Dr. B. Qu

Publications 2022 :

Bacterial identification and adhesive strength evaluation based on a mannose biosensor with dual-mode detection.

Cui F, Shen X, Cao B, Ji H, Liu J, Zhuang X, Zeng C, Qu B, Li S, Xu Y, Zhou Q.

Unspecific CTL Killing Is Enhanced by High Glucose via TNF-Related Apoptosis-Inducing Ligand.

Yang W, Denger A, Diener C, Kuppers F, Soriano-Baguet L, Schafer G, Yanamandra AK, Zhao R, Knorck A, Schwarz EC, Hart M, Lammert F, Roma LP, Brenner D, Christidis G, Helms V, Meese E, Hoth M, Qu B.

Front. Immunol., 21 February 2022
Sec.T Cell Biology

Light-Sheet Scattering Microscopy to Visualize Long-Term Interactions Between Cells and Extracellular Matrix.

Zhou X, Zhao R, Yanamandra AK, Hoth M, Qu B.

Front. Immunol., 28 January 2022
Sec.T Cell Biology

Publications 2021 :

Targeting the Microtubule-Network Rescues CTL Killing Efficiency in Dense 3D Matrices.
Zhao R, Zhou X, Khan ES, Alansary D, Friedmann KS, Yang W, Schwarz EC, Del Campo A, Hoth M, Qu B.
Front. Immunol., 17 August 2021
Sec.T Cell Biology

T cell stiffness is enhanced upon formation of immunological synapse.
Jung P, Zhou X, Iden S, Bischoff M, Qu B.

Elife. 2021 Jul 27;10:e66643. doi: 10.7554/eLife.66643

High Glucose Enhances Cytotoxic T Lymphocyte-Mediated Cytotoxicity.

Zhu J, Yang W, Zhou X, Zöphel D, Soriano-Baguet L, Dolgener D, Carlein C, Hof C, Zhao R, Ye S, Schwarz EC, Brenner D, Prates Roma L, Qu B.

Front Immunol. 2021 Jun 25;12:689337. doi: 10.3389/fimmu.2021.689337. eCollection 2021. PMID: 34248978 Free PMC article.

Optoregulated force application to cellular receptors using molecular motors.

Zheng Y, Han MKL, Zhao R, Blass J, Zhang J, Zhou DW, Colard-Itté JR, Dattler D, Çolak A, Hoth M, García AJ, Qu B, Bennewitz R, Giuseppone N, Del Campo A.

Nat Commun. 2021 Jun 11;12(1):3580. doi: 10.1038/s41467-021-23815-4.  PMID: 34117256 Free PMC article.

Profiling of cytokines, chemokines and growth factors in saliva and gingival crevicular fluid.

Liu Y, Zhao R, Reda B, Yang W, Hannig M, Qu B.

Micropatterned soft hydrogels to study the interplay of receptors and forces in T cell activation.

Zhang J, Zhao R, Li B, Farrukh A, Hoth M, Qu B, Del Campo

A. Acta Biomater. 2021 Jan 1;119:234-246. doi: 10.1016/j.actbio.2020.10.028. Epub 2020 Oct 21. PMID: 33099024

Characterization of immune cell migration using microfabrication.

Vesperini D, Montalvo G, Qu B, Lautenschläger F.

Biophys Rev13,

185–202 (2021). doi.org/10.1007/s12551-021-00787-9

Publications 2020 :

High glucose distinctively regulates Ca2+ influx in cytotoxic T lymphocytes upon target recognition and thapsigargin stimulation.

Zou H, Yang W, Schwär G, Zhao R, Alansary D, Yin D, Schwarz EC, Niemeyer BA, Qu B.

Eur J Immunol. 2020 Dec;50(12):2095-2098. doi: 10.1002/eji.202048577. Epub 2020 Aug 1

Interorganelle Tethering to Endocytic Organelles Determines Directional Cytokine Transport in CD4+ T Cells.

Zhou Y, Zhao R, Schwarz EC, Akbar R, Kaba M, Pattu V, Helms V, Rieger H, Nunes-Hasler P, Qu B.

J Immunol. 2020 Dec 1;205(11):2988-3000. doi: 10.4049/jimmunol.2000195. Epub 2020 Oct 26.

Migration of Cytotoxic T Lymphocytes in 3D Collagen Matrices.

Sadjadi Z, Zhao R, Hoth M, Qu B, Rieger H.

Biophys J. 2020 Dec 1;119(11):2141-2152. doi: 10.1016/j.bpj.2020.10.020.

ARRB1-Promoted NOTCH1 Degradation Is Suppressed by OncomiR miR-223 in T-cell Acute Lymphoblastic Leukemia.

