Center of Breath Research

2022

Population pharmacokinetic modeling of multiple-dose intravenous fosfomycin in critically ill patients during continuous venovenous hemodialysis.

Hüppe T, Götz KM, Meiser A, de Faria Fernandes A, Maurer F, Groesdonk HV, Volk T, Lehr T, Kreuer S.Sci Rep. 2023 Oct 24;13(1):18132. doi: 10.1038/s41598-023-45084-5.PMID: 37875513
 

A randomized open label, parallel-group study to evaluate the hemodynamic effects of Cafedrine/Theodrenaline vs Noradrenaline in the treatment of intraoperative hypotension after induction of general anesthesia: the "HERO" study design and rationale.

Vojnar B, Geldner G, Huljic-Lankinen S, Murst M, Keller T, Weber S, Gaik C, Koch T, Weyland A, Kranke P, Kreuer S, Chappell D, Eberhart L.Curr Med Res Opin. 2023 Jun;39(6):803-810. doi: 10.1080/03007995.2023.2213124. Epub 2023 May 23.PMID: 37211772
 

Quantification of exhaled propofol is not feasible during single-lung ventilation using double-lumen tubes: A multicenter prospective observational trial.

Hüppe T, Kreuer S, Wulf H, Freitag D, Seidel M, Teucke T, Maurer F, Kirschbaum A, Koch T, Langer F, Volk T, Feldmann C.Acta Anaesthesiol Scand. 2023 Apr;67(4):455-461. doi: 10.1111/aas.14201. Epub 2023 Jan 27.PMID: 36644966
 

Humidity and measurement of volatile propofol using MCC-IMS (EDMON).

Teucke T, Maurer F, Müller-Wirtz LM, Volk T, Sessler DI, Kreuer S.J Clin Monit Comput. 2023 Apr;37(2):493-500. doi: 10.1007/s10877-022-00907-0. Epub 2022 Sep 21.PMID: 36129642

Model-Based Analysis of SARS-CoV-2 Infections, Hospitalization and Outcome in Germany, the Federal States and Districts.

Dings C, Götz KM, Och K, Sihinevich I, Werthner Q, Smola S, Bliem M, Mahfoud F, Volk T, Kreuer S, Rissland J, Selzer D, Lehr T.Viruses. 2022 Sep 24;14(10):2114. doi: 10.3390/v14102114.PMID: 36298669
 

Exhaled Aldehydes as Biomarkers for Lung Diseases: A Narrative Review.

Floss MA, Fink T, Maurer F, Volk T, Kreuer S, Müller-Wirtz LM.Molecules. 2022 Aug 17;27(16):5258. doi: 10.3390/molecules27165258.PMID: 36014494
 

Intravenous propofol, ketamine (ketofol) and rocuronium after sevoflurane induction provides long lasting anesthesia in ventilated rats.

Kiefer D, Müller-Wirtz LM, Maurer F, Hüppe T, Mathes AM, Volk T, Kreuer S, Fink T.Exp Anim. 2022 May 20;71(2):231-239. doi: 10.1538/expanim.21-0147. Epub 2021 Dec 8.PMID: 34880161
 

2021

Intravenous propofol, ketamine (ketofol) and rocuronium after sevoflurane induction provides long lasting anesthesia in ventilated rats.

Kiefer D, Müller-Wirtz LM, Maurer F, Hüppe T, Mathes AM, Volk T, Kreuer S, Fink T.

Exp Anim. 2021 Dec 8. doi: 10.1538/expanim.21-0147. Online ahead of print. PMID: 34880161
 

Quantification of Volatile Acetone Oligomers Using Ion-Mobility Spectrometry.

Hüppe T, Lorenz D, Maurer F, Fink T, Klumpp R, Kreuer S.

J Anal Methods Chem. 2021 Aug 2;2021:6638036. doi: 10.1155/2021/6638036. eCollection 2021.PMID: 34395017
 

Differential Response of Pentanal and Hexanal Exhalation to Supplemental Oxygen and Mechanical Ventilation in Rats.

Müller-Wirtz LM, Kiefer D, Knauf J, Floss MA, Doneit J, Wolf B, Maurer F, Sessler DI, Volk T, Kreuer S, Fink T.

Molecules. 2021 May 7;26(9):2752. doi: 10.3390/molecules26092752. PMID: 34067078
 

Quantification of Volatile Aldehydes Deriving from In Vitro Lipid Peroxidation in the Breath of Ventilated Patients.

