Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes
Literatur
Leitung: Prof. Dr. Joachim Oertel

Originalarbeiten zu Hirntumoren

Wemmert S, Bettscheider M, Alt S, Ketter R, Kammers K, Feiden W, Steudel WI, Rahnenführer J, Urbschat S.p15 promoter methylation - A novel prognostic marker in glioblastoma patients.Int J Oncol. 2009 Jun;34(6):1743-8.

 

Fischer U, Keller A, Leidinger P, Deutscher S, Heisel S, Urbschat S, Lenhof HP, Meese E. A different view on DNA amplifications indicates frequent, highly complex, and stable amplicons on 12q13-21 in glioma. Mol Cancer Res. 2008 Apr;6(4):576-84.

 

Klein A, Zang KD, Steudel WI, Urbschat S.Different mechanisms of mitotic instability in cancer cell lines.Int J Oncol.2006 Dec;29(6):1389-96.


Wemmert S, Romeike BF, Ketter R, Steudel WI, Zang KD, Urbschat S.Intratumoral genetic heterogeneity in pilocytic astrocytomas revealed by CGH-analysis of microdissected tumor cells and FISH on tumor tissue sections.Int J Oncol. 2006 Feb;28(2):353-60.


Wemmert S, Ketter R, Rahnenfuhrer J, Beerenwinkel N, Strowitzki M, Feiden W, Hartmann C, Lengauer T, Stockhammer F, Zang KD, Meese E, Steudel WI, von Deimling A, Urbschat S.Patients with high-grade gliomas harboring deletions of chromosomes 9p and 10q benefit from temozolomide treatment.Neoplasia. 2005 Oct;7(10):883-93.


Klein A, Jung V, Zang KD, Henn W, Montenarh M, Kartarius S, Steudel WI, Urbschat S.Detailed chromosomal characterization of the breast cancer cell line MCF7 with special focus on the expression of the serine-threonine kinase 15.Oncol Rep. 2005 Jul;14(1):23-31.


Prowald A, Wemmert S, Biehl C, Storck S, Martin T, Henn W, Ketter R, Meese E, Zang KD, Steudel WI, Urbschat S.Interstitial loss and gain of sequences on chromosome 22 in meningiomas with normal karyotype.Int J Oncol.2005 Feb;26(2):385-93.


Klein A, Reichardt W, Jung V, Zang KD, Meese E, Urbschat S.Overexpression and amplification of STK15 in human gliomas.Int J Oncol.2004 Dec;25(6):1789-94.


Reichardt W, Jung V, Brunner C, Klein A, Wemmert S, Romeike BF, Zang KD, Urbschat S.The putative serine/threonine kinase gene STK15 on chromosome 20q13.2 is amplified in human gliomas.Oncol Rep. 2003 Sep-Oct;10(5):1275-9.


Loeper S, Romeike BF, Heckmann N, Jung V, Henn W, Feiden W, Zang KD, Urbschat S.Frequent mitotic errors in tumor cells of genetically micro-heterogeneous glioblastomas.Cytogenet Cell Genet. 2001;94(1-2):1-8.


Romeike BF, Jung V, Feiden W, Moringlane JR, Zang KD, Urbschat SM.Distribution of epidermal growth factor receptor protein correlates with gain in chromosome 7 revealed by comparative genomic hybridization after microdissection in glioblastoma multiforme.Pathol Res Pract. 2001;197(6):427-31.


Brunner C, Jung V, Henn W, Zang KD, Urbschat S.Comparative genomic hybridization reveals recurrent enhancements on chromosome 20 and in one case combined amplification sites on 15q24q26 and 20p11p12 in glioblastomas.Cancer Genet Cytogenet. 2000 Sep;121(2):124-7.


Jung V, Romeike BF, Henn W, Feiden W, Moringlane JR, Zang KD, Urbschat S.Evidence of focal genetic microheterogeneity in glioblastoma multiforme by area-specific CGH on microdissected tumor cells.J Neuropathol Exp Neurol.1999 Sep;58(9):993-9.

Henn W, Urbschat S.[Genetic factors in the pathogenesis of brain tumors]Radiologe. 1998 Nov;38(11):898-903. German.


Lutz S, Welter C, Zang KD, Seitz G, Blin N, Urbschat K.A two-colour technique for chromosome in situ hybridization in tissue sections.J Pathol. 1992 Jul;167(3):279-82.



 

Sonstige Publikationen


Schick B, Wemmert S, Bechtel U, Nicolai P, Hofmann T, Golabek W, Urbschat S. Comprehensive genomic analysis identifies MDM2 and AURKA as novel amplified genes in juvenile angiofibromas. Head Neck. 2006 Nov 22;


Schick B, Wemmert S, Jung V, Steudel WI, Montenarh M, Urbschat S. Genetic heterogeneity of the MYC oncogene in advanced juvenile angiofibromas. Cancer Genet Cytogenet. 2006 Jan 1;164(1):25-31.


