Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes
Leitung: Prof. Dr. med. Michael D. Menger
Publikationen 2019


Abdelsamie AS, Herath S, Biskupek Y, Börger C, Siebenbürger L, Salah M, Scheuer C, Marchais-Oberwinkler S, Frotscher M, Pohlemann T, Menger MD, Hartmann RW, Laschke MW, van Koppen CJ.

Targeted endocrine therapy: Design, synthesis, and proof-of-principle of 17β-hydroxysteroid dehydrogenase type 2 inhibitors in bone fracture healing.

J Med Chem. 2019;62:1362-72.


Abdelsamie AS, Salah M, Siebenbürger L, Merabet A, Scheuer C, Frotscher M, Müller ST, Zierau O, Vollmer G, Menger MD, Laschke MW, van Koppen CJ, Marchais-Oberwinkler S, Hartmann RW.

Design, Synthesis, and Biological Characterization of Orally Active 17ß-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis.

J Med Chem. 2019;62:7289-7301.


Ampofo E, Berg JJ, Menger MD, Laschke MW.

Maslinic acid alleviates ischemia/reperfusion-induced inflammation by downregulation of NFκB-mediated adhesion molecule expression.

Sci Rep. 2019;9:6119.


Ampofo E, Nalbach L, Menger MD, Montenarh M, Götz C.

Protein Kinase CK2-A Putative Target for the Therapy of Diabetes Mellitus?

Int J Mol Sci. 2019;20:4398


Ampofo E, Schmitt BM, Laschke MW, Menger MD.

Function of protein kinase CK2 in thrombus formation.

Platelets. 2019;30:421-427.


Belkacemi A, Laschke MW, Menger MD, Flockerzi V.

Scratch Migration Assay and Dorsal Skinfold Chamber for In Vitro and In Vivo Analysis of Wound Healing.

Jove-J Vis Exp. 2019;(151)


Bomberg H, Bierbach B, Flache S, Novák M, Schäfers HJ, Menger MD.

Dobutamine versus vasopressin after mesenteric ischemia.

J Surg Res. 2019;235:410-23.


Brockmeyer M, Orth P, Höfer D, Seil R, Paulsen F, Menger MD, Kohn D, Tschernig T.

The anatomy of the anterolateral structures of the knee - A histologic and macroscopic approach.

Knee. 2019;26:363-646.


Czepukojc B, Abuhaliema A, Barghash A, Tierling S, Naß N, Simon Y, Körbel C, Cadenas C, van Hui N, Sachinidis A, Hengstler JG, Helms V, Laschke MW, Walter J, Haybaeck J, Leclercq L, Kiemer AK, Kessler SM.

IGF2 mRNA Binding Protein 2 Transgenic Mice Are More Prone to Develop a Ductular Reaction and to Progress Toward Cirrhosis.

Front Med-Lausanne. 2019;6:179.


Dahmke IN, Ampofo E, Menger MD, Laschke MW.

The dorsal skinfold chamber: A valuable model for the in vivo evaluation of topical


Exp Dermatol.2019;28 940-947


Du F, Wang Y, Ding Z, Laschke MW, Thorlacius H.

Microvascular Mechanisms of Polyphosphate-Induced Neutrophil-Endothelial Cell Interactions in vivo.

Eur Surg Res. 60:53-62.


Federspiel JM, Tschernig T, Laschke MW, Wagenpfeil S, Schnabel P, Schäfers HJ.

The vasa vasorum reach deep into the human thoracic aorta.

Ann Anat. 2019;225 54-56.


Fries P, Massmann A, Robert P, Corot C, Laschke MW, Schneider G, Buecker A, Müller A.

Evaluation of gadopiclenol and P846, 2 high-relaxivity macrocyclic magnetic resonance contrast agents without protein binding, in a rodent model of hepatic metastases: Potential solutions for improved enhancement at ultrahigh field strength.

Invest Radiol. 2019;54 549-558.


Gu Y, Becker V, Zhao Y, Menger MD, Laschke MW.

miR-370 inhibits the angiogenic activity of endothelial cells by targeting smoothened (SMO) and bone morphogenetic protein (BMP)-2.

FASEB J. 2019;33 7213-7224.


Hantschel J, Weis S, Schäfer KH, Menger MD, Kohl M, Egert M, Laschke MW.

Effect of endometriosis on the fecal bacteriota composition of mice during the acute phase of lesion formation.

PLOS ONE. 2019;14 e0226835.


Hertz L, Ruppenthal S, Simionato G, Quint S, Kihm A, Abay A, Petkova-Kirova P, Boehm U, Weissgerber P, Wagner C, Laschke MW, Kaestner L.

The Evolution of Erythrocytes Becoming Red in Respect to Fluorescence.

Front Physiol. 2019;10 753.


Kiani K, Rudzitis-Auth J, Scheuer C, Movahedin M, Sadati Lamardi SN, Malekafzali Ardakani H, Becker V, Moini A, Aflatoonian R, Ostad SN, Menger MD, Laschke MW.

Calligonum comosum (Escanbil) extract exerts anti-angiogenic, anti-proliferative and anti-inflammatory effects on endometriotic lesions.