Müller-Wirtz LM, Kiefer D, Ruffing S, Brausch T, Hüppe T, Sessler DI, Volk T, Fink T, Kreuer S, Maurer F.

Molecules. 2021 May 21;26(11):3089. doi: 10.3390/molecules26113089. PMID: 34064214
 

Volutrauma Increases Exhaled Pentanal in Rats: A Potential Breath Biomarker for Ventilator-Induced Lung Injury.

Müller-Wirtz LM, Kiefer D, Maurer F, Floss MA, Doneit J, Hüppe T, Shopova T, Wolf B, Sessler DI, Volk T, Kreuer S, Fink T. Anesth Analg. 2021 Jul 1;133(1):263-273. doi: 10.1213/ANE.0000000000005576. PMID: 33929393
 

[Erratum to: Treatment of intraoperative hypotension with cafedrine/theodrenaline versus ephedrine. A prospective, national, multicenter, non-interventional study-the HYPOTENS trial].

Eberhart L, Geldner G, Kowark A, Zucker TP, Kreuer S, Przemeck M, Huljic S, Koch T, Keller T, Weber S, Kranke P; HYPOTENS study group.

Anaesthesist. 2021 Apr;70(4):358. doi: 10.1007/s00101-021-00932-9. PMID: 33635373
 

Treatment of spinal anaesthesia-induced hypotension with cafedrine/theodrenaline versus ephedrine during caesarean section: Results from HYPOTENS, a national, multicentre, prospective, noninterventional study.

Kranke P, Geldner G, Kienbaum P, Gerbershagen HJ, Chappell D, Wallenborn J, Huljic S, Koch T, Keller T, Weber S, Kunitz O, Linstedt U, Eberhart LHJ; HYPOTENS study group.

Eur J Anaesthesiol. 2021 Feb 19. doi: 10.1097/EJA.0000000000001474. Online ahead of print. PMID: 33625060
 

Quantitative Determination of Fosfomycin in 10 μL of Plasma and Dialysate by Hydrophilic Interaction Liquid Chromatography Electrospray Ionization Mass Spectrometry.

Shopova T, Hüppe T, Wolf B, Sessler DI, Volk T, Groesdonk HV, Kreuer S, Maurer F.

J Chromatogr Sci. 2021 Jan 14;59(2):165-174. doi: 10.1093/chromsci/bmaa092. PMID: 33302294
 

2020

Treatment of intraoperative hypotension with cafedrine/theodrenaline versus ephedrine : A prospective, national, multicenter, non-interventional study-the HYPOTENS trial.

Eberhart L, Geldner G, Kowark A, Zucker TP, Kreuer S, Przemeck M, Huljic S, Koch T, Keller T, Weber S, Kranke P; HYPOTENS study group.Eberhart L, et al. Among authors: kreuer s. Anaesthesist. 2020 Nov 10.

Changes in volatile organic compounds provoked by lipopolysaccharide- or alpha toxin-induced inflammation in ventilated rats.

Lorenz D, Maurer F, Philipp D, Albrecht F, Hüppe T, Sessler DI, Wolf B, Volk T, Kreuer S, Fink T.Lorenz D, et al.
J Breath Res. 2020 Oct 24;15(1):016003.

Response by the authors, reflection of volatile anesthetic by the vapor-clean filter.

Müller-Wirtz LM, Meiser A, Kermad A, Godsch C, Sessler DI, Volk T, Kreuer S, Hüppe T.

Acta Anaesthesiol Scand. 2020 Jul 19. doi: 10.1111/aas.13675.

Exhaled Volatile Organic Compounds during Inflammation Induced by TNF-α in Ventilated Rats.

Albrecht FW, Maurer F, Müller-Wirtz LM, Schwaiblmair MH, Hüppe T, Wolf B, Sessler DI, Volk T, Kreuer S, Fink T.

Metabolites. 2020 Jun 15;10(6):245.

Exhaled Propofol Concentrations Correlate With Plasma and Brain Tissue Concentrations in Rats.

Müller-Wirtz LM, Maurer F, Brausch T, Kiefer D, Floss M, Doneit J, Volk T, Sessler DI, Fink T, Lehr T, Kreuer S.

Anesth Analg. 2020 Feb 27.

