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Ausgewählte Publikationen AG Smola

Walch-Rückheim B, Ströder R, Theobald L, Pahne-Zeppenfeld J, Hegde S, Kim YJ, Bohle RM, Juhasz-Böss I, Solomayer EF, Smola S.   
Cervical cancer-instructed stromal fibroblasts enhance IL-23 expression in dendritic cells to support expansion of Th17 cells.

Cancer Res 2019 Jan 29. pii: canres.1913.2018. doi: 10.1158/0008-5472.CAN-18-1913. [Epub ahead of print]

Peretti A, Geoghegan EM, Pastrana DV, Smola S, Feld P, Sauter M, Lohse S, Ramesh M, Lim ES, Wang D, Borgogna C, FitzGerald PC, Bliskovsky V, Starrett GJ, Law EK, Harris RS, Killian JK, Zhu J, Pineda M, Meltzer PS, Boldorini R, Gariglio M, Buck CB. Characterization of BK Polyomaviruses from Kidney Transplant Recipients Suggests a Role for APOBEC3 in Driving In-Host Virus Evolution.

Cell Host Microbe 2018;23:628-35 e7.

Podgorska M, Oldak M, Marthaler A, Fingerle A, Walch-Ruckheim B, Lohse S, Muller CSL, Vogt T, Ustav M, Wnorowski A, Malejczyk M, Majewski S, Smola S. Chronic Inflammatory Microenvironment in Epidermodysplasia Verruciformis Skin Lesions: Role of the Synergism Between HPV8 E2 and C/EBPbeta to Induce Pro-Inflammatory S100A8/A9 Proteins.
Front Microbiol 2018;9:392.

Weiler G, Schwarz U, Rauch J, Rohm K, Lehr T, Theobald S, Kiefer S, Gotz K, Och K, Pfeifer N, Handl L, Smola S, Ihle M, Turki AT, Beelen DW, Rissland J, Bittenbring J, Graf N. XplOit: An Ontology-Based Data Integration Platform Supporting the Development of Predictive Models for Personalized Medicine.
Stud Health Technol Inform 2018;247:21-5.

Marthaler AM, Podgorska M, Feld P, Fingerle A, Knerr-Rupp K, Grässer F, Smola H, Roemer K, Ebert E, Kim YJ, Bohle RM, Müller CSL, Reichrath J, Vogt T, Malejczyk M, Majewski S, Smola S.
Identification of C/EBPα as a novel target of the HPV8 E6 protein regulating miR-203 in human keratinocytes.
PLoS Pathogens. 2017 2017 Jun 22;13(6):e1006406.

Bochen F, Adisurya H, Wemmert S, Lerner C, Greiner M, Zimmermann R, Hasenfus A, Wagner M, Smola S, Pfuhl T, Bozzato A, Al Kadah B, Schick B, Linxweiler M.
Effect of 3q oncogenes SEC62 and SOX2 on lymphatic metastasis and clinical outcome of head and neck squamous cell carcinomas.
Oncotarget. 2017;8:4922-4934.

Titze MI, Frank J, Ehrhardt M, Smola S, Graf N, Lehr T.
A generic viral dynamic model to systematically characterize the interaction between oncolytic virus kinetics and tumor growth.
Eur J Pharm Sci. 2017;97:38-46.

Walch-Ruckheim B, Pahne-Zeppenfeld J, Fischbach J, Wickenhauser C, Horn LC, Tharun L, Büttner R, Mallmann P, Stern P, Kim YJ, Bohle RM, Rübe C, Ströder R, Juhasz-Boss I, Solomayer EF, Smola S.   
STAT3/IRF1 pathway activation sensitizes cervical cancer cells for chemotherapeutic drugs.

Cancer Res 2016;76:3872-83.

Walch-Ruckheim B, Mavrova R, Henning M, Vicinus B, Kim YJ, Bohle RM, Juhasz-Boss I, Solomayer EF, Smola S.       
Stromal Fibroblasts Induce CCL20 through IL6/C/EBPbeta to Support the Recruitment of Th17 Cells during Cervical Cancer Progression.
Cancer Res 2015;75:5248-59.

