Topics:
Protein transport: 1. Zimmermann, R. und Mollay, C. Import of honeybee prepromelittin into the endoplasmic reticulum: requirements for membrane insertion, processing and sequestration. (1986). J. Biol. Chem. 261, 12889-12895.
Impaktfaktor 1992: 6,733 2. Müller, G. und Zimmermann, R. Import of honeybee prepromelittin into the endoplasmic reticulum: structural basis for independence of SRP and docking protein. (1987). EMBO J. 6, 2099-2107.
Impaktfaktor 1992: 12,634 3. Wiech, H., Sagstetter, M., Müller, G. und Zimmermann, R. The ATP requiring step in assembly of M 13 procoat protein into microsomes is related to preservation of transport competence of the precursor protein. (1987). EMBO J. 6, 1011-1016.
Impaktfaktor 1992: 12,634 4. Schlenstedt, G. und Zimmermann, R. Import of frog prepropeptide GLa into microsomes requires ATP but does not involve docking protein or ribosomes. (1987). EMBO J. 6, 699-703.
Impaktfaktor 1992: 12,634 5. Sagstetter, M. und Zimmermann, R. Assembly of M 13 and M 13 am8H1R1 procoat protein into microsomes is stimulated by rabbit reticulocyte lysate and ATP. (1988). Biochem. Biophys. Res. Comm. 153, 498-501.
Impaktfaktor 1992: 3,583 6. Müller, G. und Zimmermann, R. Import of honeybee prepromelittin into the endoplasmic reticulum: energy requirements for membrane insertion. (1988). EMBO J. 7, 639-648.
Impaktfaktor 1992: 12,634 7. Zimmermann, R., Sagstetter, M., Lewis, M.J. und Pelham, H.R.B. Seventy-kilodalton heat shock proteins and an additional component from reticulocyte lysate stimulate import of M 13 procoat protein into microsomes. (1988). EMBO J. 7, 2875-2880.
Impaktfaktor 1992: 12,634 8. Cobet, W., Mollay, C., Müller, G. und Zimmermann, R. Export of honeybee prepromelittin in E.coli depends on the membrane potential but does not depend on proteins secA and secY. (1989). J. Biol. Chem. 264, 10169-10176.
Impaktfaktor 1992: 6,733 9. Boman, H.G., Boman, A., Andrue, D. Li, Z., Merrifield, R.B. Schlenstedt, G. und Zimmermann, R. Chemical synthesis and enzyme processing of precursor forms of cecropin A and B. (1989). J. Biol. Chem. 264, 5852-5860.
Impaktfaktor 1992: 6,733 10. Schlenstedt, G., Gudmundsson, G.H., Boman, H.G. und Zimmermann, R. A large presecretory protein translocates both cotranslationally, using signal recognition particle and ribosomes, and posttranslationally, without these ribonucleoparticles, when synthesized in the presence of mammalian microsomes. (1990). J. Biol. Chem. 265, 13960-13968.
Impaktfaktor 1992: 6,733 11. Zimmermann, R., Sagstetter, M. und Schlenstedt, G. Ribonuleoparticle-independent import of proteins into mammalian microsomes involves a membrane protein which is sensitive to chemical alkylation. (1990). Biochimie 72, 95-101.
Impaktfaktor 1992: 1,627 12. Klappa, P., Mayinger, P., Pipkorn, R., Zimmermann, M. und Zimmermann, R. A microsomal protein is involved in ATP-dependent transport of presecretory proteins into mammalian microsomes. (1991). EMBO J. 10, 2795-2803.
Impaktfaktor 1992: 12,634 13. Zimmermann, R., Zimmermann, M., Mayinger, P. und Klappa, P. Photoaffinity labeling of mammalian microsomes with azido-ATP affects association of nascent presecretory proteins with the signal sequence receptor complex. (1991). FEBS Lett. 285, 95-99.
Impaktfaktor 1992: 3,505 14. Schlenstedt, G., Gudmundsson, G.H., Boman, H.G. und Zimmermann, R. Structural requirements for transport of preprocecropinA and related presecretory proteins into mammalian microsomes. (1992). J. Biol. Chem. 267, 24328-24332.
Impaktfaktor 1992: 6,733 15. Wiech, H., Buchner J., Zimmermann, M., Zimmermann, R. und Jakob, U. Hsc70, BiP and Hsp90 differ in their ability to stimulate transport of precursor proteins into mammalian microsomes. (1993). J. Biol. Chem. 268, 7414-7421.
Impaktfaktor 1993: 6,793 16. Schlenstedt, G., Zimmermann, M. und Zimmermann, R. A stably folded presecretory protein associates with and upon unfolding translocates across the membrane of mammalian microsomes. (1994). FEBS Lett. 340, 139-144.
