Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes
Aktuelle Publikationen
Leitung: Prof. Dr. med. Lorenz Thurner

Aktuelle Publikationen

Alle Publikationen auf PubMed (nih.gov) 

KIR2DS4 and Its Variant KIR1D in KIR-AA Genotype Donors Showed Differential Survival Impact in Patients with Lymphoid Disease after HLA-Matched Unrelated Hematopoietic Stem Cell Transplantation.
Gowdavally S, Tsamadou C, Platzbecker U, Sala E, Valerius T, Klein S, Kröger N, Wulf G, Einsele H, Thurner L, Schaefer-Eckart K, Freitag S, Casper J, Dürholt M, Kaufmann M, Hertenstein B, Ringhoffer M, Schmeller S, Neuchel C, Rode I, Amann EM, Richter A, Schrezenmeier H, Mytilineos J, Fuerst D.
Transplant Cell Ther. 2023 May 6:S2666-6367(23)01236-8. doi: 10.1016/j.jtct.2023.04.006. Online ahead of print.
PMID: 37150297
 
B-cell receptor reactivity against Rothia mucilaginosa in nodular lymphocyte-predominant Hodgkin lymphoma.
Thurner L, Fadle N, Regitz E, Roth S, Cetin O, Kos IA, Hess SM, Bein J, Bohle RM, Vornanen M, Sundström C, De Leval L, Tiacci E, Borchmann P, Engert A, Poeschel V, Held G, Schwarz EC, Neumann F, Preuss KD, Hoth M, Küppers R, Lehman K, Hansmann ML, Becker SL, Bewarder M, Hartmann S.
Haematologica. 2023 May 4. doi: 10.3324/haematol.2023.282698. Online ahead of print.
PMID: 37139600 Free article.


Comparison of IGLV2-14 light chain sequences of patients with AL amyloidosis or multiple myeloma.
Berghaus N, Schreiner S, Poos AM, Raab MS, Goldschmidt H, Mai EK, Salwender HJ, Bernhard H, Thurner L, Müller-Tidow C, Weinhold N, Hegenbart U, Schönland SO, Huhn S.
FEBS J. 2023 Apr 25. doi: 10.1111/febs.16805. Online ahead of print.
PMID: 37097223

 
Impact of newly diagnosed extramedullary myeloma on outcome after first autograft followed by maintenance: A CMWP-EBMT study.
Gagelmann N, Eikema DJ, Koster L, Netelenbos T, McDonald A, Stoppa AM, Fenk R, Anagnostopoulos A, van Gorkom G, Deconinck E, Bulabois CE, Delforge M, Bunjes D, Arcese W, Reményi P, Itälä-Remes M, Thurner L, Bolaman AZ, Nabil Y, Lund J, Labussière-Wallet H, Hayden PJ, Beksac M, Schönland S, Yakoub-Agha I.
Eur J Haematol. 2023 Apr 21. doi: 10.1111/ejh.13981. Online ahead of print.
PMID: 37082839


Daratumumab for a Patient With Refractory Antineutrophil Cytoplasmatic Antibody-Associated Vasculitis.
Rixecker TM, Lepper PM, Mang S, Espig P, Brill K, Thurner L, Bittenbring JT.
JAMA Intern Med. 2023 Jun 1;183(6):615-618. doi: 10.1001/jamainternmed.2023.0152.
PMID: 37036724

 
Ars2-containing bispecific, Fab- and IgG1-format BAR-bodies to target DLBCL cells.
Kiefer M, Thurner L, Bock T, Cetin O, Kos I, Lesan V, Kaddu-Mulindwa D, Bittenbring JT, Fadle N, Regitz E, Hoth M, Neumann F, Preuss KD, Pfreundschuh M, Christofyllakis K, Bewarder M.
EJHaem. 2022 Dec 27;4(1):125-134. doi: 10.1002/jha2.635. eCollection 2023 Feb.
PMID: 36819155 Free PMC article.

