Publikationen Claudia Götz
Montenarh, M., Grässer, F.A., Götz, C. Protein Kinase CK2 and Epstein–Barr Virus. Biomedicines 2023, 11, 358.
Nickelsen A, Götz C, Lenz F, Niefind K, König S, Jose J. Analyzing the interactome of human CK2β in prostate carcinoma cells reveals HSP70-1 and Rho guanin nucleotide exchange factor 12 as novel interaction partners. FASEB BioAdvances 2023;5:114–130.
Pack M, Gulde TN, Völcker MV, Boewe AS, Wrublewsky S, Ampofo E, Montenarh M, Götz C. Protein Kinase CK2 Contributes to Glucose Homeostasis by Targeting Fructose-1,6-Bisphosphatase 1. Int J Mol Sci 2022; 24(1):428.
Boewe AS, Wemmert S, Kulas P, Schick B, Götz C, Wrublewsky S, Montenarh M, Menger MD, Laschke MW, Ampofo E. Inhibition of CK2 Reduces NG2 Expression in Juvenile Angiofibroma. Biomedicines. (2022), 10(5):966.
Birus R, El-Awaad E, Ballentin L, Alchab F, Aichele D, Ettouati L, Götz C, Le Borgne M, Jose J. 4,5,7-Trisubstituted indeno[1,2-b]indole inhibits CK2 activity in tumor cells equivalent to CX-4945 and shows strong anti-migratory effects. FEBS Open Bio. (2022), 12(2):394-411.
Lindenblatt D, Applegate V, Nickelsen A, Klußmann M, Neundorf I, Götz C, Jose J, Niefind K. Molecular Plasticity of Crystalline CK2α' Leads to KN2, a Bivalent Inhibitor of Protein Kinase CK2 with Extraordinary Selectivity. J Med Chem. (2022) 27;65(2):1302-1312.
Pack M, Götz C, Wrublewsky S, Montenarh M SGC-CK2-1 Is an Efficient Inducer of Insulin Production and Secretion in Pancreatic β-Cells. Pharmaceutics. (2021), 14(1):19.
Becker A, Götz C, Montenarh M, Philipp SE. Control of TRPM3 Ion Channels by Protein Kinase CK2-Mediated Phosphorylation in Pancreatic β-Cells of the Line INS-1. Int J Mol Sci. (2021), 22(23):13133.
Schmitt BM, Boewe AS, Götz C, Philipp SE, Urbschat S, Oertel J, Menger MD, Laschke MW, Ampofo E. CK2 Activity Mediates the Aggressive Molecular Signature of Glioblastoma Multiforme by Inducing Nerve/Glial Antigen (NG)2 Expression. Cancers (2021), 13(7):1678
Nalbach L, Roma LP, Schmitt BM, Becker V, Körbel C, Wrublewsky S, Pack M, Später T, Metzger W, Menger MM, Frueh FS, Götz C, Lin H, Fox JEM, MacDonald PE, Menger MD, Laschke MW, and Ampofo E. Improvement of islet transplantation by the fusion of islet cells with functional blood vessels September 2020 EMBO Mol Med (2020) e12616.
Montenarh M, Götz C. Protein kinase CK2 and ion channels (Review). Biomed Rep. 2020 Dec;13(6):55. doi: 10.3892/br.2020.1362. Epub 2020 Sep 30.
Scheuer R, Philipp SE, Becker A, Nalbach L, Ampofo A, Montenarh M and Götz C. Protein Kinase CK2 Controls CaV2.1-Dependent Calcium Currents and Insulin Release in Pancreatic β-Cells. Int. J. Mol. Sci. 2020, 21, 4668; doi:10.3390/ijms21134668.
Schmitt BM; Boewe AS, Becker V, Nalbach L, Gu Y, Götz C, Menger MD, Laschke MW and Ampofo E. Protein Kinase CK2 Regulates Nerve/Glial Antigen (NG)2-Mediated Angiogenic Activity of Human Pericytes. Cells 2020, 9, 1546; doi:10.3390/cells9061546.
Schmitt BM, Ampofo E, Stumpf H, Montenarh M, Götz C. The stability of CREB3/Luman is regulated by protein kinase CK2 phosphorylation. Biochem Biophys Res Commun. 2020 Mar 12;523(3):639-644. doi: 10.1016/j.bbrc.2019.12.118.
Strätker K, Haidar S, Amesty Á, El-Awaad E, Götz C, Estévez-Braun A, Jose J. Development of an in vitro screening assay for PIP5K1α lipid kinase and identification of potent inhibitors. FEBS J. 2019 Dec 26. doi: 10.1111/febs.15194.