Impaktfaktor 1994: 3,6 17. Klappa, P., Zimmermann, M. und Zimmermann, R. The membrane proteins TRAMp and sec61ap may be involved in postranslational transport of presecretory proteins into mammalian microsmes. (1994). FEBS Lett. 341, 281-287.
Impaktfaktor 1994: 3,6 18. Jung, C. und Zimmermann, R. The relationship between size of a presecretory protein and extent of signal recognition particle mediated arrest of its translation. (1994). Biochem. Biophys. Res. Commun. 205, 603-611.
Impaktfaktor 1994: 3,4 19. Klappa, P., Freedman, R.B. und Zimmermann, R. Protein disulphide isomerase and a lumenal cyclphilin-type peptidyl prolyl cis-trans isomerase are in transient contact with secretory proteins during late stages of translocation. (1995). Eur. J. Biochem. 232, 755-764.
Impaktfaktor 1995: 3,451 20. Brunke, M., Tyedmers, J. und Zimmermann, R. Protein folding within and protein transport into dog pancreas microsomes are differentially affected by photoaffinity labeling of microsomes with 8-azido-ATP. (1996). Biochem. Biophys. Res. Commun. 218, 454-460.
Impaktfaktor 1996: 2,872 21. Dierks, T., Volkmer, J., Schlenstedt, G., Jung, C., Sandholzer, U., Zachmann, K., Schlotterhose, P., Neifer, K., Schmidt, B. und Zimmermann, R. A microsomal ATP-binding protein involved in efficient protein transport into the mammalian endoplasmic reticulum. (1996). EMBO J. 15, 6931-6942.
Impaktfaktor 1996: 13,255 22. Volkmer, J., Guth, S., Nastainczyk, W., Knippel, P., Klappa, P., Gnau, V. und Zimmermann, R. Pancreas-specific protein disulfide isomerase, PDIp, is in transient contact with secretory proteins during late stages of translocation. (1997). FEBS Lett. 406, 291-295.
Impaktfaktor 1997: 3,504 23. Elliott, J.G., Oliver, J.D., Volkmer, J., Zimmermann, R. und High, S. In vitro characterization of the interaction between newly synthesized proteins and a pancreatic isoform of protein disulfide isomerase. (1998). Eur. J. Biochem. 252, 372-377.
Impaktfaktor 1998: 3,25 24. Moeller, I., Jung, M., Beatrix, B., Levy, R., Kreibich, G., Zimmermann, R., Wiedmann, M. und Lauring, B. A general mechanism for regulation of access to the translocon: Competition for a membrane attachment site on ribosomes. (1998). Proc. Natl. Acad. Sci. USA 95, 13425-13430.
Impaktfaktor 1998: 9,821 25. Bies, C., Guth, S., Janoschek, K., Nastainczyk, W., Volkmer, J. und Zimmermann, R. A Scj1p homolog and folding catalysts present in dog pancreas microsomes. (1999). Biol. Chem. 380, 1175-1182.
Impaktfaktor 1999: 3,356 26. Tyedmers, J., Lerner, M., Bies, C., Dudek, J., Skowronek, M., Haas, I., Heim, N., Nastainczyk, W., Volkmer, J. und Zimmermann, R. Homologs of yeast transport proteins Sec62p and Sec63p are abundant proteins in the dog pancreas microsomes. (2000). Proc. Natl. Acad. Sci. USA 97, 7214-7219.
Impaktfaktor 2000: 10,789 27. Faust, M., Jung, M., Günther, J., Zimmermann, R. und Montenarh, M. Localization of individual subunits of protein kinase CK2 to the endoplasmic reticulum and to the Golgi apparatus. (2001). Mol. Cell. Biochem. 227, 73-80.
Impaktfaktor 2001: 1,548 28. Dudek, J., Volkmer, J., Bies, C., Guth, S., Müller, A., Lerner, M., Feick, P., Schäfer, K.-H., Morgenstern, E., Hennessy, F., Blatch, G. L., Janoscheck, K., Heim, N., Frien, M., Nastainczyk, W. und Zimmermann, R. A novel type of cochaperone mediates transmembrane recruitment of DnaK-like chaperones to ribosomes. (2002). EMBO J. 21, 2958-2967.
Impaktfaktor 2002: 10,698 29. Abell, B.M., Jung, M., Oliver, J.D., Knight, B.C., Tyedmers, J., Zimmermann, R. und High, S. Tail-anchored and signal-anchored proteins utilise overlapping pathways during membrane insertion. (2003). J. Biol. Chem. 278, 5669-5678.
Impaktfaktor 2003: 6,482 30. Fehrmann, F., Jung, M., Zimmerann, R. und Kräusslich, H.-G. Transport of MIA polyprotein to the endoplasmic reticulum is mediated by SRP. (2003). J. Virol. 77, 6239-6304.
