Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes
Klinische Chemie und Laboratoriumsmedizin - Zentrallabor
Leitung: Prof. Dr. med Jürgen Geisel, M.A.
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Forschung

Ansprechpartnerin: Prof (apl.) Dr. Rima Obeid

Tel: 06841-1630711, E-Mail: rima.obeid@uks.eu

 

Bachelor-, Master- und Doktorarbeiten werden regelmäßig vergeben (je nach Kapazität). Wir freuen uns auf Ihre Bewerbung!

 

Aktuelle Themen (Stand März 2021):

  • Laboranalysen rund um das Thema Nährstoffe & Stoffwechsel Interaktion, Nährstoffe & epigenetische Veränderungen, Entwicklung, Messung und Anwendung von Biomarker (z.B. im Blut oder Urin) in klinische Studien.
  • Systematische Review/Metaanalysen im Bereich Biomarker-Ernährung-und Gesundheit. Die Sys. Review ist eine strukturierte Literatur Recherche und ggf. Auswertung. Eine sehr gute English Sprachkenntnisse ist erforderlich. Weiterhin, brauchen Sie bestimmte persönliche Eigenschaften um die Arbeit erfolgreich abzuschließen (z.B. Geduld, eigen Motivation, Organisation, Genauigkeit). Zu der Methodik und Ablauf werden Sie eingeleitet.

General topics

  • Maternal nutrition and child health outcomes (e.g. neural tube defects, growth, obesity, stunting)
  • Choline nutrient in relation to maternal and child health outcomes
  • Food-, single nutrient-, and drug-induced metabolomic changes
  • Interaction between nutrients and gut bacteria
  • Method development, validation, and utility of nutritional biomarkers in clinical studies
  • Personalized nutritional supplementation recommendations
  • Intervention studies with single nutrient or multivitamin supplements – and the effect on metabolism, epigenetics, or clinical endpoints
  • Diagnosis and treatment of acquired or inherited disorders in C1-metabolism

 

Research methods

Chromatography: GCMS, LCMS/MS, HPLC, immunological assays; meta-analysis; clinical trials; cost-effectiveness studies in the fields mentioned above

 

Running/Planned Theses

Candidate, Degree

Topic

Anja Werken, MD

The association between maternal and child vitamin D from birth to the age of 6 years: Systematic review and meta-analysis

Arved Pannenbäcker, MD

The impact of plant based diets on maternal and child health; Health Technology Assessment

Christian Körber, MD

The association between maternal and child vitamin B12 from birth to the age of 6 years: Systematic review and meta-analysis

Jonas Hans, MD

The association between folate-containing supplements during pregnancy and outcomes other than neural tube defects: congenital heart defects and cleft lip: Systematic review and meta-analysis

Christoph Möller- Bechlor

Prioritization of the use of serum versus whole blood vitamin B6 based on serum homocysteine and cystathionine

Patricia Rickens- MD

Epigenetic DNA methylation in prediction of future disease outcome in patients with renal diseases

Joanne Buinier, MD

Folate intake requirements in children from age 0-36 months; a systematic review and meta-analysis

Radi Adi – External PhD Damascus University

Choline and stunting in pre-school children from Syria

NN- open

Parents’ environmental exposures, neural tube defects and sex distortion; Systematic review and meta-analysis of human studies.

NN- open

Effect of supplementation of different forms of choline (+/+ DHA) on plasma concentrations of lipids, choline, betaine, and TMAO.

 

 

 

Abgeschlossene Promotion Arbeiten

Johannes Stein, Astrid Knell, Sandra Tillmann, Hussain Awwad, Nicole Klein, Vera Kruse, Kathrin Heucke, Susanne Kirsch, Yannick Rabagny, Kouris Ninios, Jennifer Schlundt, Mariz Kasoha, Achim Schadt, Eva Raabe.

 

Abgeschlossene Bachelor Arbeiten

Shalin Zenk, Sarah Dielmann, Cosima Klein, Frank Hoffmann, Anna Lena Flammann, Cira Flammann

 

Ehemalige Stipendiaten:

Ranwa Al-Sayed (Damaskus Universität - DAAD Stipendium- 3 Monate)

Post Doc. Dr. Batool Shannan (Alexander von Humboldt)

Dr. Rasul Aziz (Post.Doc. University of Hawler, Iraq)

 

