Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes
Leitung: Prof. Dr. med. Michael D. Menger
Publikationen 2017


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Abdelsamie AS, van Koppen CJ, Bey E, Salah M, Börger C, Siebenbürger L, Laschke MW, Menger MD, Frotscher M

Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17β-HSD1 inhibitor with sub-nanomolar IC50 for a proof-of-principle study.

Eur J Med Chem 2017 127: 944-957


Ampofo E, Lachnitt N, Rudzitis-Auth J, Schmitt BM, Menger MD, Laschke MW

Indole-3-carbinol is a potent inhibitor of ischemia-reperfusion-induced inflammation.

J Surg Res2017 215:34-46


Ampofo E, Schmitt BM, Menger MD, Laschke MW

The regulatory mechanisms of NG2/CSPG4 expression.

Cell Mol Biol Lett 2017 22:4


Danielczok JG, Terriac E, Hertz L, Petkova-Kirova P, Lautenschläger F, Laschke MW, Kaestner L

Red Blood Cell Passage of Small Capillaries Is Associated with Transient Ca2+-mediatedAdaptations.

Front Physiol2017 5;8:979


Deichelbohrer M, Wu MF, Seitz B, Hüttenberger D, Laschke MW, Foth HJ, Wonnenberg B, Wagenpfeil S, Meier C, Bischoff M, Tschernig T

Bacterial keratitis: Photodynamic inactivation reduced experimental inflammation.

Exp Ther Med 2017 14:4509-4514


Emmerich J, van Koppen CJ, Burkhart JL, Hu Q, Siebenbürger L, Boerger C, Scheuer C, Laschke MW, Menger MD, Hartmann RW

Lead optimization generates CYP11B1 inhibitors of pyridylmethyl isoxazole type with improved pharmacological profile for the treatment of Cushing's disease.

J Med Chem 60:5086-5098


Frueh FS, Menger MD, Lindenblatt N, Giovanoli P, Laschke MW

Current and emerging vascularization strategies in skin tissue engineering.

Crit Rev Biotechnol2017 37: 613-625


Frueh FS, Später T, Lindenblatt N, Calcagni M, Giovanoli P, Scheuer C, Menger MD, Laschke MW

Adipose tissue-derived microvascular fragments improve vascularization, lymphangiogenesis, and integration of dermal skin substitutes.

J Invest Dermatol2017 137: 217-227


Frueh FS, Später T, Scheuer C, Menger MD, Laschke MW

Isolation of murine adipose tissue-derived microvascular fragments as vascularization units for tissue engineering.

J Vis Exp2017 Apr 30;(122). doi: 10.3791/55721.


Gu Y, Ampofo E, Menger MD, Laschke MW

miR-191 suppresses angiogenesis by activation of NF-κB signaling.

FASEBJ 2017 31:3321-3333


Jungnickel C, Schmidt LH, Bittigkoffer L, Wolf L, Wolf A, Ritzmann F, Kamyschnikow A, Herr C, Menger MD, Spieker T, Wiewrodt R, Bals R, Beisswenger C

IL-17C mediates the recruitment of tumor-associated neutrophils and lung tumor growth.

Oncogene 2017 36:4182-4190


Klein M, Laschke MW, Holstein JH, Histing T, Pohlemann T, Menger M, Garcia P

Mechanical and biological characterization of alkaline substituted orthophosphate bone substitutescontaining meta- and diphosphates.

Biomed Mater 2017 12: 055007


Koenen K, Knepper I, Klodt M, Osterberg A, Stratos I, Mittlmeier T, Histing T, Menger MD, Vollmar B, Bruhn S, Müller-Hilke B

Sprint Interval Training Induces A Sexual Dimorphism but does not Improve Peak Bone Mass inYoung and Healthy Mice.

Sci Rep 2017 7: 44047


Laschke MW, Menger MD

Life is 3D: Boosting spheroid function for tissue engineering.

Trends Biotechnol 2017 35: 133-144


Laschke MW, Menger MD

Spheroids as vascularization units: From angiogenesis research to tissue engineering applications.

Biotechnol Adv 2017 35:782-791


Linxweiler J, Körbel C, Müller A, Jüngel E, Blaheta R, Heinzelmann J, Stöckle M, Junker K, Menger MD, Saar M

Experimental imaging in orthotopic renal cell carcinoma xenograft models: comparative evaluation ofhigh-resolution 3D ultrasonography, in-vivo micro-CT and 9.4T MRI.