Impaktfaktor 2003: 5,225 31. Tyedmers, J., Lerner, M., Wiedmann, M., Volkmer, J. und Zimmermann, R. Polypeptide chain binding proteins mediate completion of cotranslational protein translocation into the mammalian endoplasmic reticulum. (2003). EMBO reports 4, 505-510.
Impaktfaktor 2003: 7,39 32. Wirth, A., Jung, M., Bies, C., Frien, M., Tyedmers, J. und Zimmermann, R. The Sec61p complex is a dynamic precursor activated channel. (2003). Mol. Cell 12, 261-268.
Impaktfaktor 2003: 16,835 33. Bies, C., Blum, R., Dudek, J., Nastainczyk, W., Oberhauser, S., Jung, M. und Zimmermann, R. Characterization of pancreatic ERj3p, a homolog of yeast DnaJ-like protein Scj1p. (2004). Biol. Chem. 385, 389-395.
Impaktfaktor 2004: 3,678 34. Guth, S., Völzing, C., Müller, A., Lerner, M., Jung, M. und Zimmermann, R. Protein transport into canine pancreatic microsomes: a quantitative approach. (2004). Eur. J. Biochem. 271, 3200-3207.
Impaktfaktor 2004: 3,26 35. Tyedmers, J., Lerner, M., Nastainczyk, W. und Zimmermann, R. Calumenin and reticulocalbin are associated with the protein translocase of the mammalian endoplasmic reticulum. (2005). J. Biol. Sci. 5, 70-75. 36. Dudek, J., Greiner, M., Müller, A., Hendershot, L.M., Kopsch, K., Nastainczyk, W. und Zimmermann, R. (2005) ERj1p has a basic role in protein biogenesis at the endoplasmic reticulum, Nat. Struct. Mol. Biol. 12, 1008-1014.
Impaktfaktor 2005:12,19 37. Blau, M., Mullapudi, S., Becker, T., Dudek, J., Zimmermann, R., Penczek, P. A. und Beckmann, R. (2005) ERj1p uses a universal ribosomal adaptor site to coordinate the 80S ribosome at the mebrane, Nat. Struct. Mol. Biol. 12, 1015-1016.
Impaktfaktor 2005: 12,19
38. Dudek, J., Diaz de Escauriaza, M., Müller, A., Nastainczyk, W., Scholtes, P. und Zimmermann, R. (2006) Signal recognition particle mediated arrest of translation involves competition with eEF2 on the ribosome, J. Biol. Sci. 6, 316-319. 39. Weitzmann A., Baldes, C., Dudek, J. und Zimmermann, R.(2007) The Hsp70-molecular chaperone network in the pancreatic endoplasmic reticulum: a quantitative approach, FEBS J. 274, 5175-5187.
Impaktfaktor 2007: 3,396 40. Zahedi, R. P., Völzing, C., Schmitt, A., Frien, M., Jung, M., Dudek, J., Wortelkamp, S., Sickmann, A. und Zimmermann, R. (2009) Analysis of the membrane proteome of canine pancreatic rough microsomes identifies a novel Hsp40, termed ERj7, Proteomics 9, 3463-3473.
Impaktfaktor2009: 4,426
41. Erdmann, F., Jung, M., Eyrisch, S., Lang, S., Helms, V., Wagner, R. und Zimmermann, R. (2009) Lanthanum inhibits the mammalian Sec61 complex in its channel dynamics and protein transport activity, FEBS Lett., 583, 2359-2364
Impaktfaktor2009: 3,541 42. Götz, C., Müller, A., Montenarh, M., Zimmermann, R. und Dudek, J. (2009) ERj1 is a substrate of phosphorylation by CK2, Biochem. Biophys. Res. Commun. 388 ,637-642. Impaktfaktor 2009: 2,548 43. Müller, L., Diaz de Escauriaza, M., Lajoie, P., Theis, M., Jung, M., Müller, A., Burgard, C., Greiner, M., Snapp E. L., Dudek, J. und Zimmermann, R. (2010) Evolutionary gain of function of the ER membrane protein Sec62 from yeast to humans, Mol. Biol. Cell 21, 691-703. Impaktfaktor 2010: 5,861 44. Erdmann, F., Jung, M., Maurer, P., Harsman, A., Zimmermann, R und Wagner, R. (2010) The mammalian and yeast translocon complexes comprise a characteristic Sec61 channel, Biochem. Biophys. Res. Commun. 