Original articles since 2016

  1. 1. Tillmann S, Awwad HM, MacPherson CW, Happ DF, Treccani G, Geisel J, Tompkins TA, Ueland PM, Wegener G, Obeid R. The kynurenine pathway is upregulated by methyl-deficient diet and changes are averted by probiotics. Mol Nutr Food Res. 2021 Mar 8:e2100078. doi: 10.1002/mnfr.202100078. Online ahead of print.
  2. 2. Stein J, Geisel J, Obeid R. Association between neuropathy and B-vitamins: A systematic review and meta-analysis. Eur J Neurol. 2021 Feb 22. doi: 10.1111/ene.14786. Online ahead of print.
  3. 3. Menzel J, Abraham K, Stangl GI, Ueland PM, Obeid R, Schulze MB, Herter-Aeberli I, Schwerdtle T, Weikert C. Vegan Diet and Bone Health-Results from the Cross-Sectional RBVD Study. Nutrients. 2021 Feb 21;13(2):685. doi: 10.3390/nu13020685.
  4. 4. Raedle-Hurst T, Wissing S, Mackenstein N, Obeid R, Geisel J, Wagenpfeil S, Abdul-Khaliq H. Determinants of soluble angiotensin-converting enzyme 2 concentrations in adult patients with complex congenital heart disease. Clin Res Cardiol. 2020 Dec 5:1-9. doi: 10.1007/s00392-020-01782-y. Online ahead of print.
  5. 5. Weikert C, Trefflich I, Menzel J, Obeid R, Longree A, Dierkes J, Meyer K, Herter-Aeberli I, Mai K, Stangl GI, Müller SM, Schwerdtle T, Lampen A, Abraham K. Vitamin and Mineral Status in a Vegan Diet. Dtsch Arztebl Int. 2020 Aug 31;117(35-36):575-582.
  6. 6. Obeid R, Schön C, Pietrzik K, et al., Pharmacokinetics of sodium and calcium (6S)-5-CH3-H4folate compared to folic acid and indirect comparison of (6S)-5-CH3-H4folate salts. Nutrients 2020;12:3623. DOI:  10.3390/nu12123623.
  7. 7. Smolders L, de Wit NJW, Balvers MGJ, Obeid R, Vissers MMM, Esser D. Natural choline from Egg Yolk phospholipids is more efficiently absorbed compared with choline bitartrate; Outcomes of a randomized trial in healthy adults. Nutrients 2019; 11:2758. doi: 10.3390/nu11112758.
  8. 8. Tillmann S, Happ DF, Mikkelsen PF, Geisel J, Wegener G, Obeid R. Behavioral and metabolic effects of S-adenosylmethionine and imipramine in the Flinders Sensitive Line rat model of depression. Behav Brain Res 2019;364:274-80.
  9. 9. Obeid R, Geisel J, Nix WA. 4-Pyridoxic Acid/Pyridoxine Ratio in Patients with Type 2 Diabetes is Related to Global Cardiovascular Risk Scores. Diagnostics (Basel) 2019; doi: 10.3390/diagnostics9010028.
  10. 10. Zant A, Awwad HM, Geisel J, Keller M, Obeid R. Vitamin B12-fortified toothpaste improves vitamin status in elderly people: a randomized, double-blind, placebo-controlled study. Aging Clin Exp Res 2019;31:1817-25.
  11. 11. Kehrmann J, Menzel J, Saeedghalati M, Obeid R, Schulze C, Holzendorf V,  Obeid et al., Gut microbiota in HIV-infected individuals linked to coronary heart disease. J Infect Dis 2019; 219:497-508.
  12. 12. Obeid R, Schön C, Wilhelm W, Pietrzik K, Pilz S. Dietary and lifestyle predictors of folate insufficiency in non-supplemented German women. International Journal of Food Science and Nutrition 2019;70:367-76.
  13. 13. Tillmann S, Awwad HM, Eskelund AR, Treccani G, Geisel J, Wegener G, Obeid R. Probiotics Affect One-Carbon Metabolites and Catecholamines in a Genetic Rat Model of Depression. Mol Nutr Food Res 2018;62:e1701070.
  14. 14. Obeid R, Awwad HM, Knell AI, Hübner U, Geisel J. Glucose and Fat Tolerance Tests Induce Differential Responses in Plasma Choline Metabolites in Healthy Subjects. Nutrients 2018;10(9). pii: E1209. doi: 10.3390/nu10091209.
  15. 15. Pilz S, Obeid R, Schwetz V, Trummer C, et al., Hormonal Contraceptive Use Is Associated With Higher Total but Unaltered Free 25-Hydroxyvitamin D Serum Concentrations. J Clin Endocrinol Metab 2018;103:2385-91.
  16. 16. Awwad HM, Ohlmann CH, Stoeckle M, Geisel J, Obeid R. Serum concentrations of folate vitamers in patients with a newly diagnosed prostate cancer or hyperplasia. Clin Biochem 2018;56:41-46.