 
Impact of vincristine dose reduction on outcomes of patients with aggressive B-cell lymphoma treated with (R) - CHOP.
Bewarder M, Kaddu-Mulindwa D, Kos IA, Lesan V, Held G, Poeschel V, Thurner L, Bittenbring JT, Schmitz N, Truemper L, Pfreundschuh M, Christofyllakis K, Loeffler M, Altmann B, Ziepert M.
Haematologica. 2023 Feb 23. doi: 10.3324/haematol.2022.282126. Online ahead of print.
PMID: 36815369 Free article.

 
Autoantibodies against SUMO1-DHX35 in long-COVID.
Thurner L, Fadle N, Regitz E, Preuss KD, Neumann F, Cetin O, Schormann C, Hoffmann MC, Herr C, Kheiroddin P, Rixecker TM, Bals R, Muller S, Thurner B, Kessel C, Kabesch M, Bewarder M, Heyne K, Lensch C, Kos IA.
J Transl Autoimmun. 2022 Nov 20;5:100171. doi: 10.1016/j.jtauto.2022.100171. eCollection 2022.
PMID: 36425003 Free PMC article.

 
Aberrant Naive CD4-Positive T Cell Differentiation in Systemic Juvenile Idiopathic Arthritis Committed to B Cell Help.
Kuehn J, Schleifenbaum S, Hendling M, Siebenhandl S, Krainer J, Fuehner S, Hellige A, Park C, Hinze C, Wittkowski H, Holzinger D, Thurner L, Weinhäusel A, Foell D, Kessel C.
Arthritis Rheumatol. 2023 May;75(5):826-841. doi: 10.1002/art.42409. Epub 2023 Mar 17.
PMID: 36409585

 
TREM2 Is Associated with Advanced Stages and Inferior Prognosis in Oral Squamous Cell Carcinoma.
Struckmeier AK, Radermacher A, Fehrenz M, Alansary D, Wartenberg P, Wagner M, Scheller A, Hess J, Moratin J, Freudlsperger C, Hoffmann J, Thurner L, Roemer K, Freier K, Horn D.
Cancers (Basel). 2022 Sep 24;14(19):4635. doi: 10.3390/cancers14194635.
PMID: 36230558 Free PMC article.

 
IL-1RA Antibodies in Myocarditis after SARS-CoV-2 Vaccination.
Thurner L, Kessel C, Fadle N, Regitz E, Seidel F, Kindermann I, Lohse S, Kos I, Tschöpe C, Kheiroddin P, Kiblboeck D, Hoffmann MC, Bette B, Carbon G, Cetin O, Preuss KD, Christofyllakis K, Bittenbring JT, Pickardt T, Fischer Y, Thiele H, Baldus S, Stangl K, Steiner S, Gietzen F, Kerber S, Deneke T, Jellinghaus S, Linke A, Ibrahim K, Grabmaier U, Massberg S, Thilo C, Greulich S, Gawaz M, Mayatepek E, Meyer-Dobkowitz L, Kindermann M, Birk E, Birk M, Lainscak M, Foell D, Lepper PM, Bals R, Krawczyk M, Mevorach D, Hasin T, Keren A, Kabesch M, Abdul-Khaliq H, Smola S, Bewarder M, Thurner B, Böhm M, Pfeifer J, Klingel K.
N Engl J Med. 2022 Oct 20;387(16):1524-1527. doi: 10.1056/NEJMc2205667. Epub 2022 Sep 21.
PMID: 36130012 Free PMC article. No abstract available.

 
Fewer neurocognitive deficits and less brain atrophy by third ventricle measurement in PLWH treated with modern ART: A prospective analysis.
Kaddu-Mulindwa D, Heit M, Wagenpfeil G, Bewarder M, Fassbender K, Behnke S, Yilmaz U, Fousse M.
Front Neurol. 2022 Aug 23;13:962535. doi: 10.3389/fneur.2022.962535. eCollection 2022.
PMID: 36081869 Free PMC article.