396, 714-720. Impaktfaktor 2010: 2,595 45. Benedix, J., Lajoie, P., Jaiswal, H., Burgard, C., Greiner, M., Zimmermann, R., Rospert, S., Snapp, E.L. und Dudek, J. (2010) BiP modulates the affinity of its co-chaperone ERj1 to ribosomes , J. Biol. Chem. 285, 36427-36433. Impaktfaktor 2010: 5,328 46. Meissner, M., Obmann, V.C., Hoschke, M., Link, S., Jung, M., Held, G., Philipp, S.E., Zimmermann, R. und Flockerzi, V. (2010) Lessons of studying TRP channels wih antibodies, in TRP channels, CRC methods in signal transduction series (M.X. Zhu, ed.) CRC Press, New York, 135-148 (2011). 47. Ott, M., Tascher, G., Haßdenteufel, S., Zimmermann, R., Haas, J. und Bailer, S.M.(2011) "Functional characterization of the essential tail-anchor of the HSV-1 nuclear egress protein UL34". J. Gen. Virol. 92, 2734-2745. Impaktfaktor 2011: 3,363 48. Haßdenteufel, S., Schäuble, N., Cassella, P., Leznicke, P., Müller, A., High, S., Jung, M. und Zimmermann, R. (2011) "Calcium-calmodulin inhibits tail-anchored protein insertion into the mamalian endoplasmic reticulum membrane", FEBS Lett. 585, 3485-3490. Impaktfaktor 2011: 3,538 49. Lang, S., Benedix, J., Fedeles, S.V., Schorr, S., Schirra, C., Schäuble, N., Jalal, C., Greiner, M., Haßdenteufel, Sl, Tatzelt, J., Kreutzer, B., Edelmann, L., Krause, E., Rettig J., Somlo, S., Zimmermann, R., und Dudek, J. (2012) "Differential effects of Sec61a-, Sec62 and Sec63-depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells", J. Cell Sci. 125,1958-1969. Impaktfaktor 2012: 5,877 50. Pfeffer, S., Brandt, F., Hrabe, T., Eibauer, M., Lang, S., Zimmermann, R. und Förster, F. (2012) "Structure and 3D arrangement of ER-membrane associated ribosomes", Structure 20, 1508-1518. Impaktfaktor 2012: 6,347 51. Johnson, N., Vilardi, F., Lang, S., Leznicki, P., Zimmermann, R. und High, S. (2012) "TRC-40 can deliver short secretory proteins to the Sec61 translocon", J. Cell Sci. 125, 3612-3620. Highlighted in JCS 125, issue 15 (125:e 1502) Impaktfaktor 2012: 5,877 52. Ampofo, E., Welker, S., Jung, M., Müller, L., Greiner, M., Zimmermann, R. und Montenarh, M., (2013) "CK2 phosphorylation of human Sec63 regulates its interaction with Sec62", Biochim. Biophys. Acta 1830, 2938-2945. Impaktfaktor 2012: 3,848 53. Pfeiffer, N.V., Dirndorfer, D., Lang, S., Resenberger, U.K. Restelli, L.M, Hemion, C., Miesbauer, M., Frank, S., Neutzner, A., Zimmermann, R., Winklhofer, K.F. und Tatzelt, J. (2013) "Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria", EMBO J. 32,1036-1051 Impaktfaktor 2012: 9,822 54. Dirndorfer, D., Seidel, R.P., Nimrod., G., Miesbauer, M., Ben-Tal,N., Engelhard, M., Zimmermann, R., Winklhofer, K.F. und Tatzelt, J. (2013) "The alpha-helical structure of prodomains promotes translocation of intrinsically disordered neuropeptide hormones into the endoplasmicx reticulum", J.Biol. Chem. 288, 13961-13973. Impaktfaktor 2012: 4,651 55. *Johnson, N., *Haßdenteufel, S., Theis, M., Paton, A.W., Paton, J.C., Zimmermann, R. und High, S. (2013) "The signal sequence influences posttranslational ER translocation at distinct stages", PLOS ONE 8, e75394. doi10.1371/journal.pone0075394 Impaktfaktor 2012: 3,73 56. *Pfeffer, S. ,*Dudek, J., Gogala, M., Schorr, S., Linxweiler, J., Lang, S. Beckmann, R., Zimmermann, R., und Förster, F. (2013) "3D arrangement of TRAP complex and oligosaccharyl transferase in the native human ER-membrane", Nature Commun. Doi: 10.1038/ncomms4072. *equal contribution Impaktfaktor 2012: 10,015