Ampofo E, Nalbach L, Menger MD, Montenarh M, Götz C. Protein Kinase CK2-A Putative Target for the Therapy of Diabetes Mellitus? Int J Mol Sci. 2019 20(18). pii: E4398. doi: 10.3390/ijms20184398.
Lindenblatt D, Horn M, Götz C, Niefind K, Neundorf I, Pietsch M. Design of CK2β-Mimicking Peptides as Tools To Study the CK2α/CK2β Interaction in Cancer Cells. ChemMedChem. (2019),14:833-841.
Chi TF, Horbach T, Götz C, Kietzmann T, and Dimova EY. Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2(USF2) Contributes to Carcinogenesis. Cancers (2019), 11, 523.
Montenarh M, Götz C. Ecto-protein kinase CK2, the neglected form of CK2. Biomed Rep. (2018), 8:307-313.
Schnitzler A., Gratz A., Bollacke A., Weyrich M., Kuckländer U., Wünsch B., Götz C., Niefind K. and Jose J. A p-halogen bond of dibenzofuranones with the gatekeeper Phe113 in human protein kinase CK2 leads to potent tight binding inhibitors. Pharmaceuticals (2018), 11, 23.
Spohrer S, Groß R, Nalbach L, Schwind L, Stumpf H, Menger MD, Ampofo EA, Montenarh M and Götz C. Functional interplay between the transcription factors USF1 and PDX-1 and protein kinase CK2 in pancreatic beta-cells. Scientific Reports (2017), 7: 16367
Schwind L, Nalbach L, Zimmer AD, Kostelnik KB, Menegatti J, Grässer F, Götz C, and Montenarh M. Quinalizarin inhibits adipogenesis through down-regulation of transcription factors and microRNA modulation. BBA - General Subjects 1861: 3272-3281 (2017).
Bender M, Schwind L, Grundmann D, Martin M, Klotz M, Götz C, Montenarh M, Schäfer KH. Impact of protein kinase CK2 inhibitors on proliferation and differentiation of neural stem cells. Heliyon 3(6):e003182017 Jun 9; (2017)
Servas, C., Kiehlmeier, S., Hach, J., Gross, R., Götz, C., and Montenarh, M. The mammalian STE20-like kinase 1 (MST1) is a substrate for the apoptosis inhibiting protein kinase CK2. Cell Signal 36: 163–175 (2017).
Götz, C. and Montenarh, M. Protein kinase CK2 in development and differentiation. Biomedical Reports 6: 127-133 (2017)
Nienberg C., Garmann C., Gratz A., Bollacke A., Götz C. and Jose J. Identification of a Potent Allosteric Inhibitor of Human Protein Kinase CK2 by Bacterial Surface Display Library Screening. Pharmaceuticals 2017, 10(1), 6; doi: 10.3390/ph10010006.
Klein S., Meng R., Montenarh M., and Götz C. The phosphorylation of PDX-1 by protein kinase CK2 Is crucial for its stability. Pharmaceuticals 2017, 10, 2. doi: 10.3390/ph10010002.
Spohrer S., Dimova E.Y., Kietzmann T., Montenarh M., and Götz C. The nuclear fraction of protein kinase CK2 binds to the upstream stimulatory factors (USFs) in the absence of DNA. Cell Signal. 28: 23-31 (2016).
Rezk Allah D., Schwind L., Abu Asali I., Nasim J., Jacob C., Götz C., and Montenarh M. A scent of therapy: Synthetic polysulfanes with improved physico-chemical properties induce apoptosis in human cancer cell lines. Int. J. Oncol. 47: 991-1000 (2015).
Gratz A, Bollacke A, Stephan S, Nienberg C, Le Borgne M, Götz C, and Jose J. Functional display of heterotetrameric human protein kinase CK2 on Escherichia coli: a novel tool for drug discovery. Microb Cell Fact. 2015 Jun 3;14:74.
Schwind L, Wilhelm N, Kartarius S, Montenarh M, Gorjup E, and Götz C. Protein kinase CK2 is necessary for the adipogenic differentiation of human mesenchymal stem cells. Biochim Biophys Acta. 1853: 2207-2216 (2015).
Horbach T, Götz C, Kietzmann T, and Dimova EY. Protein kinases as switches for the function of upstream stimulatory factors: implications for tissue injury and cancer. Front Pharmacol. 2015; 6: 3. doi: 10.3389/fphar.2015.00003
Schwind L, Zimmer AD, Götz C, Montenarh M. CK2 phosphorylation of C/EBPδ regulates its transcription factor activity. Int J Biochem Cell Biol. 61: 81 - 89 (2015).
