Inflammation, Lipoprotein Metabolism and Kidney Damage in early atherogenesis — The Homburg Evaluation

Inclusion Criteria:

Apparently healthy subjects without manifest cardiovascular disease (CVD)

Exclusion Criteria:

Age < 20 years / > 60 years
Intake of Systemic Immunosuppressive Agents
Prevalent CVD (Coronary / Cerebrovascular / Peripheral Artery Disease)

Parameters:

Traditional cardiovascular risk factors
Common carotid intima media thickness
Cell counts of monocyte subsets
Parameters of cholesterol homeostasis

Number of Participants:

622 Participants recruited
7 Participants met predefined exclusion criteria
3 Participants had no ultrasound measurements

Cooperation Partners:

Dr. Oliver Weingärtner, Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes
Professor Dieter Lütjohann, Abteilung für Klinische Pharmakologie der Universität Bonn
Dr. Yvonne Grenner, Leitende Betriebsärztin, Klinik für Innere Medizin II, Universitätsklinikum des Saarlandes

Publications:

Zawada AM, Rogacev KS, Hummel B, Berg JT, Friedrich A, Roth HJ, Obeid R, Geisel J, Fliser D, Heine GH.

S-adenosylhomocysteine is associated with subclinical atherosclerosis and renal function in a cardiovascular low-risk population.

Atherosclerosis 2014 May;234(1):17-22. Impact Punkte: 3,7 Abstract

Weingärtner O, Pinsdorf T, Rogacev KS, Blömer L, Grenner Y, Gräber S, Ulrich C, Girndt M, Böhm M, Fliser D, Laufs U, Lütjohann D, Heine GH.

The relationships of markers of cholesterol homeostasis with carotid intima-media thickness.

PLoS One 2010; 5(10):e13467. Abstract

Rogacev KS, Ulrich C, Blomer L, Hornof F, Oster K, Ziegelin M, Cremers B, Grenner Y, Geisel J, Schlitt A, Kohler H, Fliser D, Girndt M, Heine GH.
Monocyte heterogeneity in obesity and subclinical atherosclerosis.
Eur Heart J 2010 Feb;31(3):369-76. Abstract

Medical Theses:

Lutz Blömer
Lymphozytensubpopulationen des peripheren Blutes als Marker subklinischer Atherosklerose

Kyrill Rogacev
Monozytenheterogenität und subklinische Atherosklerose

Stéphanie Bertrang

Nikotinkonsum und Monozytenheterogenität

Judith Berg / Annika Friedrich (ongoing)