Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes
Institut für Medizinische Mikrobiologie und Hygiene
Leitung: Prof. Dr. Dr. Sören Becker
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Optimization of chlorotonils for pre-clinical assessment as potent novel antibacterial agents
active against multidrug-resistant pathogens


Antimicrobial resistance (AMR) is spreading in clinics at an alarming rate causing a pressing need to develop new antibiotics. AMR has been defined by the World Health Organization (WHO) as one of the biggest threats to global health today. Therefore, society faces substantial pressure for the discovery of efficient novel anti-infective compounds against microbial infections, ideally addressing so far unexploited molecular targets or target sites to avoid potential cross-resistance with known antibiotics. One such compound is chlorotonil A, a natural product isolated from the myxobacterium Sorangium cellulosum. Purified chlorotonil A exhibits a promising activity against gram-positive ESKAPE organisms, however, displays also a very low water solubility.

In close collaboration with the Helmholtz-Institut für Pharmazeutische Forschung Saarland (HIPS) and the Institut für Pharmakologie und Toxikologie, UdS, we’ll develop chlorotonil A derivatives with an increased water solubility, determine the key pharmacokinetic parameters of these compounds, and test their in vitro and in vivo antibacterial activities against multidrug-resistant ESKAPE bacteria.

This research project is part of the Network project ChloroClinaria supported by BMBF. For further Information on this project, please contact L. Pätzold or M. Bischoff