Residual volatile anesthetics after workstation preparation and activated charcoal filtration.

Müller-Wirtz LM, Godsch C, Sessler DI, Volk T, Kreuer S, Hüppe T.

Acta Anaesthesiol Scand. 2020 Mar 9.

Volatile organic compounds in head and neck squamous cell carcinoma-An in vitro pilot study.

Kulas P, Seidel M, Bozzato A, Schick B, Sessler DI, Kreuer S, Hüppe T.

Biomed Chromatogr. 2020 Feb 14:e4811.

2019

Retrospective comparison of Eleveld, Marsh, and Schnider propofol pharmacokinetic models in 50 patients.

Hüppe T, Maurer F, Sessler DI, Volk T, Kreuer S.

Br J Anaesth. 2019 Dec 2. pii: S0007-0912(19)30847-5

Plasma Disappearance Rate of Indocyanine Green for Determination of Liver Function in Three Different Models of Shock.

Mathes A, Plata C, Rensing H, Kreuer S, Fink T, Raddatz A.

Diagnostics (Basel). 2019 Aug 31;9(3).

Stability of Propofol (2,6-Diisopropylphenol) in Thermal Desorption Tubes during Air Transport.

Maurer F, Geiger M, Volk T, Sessler DI, Kreuer S, Hüppe T.

Int J Anal Chem. 2019 May 2;2019:3987417.

Performance of target-controlled infusion of propofol in plasma versus effect-site control during induction in elderly patients: A Letter To The Editor.

Schraag S, Petscher M, Wachter U, Kreuer S, Kenny G, Wagner F.

J Clin Anesth. 2019 Apr 24;58:9-11.

Simultaneous quantification of propofol, ketamine and rocuronium in just 10 μL plasma using liquid chromatography coupled with quadrupole mass spectrometry and its pilot application to a pharmacokinetic study in rats.

Shopova T, Kiefer D, Wolf B, Maurer F, Sessler DI, Volk T, Fink T, Kreuer S.

Biomed Chromatogr. 2019 Aug;33(8):e4540.
 

Modern breath analysis.

Wirtz LM, Kreuer S, Volk T, Hüppe T.

Med Klin Intensivmed Notfmed. 2019 Feb 6. doi: 10.1007/s00063-019-0544-0. [Epub ahead of print] Review. German.
 

Volatile Organic Compounds in Patients With Acute Kidney Injury and Changes During Dialysis.

Hüppe T, Klasen R, Maurer F, Meiser A, Groesdonk HV, Sessler DI, Fink T, Kreuer S.

Crit Care Med. 2019 Feb;47(2):239-246.

 

2018
 

Developments to monitor the exhalome in organ failure in critically ill patients—a look into the future

Hüppe T, Volk T, Kreuer S.

J Breath Res. 2018 Oct 30;13(1):017101. doi: 10.1088/1752-7163/aae210.
 

Corrigendum to "Design and validation of an automated solid phase extraction liquid chromatography coupled mass spectrometry method for the quantification of propofol in plasma" [J. Pharm. Biomed. Anal. 150 (2018) 341-346].

Maurer F, Shopova T, Wolf B, Kiefer D, Hüppe T, Volk T, Sessler DI, Kreuer S.

J Pharm Biomed Anal. 2018 Apr 15;152:322. doi: 10.1016/j.jpba.2018.02.039
 

Design and validation of an automated solid phase extraction liquid chromatography coupled mass spectrometry method for the quantification of propofol in plasma

Maurer F, Shopova T, Wolf B, Kiefer D, Hüppe T, Volk T, Sessler DI, Kreuer S

J Pharm Biomed Anal. 2018 Apr 15;152:322

 

2017
 

The central nervous system as the target organ of general anesthesia.

Kreuer S, Hüppe T.

Anaesthesist. 2017 Sep;66(9):643-644.

Design and validation of an automated solid phase extraction liquid chromatography coupled mass spectrometry method for the quantification of propofol in plasma.

Maurer F, Shopova T, Wolf B, Kiefer D, Hüppe T, Volk T, Sessler DI, Kreuer S.

J Pharm Biomed Anal. 2017 Dec 21;150:341-346.
 

Dissection of iron signaling and iron accumulation by overexpression of subgroup Ib bHLH039 protein.

Naranjo-Arcos MA, Maurer F, Meiser J, Pateyron S, Fink-Straube C, Bauer P.

