13th ER & REDOX CLUB MEETING
Homburg/Saar, Germany, April 26-29, 2017
Organization
Richard Zimmermann, Medical Biochemistry & Molecular Biology, Homburg, Germany (richard.zimmermann @uks.eu)
Martin van der Laan, Physiological Chemistry, Homburg, Germany (martin.van-der-laan @uks.eu)
Conference Venue
Schloßberghotel Homburg, 66424 Homburg/Saar, Germany (http://www.schlossberghotel-homburg.de)
Program
| (Download Program) | |
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Wednesday April 26, 2017 | |
10:00 – 13:55 13:55 – 14:00 | Arrival and Check-in Richard Zimmermann: Welcome Address |
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Session I | Protein Targeting to and Translocation into the ER |
14:00 – 18:00 | Discussion Leader: Nica Borgese (Milan, I) |
14:00 – 14:25 | Stefan Pfeffer (Martinsried, D) Structure of the native ER protein translocon |
14:25 – 14:50 | Sven Lang (Homburg, D) Components and mechanisms of transport of precursor polypeptides into the human ER |
14:50 – 15:15 | Mike McKenna (Manchester, UK) Biogenesis of membrane proteins in mammalian cells |
15:15 – 15:40 | Maya Schuldiner (Rehovot, IL) SNDing proteins to the ER |
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15:40 – 16:10 | Coffee Break |
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16:10 – 16:35 | Sabine Rospert (Freiburg, D) Intersection of SRP- and GET-pathways |
16:35 – 17:00 | Jörg Tatzelt (Bochum, D) An evolutionary conserved impairment of the Sec61/SecY complex to translocate intrinsically disordered proteins |
17:00 – 17:25 | Karin Römisch (Saarbrücken, D) Regulation of protein transport across the ER membrane |
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17:25 – 18:00 | Lightning Talks as appetizers for poster session |
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18:00 – 19:00 | Poster Session I |
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19:00 – 21:00 | Dinner |
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21:00 – 22:00 | Poster Session II with drinks |
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Thursday April 27, 2017 | |
7:00 – 8:35 | Breakfast |
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Session II | Protein Folding and Modification in the ER |
8:35 – 12:00 | Discussion Leader: Neil Bulleid (Glasgow, UK) |
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8:35 – 9:00 | Philip Robinson (Glasgow, UK) Early stages of protein folding and disulfide formation |
9:00 – 9:25 | Nicholas McCaul (Utrecht, NL) Signal-peptide cleavage of HIV-1 gp160 as a functional folding checkpoint |
9:25 – 9:50 | Benedikt Weber (München (D) Principles of IgM assembly |
9:50 – 10:15 | Matthias Feige (München, D) Interleukin folding pathways |
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10:15 – 10:45 | Coffee Break |
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10:45 – 11:10 | Linda Hendershot (Memphis, USA) Mechanisms of immunoglobulin assembly |
11:10 – 11:35 | Thomas Dierks (Bielefeld, D) Formylglycine formation – a unique and essential redox catalysis in the ER |
11:35 – 12:00 | Minttu Virolainen (Kopenhagen, DK) New regulatory features of BiP AMPylation mediated by human FICD |
12:00 – 12:25 | Barbara Niemeyer (Homburg, D) ER-operated Ca2+ entry – Mechanism and regulation |
12:30 – 14:00 | Lunch |
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Session III | Oxidoreductases of ER and Mitochondria |
14:00 – 18:00 | Discussion Leader: Roberto Sitia (Milan, I) |
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14:00 – 14:25 | Naomi Carne (Durham, UK) The effect of the redox environment on Ero1 & PDI |
14:25 – 14:50 | Christoph Maack (Homburg, D) Redox regulation by SR-mitochondrial calcium transfer |
14:50 – 15:15 | Deborah Fass (Rehovot, IL) Single-molecule enzymology of QSOX |