Calcium homeostase 1.*Erdmann, F., *Schäuble, N., Lang, S., Jung, M., Honigmann, A., Ahmad, M., Benedix, J., Dudek, J., Kopp, A., Helms, V., #Cavalie, A., #Wagner, R. und #Zimmermann, R. (2010) Interaction of calmodulin with Sec61 limits Ca²+ leakage from the endoplasmic reticulum, EMBO J. 30, 17-31. *equal contribution, #corresponding authors Impaktfaktor 2011: 9,205 2. Lang, S., Erdmann, F., Jung, M., Wagner, R., Cavalié, A. und Zimmermann, R. (2011) Sec 61 complexes form ubiquitous ER Ca2+ leak channels, Channels 5, 228-235. Impaktfaktor 2011: 2,14 3. Lang, S., Schäuble, N., Cavalié, A. und Zimmermann, R. (2011) Live cell calcium imaging in combination with siRNA mediated gene silencing identifies Ca2+ leak channels in the ER membrane and their regulatory mechanisms, J. Vis. Exp. (53) e2730. 4. Harsman, A., Kopp, A., Wagner, R., Zimmermann, R. und Jung, M. (2011), Calmodulin regulation of the calcium-leak channel Sec61 is unique to vertebrates, Channels 5, 293-298. Impaktfaktor 2011: 9,205 5. *Schäuble, N., *Lang, S., Jung, M., Cappel, S., Ulucan, Ö., Linxweiler, J., Dudek, J., Blum, R., Helms, V., Paton, A.W., Paton, J.C., # Cavalié, A. und #Zimmermann, R. (2012) BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER. EMBO J. 31, 3282-3296. *equal contribution #corresponding authors Impaktfaktor 2012: 9,822 6. Schäuble, N., Cavalié, A., Zimmermann, R. und Jung, M. (2014) "Interaction of Pseudomonas aeruginosa Exotoxin A with the human Sec61 complex suppresses passive calcium efflux from the endoplasmatic reticulum, Channesl, in press. Impaktfaktor 2011: 2,159
Medical aspects: 1. Jung, V., Kamradt, J., Kindich, R., Jung, M., Müller, M., Schulz, W.A., Engers, R., Stöckle, M., Zimmermann, R. und Wullich B. (2006) "Genomic and expression analysis of the 3q25-q26 amplication unit reveals TLOC1/SEC62 as a problable target gene in prostate cancer", Mol. Cancer Res. 4, 169-176. Impaktfaktor 2006: 4,759
2. Weitzmann, A., Volkmer, J. und Zimmermann, R. (2006) The nucleotide exchange factor activity of Grp170 may explain the non-lethal phenotype of loss of Sil1 function in man and mouse, FEBS Lett. 580, 5237-5240.
Impaktfaktor 2006: 3,372 3. Greiner, M., Kreutzer, B., Jung, V., Grobholz, R., Hasenfus, A., Stöhr, R., Franz, R., Tornillo, L., Dudek, J., Stöckle, M., Unteregger, G., Kamradt, J., Wullich, B. und Zimmermann, R. (2011) Silencing of the SEC62 gene inhibits migratory and invasive potential of various tumor cells, Int. J. Cancer 128, 2284-2295. Impaktfaktor 2011: 5,444 4. Greiner, M., Kreutzer, B., Jung, V., Lang, S., Cavalié, A., Unteregger, G. , Zimmermann, R. and Wullich, B. (2011) Sec62 protein level is crucial for ER-stress tolerance of prostate cancer. The Prostate 71, 1074-1083. Impaktfaktor 2011: 3,485 5. Müller, L., Funato Y., Miki, H. and Zimmermann, R. (2011) An interaction between human Sec63 with nucleoredoxin may provide the missing link between the SEC63 gene and polycystic liver disease, FEBS Lett. 585, 596-600. Impaktfaktor 2011: 3,538 6. *Linxweiler, M., *Linxweiler, J., Barth, M., Benedix, J., Jung, V., Kim, Y.-J., Bohle, R., Zimmermann, R. und Greiner, M. (2012) "Sec62 bridges the gap from 3q amplification to molecular cell biology in NSCLC", Am.J. Pathol. 180, 473-483. *equal contribution Impaktfaktor 2012: 4,522 7. Roos, A., Buchlremer, S., Labisch, T., Gatz, C., Brauers, W., Nolte, K., Goebel, H.H., Zimmermann, R., Senderek, J. und Weis, J. (2014) "Severe degenerative myopathy in woozy mice chaperonopathy and specific noclear enveloge pathology due to Sil1 dysfunction in a model for Marinesco-Sjögren syndrome", Acta Neuropathologica, in press. Impaktfaktor 2012: 9,734 8.*Linxweiler, M., *Schorr, S., Jung, M., Schäuble, N., Linxweiler, J., Langer F., Schäfers, H.