Shu Y, Wang Y, Lv WQ, Peng DY, Li J, Zhang H, Jiang GJ, Yang BJ, Liu S, Zhang J, Chen YH, Tang S, Wan KX, Yuan JT, Guo W, Fu G, Qi XK, Liu ZD, Liu HY, Yang C, Zhang LH, Liu FJ, Yu J, Zhang PH, Qu B, Zhao H, He TC, Zou L.

Cancer Res. 2020 Mar 1;80(5):988-998. doi: 10.1158/0008-5472.CAN-19-1471. Epub 2019 Dec 1

Deterministic actin waves as generators of cell polarization cues.

Stankevicins L, Ecker N, Terriac E, Maiuri P, Schoppmeyer R, Vargas P, Lennon-Duménil AM, Piel M, Qu B, Hoth M, Kruse K, Lautenschläger F.

PNAS. 2020 Jan 14;117(2):826-835; first published December 27, 2019. doi :10.1073/pnas.1907845117

Publications 2019 :

A cancer-testis non-coding RNA LIN28B-AS1 activates driver gene LIN28B by interacting with IGF2BP1 in lung adenocarcinoma.

Wang C, Gu Y, Zhang E, Zhang K, Qin N, Dai J, Zhu M, Liu J, Xie K, Jiang Y, Guo X, Liu M, Jin G, Ma H, Jiang T, Yin R, Xia Y, Liu L, Wang S, Shen B, Huo R, Xu L, Sha J, Qu B, Shen H, Hu Z.

Oncogene 38. 2019 Mar 07;1611-1624. doi: 10.1038/s41388-018-0548-x

Deterministic actin waves as generators of cell polarization cues.

Stankevicins L, Ecker N, Terriac E, Maiuri P, Schoppmeyer R, Vargas P, Lennon AM, Piel M, Qu B, Hoth M, Kruse K, Lautenschlaeger F.

Proc Natl Acad Sci USA. (in press)

Publications 2018 :

A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity.

Zhou X, Friedmann KS, Lyrmann H, Zhou Y, Schoppmeyer R, Knörck A, Mang S, Hoxha C, Angenendt A, Backes CS, Mangerich C, Zhao R, Cappello S, Schwär G, Hässig C, Neef M, Bufe B, Zufall F, Kruse K, Niemeyer BA, Lis A, Qu B, Kummerow C, Schwarz EC, Hoth M.

J Physiol. 2018 Jul 15;596(14):2681-2698.

Light-Sheet microscopy for three-dimensional visualization of human immune cells.

Schoppmeyer R, Zhao R, Hoth M, Qu B.

J Vis Exp. 2018 Jun 13;(136)

Publications 2017 :

Human profilin 1 is a negative regulator of CTL mediated cell-killing and migration.

Schoppmeyer R, Zhao R, Cheng H, Hamed M, Liu C, Zhou X, Schwarz EC, Zhou Y, Knörck A, Schwär G, Ji S, Liu L, Long J, Helms V, Hoth M, Yu X, Qu B.

Eur J Immunol. 2017 Sep;47(9):1562-1572. doi: 10.1002/eji.201747124. Epub 2017 Jul 31.

Bystander cells enhance NK cytotoxic efficiency by reducing search time.

Zhou X, Zhao R, Schwarz K, Mangeat M, Schwarz EC, Hamed M, Bogeski I, Helms V, Rieger H, Qu B.

Sci Rep. 2017 Mar 13;7:44357. doi: 10.1038/srep44357

Publications 2016 :

Cytoskeleton rotation relocates mitochondria to the immunological synapse and increases calcium signals.

Maccari I, Zhao R, Peglow M, Schwarz K, Hornak I, Pasche M, Quintana A, Hoth M, Qu B, Rieger H.

Cell Calcium. 2016 Nov;60(5):309-321. doi: 10.1016/j.ceca.2016.06.007.

DNA methylation array analysis identifies breast cancer associated RPTOR, MGRN1 and RAPSN hypomethylation in peripheral blood DNA.

Tang Q, Holland-Letz T, Slynko A, Cuk K, Marme F, Schott S, Heil J, Qu B, Golatta M, Bewerunge-Hudler M, Sutter C, Surowy H, Wappenschmidt B, Schmutzler R, Hoth M, Bugert P, Bartram CR, Sohn C, Schneeweiss A, Yang R, Burwinkel B.

Oncotarget. 2016 Sep 27;7(39):64191-64202. doi: 10.18632/oncotarget.11640.

Optimality of Spatially Inhomogeneous Search Strategies.