J Ethnopharmacol. 2019;239: #111918.


Laschke MW, Heß A, Scheuer C, Karschnia P, Kontaxi E, Menger MD.

University of Wisconsin solution for the xeno-free storage of adipose tissue-derived microvascular fragments.

Regen Med. 2019;14 681-691.


Laschke MW, Heß A, Scheuer C, Karschnia P, Menger MD.

Subnormothermic short-term cultivation improves the vascularization capacity of adipose tissue-derived microvascular fragments.

J Tissue Eng Regen Med. 2019;13:131-142.


Laschke MW, Kontaxi E, Scheuer C, Heß A, Karschnia P, Menger MD.

Insulin-like growth factor 1 stimulates the angiogenic activity of adipose tissuederived microvascular fragments.

J Tissue Eng. 2019;10:2041731419879837.


Laschke MW, Seifert MS, Scheuer C, Kontaxi E, Metzger W, Menger MD.

High glucose exposure promotes proliferation and in vivo network formation of adipose-tissue-derived microvascular fragments.

Eur Cells Mater. 2019;38:188-200.


Mvondo MA, Ekenfack JD, Minko Essono S, Saah Namekong H, Awounfack CF, Laschke MW, Njamen D.

Soy intake since the prepubertal age may contribute to the pathogenesis of endometriosis in adulthood.

J Med Food. 2019;22:631-638.


Nalbach L, Schmitt BM, Becker V, Scheller A, Laschke MW, Menger MD, Ampofo E.

Nerve/glial antigen 2 is crucially involved in the revascularization of freely transplanted pancreatic islets.

Cell Tissue Res. 2019;378:195-205.


Orth M, Baudach J, Scheuer C, Osche D, Veith NT, Braun BJ, Rollmann MF, Herath SC, Pohlemann T, Menger MD, Histing T.

Erythropoietin does not improve fracture healing in aged mice.

Exp Gerontol. 2019;122:1-9.


Orth M, Scheuer C, Backes C, Keller A, Rollmann MF, Braun BJ, Ludwig N, Meese E, Pohlemann T, Laschke MW, Menger MD, Histing T.

Profiling microRNA expression in murine bone healing and non-union formation: Role of miR-140 during the early stage of bone healing.

PLOS ONE. 2019;14 eO218395.


Orth M, Shadmanov T, Scheuer C, Braun BJ, Fritz T, Holstein JH, Histing T, Laschke MW, Pohlemann T, Menger MD.

Marble-derived microcalcite improves bone healing in mice osteotomy.

Iomed Mater. 2019;14 025001.


Orth M, Shenar AK, Scheuer C, Braun BJ, Herath SC, Holstein JH, Histing T, Yu X, Murphy WL, Pohlemann T, Laschke MW, Menger MD.

VEGF-loaded mineral-coated microparticles improve bone repair and are associated with increased expression of epo and RUNX-2 in murine non-unions.

J Orthop Res. 2019;37:821-31.


Regelin N, Heyder S, Laschke MW, Hadizamani Y, Borgmann M, Moehrlen U, Schramm R, Bals R, Menger MD, Hamacher J.

A murine model to study vasoreactivity and intravascular flow in lung isograft microvessels.

Sci Rep. 2019;9:5170.


Ritzmann F, Jungnickel C, Vella G, Kamyschnikow A, Herr C, Li D, Menger MM, Angenendt A, Hoth M, Lis A, Bals R, Beisswenger C.

IL-17C-mediated innate inflammation decreases the response to PD-1 blockade in a model of Kras-driven lung cancer.

Sci Rep-Uk. 2019;9:10353.


Rollmann MF, Herath SC, Braun BJ, Holstein JH, Pohlemann T, Menger MD, Histing T.

In-hospital mortality of pelvic ring fractures in older adults now and then: A pelvic registry study.

Geriatr Gerontol Int.2019;19:24-29.


Schaefer N, Kröll AK, Körbel C, Laschke MW, Menger MD, Maurer HH, Meyer MR, Schmidt PH.

Distribution of the (synthetic) cannabinoids JWH-210, RCS-4, as well as A9-tetrahydrocannabinol following pulmonary administration to pigs.

Arch Toxicol. 2019;93:2211-2218


Seitz B, Graf N, Menger M, Monz D, Käsmann-Kellner B.

[Establishment of a PJ Faculty at the Medical Faculty of Saarland University UdS : "Docendo discimus", "transparency and communication"].



Zhang X, Gibhardt CS, Will T, Stanisz H, Körbel C, Mitkovski M, Stejerean I, Cappello S, Pacheu-Grau D, Dudek J, Tahbaz N, Mina L, Simmen T, Laschke MW, Menger MD, Schön MP, Helms V, Niemeyer BA, Rehling P, Vultur A, Bogeski I.

Redox signals at the ER-mitochondria interface control melanoma progression.

EMBO J. 2019; 38:el00871.


Ziemann C, Roller J, Malter MM, Keller K, Kollmar O, Glanemann M, Menger MD, Sperling J.

Intra-arterial EmboCept S® and DC Bead® effectively inhibit tumor growth of colorectal rat liver metastases.

BMC CANCER. 2019; 19:938