Hochscherf J, Lindenblatt D, Steinkrüger M, Yoo E, Ulucan O, Herzig S, Issinger OG, Helms V, Götz C, Neundorf I, Niefind K, Pietsch M: Development of a HTS-compatible assay to identify inhibitors of the CK2α/CK2β interaction. Anal Biochem. 468: 4 – 14 (2015).
Horbach T, Chi TF, Götz C, Sharma S, Juffer AH, et al. (2014) GSK3β-Dependent Phosphorylation Alters DNA Binding, Transactivity and Half-Life of the Transcription Factor USF2. PLoS ONE 9(9): e107914
Lupp S., Götz C., Khadouma S., Horbach T., Dimova EY., Bohrer A.M., Kietzmann T., and Montenarh M. The upstream stimulatory factor USF1 is regulated by protein kinase CK2 phosphorylation. Cell Signal. 26:2809-2817 (2014).
Götz C. and Montenarh M: Protein kinase CK2 in the ER response. Ad. Biol.Chem. 3: 1-5 (2013).
Welker S., Götz C., Servas C., Laschke M.W., Menger M.D., Montenarh M. Glucose regulates protein kinase CK2 in pancreatic β-cells and its interaction with PDX-1. Int J Biochem Cell Biol. 45:2786-95 (2013).
Ampofo E., Sokolowsky T., Götz C., Montenarh M. Functional interaction of protein kinase CK2 and activating transcription factor 4 (ATF4), a key player in the cellular stress response. Biochim. Biophys. Acta Mol. Cell. Res. 1833: 439- 451 (2013)
Hundsdörfer C., Hemmerling HJ, Hamberger J., Le Borgne M., Bednarski P., Götz C., Totzke F., Jose J. Novel indeno[1,2-b]indoloquinones as inhibitors of the human protein kinase CK2 with antiproliferative activity towards a broad panel of cancer cell lines. Biochem Biophys Res Commun. 424: 71-5. (2012).
Hundsdörfer, C., Hemmerling, H.J., Götz, C., Totzke, F., Bednarski, P., Le Borgne, M., and Jose, J. Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors. Bioorg Med Chem. 20: 2282-2289 (2012).
Götz, C., Gratz, A., Kucklaender, U., and Jose, J. TF - a novel cell-permeable and selective inhibitor of human protein kinase CK2 induces apoptosis in the prostate cancer cell line LNCaP. BBA – General subjects 1820: 970-977 (2012).
Wilhelm N., Kostelnik K., Götz C., and Montenarh M. Protein kinase CK2 is implicated in early steps of the differentiation of pre-adipocytes into adipocytes. Mol. Cell. Biochem. 365: 37-45 (2012).
Hessenauer A., Schneider C.C., Götz C., and Montenarh M. CK2 inhibition induces apoptosis via the ER stress response. Cellular Signalling 23: 145 – 151 (2011).
Schneider CC, Götz C, Hessenauer A, Günther J, Kartarius S, Montenarh M. Down-regulation of CK2 activity results in a decrease in the level of cdc25C phosphatase in different prostate cancer cell lines. Mol Cell Biochem. 356:177-84. (2011).
Gratz A, Kuckländer U, Bollig R, Götz C, Jose J. Identification of novel CK2 inhibitors with a benzofuran scaffold by novel non-radiometric in vitro assays. Mol Cell Biochem. 356: 83-90 (2011).
Meng R., Götz, C., and Montenarh M. The role of protein kinase CK2 in the regulation of the insulin production of pancreatic islet cells. Biochem. Biophys. Res. Comm. 401: 203 – 206 (2010).
Ampofo E., Kietzmann T., Zimmer A., Jakupovic M., Montenarh M. and Götz C. Phosphorylation of the von Hippel-Lindau protein (VHL) by protein kinase CK2 reduces its protein stability and affects p53 and HIF-1alpha mediated transcription: Int.J.Biochem.Cell Biol. 42: 1729 – 1735 (2010)
Meng R., Al-Quobaili F., Müller I., Götz C., Thiel G., and Montenarh M. CK2 phosphorylation of Pdx-1 regulates its transcription factor activity. Cell. Mol. Life Sci. 67(14):2481-9 (2010)
Gratz A., Götz C., and José J. A CE-based assay for human protein kinase CK2 activity measurement and inhibitor screening. Electrophoresis 31: 634 – 640 (2010).
Gratz A, Götz C, José J. A FRET-based microplate assay for human protein kinase CK2, a target in neoplastic disease. J Enzyme Inhib. Med. Chem. 25:234-9 (2010)
Schneider,C.C., Hessenauer,A., Montenarh,M. and Götz,C. p53 is dispensable for the induction of apoptosis after inhibition of protein kinase CK2. Prostate 70:126-34 (2010).