 
Preclinical Evaluation of a New ECCO2R Setup.
Schwärzel LS, Jungmann AM, Schmoll N, Caspari S, Seiler F, Muellenbach RM, Bewarder M, Thai Dinh Q, Bals R, Lepper PM, Omlor AJ.
ASAIO J. 2022 Sep 1;68(9):1197-1203. doi: 10.1097/MAT.0000000000001638. Epub 2021 Dec 1.
PMID: 36066356

 
B-cell receptors of EBV-negative Burkitt lymphoma bind modified isoforms of autoantigens.
Bock T, Bewarder M, Cetin O, Fadle N, Regitz E, Schwarz EC, Held J, Roth S, Lohse S, Pfuhl T, Wagener R, Smola S, Becker SL, Bohle RM, Trümper L, Siebert R, Hansmann ML, Pfreundschuh M, Drexler HG, Hoth M, Kubuschok B, Roemer K, Preuss KD, Hartmann S, Thurner L.
EJHaem. 2022 Jun 16;3(3):739-747. doi: 10.1002/jha2.475. eCollection 2022 Aug.
PMID: 36051037 Free PMC article.

 
Adaptive humoral immune response and cellular immune status in cancer patients and patients under immunosuppression vaccinated against SARS-CoV-2.
Kos IA, Kiefer M, Brill K, Cetin O, Bittenbring JT, Ahlgrimm M, Smola S, Lohse S, Christofyllakis K, Kaddu-Mulindwa D, Neumann F, Bewarder M, Thurner L.
Expert Rev Vaccines. 2022 Nov;21(11):1683-1689. doi: 10.1080/14760584.2022.2116009. Epub 2022 Aug 26.
PMID: 35994606

 
IDO1 is highly expressed in macrophages of patients in advanced tumour stages of oral squamous cell carcinoma.
Struckmeier AK, Radermacher A, Fehrenz M, Bellin T, Alansary D, Wartenberg P, Boehm U, Wagner M, Scheller A, Hess J, Moratin J, Freudlsperger C, Hoffmann J, Thurner L, Roemer K, Freier K, Horn D.
J Cancer Res Clin Oncol. 2022 Aug 13. doi: 10.1007/s00432-022-04277-7. Online ahead of print.
PMID: 35963900

 
Cardiac affection associated to severe Multisystem Inflammatory Syndrome in Children (MIS-C) in a 6-year-old girl with a single coronary artery.
Pfeifer J, Fries P, Thurner L, Abdul-Khaliq H.
Clin Res Cardiol. 2022 Oct;111(10):1184-1187. doi: 10.1007/s00392-022-02060-9. Epub 2022 Jul 29.
PMID: 35904641 Free PMC article. No abstract available.

 
Comparison of immersive and non-immersive virtual reality videos as substitute for in-hospital teaching during coronavirus lockdown: a survey with graduate medical students in Germany.
Omlor AJ, Schwärzel LS, Bewarder M, Casper M, Damm E, Danziger G, Mahfoud F, Rentz K, Sester U, Bals R, Lepper PM.
Med Educ Online. 2022 Dec;27(1):2101417. doi: 10.1080/10872981.2022.2101417.
PMID: 35850619 Free PMC article.

 
Higher risk for chronic graft-versus-host disease (GvHD) in HLA-G mismatched transplants following allogeneic hematopoietic stem cell transplantation: A retrospective study.
Neuchel C, Gowdavally S, Tsamadou C, Platzbecker U, Sala E, Wagner-Drouet E, Valerius T, Kröger N, Wulf G, Einsele H, Thurner L, Schaefer-Eckart K, Freitag S, Casper J, Dürholt M, Kaufmann M, Hertenstein B, Klein S, Ringhoffer M, Frank S, Amann EM, Rode I, Schrezenmeier H, Mytilineos J, Fürst D.
HLA. 2022 Oct;100(4):349-360. doi: 10.1111/tan.14733. Epub 2022 Jul 27.
PMID: 35799419

 
Management of Extranodal Marginal Zone Lymphoma: Present and Upcoming Perspectives.
Kaddu-Mulindwa D, Thurner L, Christofyllakis K, Bewarder M, Kos IA.
Cancers (Basel). 2022 Jun 19;14(12):3019. doi: 10.3390/cancers14123019.
PMID: 35740684 Free PMC article. Review.