-J. Cavalié, A., Zimmermann, R., und Greiner, M. (2013) "Targeting cell migration and the ER stress response with calmodulin antagonists: a clinically testd small molecule phenocopy of SEC62 gene silcneing in human tumor cells", BMC-cancer 13, 573. *equal contribution Impaktfaktor 2012: 3,33 9. Linxweiler, J., Kollipara, L., Zahedi, R., Lampel, P., Zimmermann, R. und Greiner, M. (2014) "Proteomic insights into non-small lung cancer: new ideas for cancer diagnosis and therapy from a functional viewpoint", EuPA Open Proteomics, dx.doi.org/10.1016/j.euprot. 2014.05.004. 10. Harz, C., Ludwig, N., Lang, S., Werner, T.V., Galata, V., Backes, C., Schmitt, K., Nickels, R., Krause, E., Jung, M., Rettig, J., Menger, M., Zimmermann, R. und Meese, E. (2014) "Preferential secretion of meningioma cells may explain the production of autoantibodies", J.Immunology 193, 3146-3154. Impaktfaktor 2011: 5,52 11. Synofzik, M., Haack, T.B., Kopajtich, R., Gorza, M., Rapoport, D., Greiner, M., Schönfeld, C., Freiberg ,C., Schorr, S., holl, R.W., Gonzalez, M.A., Fritsche, A., Fallier-Becker, P., Zimmermann, R., Strom, T.M., Meitinger, T., Züchner, S., Schüle, R., Schöls, L. und Prokisch, H. (2014) "Absence of BiP co-chaperone DNAJC3 causes diabetes mellitus and multisystemic neurodegeneration", Am.J.Hum.Gen. 95, 689-697. Impaktfaktor 2013: 10,987 12. Vilas, G., Krishnan, D., Loganathan, S.K., Malhotra, D., Liu, L., Beggs, M., Gena, P., Calamita, G., Jung, M., Zimmermann, R., Tamma, G., Casey, J.R. und Alexander, T. (2015) "Increased water flux induced by an aquaporin-1/Carbonic anhydrase II interaction", Mol.Biol.Cell 26, 1106-1118. Impaktfaktor 2013: 5,98
Protein folding: 1. Wiech, H., Buchner, J., Zimmermann, R. und Jakob, U. Hsp90 chaperones protein folding in vitro. (1992). Nature 358, 169-170.
Impaktfaktor 1992: 22,139 2. Kruse, M., Brunke, M., Escher, A., Szalay, A.A., Tropschug, M. und Zimmermann, R. Enzyme assembly after de novo synthesis in rabbit reticulocyte lysates involves molecular chaperones and immunophilins. (1995). J. Biol. Chem. 270, 2588-2594.
Impaktfaktor 1995: 7,385 3. Brunke, M., Dierks, T., Schlotterhose, P., Escher, A., Schmidt, B., Szalay, A. A., Lechte, M., Sandholzer, U. und Zimmermann, R. Luciferase assembly after transport into mammalian microsomes involves molecular chaperones and peptidylprolyl cis/trans isomerases (1996). J. Biol. Chem. 271, 23487-23494.
Impaktfaktor 1996: 7,542 4. Tyedmers, J., Brunke, M., Lechte, M., Sandholzer, U., Dierks, T., Schlotterhose, P., Schmidt, B. und Zimmermann, R. Efficient folding of firefly luciferase after transport into mammalian microsomes in the absence of lumenal chaperones and folding catalysts. (1996) . J. Biol. Chem. 271, 19509-19513.
Impaktfaktor 1996: 7,452 5. Klappa, p., Stromer, T., Zimmermann, R., Ruddock, L.W. und Freedman, R.B. A pancreas-specific glycosylated protein disulfide-isomerase binds to misfolded proteins and peptides with an interaction inhibited by oestrogens. (1998). Eur. J. Biochem. 254, 63-69.
Impaktfaktor 1998: 3,25 6. Lüders, J., Demand, J., Schönfelder, S., Frien, M., Zimmermann, R. und Höhfeld, J. Cofactor-induced modulation of the functional specificity of the molecular chaperon Hsc70. (1998). Biol. Chem. 379, 1217-1226.
Impaktfaktor 1998: 2,636 7. Tyedmers, J., Kruse, M., Lerner, M., Demand, J., Höhfeld, J., Solsbacher, J., Volkmer, J. und Zimmermann, R. Assembly of heterodimeric luciferase after de novo synthesis in rabbit reticulocyte lysate involves Hsc70 and Hsp40 at a posttranslational stage. (2000). Eur. J. Biochem. 267, 3575-3582.
Impaktfaktor 2000: 10,789 8. Odunuga, O. O., Hornby, J. A., Bies, C., Zimmermann, R., Pugh, D. J. und Blatch, G. L. Tetratricopeptide repeat motif-mediated Hsc70-mSTI1 interaction: molecular characterization of the critical contacts for successful binding and specificity. (2003). J. Biol. Chem. 278, 6896-6904.