  17. 17. Obeid R, Hübner U, Bodis M, Graeber S, Geisel J. Effect of adding B-vitamins to vitamin D and calcium supplementation on CpG methylation of epigenetic aging markers. Nutr, Metabolism & Cardiovascular Diseases 2018: 28:411-417.
  18. 18. Obeid R, Schoen C, Wilhelm M, Pilz S, Pietrik K. Response of red blood cell folate to supplementation in non-pregnant women is predictable: a proposal for personalized supplementation. Mol Nutr Food Res 2018;62:1700537.
  19. 19. Speckmann B, Schulz S, Hiller F, Hesse D, Schumacher F, Kleuser B, Geisel J, Obeid R, et al., Selenium increases hepatic DNA methylation and modulates one-carbon metabolism in the liver of mice. J Nutr Biochem 2017; 48:112-119.
  20. 20. Obeid R, Schoen C, Wilhelm M, Pietrzik K, Pilz S. The effectiveness of daily supplementation with 400 or 800 µg folate in reaching protective red blood cell folate concentrations in non-pregnant women; a randomized trial. Eur J Nutr 2018;57(5):1771-1780.
  21. 21. Pilz S, Hahn A, Schoen C, Wilhelm M, Obeid R. Effect of two different multimicronutrient supplements on vitamin D status in women of childbearing age: a randomized trial. Nutrient 2017, Doi: 10.3390/nu9010030.
  22. 22. Siebert AK*, Obeid R*, Weder S, Awwad HM, Sputtek A, Geisel J, Keller M. Vitamin B-12 fortified toothpaste improves vitamin status in vegans: a 12-week randomized placebo-controlled study. Am J Clin Nutr 2017:105:618-625. * Shared first authorship
  23. 23. Awwad HM, Geisel J, Obeid R. Determination of trimethylamine, trimethylamine N-oxide, and taurine in human plasma and urine by UHPLC-MS/MS technique. J Chromatogr B Analyt Technol Biomed Life Sci 2016;1038:12-18.
  24. 24. Obeid R, Awwas HM, Keller M, Geisel J. Trimethylamine-N-oxide and its biological variations in vegetarians. Eur J Nutr 2017;56:2599-2609.
  25. 25. Obeid R, Awwad MH, Kisch SH, Waldura C, Herrmann W, Graeber S, Geisel J. Plasma trimethylamine-N-oxide following supplementation with vitamin D or D plus B-vitamins. Mol Nutr & Food Res. 2017. DOI: 10.1002/mnfr.201600358.
  26. 26. Obeid R, Hübner U, Bodis M, Geisel J. Plasma Amyloid Beta 1-42 and DNA Methylation Pattern Predict Accelerated Aging in Young Subjects with Down Syndrome. Neuromolecular Med 2016;18:593-601.
  27. 27. Abuyaman O, Torring N, Obeid R, Nexo E. First trimester serum levels of the soluble transcobalamin receptor, holo-transcobalamin, and total transcobalamin in relation to preeclampsia risk. The Scandinavian Journal of Clinical & Laboratory Investigation 2016;76:641-644.
  28. 28. Obeid R, Awwad MH, Rabagny Y, Graeber S, Herrmann W, Geisel J. Plasma trimethylamine N-oxide concentration is associated with choline, phospholipid, and methyl metabolism. Am J Clin Nutr 2016;103:703-11.
  29. 29. Awwad MH, Ohlmann CH, Stoeckle M, Aziz R, Geisel J, Obeid R. Disturbed choline-phospholipids inter-conversion in elderly patients with prostate cancer. Biochimie 2016;126:108-14.
  30. 30. Weinhold A, Obeid R, Vogt T, Reichrath J. Prospective Investigation of 25(OH)D3 serum concentrations following UVB narrow band phootherapy in patients with psoriasis and atopic dermatitis. Anticancer Res 2016;36:1439-44.
  31. 31. Zawada AM, Schneider JS, Michel AI, Rogacev KS, Hummel B, Krezdorn N, Müller S, Rotter B, Winter P, Obeid R, et al. DNA methylation profiling reveals differences in the three human monocyte subsets and identifies uremia to induce DNA methylation changes during differentiation. Epigenetics 2016; 11:259-72.
  32. 32. Nillson T, Hurtig-Wennloef A, Sjoestroem M, Herrmann W, Obeid R, Owen JR, Zeisel S. Plasma 1-carbon metabolites and academic achievement in 15-year-old Swedish adolescents. FASEB 2016;30:1683-8.
  33. 33. Obeid R, Kirsch SH, Dilmann S, Klein C, Eckert R, et al. Folic acid causes higher prevalence of detectable unmetabolized folic acid in serum than B-complex: a randomized trial. Eur J Nutr 2016;55:1021-28.