 
Long-term efficacy, safety and neurotolerability of MATRix regimen followed by autologous transplant in primary CNS lymphoma: 7-year results of the IELSG32 randomized trial.
Ferreri AJM, Cwynarski K, Pulczynski E, Fox CP, Schorb E, Celico C, Falautano M, Nonis A, La Rosée P, Binder M, Fabbri A, Ilariucci F, Krampera M, Roth A, Hemmaway C, Johnson PW, Linton KM, Pukrop T, Gørløv JS, Balzarotti M, Hess G, Keller U, Stilgenbauer S, Panse J, Tucci A, Orsucci L, Pisani F, Zanni M, Krause SW, Schmoll HJ, Hertenstein B, Rummel M, Smith J, Thurner L, Cabras G, Pennese E, Ponzoni M, Deckert M, Politi LS, Finke J, Ferranti A, Cozens K, Burger E, Ielmini N, Cavalli F, Zucca E, Illerhaus G; IELSG32 study investigators.
Leukemia. 2022 Jul;36(7):1870-1878. doi: 10.1038/s41375-022-01582-5. Epub 2022 May 13.
PMID: 35562406 Clinical Trial.

 
Biomarker guided treatment in oncogene-driven advanced non-small cell lung cancer in older adults: A Young International Society of Geriatric Oncology report.
Christofyllakis K, Monteiro AR, Cetin O, Kos IA, Greystoke A, Luciani A.
J Geriatr Oncol. 2022 Nov;13(8):1071-1083. doi: 10.1016/j.jgo.2022.04.013. Epub 2022 May 5.
PMID: 35525790 Review.

 
Cytotoxic Efficiency of Human CD8+ T Cell Memory Subtypes.
Knörck A, Schäfer G, Alansary D, Richter J, Thurner L, Hoth M, Schwarz EC.
Front Immunol. 2022 Apr 13;13:838484. doi: 10.3389/fimmu.2022.838484. eCollection 2022.
PMID: 35493468 Free PMC article.

 
Autoantibodies against interleukin-1 receptor antagonist in multisystem inflammatory syndrome in children: a multicentre, retrospective, cohort study.
Pfeifer J, Thurner B, Kessel C, Fadle N, Kheiroddin P, Regitz E, Hoffmann MC, Kos IA, Preuss KD, Fischer Y, Roemer K, Lohse S, Heyne K, Detemple MC, Fedlmeier M, Juenger H, Sauer H, Meyer S, Rohrer T, Wittkowski H, Becker SL, Masjosthusmann K, Bals R, Gerling S, Smola S, Bewarder M, Birk E, Keren A, Böhm M, Jakob A, Abdul-Khaliq H, Anton J, Kabesch M, Pino-Ramirez RM, Foell D, Thurner L.
Lancet Rheumatol. 2022 May;4(5):e329-e337. doi: 10.1016/S2665-9913(22)00064-9. Epub 2022 Mar 29.
PMID: 35368387 Free PMC article.

 
High Mortality of COVID-19 Early after Allogeneic Stem Cell Transplantation: A Retrospective Multicenter Analysis on Behalf of the German Cooperative Transplant Study Group.
Schaffrath J, Brummer C, Wolff D, Holtick U, Kröger N, Bornhäuser M, Kraus S, Hilgendorf I, Blau IW, Penack O, Wittke C, Steiner N, Nachbaur D, Thurner L, Hindahl H, Zeiser R, Maier CP, Bethge W, Müller LP.
Transplant Cell Ther. 2022 Jun;28(6):337.e1-337.e10. doi: 10.1016/j.jtct.2022.03.010. Epub 2022 Mar 13.
PMID: 35296445 Free PMC article.