15:15 – 15:40 | Hannes Herrmann (Kaiserslautern, D) The disulfide relay system in the mitochondrial intermembrane space: Similarities and differences to the Ero-Pdi1 system of the ER |
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15:40 – 16:10 | Coffee Break |
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16:10 – 16:35 | Roberto Sitia (Milan, I) Proteostasis and redoxstasis in the secretory pathway |
16:35 – 17:00 | Ivan Bogeski (Göttingen, D) The role of TMX oxidoreductases in melanoma growth and invasion |
17:00 – 17:25 | Xi Wang (Beijing, CN) Thiol-mediated protein retention in the ER |
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17:25 – 18:00 | Lightning Talks as appetizers for poster session |
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18:00 – 19:00 | Poster Session III |
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19:00 – 21:00 | Dinner |
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21:00 – 22:00 | Poster Session IV with drinks |
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Friday April 28, 2017 | |
7:00 – 8:35 | Breakfast |
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Session IV | UPR, Quality Control, ERAD and ER-phagy |
8:35 – 12:00 | Discussion Leader: Aldo Ceriotti (Milan, I) |
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8:35 – 9:00 | Robert Ernst (Homburg, D) The activation of the unfolded protein response by lipid bilayer stress |
9:00 – 9:25 | Boaz Tirosh (Rehovot, IL) Modulation of natural killer cell ligand expression by the unfolded protein response |
9:25 – 9:50 | Norbert Volkmar (Oxford, UK) A role for the mEMC in cholesterol homeostasis |
9:50 – 10:15 | Gerardo Lederkremer (Tel Aviv, IL) Novel quality control vesicles in the timing of ERAD |
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10:15 – 10:45 | Coffee Break |
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10:45 – 11:10 | Marius Lemberg (Heidelberg, D) Role of intramembrane proteolysis in the control of ER protein homeostasis |
11:10 – 11:35 | Ilaria Fregno (Belinzona, CH) Role of Sec62 in ER-phagy |
11:35 – 12:00 | Carmine Settembre (Pozzuoli, I) Molecular characterisation of Collagen-phagy: a new type of developmentally regulated autophagy |
12:00 – 12:25 | Thomas Sommer (Berlin, D) Role of Htm1p in glycoprotein ERAD |
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12:30 – 14:00 | Lunch |
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Session V | ER-Homeostasis in Health and Disease |
14:00 – 17:50 | Discussion Leader: Maya Schuldiner (Rehovot, IL) |
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14:00 – 14:25 | Maurizio D´Antonio (Milan, I) The Ire1/Xbp1 pathway of the UPR protects peripheral nerves from dysmyelination in ER-related neuropathies |
14:25 – 14:50 | Sara Colombo (Milan, I) Export of pentameric nicotinic acetylcholine receptors from the ER is exclusively determined by the fifth, accessory subunit |
14:50 – 15:15 | Kenji Inaba (Aobaku, JP) Structural and mechanistic basis of pH- and zinc-dependent regulation of ERp44 for protein quality control in the early secretory pathway |
15:15 – 15:40 | Celine Schaeffer (Milan, I) Altered protein homeostasis in the ER and induction of the unfoded protein response in models of mutant uromodulin expression |
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15:40 – 16:10 | Coffee Break |
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16:10 – 16:35 | Edward Avezov (Cambridge, UK) New insights into paticle progression in the ER lumen |
16:35 – 17:00 | Joy Ogbechi (Surrey, UK) Inhibition of Sec61-dependent translocation by mycolactone activates an atypical stress response that drives autophagy and apoptosis |
17:00 – 17:25 | Eelco van Anken (Milan, I) How homeostatic control of the endoplasmic reticulum ties in with life/death decisions by IRE1 |
17:25 – 17:50 | Simone Cenci (Milan, I) Autophagy in plasma cell pathophysiology |