Sci Rep. 2017 Sep 7;7(1):10911
 

Remifentanil up2date – Teil 2.

Bushuven F, Kreuer S, Kranke P.

Anästhesiol Intensivmed Notfallmed Schmerzther 2017; 52: 630–639
 

The central nervous system as the target organ of general anesthesia.

Kreuer S, Hüppe T.

Anaesthesist. 2017 Aug 22
 

Volatile organic compounds in ventilated critical care patients: a systematic evaluation of cofactors.

Hüppe T, Lorenz D, Wachowiak M, Maurer F, Meiser A, Groesdonk H, Fink T, Sessler DI, Kreuer S.

BMC Pulm Med. 2017 Aug 22;17(1):116.
 

Adhesion of volatile propofol to breathing circuit tubing.

Lorenz D, Maurer F, Trautner K, Fink T, Hüppe T, Sessler D, Baumbach JI, Volk T and Kreuer S.

J. Breath Res.  2017 Aug 21;11(3):036005
 

Remifentanil up2date – Teil 1.

Bushuven F, Kreuer S.

Anästhesiol Intensivmed Notfallmed Schmerzther 2017; 52: 543–553
 

Calibration and validation of a MCC/IMS prototype for exhaled propofol online measurement.

Maurer F, Walter L, Geiger M, Baumbach JI, Sessler DI, Volk T, Kreuer S.

Journal of Pharmaceutical and Biomedical Analysis 2017 Jul 1;145:293-297
 

Validation of liquid and gaseous calibration techniques forquantification of propofol in breath with sorbent tube ThermalDesorption System GC–MS.

Maurer F, Geiger M, Volk T, Sessler D, Kreuer S.

Journal of Pharmaceutical and Biomedical Analysis 2017 Sep 5;143:116-122
 

Adherence of volatile propofol to various types of plastic tubing.

Maurer F, Lorenz DJ, Pielsticker G, Volk T, Sessler DI, Baumbach JI, Kreuer S.

J Breath Res. 2017 Jan 23;11(1):016009
 

Factor XIII : Pharmacodynamic and pharmacokinetic characteristics.

Adam EH, Kreuer S, Zacharowski K, Weber CF, Wildenauer R.

Anaesthesist. 2017 Jan;66(1):52-59

 

2016
 

Metabolism of 3-pentanone under inflammatory conditions.

Kleber A , Maurer F, Lorenz D, Wolf B, Albrecht F, Shopova T, Sessler DI, Volk T, Kreuer S, Fink T.

J Breath Res. 2016; 28;10:047101
 

Exhalation of volatile organic compounds during hemorrhagic shock and reperfusion in rats: an exploratory trial.

Hüppe T, Lorenz D, Maurer F, Albrecht FW, Schnauber K, Wolf B, Sessler DI, Volk T, Fink T, Kreuer S.

J Breath Res. 2016; 14; 10: 016016
 

On the origin and nature of the grating interferometric dark-field contrast obtained with low-brilliance x-ray sources.

Koenig T, Zuber M, Trimborn B, Farago T, Meyer P, Kunka D, Albrecht F, Kreuer S, Volk T, Fiederle M, Baumbach T.

Phys Med Biol. 2016; 7; 6: 3427-42
 

Imaging properties of high aspect ratio absorption gratings for use in preclinical x-ray grating interferometry.

Trimborn B, Meyer P, Kunka D, Zuber M, Albrecht F, Kreuer S, Volk T, Baumbach T, Koenig T.

Phys Med Biol. 2016; 21; 61: 527-41

 

2015
 

Exhalation pattern changes during fasting and low dose glucose treatment in rats.

Fink T, Albrecht FW, Maurer F, Kleber A, Hüppe T, Schnauber K, Wolf B, Baumbach JI, Volk T, Kreuer S.

Anal Bioanal Chem. 2015; 407: 3763-73
 

Influence of the respirator on volatile organic compounds: an animal study in rats over 24 hours.

Albrecht FW, Hüppe T, Fink T, Maurer F, Wolf A, Wolf B, Volk T, Baumbach JI, Kreuer S.

J Breath Res. 2015; 9; 9: 016007
 

Volatile organic compounds during inflammation and sepsis in rats: a potential breath test using ion-mobility spectrometry.