 
KIR2DS1-HLA-C status as a predictive marker for benefit from rituximab: a post-hoc analysis of the RICOVER-60 and CLL8 trials.
Kaddu-Mulindwa D, Altmann B, Robrecht S, Ziepert M, Regitz E, Tausch E, Held G, Poeschel V, Lesan V, Bittenbring JT, Thurner L, Pfreundschuh M, Christofyllakis K, Truemper L, Loeffler M, Schmitz N, Hoth M, Hallek M, Fischer K, Stilgenbauer S, Bewarder M, Rixecker TM.
Lancet Haematol. 2022 Feb;9(2):e133-e142. doi: 10.1016/S2352-3026(21)00369-0.
PMID: 35114151 Clinical Trial.

 
Salvage High-dose Melphalan With Autologous Stem cell Transplantation as Bridge to Consolidation Therapy for Chemoresistant Aggressive B-cell Lymphoma.
Kaddu-Mulindwa D, Gödel P, Kutsch N, Heger JM, Scheid C, Borchmann P, Holtick U, Held G, Thurner L, Bewarder M, Rixecker T, Bittenbring JT.
Clin Lymphoma Myeloma Leuk. 2022 Jul;22(7):e498-e506. doi: 10.1016/j.clml.2022.01.007. Epub 2022 Jan 13.
PMID: 35094950 Review.

 
Prolonged Remissions After Nivolumab Plus Gemcitabine/Oxaliplatin in Relapsed/Refractory T-cell Lymphoma.
Houot R, Poeschel V, Altmann B, Angel S, Thurner L, Illmer T, Andre M, Dreyling M, Maisonneuve H, Tilly H, Mayer S, Casasnovas O, Le Gouill S, Offner F, Cartron G, Kerkhoff A, Weber T, Hoffmann J, Ziepert M, Klapper W, Itti E, Hellwig D, Natchkebia G, de Leval L, Rosenwald A, Haioun C, Dercle L, Gaulard P, Held G.
Hemasphere. 2022 Jan 10;6(2):e672. doi: 10.1097/HS9.0000000000000672. eCollection 2022 Feb.
PMID: 35028526 Free PMC article.

 
Epigastric Pain After COVID-19 Vaccination.
Casper M, Thurner L, Holz R, Krawczyk M, Link A.
Am J Gastroenterol. 2022 Mar 1;117(3):371. doi: 10.14309/ajg.0000000000001609.
PMID: 35020675 No abstract available.

 
Advances in Lymphoma Molecular Diagnostics.
Kos IA, Thurner L, Bittenbring JT, Christofyllakis K, Kaddu-Mulindwa D.
Diagnostics (Basel). 2021 Nov 23;11(12):2174. doi: 10.3390/diagnostics11122174.
PMID: 34943410 Free PMC article. Review.

 
Cost-effectiveness of precision cancer medicine-current challenges in the use of next generation sequencing for comprehensive tumour genomic profiling and the role of clinical utility frameworks (Review).
Christofyllakis K, Bittenbring JT, Thurner L, Ahlgrimm M, Stilgenbauer S, Bewarder M, Kaddu-Mulindwa D.
Mol Clin Oncol. 2022 Jan;16(1):21. doi: 10.3892/mco.2021.2453. Epub 2021 Nov 25.
PMID: 34909199 Free PMC article. Review.

 
IgG seroprevalence of COVID-19 among people living with HIV or at high risk of HIV in south-west Germany: A seroprevalence study.
Kaddu-Mulindwa D, Keuser L, Lesan V, Rissland J, Smola S, Werdecker V, Stilgenbauer S, Christofyllakis K, Thurner L, Bewarder M, Lohr B, Lutz J, Lohse S, Rieke A.
HIV Med. 2022 May;23(5):564-569. doi: 10.1111/hiv.13207. Epub 2021 Nov 22.
PMID: 34811869 Free PMC article.

 
Prophylactic Peripheral Blood Stem Cell Collection in Patients with Extensive Bone-Marrow Infiltration of Neuroendocrine Tumours Prior to Peptide Receptor Radionuclide Therapy with 177Lu-DOTATATE.
Sabet A, Mader N, Bittenbring JT, Khreish F, Grünwald F, Biersack HJ, Ezziddin S.
Pharmaceuticals (Basel). 2021 Oct 5;14(10):1022. doi: 10.3390/ph14101022.
PMID: 34681247 Free PMC article.