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18:00 – 19:00 | Poster Session V |
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19:00 – 21:00 | Dinner |
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21:00 – 22:00 | Poster Session VI with drinks |
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Saturday April 29, 2017 | |
7:00 – 8:35 | Breakfast |
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Session VI | ER contacts and communication |
8:35 – 12:00 | Discussion Leader: Ineke Braakman (Utrecht, NL) |
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8:35 – 9:00 | Bruce Morgan (Kaiserslautern, D) Identification and characterization of novel intracellular glutathione transporters |
9:00 – 9:25 | Ryo Ushioda (Kyoto, JP) Regulation of proteostasis and Ca2+ homeostasis in the ER by the disulfide reductase ERdj5 |
9:25 – 9:50 | Adolfo Cavalié (Homburg, D) The function of Sec61 complexes in cellular Ca2+ homeostasis |
9:50 – 10:15 | Axel Methner (Mainz, D) Bax inhibitor-1 is a pH-dependent Ca2+ channel in the ER |
10:15 – 10:40 | Jan Riemer (Köln, D) The mitochondrail adenylate kinase 2 is target of a novel cytosolic quality control pathway |
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10:40 – 11:10 | Coffee Break |
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11:10 – 11:35 | Manfred Schmitt (Saarbrücken, D) Novel roles of the KDEL receptor |
11:35 – 12:00 | Martin van der Laan (Homburg, D) Biogenesis and functional architecture of mitochondrial membranes |
12:00 – 12:25 | Blanche Schwappach (Göttingen, D) Physiological integration of the GET pathway |
12:25 – 12:30 | Martin van der Laan: Farewell Address (including awards & election of new organizer) |
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12:30 – 14:00 | Lunch and Departure |
Poster Titles
(Download List with Poster Titles)
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David Beal (Warwick, UK)
Quantitative analysis of the operation and control of yeast oxidative protein folding
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Tobias Beuel (Bielefeld, D)
An intramolecular disulfide relay system within Formylglycine-generating enzyme
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Nica Borgese (Milan, I)
Targeting of spontaneously inserting tail-anchored proteins to the ER
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Xiaofei Cao (Glasgow, UK)
The role of the cytosolic reductive pathway in resolving non-native disulfides
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Joe Casson (Manchester, UK)
Exploring alternative pathways for tail-anchored protein biogenesis
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Aldo Ceriotti & Alessandro Occhialini (Milan, I)
Vacuolar targeting of a Type I ribosome-inactivating protein from Saponaria officinalis
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Nir Cohen (Rehovot, IL)
Iron and heme homeostasis affect Ire1 clustering propensity and the amplitude of endoplasmic reticulum stress signaling
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Emma Fenech (Cambridge, UK)
Constructing the interaction networks of ER-resident E3 ubiquitin ligases
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Daniel Fonseca (Utrecht, NL)
Hsp90 supports a critical folding step of the ABC transporter CFTR
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Igor Gamayun (Homburg, D)
Modulation of the calcium leak through Sec61 complexes by small molecules
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Chiara Giannone & Tiziana Tempio (Milan, I)
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Belinda Hall (Surrey, UK)
Translational microarray analysis reveals an atypical stress response following Sec61 inhibition
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Katja Hansen (Kaiserslautern, D)