Impaktfaktor 2003: 6,482 9. Nicoll, W. S., Botha, M., McNamara, C., Schlange, M., Pesce, E.-R., Boshoff, A., Ludewig, M. H., Zimmermann, R., Cheetham, M. E., Chapple, J. P. und Blatch, G. L. (2007) Cytoslic and ER J-domains of mammalian and parasitic origin can functionally interact with DnaK, Int. J. Biochem. Cell Biol. 39, 736-751.
Impaktfaktor 2007: 4,009
Export and degradation of proteins: Klappa, P., Dierks, T. und Zimmermann, R. Cyclosporin A inhibits thedegradation of sig nal sequences after processing of presecretory proteins by signal peptidase. (1996). Eur. J. Biochem. 239, 509-518.
Impaktfaktor 1996: 3,275
Reviews and books: 1. Zimmermann, R. und Meyer, D.I. (1986) 1986: A year of new insights into how proteins cross membranes, Trends in Biochem. Sci. 11, 512-515.
Impaktfaktor 1992: 15,788 2. Zimmermann, R., Sagstetter, M., Schlenstedt, G., Wiech, H., Kaßeckert, B. und Müller, G. (1988) Import of small secretory and plasma membrane proteins into the endoplasmic reticulum, in "Membrane Biogenesis" (Op den Kamp, J.A.F., ed.) Springer Verlag, Berlin-Heidelberg, 337-350. 3. Müller, G., Schlenstedt, G., Wiech, H. und Zimmermann, R. (1988) Import of proteins into the endoplasmic reticulum, Biochemical Society Transactions 16, 708-709.
Impaktfaktor 1992: 1,476 4. Müller, G. und Zimmermann, R. (1988) Import of honeybee prepromelittin into the endoplasmic reticulum, in "Gene Expression and Regulation" (Bissell, M. et al., eds) Elsevier Science Publishers B.V., Amsterdam, 199-208. 5. Schlenstedt, G., Cobet, W.W.E., Wiech, H. und Zimmermann, R. (1989) Mechanisms of protein import into the endoplasmic reticulum and protein export in E. coli, Biochemical Society Transactions 17, 822-823.
Impaktfaktor 1992: 1,476 6. Schlenstedt, G., Wachter, E., Sagstetter, M., Morel, F., Zimmermann, R., Gudmundsson, G.H. und Boman, H.G. (1990) Import of preprocecropin A and related precursor proteins into the endoplasmic reticulum, in "Dynamics and Biogenesis of Membranes" (Op den Kamp, J.A.F., ed.) Springer Verlag, Berlin-Heidelberg, 311-326. 7. Wiech, H. Stuart, R. und Zimmermann, R. (1990) Role of cytosolic factors in the transport of proteins across membranes, Seminars in Cell Biology 1, 55-64. 8. Zimmermann, R., Zimmermann, M., Wiech, H., Schlenstedt, G., Müller, G., Morel, F., Klappa, P., Jung, C. und Cobet, W.W.E (1990) Ribonuleoparticle-independent transport of proteins into mammalian microsomes, J. Bioenergetics and Biomembranes 22, 711-723. Impaktfaktor: 2002 : 2,920 9. Wiech, H., Klappa, P. und Zimmermann, R. (1991) Protein export in prokaryotes and eukaryotes: Theme with variations, FEBS Lett. 285, 182-188.
Impaktfaktor 1992: 3,505 10. Klappa, P., Müller, G., Schlenstedt, G., Wiech, H. und Zimmermann, R. (1992) Consecutive steps of nucleoside triphosphate-hydrolysis are driving transport of precursor proteins into the endoplasmic reticulum, New Comprehensive Biochemistry 22, 137-146. 11. Wiech, H. und Zimmermann, R. (1993) Role of molecular chaperones in transport of proteins into the mammalian endoplasmic reticulum, in "Protein Folding: in vivo and in vitro" (Cleland, J.L., ed.) American Chemical Society Symposium Series 526, Washington, 84-101. 12. Klappa, P., Zimmermann, M., Dierks, T. und Zimmermann, R. (1993) Components and mechanisms involved in transport of proteins into the endoplasmic reticulum, Subcellular Biochemistry 21, 17-40. 13. Dierks, T., Klappa, P., Wiech, H. und Zimmermann, R. (1993) Role of molecular chaperones in protein transport into the endoplasmic reticulum, Philosophical Transactions of the Royal Society 339, 335-341. Impaktfaktor 1993: 1,768 14. Dierks, T., Klappa, P., Wiech, H. und Zimmermann, R. (1993) Role of molecular chaperones in protein transport into the endoplasmic reticulum, in "Molecular Chaperones" (Ellis, R.J., Laskey, R.A. und Lorimer, G.H., eds) Chapman and Hall, London-New York, 79-85. 15. Zimmermann, M. und Zimmermann, R. (1994) Incorporation of biotinylated lysine into nascent polypeptides does not interfere with protein folding and protein transport, Boehringer Mannheim Biochemica 11, 25-27. 16. Hoeltke, H.-J., Ettl, I., Strobel, E., Leying, H., Zimmermann, M. und Zimmermann, R. (1995) Biotin in vitro translation, nonradioactive detection of cell-free synthesized proteins, Biotechniques 18, 900- 903.
