Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes
Leitung: Prof. Dr. med. Michael D. Menger
Publikationen 2007

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Abshagen K, Eipel C, Kalff JC, Menger MD, Vollmar B.

Loss of NF-kappaB activation in Kupffer cell-depleted mice impairs liver regeneration after partial hepatectomy.

Am J Physiol Gastrointest Liver Physiol.2007;292:G1570-7.

Contaldo C, Meier C, Elsherbiny A, Harder Y, Trentz O, Menger MD, Wanner GA.

Human recombinant erythropoietin protects the striated muscle microcirculation of the dorsal skinfold from postischemic injury in mice.

Am J Physiol Heart Circ Physiol.2007;293:H274-83.

Eipel C, Kidess E, Abshagen K, Leminh K, Menger MD, Burkhardt H, Vollmar B.

Antileukoproteinase protects against hepatic inflammation, but not apoptosis in the response of D-galactosamine-sensitized mice to lipopolysaccharide.

Br J Pharmacol.2007;151:406-13.

Eipel C, Hirschmann M, Abshagen K, Menger MD, Vollmar B.

Local interaction of apoptotic hepatocytes and Kupffer cells in a rat model of systemic endotoxemia.

Hepatol Res.2007;37:863-71.

Gierer P, Hoffmann JN, Mahr F, Menger MD, Mittlmeier T, Gradl G, Vollmar B.

Activated protein C reduces tissue hypoxia, inflammation, and apoptosis in traumatized skeletal muscle during endotoxemia.

Crit Care Med.2007;35:1966-71.

Harder Y, Amon M, Georgi M, Scheuer C, Schramm R, Rücker M, Pittet B, Erni D, Menger MD.

Aging is associated with an increased susceptibility to ischaemic necrosis due to microvascular perfusion failure but not a reduction in ischaemic tolerance.

Clin Sci (Lond).2007;112:429-40.

Holstein JH, Menger MD, Culemann U, Meier C, Pohlemann T.

Development of a locking femur nail for mice.

J Biomech.2007;40:215-19.

Holstein JH, Menger MD, Scheuer C, Meier C, Culemann U, Wirbel RJ, Garcia P, Pohlemann T.

Erythropoietin (EPO): EPO-receptor signaling improves early endochondral ossification and mechanical strength in fracture healing.

Life Sci.2007;80:893-900.

Kollmar O, Rupertus K, Scheuer C, Junker B, Tilton B, Schilling MK, Menger MD.

Stromal cell-derived factor-1 promotes cell migration and tumor growth of colorectal metastasis.


Kollmar O, Junker B, Rupertus K, Menger MD, Schilling MK.

Studies on MIP-2 and CXCR2 expression in a mouse model of extrahepatic colorectal metastasis.

Eur J Surg Oncol.2007;33:803-11.

Kollmar O, Corsten M, Scheuer C, Vollmar B, Schilling MK, Menger MD.

Portal branch ligation induces a hepatic arterial buffer response, microvascular remodeling, normoxygenation, and cell proliferation in portal blood-deprived liver tissue.

Am J Physiol Gastrointest Liver Physiol.2007;292:G1534-42.

Laschke MW, Witt K, Pohlemann T, Menger MD.
Injectable nanocrystalline hydroxyapatite paste for bone substitution: in vivo analysis of biocompatibility and vascularization.

J Biomed Mater Res B Appl Biomater.2007;82:494-505.

Laschke MW, Menger MD.
In vitro and in vivo approaches to study angiogenesis in the pathophysiology and therapy of endometriosis.

Hum Reprod Update.2007;13:331-42.

Laschke MW, Menger MD, Wang Y, Lindell G, Jeppsson B, Thorlacius H.

Sepsis-associated cholestasis is critically dependent on P-selectin-dependent leukocyte recruitment in mice.

Am J Physiol Gastrointest Liver Physiol.2007;292:G1396-1402.

Laschke MW, Elitzsch A, Scheuer C, Vollmar B, Menger MD.

Selective cyclo-oxygenase-2 inhibition induces regression of autologous endometrial grafts by down-regulation of vascular endothelial growth factor-mediated angiogenesis and stimulation of caspase-3-dependent apoptosis.

Fertil Steril.2007;87:163-71.

Le Minh K, Klemm K, Abshagen K, Eipel C, Menger MD, Vollmar B.