The J protein Djp1 is an ER protein involved in the mitochondrial biogenesis
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Sarah Haßdenteufel (Homburg, D)
Chaperone mediated Sec61 channel gating during import of small presecretory proteins into the human ER
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Pamina Kazman (München, D)
Disease-associated mutations in antibody VL domains
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Marie-Christine Klein (Homburg, D)
Characterization of ERAC as an ATP carrier in the human ER membrane
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Mike McKenna (Manchester, UK)
Mycolactone reveals substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis
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Andrea Orsi (Milan, I)
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Florentina Pena (Bucharest, RO)
P5 has a dual role in the endoplasmic reticulum
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Fábio Pereira (Saarbrücken, D)
Identification of Sec61p interacting partners in the ER lumen
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Stefan Pfeffer (Martinsried, D)
Dissecting the molecular organization of the translocon-associated protein complex
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Tillman Pick (Homburg, D)
Mechanisms and regulation of the calcium leak from the endoplasmic reticulum
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Karthikeyan Radhakrishnan (Bielefeld, D)
Recognition and ER quality control of misfolded Formylglcine-generating enzyme by PDI
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Dr. Priyanka Sahasrabude (Utrecht, NL)
The novel potentiator GLPG1837 modulates CFTR through different mode-of-action than Ivacaftor (Kalydeco)
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Cristina Scapin (Milan, I)
Role of eIF2alpha phosphorylation in a CMT1B neuropathy mouse model
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Stefan Schorr (Homburg, D)
The signal sequence plus a cluster of positive charges dictates Hsp40 mediated BiP gating of the translocon
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Sara Schwartz (Saarbrücken, D)
Structural and functional analysis of the yeast viral A/B toxin K28
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Regine Stutz (Homburg, D)
Client spectrum of the translocon-associated protein complex
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Christina Stutzer (München, D)
Regulation of BiP by the nucleotide exchange factor Bap/Sil1
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Yutaka Suzuki (Saarbrücken, D)
Redox control of A/B toxin activity and compartmental trafficking in host cells
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René Tinschert & Sebastian Bender (Homburg, D)
ER-Ca2+-leakage in fibroblasts of Sec61a1 Y344H+/+ mutant mice
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Karina von der Malsburg (Homburg, D)
The Mitochondrial Contact Site and Cristae Organizing System
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Ying Zhang (Freiburg, D)
Cotranslational intersection between the SRP and GET targeting pathways to the ER of Saccharomyces cerevisiae
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Eva Zöller (Kaiserslautern, D)
Cellular stress response mechanisms during inhibited mitochondrial protein import in S. cerevisiae
Participants (PIs in bold)
| (Download List of Participants) | |
| . | |
Dr. David Beal (Canterbury, UK) | |
Dr. Adam Benham (Durham, UK) | |
Naomi Carne (Durham, UK) | |
Dr. Ivan Bogeski (Göttingen, D) | |
Kathi Zimmermann (Homburg, D) | |
Dr. Nica Borgese (Milan, I) | |
Sara Colombo (Milan, I) | |
Dr. Ineke Braakman (Utrecht, NL) | |
Nicholas McCaul (Utrecht, NL) | |
Daniel Fonseca (Utrecht, NL) | |
Priyanka Sahasrabudhe (Utrecht, NL) | |
Dr. Johannes Buchner (München, D) | |
Benedikt Weber (München, D) | |