 
Landscape of 4D Cell Interaction in Hodgkin and Non-Hodgkin Lymphomas.
Hartmann S, Scharf S, Steiner Y, Loth AG, Donnadieu E, Flinner N, Poeschel V, Angel S, Bewarder M, Bein J, Brunnberg U, Bozzato A, Schick B, Stilgenbauer S, Bohle RM, Thurner L, Hansmann ML.
Cancers (Basel). 2021 Oct 17;13(20):5208. doi: 10.3390/cancers13205208.
PMID: 34680356 Free PMC article.

 
Significant reduced loss of bone mineral density after four vs. six cycles of R-CHOP: an analysis of the FLYER-trial.
Kaddu-Mulindwa D, Lesan V, Berdel C, Stilgenbauer S, Bewarder M, Thurner L, Witzens-Harig M, Viardot A, Soekler M, Keller U, Truemper L, Christofyllakis K, Fleser O, Bittenbring JT, Poeschel V, Held G, Jagoda P.
Leuk Lymphoma. 2022 Feb;63(2):326-334. doi: 10.1080/10428194.2021.1975193. Epub 2021 Oct 20.
PMID: 34668817

 
Killer immunoglobulin-like receptor 2DS5 is associated with recovery from coronavirus disease 2019.
Lesan V, Bewarder M, Metz C, Becker A, Mang S, Regitz E, Thurner L, Neumann F, Kos I, Christofyllakis K, Danziger G, Stilgenbauer S, Bals R, Lepper PM, Kaddu-Mulindwa D, Rixecker T.
Intensive Care Med Exp. 2021 Sep 3;9(1):45. doi: 10.1186/s40635-021-00409-4.
PMID: 34476598 Free PMC article.


Application of the FilmArray® BioThreat Panel for molecular diagnosis of human tularemia.
Roth S, Thurner L, Becker SL.
Ticks Tick Borne Dis. 2021 Sep;12(5):101792. doi: 10.1016/j.ttbdis.2021.101792. Epub 2021 Jul 21.
PMID: 34330678 No abstract available.


[Conjunctival mantle cell lymphoma-a therapeutic challenge].
Trouvain AM, Bocqué C, Müller LJ, Heinrich C, Bewarder M, Pérez Guerra N, Szurman G, Becker SL, Rickmann A.
Ophthalmologie. 2022 Aug;119(8):837-840. doi: 10.1007/s00347-021-01462-w. Epub 2021 Jul 28.
PMID: 34319474 German. No abstract available.

 
The B-cell Receptor Autoantigen LRPAP1 Can Replace Variable Antibody Regions to Target Mantle Cell Lymphoma Cells.
Bewarder M, Kiefer M, Will H, Olesch K, Moelle C, Stilgenbauer S, Christofyllakis K, Kaddu-Mulindwa D, Bittenbring JT, Fadle N, Regitz E, Kaschek L, Hoth M, Neumann F, Preuss KD, Pfreundschuh M, Thurner L.
Hemasphere. 2021 Jul 13;5(8):e620. doi: 10.1097/HS9.0000000000000620. eCollection 2021 Aug.
PMID: 34263144 Free PMC article.

 
SARS-CoV-2 vaccination in cardiothoracic organ transplant recipients: effective strategies wanted.
Ewen S, Neumann F, Bittenbring JT, von Scheidt W, Böhm M.
Clin Res Cardiol. 2021 Aug;110(8):1139-1141. doi: 10.1007/s00392-021-01876-1. Epub 2021 Jul 9.
PMID: 34241675 Free PMC article. No abstract available.