Impaktfaktor 1995: 2,305 17. Hoeltke, H.-J., Ettl, I., Strobel, E., Leying, H., Zimmermann, M. und Zimmermann, R. (1996) Biotin in vitro translation, a nonradioactive method for the synthesis of biotin-labeled proteins in vitro: protocol and applications, in "BioMethods: A Laboratory Guide to Biotin- Labeling in Biomolecule Analysis" (T. Meier and F. Fahrenholz, eds), Birkhäuser, Basel, 183-199. 18. Zimmermann, R. (1998) The role of molecular chaperones in protein transport into the mammalian endoplasmic reticulum, Biol. Chem. 379, 275-282.
Impaktfaktor 1998: 2,636 19. Haas, I. und Zimmermann, R. (1999) Protein transport into and folding within the endoplasmic reticulum, in Molecular Biology of Chaperones and Folding Catalysts (B. Bukau, ed.) Harwood Academic Publishers, 205-233. 20. Jung, M., Bies, C., Dudek, J., Frien, M., Guth, S., Tyedmers, J. und Zimmermann, R. (2003) Multiple roles of molecular chaperones in protein transport into the mammalian endoplasmic reticulum, Signpost reviews, recent research developments in Molecular & Cellular Biology 3, 549-562. 21. Frien, M., Jung, M., Völzing, C. und Zimmermann, R. (2003) The rough endoplasmic reticulum: a proteomic analysis, Research Signpost, recent research developments in Biochemistry 4, 113-124. 22. Maurer, P., Moratzky, A., Fecher-Trost, C., Flockerzi, V., Lenk, U., Sommer, T., Völzing, C. und Zimmermann, R. (2003) Cell-free synthesis of membrane proteins on a preparative scale, in Cell-free protein expression (J. R. Swartz ed.) Springer Verlag, Heidelberg, 133-139. 23. Hennessy, F., Zimmermann, R., Cheetham, M.E. und Blatch, G.L. (2005) Not all J domains are created equal: implications for the specificity of Hsp40-Hsp70 interactions, Prot. Sci. 14, 1697-1709.
Impaktfaktor 2005: 3,618 24. Flockerzi, V., Aberle, T., Meissner, M., Freichel, M., Philipp, S., Nastainczyl, W., Maurer, P. und Zimmermann, R. (2005) Specific detection and semi quantitative analysis of TRPC4 protein expression by antibodies, Pflügers Archiv. Europ. J. Physiol. 451, 81-86.
Impaktfaktor 2005: 3,564 25. Dudek, J., Jung, M., Weitzmann, A., Greiner, M. und Zimmermann, R. (2006) Co-chaperones of the endoplasmic reticulum, in The networking of chaperones by co-chaperones (G. Blatch, ed.) Landes Bioscience, 88-98. 26. Zimmermann, R., Müller, L. und Wullich, B. (2006) Protein transport into the endoplasmic reticulum: mechanisms and pathologies, Trends in Molecular Medicine 12, 567-573.
Impaktfaktor 2006: 5,864
27. Dudek, J., Benedix, J., Cappel, S., Greiner, M., Jalal, C., Müller, L. und Zimmermann, R. (2009) Functions and pathologies of BiP and its interaction partners. Cell. Mol. Life Sci. 65, 1556-1569.
Impaktfaktor2009: 6,09
28. Zimmermann, R. und Blatch, G.L. (2009) A novel twist to protein secretion in eukaryotes, Trends in Parasitology 25, 147-150.
Impaktfaktor2009: 4,928 29. Müller, L., Wullich, B. und Zimmermann, R. (2009). "Pathologies of protein transport into the endoplasmic reticulum". In: "Protein transport into the endoplasmic reticulum." (Zimmermann, R., ed.), Landes Bioscience, 103-109. 30. Zimmermann, R. (2009) Protein transport into the endoplasmic reticulum, Landes Bioscience. 31. Zimmermann, R., Eyrisch, S., Ahmad, M. und Helms, V. (2011) Protein translocation across the ER membrane, Biochim, Biophys. Acta, 1808,912-924. Impaktfaktor 2011: 3,99 32. Dudek, J., Lang, S., Schorr, S., Linxweiler, J., Greiner, M., und Zimmermann, R. (2013) "Analysis of protein translocation into the endoplasmic reticulum of mammalian cells", in Methods in Molecular Biology 1033 (Herrmann, J. and Raaport, D.,eds) Humana Press, New York, USA, 285-299. Impaktfaktor 2010: 1,29
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