Schwarz K, Schröder Y, Qu B, Hoth M, Rieger H.

Phys Rev Lett. 2016 Aug 5;117(6):068101. doi: 10.1103/PhysRevLett.117.068101.

Syntaxin 8 is required for efficient lytic granule trafficking in cytotoxic T lymphocytes.

Bhat SS,Friedmann KS, Knörck, Hoxha C, Leidinger P, Backes C, Meese E, Keller A, Rettig J, Hoth M, Qu B, Schwarz EC.

Biochim Biophys Acta - Molecular Cell Research. 2016 Jul;Vol. 1863, Issue 7 Part A:pp 1653-1664

Publications 2015 :

Human T cells monitored by impedance spectrometry using field-effect transistor arrays: A novel tool for single-cell adhesion and migration studies.

DNA methylation array analyses identified breast cancer-associated HYAL2 methylation in peripheral blood.

Yang R, Pfütze K, Zucknick M, Sutter C, Wappenschmidt B, Marme F, Qu B, Cuk K, Engel C, Schott S, Schneeweiss A, Brenner H, Claus R, Plass C, Bugert P, Hoth M, Sohn C, Schmutzler R, Bartram CR, Burwinkel B.

Int J Cancer. 2015 Apr 15;136(8):1845-55. doi: 10.1002/ijc.29205. Epub 2014 Sep 24.

Publications 2014 :

A simple, economic, time-resolved killing assay.

Publications 2013 :

Shaw PJ, Qu B, Hoth M, Feske S.

Molecular regulation of CRAC channels and their role in lymphocyte function.

Cell Mol Life Sci. 2013 Aug;70(15):2637-15

Schwarz EC, Qu B, Hoth M.

Calcium, cancer and killing: The role of calcium in killing cancer cells by cytotoxic T lymphocytes and natural killer cells.

Biochim Biophys Acta. 2013 Jul;1833(7):1603-1611.

Yao W, Cai X, Liu C, Qin Y, Cheng H, Ji S, Xu W, Wu C, Chen T, Xu J, Long J, Fang Z, Qu B, Hoth M, Ni Q, Zha X, Yu X.

Profilin1 potentiates apoptosis induced by staurosporine in cancer cells.

Curr Mol Med. 2013 Mar;13(3):417-428.

Publications 2012 :

Pattu V, Qu B, Schwarz EC, Strauß B, Weins L, Bhat SS, Halimani M, Marshall M, Rettig J, Hoth M.

SNARE protein expression and localization in human cytotoxic T lymphicytes

European Journal of Immunology. 2012 Feb;42(2):470-475.

Publications 2011 :

Qu B, Al-Ansary D, Kummerow C, Hoth M, Schwarz EC.

ORAI-mediated calcium influx in T cell proliferation, apoptosis and tolerance.

Pattu V, Qu B, Marshall M, Becherer U, Junker C, Matti U, Schwarz EC, Krause E, Hoth M, Rettig J.

Syntaxin7 is required for lytic granule release from cytotoxic T lymphocytes.

Qu B, Pattu V, Junker C, Schwarz EC, Bhat SS, Kummerow C, Marshall M, Matti U, Neumann F, Pfreundschuh M, Becherer U, Rieger H, Rettig J, Hoth M.

Docking of Lytic Granules at the Immunological Synapse in Human CTL Requires Vti1b-Dependent Pairing with CD3 Endosomes.

Publications 2010 :

Bogeski I, Al-Ansary D, Qu B, Niemeyer BA, Hoth M, Peinelt C.

Pharmacology of ORAI channels as a tool to understand their physiological functions.

Expert Review of Clinical Pharmacology. 2010 May;3(3):291-303.

Publications 2005 :

Kang J, Shi Y, Xiang B, Qu B, Su W, Zhu M, Zhang M, Bao G, Wang F, Zhang X, Yang R, Fan F, Chen X, Pei G, Ma L.

A Nuclear Function of β-Arrestin1 in GPCR Signaling: Regulation of Histone Acetylation and Gene Transcription.

Cell. 2005 Dec;123(5):833-847.

Publications 2004 :

Gao H, Sun Y, Wu Y, Luan B, Wang Y, Qu B, Pei G.

Identification of β-Arrestin2 as a G Protein-Coupled Receptor-Stimulated Regulator of NF-κB Pathways.

Molecular Cell. 2004 May;14(3):303-317

Publications 2003 :

Lin GF, Geng X, Chen Y, Qu B, Wang F, Hu R, Ding X.

T-box binding site mediates the dorsal activation of myf-5 in Xenopus gastrula embryos.

Dev Dyn. 2003 Jan;226(1):51-8.