 
Comparison of Circular and Parallel-Plated Membrane Lungs for Extracorporeal Carbon Dioxide Elimination.
Schwärzel LS, Jungmann AM, Schmoll N, Caspari S, Seiler F, Muellenbach RM, Bewarder M, Dinh QT, Bals R, Lepper PM, Omlor AJ.
Membranes (Basel). 2021 May 27;11(6):398. doi: 10.3390/membranes11060398.
PMID: 34072067 Free PMC article.

 
Current Treatment Options in CLL.
Bewarder M, Stilgenbauer S, Thurner L, Kaddu-Mulindwa D.
Cancers (Basel). 2021 May 19;13(10):2468. doi: 10.3390/cancers13102468.
PMID: 34069354 Free PMC article. Review.

 
FDG PET/CT to detect bone marrow involvement in the initial staging of patients with aggressive non-Hodgkin lymphoma: results from the prospective, multicenter PETAL and OPTIMAL>60 trials.
Kaddu-Mulindwa D, Altmann B, Held G, Angel S, Stilgenbauer S, Thurner L, Bewarder M, Schwier M, Pfreundschuh M, Löffler M, Menhart K, Grosse J, Ziepert M, Herrmann K, Dührsen U, Hüttmann A, Barbato F, Poeschel V, Hellwig D.
Eur J Nucl Med Mol Imaging. 2021 Oct;48(11):3550-3559. doi: 10.1007/s00259-021-05348-6. Epub 2021 Apr 29.
PMID: 33928400 Free PMC article.


Fatigue, weight loss, hypotension and electrolyte imbalance after a long-term stay in Thailand: A diagnostic challenge.
Becker SL, Gauer A, Thurner L.
Travel Med Infect Dis. 2021 May-Jun;41:102063. doi: 10.1016/j.tmaid.2021.102063. Epub 2021 May 8.
PMID: 33857593 No abstract available.


Increased B-cell activity with consumption of activated monocytes in severe COVID-19 patients.
Kos I, Balensiefer B, Lesan V, Kaddu-Mulindwa D, Thurner L, Christofyllakis K, Bittenbring JT, Ahlgrimm M, Seiffert M, Wagenpfeil S, Bewarder Y, Neumann F, Rixecker T, Smola S, Link A, Krawczyk M, Lammert F, Lepper PM, Bals R, Stilgenbauer S, Bewarder M.
Eur J Immunol. 2021 Jun;51(6):1449-1460. doi: 10.1002/eji.202049163. Epub 2021 Apr 19.
PMID: 33788264 Free PMC article. Clinical Trial.
 

Adjuvant Therapy of High-Risk (Stages IIC-IV) Malignant Melanoma in the Post Interferon-Alpha Era: A Systematic Review and Meta-Analysis.

Christofyllakis K, Pföhler C, Bewarder M, Müller CSL, Thurner L, Rixecker T, Vogt T, Stilgenbauer S, Yordanova K, Kaddu-Mulindwa D.

Front Oncol. 2021 Feb 18;10:637161. doi: 10.3389/fonc.2020.637161. https://pubmed.ncbi.nlm.nih.gov/33680957/
 

Protection strategy against outbreak of COVID-19 at a tertiary hematology-oncology: strengths and pitfalls.

Kaddu-Mulindwa D, Thurner L, Bewarder M, Murawski N, Ahlgrimm M, Pfuhl T, Gärtner B, Smola S, Stilgenbauer S.Kaddu-Mulindwa D, et al.
Infect Agent Cancer. 2021 Feb 24;16(1):17. doi: 10.1186/s13027-021-00356-5.
https://pubmed.ncbi.nlm.nih.gov/33627114/
 

LRPAP1-autoantibodies in mantle cell lymphoma are associated with superior outcome.