Attenuation of inflammation and apoptosis by pre- and posttreatment of darbepoetin-alpha in acute liver failure of mice.

Am J Pathol.2007;170:1954-63.

Lindenblatt N, Menger MD, Klar E, Vollmar B.

Darbepoetin-alpha does not promote microvascular thrombus formation in mice: role of eNOS-dependent protection through platelet and endothelial cell deactivation.

Arterioscler Thromb Vasc Biol.2007;27:1191-8.

Lindenblatt N, Platz U, Hameister J, Klar E, Menger MD, Vollmar B.

Distinct effects of acute and chronic nicotine application on microvascular thrombus formation and endothelial function in male and female mice.

Langenbecks Arch Surg.2007;392:285-95.

Meier C, Contaldo C, Schramm R, Holstein JH, Hamacher J, Amon M, Wanner GA, Trentz O, Menger MD.

Microdialysis of the rectus abdominis muscle for early detection of impending abdominal compartment syndrome.

Intensive Care Med.2007;33:1434-43.

Meier C, Contaldo C, Schramm R, Holstein JH, Hamacher J, Amon M, Wanner G, Trentz O, Menger MD.

A new model for the study of the abdominal compartment syndrome in rats.

J Surg Res. 2007;139:209-16.

Menger MD, Vollmar B.

Pathomechanisms of ischemia-reperfusion injury as the basis for novel preventive strategies: is it time for the introduction of pleiotropic compounds?

Transplant Proc.2007;39:485-8.

Moussavian MR, Slotta JE, Kollmar O, Menger MD, Schilling MK, Gronow G.

Hemoglobin induces cytotoxic damage of glycine-preserved renal tubules.

Transpl Int.2007;20:884-94.

Rupertus K, Kollmar O, Scheuer C, Junker B, Menger MD, Schilling MK.

Major but not minor hepatectomy accelerates engraftment of extrahepatic tumor cells.

Clin Exp Metastasis.2007;24:39-48.

Samnick S, Nestle U, Wagner M, Fozing T, Schaefer A, Menger MD, Kirsch CM.

Validation of 8-[123I]iodo-L-1,2,3,4-tetrahydro-7-hydroxyisoquinoline-3-carboxylic acid as an imaging agent for prostate cancer in experimental models of human prostate cancer.

Nucl Med Biol.2007;34:99-107.

Santen S, Schramm R, Menger MD, Wang Y, Jeppsson B, Thorlacius H.

P-selectin glycoprotein ligand-1 regulates chemokine-dependent leukocyte recruitment in colonic ischemia-reperfusion.

Inflamm Res.2007;56:452-8.

Schramm R, Menger MD, Harder Y, Schmits R, Adam O, Weitz-Schmidt G, Schäfers HJ.

Statins inhibit lymphocyte homing to peripheral lymph nodes.


Schramm R, Menger MD, Kirsch S, Langer F, Harder Y, Hamacher J, Schäfers HJ.

The subepicardial microcirculation in heterotopically transplanted mouse hearts: an intravital multifluorescence microscopy study.

J Thorac Cardiovasc Surg.2007;134:210-17.

Schramm R, Menger MD, Schmits R, Harder Y, Kirsch S, Meier C, Schäfers HJ.

Role of PECAM-1 in acute rejection of fully major histocompatibility complex class II-mismatched cardiac allografts in mice.


Schuett H, Eipel C, Maletzki C, Menger MD, Vollmar B.

NO counterbalances HO-1 overexpression-induced acceleration of hepatocyte proliferation in mice.

Lab Invest.2007;87:602-12.

Seehofer D, Stockmann M, Schirmeier A, Nüssler AK, Cho SY, Rayes N, Koch M, Schiller R, Menger MD, Neuhaus P.

Intraabdominal bacterial infections significantly alter regeneration and function of the liver in a rat model of major hepatectomy.

Langenbecks Arch Surg.2007;392:273-84.

Sorg H, Hoffmann JN, Rumbaut RE, Menger MD, Lindenblatt N, Vollmar B.

Efficacy of antithrombin in the prevention of microvascular thrombosis during endotoxemia: an intravital microscopic study.

Thromb Res.2007;121:241-48.

Wettstein R, Mörsdorf P, Bächle A, Amon M, Pittet B, Menger MD, Harder Y.

Selective blockade of endothelin-B receptor improves survival of critically perfused musculocutaneous flaps.

Langenbecks Arch Surg.2007;392:331-8.