Rolfs F, Huber M, Kuehne A, Kramer S, Haertel E, Muzumdar S, Wagner J, Tanner Y, Bohm F, Smola S, Zamboni N, Levesque MP, Dummer R, Beer HD, Hohl D, Werner S, Schafer M.
Nrf2 Activation Promotes Keratinocyte Survival during Early Skin Carcinogenesis via Metabolic Alterations.  
Cancer Res 2015;75:4817-29.

Schmidt SV, Seibert S, Walch-Ruckheim B, Vicinus B, Kamionka EM, Pahne-Zeppenfeld J, Solomayer EF, Kim YJ, Bohle RM, Smola S.      
RIPK3 expression in cervical cancer cells is required for PolyIC-induced necroptosis, IL-1alpha release, and efficient paracrine dendritic cell activation.  
Oncotarget 2015;6:8635-47.

Strittmatter GE, Sand J, Sauter M, Seyffert M, Steigerwald R, Fraefel C, Smola S, French LE, Beer HD.       
IFN-gamma primes keratinocytes for HSV-1-induced inflammasome activation.           
J Invest Dermatol 2015.

Held G, Luescher IF, Neumann F, Papaioannou C, Schirrmann T, Sester M, Smola S, Pfreundschuh M.       
MHC/Peptide-Specific Interaction of the Humoral Immune System: A New Category of Antibodies.
J Immunol 2015;195:4210-7.

Bufe B, Schumann T, Kappl R, Bogeski I, Kummerow C, Podgorska M, Smola S, Hoth M, Zufall F.    
Recognition of bacterial signal peptides by mammalian formyl peptide receptors: a new mechanism for sensing pathogens.     
J Biol Chem 2015;290:7369-87.

Pahne-Zeppenfeld J, Schroer N, Walch-Ruckheim B, Oldak M, Gorter A, Hegde S, Smola S.
Cervical cancer cell-derived interleukin-6 impairs CCR7-dependent migration of MMP-9-expressing dendritic cells.           
Int J Cancer 2014;134:2061-73.

Tappe D, Rissland J, Gabriel M, Emmerich P, Gunther S, Held G, Smola S, Schmidt-Chanasit J.       
First case of laboratory-confirmed Zika virus infection imported into Europe, November 2013.
Euro Surveill 2014;19.

Sperling T, Ołdak M, Walch-Rückheim B, Wickenhauser C, Doorbar J, Pfister H, Malejczyk M, Majewski S, Keates AC, Smola S.            
Human Papillomavirus Type 8 Interferes with a Novel C/EBPbeta-Mediated Mechanism of Keratinocyte CCL20 Chemokine Expression and Langerhans Cell Migration.    
PLoS Pathogens 2012;8:e1002833.

Schroer N, Pahne J, Walch B, Wickenhauser C, Smola S.           
Molecular Pathobiology of Human Cervical High-Grade Lesions: Paracrine STAT3 Activation in Tumor-Instructed Myeloid Cells Drives Local MMP-9 Expression.     
Cancer Res 2011;71:87-97.

Oldak M, Tolzmann L, Wnorowski A, Podgorska MJ, Silling S, Lin R, Hiscott J, Muller CS, Vogt T, Smola H, Smola S.       
Differential regulation of human papillomavirus type 8 by interferon regulatory factors 3 and 7.
J Virol 2011;85:178-88.

Übersichtsartikel/Editorials

Pfister HJ, Gariglio M, Smola S.
Editorial: Human Papillomaviruses and Polyomaviruses in Skin Cancer.
Front Microbiol. 2018 Nov 15;9:2778. doi: 10.3389/fmicb.2018.02778. eCollection 2018.

Smola S.
Immunopathogenesis of HPV-Associated Cancers and Prospects for Immunotherapy.
Viruses. 2017 Sep 12;9(9). pii: E254.

Smola S, Trimble C, Stern PL.
Human papillomavirus-driven immune deviation: challenge and novel opportunity for immunotherapy.
Ther Adv Vaccines. 2017 Jun;5(3):69-82.

Smola S. RIPK3-a predictive marker for personalized immunotherapy?  
OncoImmunology 2016;5:e1075695.

Links

Zentrum für Human- und Molekularbiologie (ZHMB)
Universität des Saarlandes