HOMe ALONE
Heterogenetiy of Monocytes and Echocardiography among allograft recipients in nephrology |
Inclusion Criteria:
Subjects after allogenic renal transplantation (time since transplantation ≥ 12 months)
Exclusion Criteria:
Acute infectious disease
Active malignant disease
Acute renal injury
Baseline Parameters:
Traditional cardiovascular risk factors
Parameters of calcium-phosphate metabolism
Echocardiography
Ultrasound renal resistive indices
Cell counts of monocyte subsets
Number of Participants:
222 Participants scheduled to be included (recruitment ongoing)
Combined primary cardiovascular outcome:
Any cardiovascular event (acute myocardial infarction; surgical or interventional coronary / cerebrovascular / peripheral-arterial revascularization; stroke [symptoms ≥ 24 hours]; amputation above the ankle; death)
Combined primary renal outcome:
Reduction of eGFR ≤50% baseline, ESRD (renal replacement therapy for ≥ 3 months), death
Secondary cardiovascular outcome:
Acute myocardial infarction, ischemic stroke (symptoms ≥ 24 hours), cardiovascular death
Secondary renal outcome:
Reduction of eGFR ≤50% baseline, ESRD (renal replacement therapy for ≥ 3 months)
Pulications:
Rogacev KS1, Zawada AM1, Hundsdorfer J, Achenbach M, Held G, Fliser D, Heine GH.
Immunosuppression and monocyte subsets.
Nephrol Dial Transplant 2015 Jan;30(1):143-53. Abstract
Medical Theses:
Johanna Hundsdorfer
Lucie Bauer (ongoing)
Kontakt
Fabio Lizzi
Fabio.Lizzi @uks.eu
Tel. 06841/16-15849