Schlade-Bartusiak K, Sasiadek MM, Bar JK, Urbschat S, Blin N, Montenarh M, Harlozinska-Szmyrka A. Cytogenetic and molecular cytogenetic characterization of the stable ovarian carcinoma cell line (OvBH-1).  Cancer Genet Cytogenet. 2006 Jan 1;164(1):10-5.


Schick B, Veldung B, Wemmert S, Jung V, Montenarh M, Meese E, Urbschat S. p53 and Her-2/neu in juvenile angiofibromas. Oncol Rep. 2005 Mar;13(3):453-7.

 

Peters I, Brunner C, Urbschat S, Schick B. A case of nasal leiomyosarcoma: the first comparative genomic hybridization analysis. Kulak Burun Bogaz Ihtis Derg. 2003 Oct;11(4):113-6.


Schick B, Urbschat S. New aspects of pathogenesis of juvenile angiofibroma. Hosp Med. 2004 May;65(5):269-73. Review


Schick B, Rippel C, Brunner C, Jung V, Plinkert PK, Urbschat S. Numerical sex chromosome aberrations in juvenile angiofibromas: genetic evidence for an androgen-dependent tumor? Oncol Rep. 2003 Sep-Oct;10(5):1251-5


Brunner C, Urbschat S, Jung V, Praetorius M, Schick B, Plinkert PK.Chromosomal alterations in juvenile angiofibromas] HNO. 2003 Dec;51(12):981-5. German.


Muller P, Pfeiffer P, Koglin J, Schafers HJ, Seeland U, Janzen I, Urbschat S, Bohm M. Cardiomyocytes of noncardiac origin in myocardial biopsies of human transplanted hearts. Circulation. 2002 Jul 2;106(1):31-5.


Steinhart H, Bohlender JE, Constantinidis J, Urbschat S, Fischer U, Iro H, Pahl S, Meese E. Genetic imbalances in preinvasive tissue of hypopharynx provide evidence for cytogenetic heterogeneity. Oncol Rep. 2001 Nov-Dec;8(6):1229-31.


Schick B, Brunner C, Praetorius M, Plinkert PK, Urbschat S. First evidence of genetic imbalances in angiofibromas. Laryngoscope. 2002 Feb;112(2):397-401.


Steinhart H, Bohlender J, Iro H, Jung V, Constantinidis J, Gebhart E, Pahl S, Urbschat S. DNA amplification on chromosome 7q in squamous cell carcinoma of the tongue.Int J Oncol.2001 Oct;19(4):851-5.


Breitkreuz T., Konstantinos R., Lutz S., Seitz.G., Bonkhoff H., Unteregger G., Zwergel T., Zang K.D., Wullich B. Genotypic characterization of prostatic carcinomas: A combined cytogenetic, Flow Cytometry, and in situ DNA hybridization study. Cancer Res 1993 53:4035-4040


Lutz S., Welter C., Urbschat K., Seitz G., Blin N. Regional loss of the Y chromosome in urothelial carcinoma. Internat J of Oncol 1992, 1:115-119


Schneider G., Lutz S., Henn W., Zang K.D. Blin N. Search for putative suppressor genes in meningeoma: significance of chromosome 22. Hum Genet. 1992, 88:579-582


Müllenbach R., Lutz S., Holzmann K., Dooley S., Blin N. Non-alphoid repetitive DNA sequence from human chromosome 21. Hum Genet 1992, 89:519-523


Herzog R., Lutz S., Blin N., Marasa J.C., Blinder M. A., Tollefsen D. M. Complete nucleotide sequence of the gene for human heparin growth factor II and mapping of chromosomal band 22q11. Biochemistry 1991, 30:1350-1357


Holzmann K., Herzog R., Lutz S., Theisinger B., Müllenbach R., Klein V., Blin N. New RFLP markers for human G-group chromosomes. BTF 5, Adv  Mol Gen 1991, 3:189-192


Scherthan H., Lutz S., Metzdorf R., Blin N. Interspecies relationship of a chromosome specific DNA. Hereditas 1989, 111:183-188

 


Übersichtsarbeiten

Henn W., Urbschat S. (1998) Genetische Grundlagen der Entstehung von Hirntumoren.Radiologe 38:898-903


Schick B., Urbschat S. (2004) New aspects of pathogenesis of juvenile angiofibroma.Hospital Medicine 65 (5):269-273



Buchbeitrag


Steilen-Gimbel H. and Urbschat S. Simultaneous multicolor-FISH and immunocytochemical analysis of fresh tumor material. FISH Technology (Rautenstrauß/Liehr Eds.)Springer Lab Manual, 2002 Chapter 33 (experimental chapter)