Morgan B, Roma LP.

Transient NADPH oxidase 2-dependent H2O2 production drives early palmitate-induced lipotoxicity in pancreatic islets.

Free Radic Biol Med. 2021;162:1-13.


Walle N, Doerr AA, Laschke MW, Menger MD, Meyer MR, Schmidt PH, Schaefer N.

Systematic Studies on Temperature-Dependent in Vitro Stability During Storage and Smoking of the Synthetic Cannabinoid 5F-MDMB-P7AICA.

J Anal Toxicol. 2021:bkab022. Online ahead of print.


Walle N, Nordmeier F, Doerr AA, Peters B, Laschke MW, Menger MD, Schmidt PH, Meyer MR, Schaefer N.

Comparison of in vitro and in vivo models for the elucidation of metabolic patterns of 7-azaindole-derived synthetic cannabinoids exemplified using cumyl-5F-P7AICA.

Drug Test Anal. 2021;13(1):74-90.


Weinzierl A, Harder Y, Schmauss D, Ampofo E, Menger MD, Laschke MW.

Improved Vascularization and Survival of White Compared to Brown Adipose Tissue Grafts in the Dorsal Skinfold Chamber.

Biomedicines. 2021;10(1):23.