Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes
Leitung: Prof. Dr. med. Michael D. Menger
Publikationen 2022

Boewe AS, Wemmert S, Kulas P, Schick B, Götz C, Wrublewsky S, Montenarh M, Menger MD, Laschke MW, Ampofo E.

Inhibition of CK2 reduces NG2 expression in juvenile angiofibroma.

Biomedicines 2022; 10(5):966.

Fritz T, Schäfer J, Scheuer C, Stutz J, Histing T, Pohlemann T, Menger MD, Laschke MW, Klein M, Orth M.

Macrophage-activating lipoprotein (MALP)-2 impairs the healing of partial tendon injuries in mice.

Ann Anat 2022; 239:151818.

Frueh FS, Gassert L, Scheuer C, Müller A, Fries P, Boewe AS, Ampofo E, Rübe CE, Menger MD, Laschke MW.

Adipose tissue-derived microvascular fragments promote lymphangiogenesis in a murine lymphedema model.

J Tissue Eng 2022; 13:20417314221109957.

Gu Y, Becker V, Qiu M, Tang T, Ampofo E, Menger MD, Laschke MW.

Brassinin promotes the degradation of Tie2 and FGFR1 in endothelial cells and inhibits triple-negative breast cancer angiogenesis.

Cancers (Basel) 2022; 14(14):3540.

Körner S, Pick T, Bochen F, Wemmert S, Körbel C, Menger MD, Cavalié A, Kühn JP, Schick B, Linxweiler M.

Antagonizing Sec62 function in intracellular Ca2+ homeostasis represents a novel therapeutic strategy for head and neck cancer.

Front Physiol 2022; 13:880004.

Laschke MW, Menger MD.

Microvascular fragments in microcirculation research and regenerative medicine.

Tissue Eng Part B Rev 2022; 28(5):1109-1120.

Laschke MW, Gu Y, Menger MD.

Replacement in angiogenesis research: studying mechanisms of blood vessel development by animal-free in vitro, in vivo and in silico approaches.

Front Physiol 2022; 13:981161.

Laschke MW, Menger MD.

The simpler, the better: tissue vascularization using the body's own resources.

Trends Biotechnol 2022; 40(3):281-290.

Leyendecker G, Wildt L, Laschke MW, Mall G.

Archimetrosis: the evolution of a disease and its extant presentation : Pathogenesis and pathophysiology of archimetrosis (uterine adenomyosis and endometriosis).

Arch Gynecol Obstet. 2022. Online ahead of print.

Linxweiler J, Hajili T, Zeuschner P, Menger MD, Stöckle M, Junker K, Saar M.

Primary Tumor Resection Decelerates Disease Progression in an Orthotopic Mouse Model of Metastatic Prostate Cancer.

Cancers (Basel). 2022; 14(3):737.

Luo Q, Schnöder L, Hao W, Litzenburger K, Decker Y, Tomic I, Menger MD, Liu Y, Fassbender K.

p38α-MAPK-deficient myeloid cells ameliorate symptoms and pathology of APP-transgenic Alzheimer's disease mice.

Aging Cell. 2022; 21(8):e13679.

Menger MM, Bauer D, Bleimehl M, Scheuer C, Ehnert S, Menger MD, Histing T, Laschke MW.

Comparison of two non-union models with damaged periosteum in mice: Segmental defect and pin-clip fixation versus transverse fracture and K-wire stabilization.

Bone. 2022; 162:116475.

Menger MM, Laschke MW, Scheuer C, Bauer D, Bleimehl M, Später T, Rollmann MF, Braun BJ, Herath SC, Raza A, Menger MD, Histing T.

Establishment of a Reliable Model to Study the Failure of Fracture Healing in Aged Mice.

J Gerontol A Biol Sci Med Sci. 2022; 77(5):909-917.

Menger MM, Stutz J, Ehnert S, Nussler AK, Rollmann MF, Herath SC, Braun BJ, Pohlemann T, Menger MD, Histing T.

Development of an ischemic fracture healing model in mice.

Acta Orthop. 2022; 93:466-471.

Menger MM, Körbel C, Bauer D, Bleimehl M, Tobias AL, Braun BJ, Herath SC, Rollmann MF, Laschke MW, Menger MD, Histing T.

Photoacoustic imaging for the study of oxygen saturation and total hemoglobin in bone healing and non-union formation.

Photoacoustics. 2022; 28:100409.

Menger MM, Laschke MW, Nussler AK, Menger MD, Histing T.

The vascularization paradox of non-union formation.

Angiogenesis. 2022; 25(3):279-290.

Nordmeier F, Doerr AA, Potente S, Walle N, Laschke MW, Menger MD, Schmidt PH, Meyer MR, Schaefer N.

Are the (New) Synthetic Opioids U-47700, Tramadol and Their Main Metabolites Prone to Time-dependent Postmortem redistribution? - A Systematic Study Using an in Vivo Pig Model.

J Anal Toxicol. 2022; bkac082.

Nordmeier F, Doerr AA, Potente S, Walle N, Laschke MW, Menger MD, Schmidt PH, Meyer MR, Schaefer N.