SciRep 2017 7:14249


Müller A, Fries P, Jelvani B, Lux F, Rübe CE, Kremp S, Giovanoli P, Buecker A, Menger MD, Laschke MW, Frueh FS

Magnetic resonance lymphography at 9.4 T using a Gadolinium-based nanoparticle in rats:Investigations in healthy animals and in a hindlimb lymphedema model.

Invest Radiol 2017 52:725-732


Nenicu A, Gu Y, Körbel C, Menger MD, Laschke MW

Combination therapy with telmisartan and parecoxib induces regression of endometriotic lesions.

Br J Pharmacol2017 174:2623-2635


Orth M, Kruse NJ, Braun BJ, Scheuer C, Holstein JH, Khalil A, Yu X, Murphy WL, Pohlemann T, Laschke MW, Menger MD

BMP-2-coated mineral coated microparticles improve bone repair in atrophic non-unions.

Eur Cell Mater 2017 33: 1-12


Rollmann MF, Herath SC, Holstein JH, Pohlemann T, Menger MD, Histing T

Surgical treatment of pelvic ring fractures in the elderly now and then: a pelvic registry study.

Aging Clin Exp Res 2017 29:639-646


Rollmann MF, Herath SC, Kirchhoff F, Braun BJ, Holstein JH, Pohlemann T, Menger MD, Histing T

Pelvic ring fractures in the elderly now and then - a pelvic registry study.

Arch Gerontol Geriatr 2017 71: 83-88


Schaefer N, Helfer AG, Kettner M, Laschke MW, Schlote J, Ewald AH, Meyer MR, Menger MD, Maurer HH, Schmidt PH

Metabolic patterns of JWH-210, RCS-4, and THC in pig urine elucidated using LC-HR-MS/MS: Dothey reflect patterns in humans?

Drug Test Anal 2017 9: 613-625


Schaefer N, Kettner M, Laschke MW, Schlote J, Ewald AH, Menger MD, Maurer HH, Schmidt PH

Distribution of synthetic cannabinoids JWH-210, RCS-4 and ∆ 9-tetrahydrocannabinol after intravenous administration to pigs.

Curr Neuropharmacol2017 15:713-723


Senger S, Sperling J, Oberkircher B, Schilling MK, Kollmar O, Menger MD, Ziemann C

Portal branch ligation does not counteract the inhibiting effect of temsirolimus on extrahepaticcolorectal metastatic growth.

Clin Exp Metastasis2017 Jun;34(5):323-332


Später T, Frueh FS, Menger MD, Laschke MW

Potentials and limitations of Integra® flowable wound matrix seeded with adipose tissue-derivedmicrovascular fragments.

Eur Cell Mater 2017 33:268-278


Später T, Körbel C, Frueh FS, Nickels RM, Menger MD, Laschke MW

Seeding density is a crucial determinant for the in vivo vascularisation capacity of adipose tissue-derived microvascular fragments.

Eur Cell Mater 2017 34: 55-69


Spohrer S, Groß R, Nalbach L, Schwind L, Stumpf H, Menger MD, Ampofo E, Montenarh M, Götz C

Functional interplay between the transcription factors USF1 and PDX-1 and protein kinase CK2 inpancreatic β-cells.

Sci Rep 2017 7:16367


Veith NT, Histing T, Menger MD, Pohlemann T, Tschernig T

Helping prometheus: liver protection in acute hemorrhagic shock.

AnnTranslMed 2017 5:206


Werner TV, Hart M, Nickels R, Kim YJ, Menger MD, Bohle RM, Keller A, Ludwig N, Meese E

MiR-34a-3p alters proliferation and apoptosis of meningioma cells in vitro and is directly targetingSMAD4, FRAT1 and BCL2.

Aging2017 23;9(3):932-954


Wu MF, Deichelbohrer M, Tschernig T, Laschke MW, Szentmáry N, Hüttenberger D, Foth HJ, Seitz B, Bischoff M

Chlorin e6 mediated photodynamic inactivation for multidrug resistant Pseudomonas aeruginosakeratitis in mice in vivo.

Sci Rep2017 15;7:44537