Fink T, Wolf A, Maurer F, Albrecht FW, Heim N, Wolf B, Hauschild AC, Bödeker B, Baumbach JI, Volk T, Sessler DI, Kreuer S.

Anesthesiology. 2015; 122: 117-26
 

On-chip three-dimensional cell culture in phaseguides improves hepatocyte functions in vitro.

Jang M, Neuzil P, Volk T, Manz A, Kleber A.

Biomicrofluidics. 2015; 23; 9: 034113
 

Melatonin or ramelteon therapy differentially affects hepatic gene expression profiles after haemorrhagic shock in rat-A microarray analysis.

Kleber A, Ruf CG, Wolf A, Fink T, Glas M, Wolf B, Volk T, Abend M, Mathes AM.

Exp Mol Pathol. 2015; 99: 189-97

 

2014
 

Two different approaches for pharmacokinetic modeling of exhaled drug concentrations.

Kreuer S, Hauschild A, Fink T, Baumbach JI, Maddula S, Volk T.

Sci Rep. 2014; 24; 4: 5423
 

Ion mobility spectrometry in breath research.

Fink T, Baumbach JI, Kreuer S.

J Breath Res. 2014; 8: 027104
 

Wash-out of ambient air contaminations for breath measurements.

Maurer F, Wolf A, Fink T, Rittershofer B, Heim N, Volk T, Baumbach JI, Kreuer S.

J Breath Res. 2014; 8: 027107
 

Multi-capillary column-ion mobility spectrometer (MCC-IMS) breath analysis in ventilated rats: a model with the feasibility of long-term measurements.

Wolf A, Baumbach JI, Kleber A, Maurer F, Maddula S, Favrod P, Jang M, Fink T, Volk T, Kreuer S.

J Breath Res. 2014; 8: 016006
 

Melatonin modifies cellular stress in the liver of septic mice by reducing reactive oxygen species and increasing the unfolded protein response.

Kleber A, Kubulus D, Rössler D, Wolf B, Volk T, Speer T, Fink T.

Exp Mol Pathol. 2014; 97: 565-71
 

Melatonin receptors mediate improvements of survival in a model of polymicrobial sepsis.Fink T, Glas M, Wolf A, Kleber A, Reus E, Wolff M, Kiefer D, Wolf B, Rensing H, Volk T, Mathes AM.

Crit Care Med. 2014; 42: e22-31
 

Inhibition of glycogen synthase kinase (GSK)-3-β improves liver microcirculation and hepatocellular function after hemorrhagic shock.

Jellestad L, Fink T, Pradarutti S, Kubulus D, Wolf B, Bauer I, Thiemermann C, Rensing H.

Eur J Pharmacol. 2014;724: 175-84
 

Impact of melatonin receptor deletion on intracellular signaling in spleen cells of mice after polymicrobial sepsis.

Kleber A, Altmeyer S, Wolf B, Wolf A, Volk T, Fink T, Kubulus D.

Inflamm Res. 2014;63: 1023-33
 

MIMA—a software for analyte identification in MCC/IMS chromatograms by mapping accompanying GC/MS measurements

Maurer F, Hauschild A, Eisinger K, Baumbach J, Mayor A, Baumbach JI

International Journal for Ion Mobility Spectrometry 2014; 2: 95-101

 

2013
 

Melatonin receptors mediate improvements of survival in a model of polymicrobial sepsis.

Fink T, Glas M, Wolf A, Kleber A, Reus E, Wolff M, Kiefer D, Wolf B, Rensing H, Volk T, Mathes AM.

Crit Care Med. 2014;42: 22-31
 

Development of a device to measure MCC-IMS peaks of pure analytes (IMS-BOX)

Kreuer S, Hellbrück R, Fink T, Heim N, Volk T, Baumbach J, Wolf A

Int. J. Ion Mobil. Spec. 2013;16: 281–286
 

Dobutamine pretreatment improves survival, liver function, and hepatic microcirculation after polymicrobial sepsis in rat.

Fink T, Heymann P, Taha-Melitz S, Taha A, Wolf B, Rensing H, Volk T, Mathes AM.

Shock. 2013;40: 129-35
 

Minimal retarded Propofol signals in human breath using ion mobility spectrometry.

Buchinger H, Kreuer S, Hellbrück R, Wolf A, Fink T, Volk T, Bödeker B, Maddula S, Baumbach J

Int. J. Ion Mobil. Spec. 2013; 16: 185–190