Perimortem Distribution of U-47700, Tramadol and Their Main Metabolites in Pigs Following Intravenous Administration.

J Anal Toxicol. 2022; 46(5):479-486.

Oláh T, Reinhard J, Laschke MW, Goebel LKH, Walter F, Schmitt G, Speicher-Mentges S, Menger MD, Cucchiarini M, Pape D, Madry H.

Axial alignment is a critical regulator of knee osteoarthritis.

Sci Transl Med. 2022; 14(629):eabn0179.

Orth M, Fritz T, Stutz J, Scheuer C, Ganse B, Bullinger Y, Lee JS, Murphy WL, Laschke MW, Menger MD, Pohlemann T.

Local Application of Mineral-Coated Microparticles Loaded With VEGF and BMP-2 Induces the Healing of Murine Atrophic Non-Unions.

Front Bioeng Biotechnol. 2022; 9:809397.

Rudzitis-Auth J, Becker M, Scheuer C, Menger MD, Laschke MW.

Indole-3-Carbinol Inhibits the Growth of Endometriotic Lesions by Suppression of Microvascular Network Formation.

Nutrients. 2022; 14(22):4940.

Rudzitis-Auth J, Huwer SI, Scheuer C, Menger MD, Laschke MW.

The ischemic time window of ectopic endometrial tissue crucially determines its ability to develop into endometriotic lesions.

Sci Rep. 2022; 12(1):5625.

Schrenker S, Cucchiarini M, Goebel L, Oláh T, Venkatesan JK, Schmitt G, Speicher-Mentges S, Maihöfer J, Gao L, Zurakowski D, Menger MD, Laschke MW, Madry H.

In vivo rAAV-mediated human TGF-β overexpression reduces perifocal osteoarthritis and improves osteochondral repair in a large animal model at one year.

Osteoarthritis Cartilage. 2022: S1063-4584(22)00937-2.

Später T, Assunção M, Lit KK, Gong G, Wang X, Chen YY, Rao Y, Li Y, Yiu CHK, Laschke MW, Menger MD, Wang D, Tuan RS, Khoo KH, Raghunath M, Guo J, Blocki A.

Engineering microparticles based on solidified stem cell secretome with an augmented pro-angiogenic factor portfolio for therapeutic angiogenesis.

Bioact Mater. 2022; 17:526-541.

Später T, Marschall JE, Brücker LK, Nickels RM, Metzger W, Menger MD, Laschke MW.

Vascularization of Microvascular Fragment Isolates from Visceral and Subcutaneous Adipose Tissue of Mice.

Tissue Eng Regen Med. 2022; 19(1):161-175.

Stachel N, Orth P, Zurakowski D, Menger MD, Laschke MW, Cucchiarini M, Madry H.

Subchondral Drilling Independent of Drill Hole Number Improves Articular Cartilage Repair and Reduces Subchondral Bone Alterations Compared With Debridement in Adult Sheep.

Am J Sports Med. 2022; 50(10):2669-2679.

Walle N, Doerr AA, Laschke MW, Menger MD, Meyer MR, Schmidt PH, Schaefer N.

Systematic Studies on Temperature-Dependent In Vitro Stability during Storage and Smoking of the Synthetic Cannabinoid 5F-MDMB-P7AICA.

J Anal Toxicol. 2022 Apr; 46(4):374-382.

Weinzierl A, Ampofo E, Menger MD, Laschke MW.

Tissue-Protective Mechanisms of Bioactive Phytochemicals in Flap Surgery.

Front Pharmacol. 2022; 13:864351.

Weinzierl A, Harder Y, Schmauss D, Menger MD, Laschke MW.

Bromelain Protects Critically Perfused Musculocutaneous Flap Tissue from Necrosis.

Biomedicines. 2022; 10(6):1449.

Weinzierl A, Harder Y, Schmauss D, Menger MD, Laschke MW.

Boosting Tissue Vascularization: Nanofat as a Potential Source of Functional Microvessel Segments.

Front Bioeng Biotechnol. 2022; 10:820835.

Wrublewsky S, Weinzierl A, Hornung I, Prates-Roma L, Menger MD, Laschke MW, Ampofo E.

Co-transplantation of pancreatic islets and microvascular fragments effectively restores normoglycemia in diabetic mice.

NPJ Regen Med. 2022; 7(1):67.

Wrublewsky S, Speer T, Nalbach L, Boewe AS, Pack M, Alansary D, Roma LP, Hoffmann MDA, Schmitt BM, Weinzierl A, Menger MD, Laschke MW, Ampofo E.

Targeting Pancreatic Islet NLRP3 Improves Islet Graft Revascularization.

Diabetes. 2022.

Wrublewsky S, Glas J, Carlein C, Nalbach L, Hoffmann MDA, Pack M, Vilas-Boas EA, Ribot N, Kappl R, Menger MD, Laschke MW, Ampofo E, Roma LP.

The loss of pancreatic islet NADPH oxidase (NOX)2 improves islet transplantation.

Redox Biol. 2022; 55:102419.