Pamina Kazman (München, D) | |
Christina Stutzer (München, D) | |
Dr. Neil Bulleid (Glasgow, UK) | |
Philip Robinson (Glasgow, UK) | |
Xiaofei Cao (Glasgow, UK) | |
Dr. Adolfo Cavalié (Homburg, D) | |
Igor Gamayun (Homburg, D) | |
Tillman Pick (Homburg, D) | |
René Tischert (Homburg, D) | |
Dr. Simone Cenci (Milan, I) | |
Dr. John Christianson (Oxford, UK) | |
Dr. Norbert Volkmar (Oxford, UK) | |
Emma Fenech (Oxford, UK) | |
Dr. Aldo Ceriotti (Milan, I) | |
Dr. Maurizio D´Antonio (Milan, I) | |
Cristina Scapin (Milan, I) | |
Dr. Thomas Dierks (Bielefeld, D) | |
Dr. Karthikeyan Radhakrishnan (Bielefeld, D) | |
Tobias Beuel (Bielefeld, D) | |
Mareile Boschanski(Bielefeld, D) Dr. Bernhard Dobberstein (Heidelberg, D) | |
Dr. Lars Ellgaard (Kopenhagen, DK) | |
Minttu Virolainen (Kopenhagen, DK ) Dr. Robert Ernst (Homburg, D) Stephanie Ballweg (Frankfurt, D) Kristina Pesek (Frankfurt, D) | |
Dr. Deborah Fass (Rehovot, IL) | |
Dr. Matthias Feige (München, D) | |
Joao Coelho (München, D) | |
Stephanie Müller (München, D) | |
Dr. Friedrich Förster (Utrecht, NL) | |
Dr. Stefan Pfeffer (Martinsried, D) | |
Max Gemmer (Utrecht, NL) | |
| Dr. Ilka Haferkamp (Kaiserslautern, D) | |
Dr. Ingrid Haas (Freiburg, D) | |
| Dr. Linda Hendershot (Memphis, USA) | |
Dr. Johannes Herrmann (Kaiserslautern, D) | |
Katja Hansen (Kaiserslautern, D) | |
Anna Schlagowski (Kaiserslautern, D) | |
Eva Zöller (Kaiserslautern, D) | |
Dr. Stephen High (Manchester, UK) | |
Joe Casson (Manchester, UK) | |
Michael McKenna (Manchester, UK) | |
Dr. Peri Roboti (Manchester, UK) | |
Dr. Kenji Inaba (Aobaku, JPN) | |
Dr. Gerardo Lederkremer (Tel Aviv, IL) | |
Dr. Christoph Maack (Homburg, D) | |
Dr. Michael Kohlhaas (Homburg, D) | |
Dr. Alexander Nickel (Homburg, D) | |
Dr. Marius Lemberg (Heidelberg, D) | |
Dr. Axel Methner (Mainz, D) | |
Dr. Maurizio Molinari (Bellinzona, CH) Ilaria Fregno (Bellinzona, CH) | |
Dr. Bruce Morgan (Kaiserslautern, D) | |
Julian Ostereicher (Kaiserslautern, D) | |
Dr. Barbara Niemeyer (Homburg, D) | |
Anna-Maria Miederer (Homburg, D) | |
Dr. Dalia Alansary (Homburg, D) | |
Dr. Florentina Pena (Bucharest, RO) | |
Dr. Luca Rampoldi (Milan, I) | |
Celine Schaeffer (Milan, I) | |
Dr. Jan Riemer (Köln, D) | |
Markus Habich (Köln, D) | |
Dr. Karin Römisch (Saarbrücken, D) | |
Fábio Pereira (Saarbrücken, D) | |
Guido Barbieri (Saarbrücken, D) | |
Sami Sandakly Saarbrücken, D) | |
Dr. David Ron (Cambridge, UK) | |
Dr. Edward Avezoc (Cambridge, UK) | |
Dr. Sabine Rospert (Freiburg, D) | |
Dr. Ying Zhang (Freiburg, D) | |
Dr. Manfred Schmitt (Saarbrücken, D) | |
Dr. Yutaka Suzuki (Saarbrücken, D) | |
Sara Schwartz (Saarbrücken, D) | |
Dr. Maya Schuldiner (Rehovot, IL) | |
Nir Cohen (Rehovot, IL) | |
Dr. Blanche Schwappach (Göttingen, D) | |
Dr. Carmine Settembre (Pozzuoli, I) | |
Dr. Rachel Simmonds (Surrey, UK) | |
Joy Ogbechi (Surrey, UK) | |
Belinda Hall (Surrey, UK) | |
Dr. Roberto Sitia (Milan, I) | |
Dr. Andrea Orsi (Milan, I) | |
Chiara Giannone (Milan, I) | |
Tiziana Tempio (Milan, I) | |
Dr. Thomas Sommer (Berlin, D) | |
Dr. Ernst Jarosch (Berlin, D) | |
Dr. Jörg Tatzelt (Bochum, D) | |
Dr. Boaz Tirosh (Jerusalem, IL) | |
Dr. Ryo Ushioda (Kyoto, JPN) | |
Dr. Eelco van Anken (Milan, I) | |
Alberto Danielli (Milan, I) | |
Dr. Martin van der Laan (Homburg, D) | |
Dr. Karina von der Malsburg (Homburg, D) | |
Dr. Stefan Schorr (Homburg, D) Nilam Yadao (Homburg, D) | |
Florian Wollweber (Homburg, D) | |
Dr. Xi Wang (Beijing, CN) | |
Dr. Richard Zimmermann (Homburg, D) | |
Dr. Sven Lang (Homburg, D) | |
Sarah Haßdenteufel (Homburg, D) | |
Tina Klein (Homburg, D) | |
Regine Stutz (Homburg, D) Dr. Johanna Dudek (Homburg, D) | |
Antonietta Russo (Homburg, D) | |
Dr. Martin Jung (Homburg, D) Mark Sicking (Homburg, D) | |
Maria Zimmermann (Homburg, D) | |
Dr. Gabi Amoroso (Homburg, D) | |
| Anke Ziska (Homburg, D) | |
| Armin Melnyk (Homburg, D) |
