RDN CKD
INCLUSION Criteria
- CKD stage 3 (eGFR 30-59 ml/min/1.73m2 [according to the currently usedestimation formulas (MDRD, CKD-EPI]) with diabetic or non-diabetic nephropathy
- Uncontrolled hypertension with 1-5 drug classes (RAS blockade is mandatory) andsystolic office (attended) BP ≥140 mmHg and diastolic office (attended) BP ≥90confirmed by 24-h ambulatory BP systolic ≥130 mmHg and diastolic ≥80mmHg)
- Patient is adhering to a stable drug regimen including RAS blockade without changesfor a minimum of 4 weeks.
- Individual is ≥18 years of age, both genders are included.
EXCLUSION Criteria
- Anatomically significant renal artery abnormality in either renal artery which in theeyes of the interventionalist would interfere with safe catheter placement
- Other cause of hypertension that can be treated by intervention/surgery ( e.g.hemodynamically relevant renal artery stenosis, functional adrenal adenoma)
- Prior renal denervation procedure
- Office (attended) BP ≥180 mmHg systolic and/or ≥110 mmHg diastolic
- 24-h ambulatory BP ≥160 mmHg systolic
- Anatomic or functional solitary kidney, kidney transplantation
- Lack of capturing serum creatinine levels in the past
- Type I diabetes mellitus
- Nephrotic syndrome
- Contraindication to MRI
- Individual has experienced a myocardial infarction, unstable angina pectoris, or a cerebrovascular accident within 3 months of the screening visit
- Acute episode of renal disease requiring uptitration of any immunosuppressive drug regimen within the last 3 months
- Subject is pregnant, nursing, or intends to become pregnant
- Enrollment in another interventional research protocol.
- Any condition that, at the discretion of the investigator, would preclude participation in the study (e.g. non-adherence)
Ansprechpartner im Studienzentrum
Neurath,
Barbara
Leitung Studienambulanz (Geb. 24)
Dr.
Wachter,
Angelika
Stellv. Leitung Studienzentrum (Geb. 24)
