HOM sweet HOMe
Heterogeneity of monocytes in subjects who undergo elective coronary angiography – The Homburg evaluation |
Inclusion Criteria:
Patients undergoing elective coronary angiography
Exclusion Criteria:
Missing baseline data / coronary angiography cancelled
Cooperation Partners:
Prof. Dr. Michael Böhm, Dr. Bodo Cremers / Prof. Dr. Bruno Scheller, Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes
Baseline Parameters:
Traditional cardiovascular risk factors
Parameters of calcium-phosphate metabolism
Left-ventricular function by ventriculography (analysed in 1001 participants)
Ultrasound renal resistive indices (analysed in ~500 participants)
Cell counts of monocyte subsets (analysed in 951 participants)
Number of Participants:
1368 Participants recruited at baseline
32 Participants excluded at baseline because of missing data and / or cancelled coronary angiography
Combined primary outcome:
First acute myocardial infarction; ischemic stroke (symptoms ≥ 24 hours); cardiovascular death
Combined secondary outcome:
Any cardiovascular event (acute myocardial infarction; surgical or interventional coronary / cerebrovascular / peripheral-arterial revascularization; stroke [symptoms ≥ 24 hours]; amputation above the ankle; death)
Tertiary outcome:
Overall survival
Publications:
Rogacev KS, Cremers B, Zawada AM, Seiler S, Binder N, Ege P, Grosse-Dunker G, Heisel I, Hornof F, Jeken J, Rebling NM, Ulrich C, Scheller B, Bohm M, Fliser D, Heine GH.
CD14++CD16+ Monocytes Independently Predict Cardiovascular Events: A Cohort Study of 951 Patients Referred for Elective Coronary Angiography.
J Am Coll Cardiol 2012 Sep 8. Abstract
Seiler S, Cremers B, Rebling NM, Hornof F, Jeken J, Kersting S, Steimle C, Ege P, Fehrenz M, Rogacev KS, Scheller B, Bohm M, Fliser D, Heine GH.
The phosphatonin fibroblast growth factor 23 links calcium-phosphate metabolism with left-ventricular dysfunction and atrial fibrillation.
Eur Heart J 2011 Nov;32(21):2688-96. Abstract
Medical Theses:
Florian Hornof
Bedeutung der Monozytenheterogenität bei Adipositas und Atherosklerose
Niko Rebling
FGF-23 und linksventrikuläre Dysfunktion
Gunnar Große-Dunker / Ursula Ulbricht (ongoing)
Kontakt
Fabio Lizzi
Fabio.Lizzi @uks.eu
Tel. 06841/16-15849