Thurner L, Fadle N, Bittenbring JT, Regitz E, Schuck R, Cetin O, Stuhr A, Rixecker T, Murawski NM, Poeschel V, Kaddu-Mulindwa D, Preuss KD, Stilgenbauer S, Hermine O, Kluin-Nelemans JC, Hartmann S, Dreyling M, Pott C, Bewarder M, Hoster E.Thurner L, et al.
Blood. 2021 Jan 29:blood.2020008835. doi: 10.1182/blood.2020008835. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/33513604/
 

Lymphocyte Predominant Cells Detect Moraxella Catarrhalis-Derived Antigens in Nodular Lymphocyte-Predominant Hodgkin Lymphoma

Lorenz Thurner, Sylvia Hartmann, Natalie Fadle, Evi Regitz, Maria Kemele, Yoo-Jin Kim, Rainer Maria Bohle, Anna Nimmesgern, Lutz von Müller, Volkhard A J Kempf, Marc A Weniger, Frank Neumann, Nadine Schneider, Martine Vornanen, Christer Sundström, Laurence de Leval, Andreas Enger, Dennis A Eichenauer, Ralf Küppers, Klaus-Dieter Preuss, Martin-Leo Hansmann, Michael Pfreundschuh.

Nature Communications. 2020 May 18;11(1):2465.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235000/
 

Feasibility and Safety of CD19 CAR T Cell Treatment for B-cell Lymphoma Relapse After Allogeneic Hematopoietic Stem Cell Transplantation

Maria-Luisa Schuber, Sascha Dietrich, Stephan Stilgenbauer, Anita Schmitt, Petra Pavel, Alexander Kunz, Andrea Bondong, Mandy Wegner, Peter Stadtherr, Susanne Jung, Anthony D Ho, Carsten Müller-Tidow, Michael Schmitt, Peter Dreger 

Biol Blood Marrow Transplant 2020 May 5; S083-879(20)30258-5.

https://pubmed.ncbi.nlm.nih.gov/32422254/

Characterization of an HLA-restricted and human cytomegalovirus-specific antibody repertoire with therapeutic potential.

Bewarder M, Held G, Thurner L, Stilgenbauer S, Smola S, Preuss KD, Carbon G, Bette B, Christofyllakis K, Bittenbring JT, Felbel A, Hasse A, Murawski N, Kaddu-Mulindwa D, Neumann F.

Cancer Immunol Immunother 2020 Apr 16.

https://pubmed.ncbi.nlm.nih.gov/32300857/
 

International prognostic indices in diffuse large B-cell lymphoma (DLBCL): a

comparison of IPI, R-IPI and NCCN-IPI.

Ruppert AS, Dixon JG, Salles GA, Wall A, Cunningham D, Poeschel V, Haioun C,

Tilly H, Ghesquieres H, Ziepert M, Flament J, Flowers C, Shi Q, Schmitz N.

Blood 2020 Mar 13. pii: blood.2019002729.

https://pubmed.ncbi.nlm.nih.gov/32232482/
 

A novel lymphoma-associated macrophage interaction signature (LAMIS) provides robust risk prognostication in diffuse large B-cell lymphoma clinical trial cohorts of the DSHNHL.

Staiger AM, Altenbuchinger M, Ziepert M, Kohler C, Horn H, Huttner M, Hüttl KS, Glehr G, Klapper W, Szczepanowski M, Richter J, Stein H, Feller AC, Möller P, Hansmann ML, Poeschel V, Held G, Loeffler M, Schmitz N, Trümper L, Pukrop T, Rosenwald A, Ott G, Spang R; Emed Demonstrator Project; German High Grade Non-Hodgkin’s Lymphoma Study Group (DSHNHL).

Leukemia 2020 Feb;34(2):543-552.

https://pubmed.ncbi.nlm.nih.gov/31530861/
 

Anthracycline-related cardiotoxicity in older patients with acute myeloid leukemia: A Young SIOG review paper.

Neuendorff NR, Loh KP, Mims AS, Christofyllakis K, Soo WK, Bölükbasi B, Oñoro-Algar C, Hundley WG, Klepin HD (2020) Blood Adv 4:762–775

https://pubmed.ncbi.nlm.nih.gov/32097461/
 

Four versus six cycles of CHOP chemotherapy in combination with six applications of rituximab in patients with aggressive B-cell lymphoma with favourable prognosis (FLYER): a randomised, phase 3, non-inferiority trial.

Poeschel V, Held G, Ziepert M, Witzens-Harig M, Holte H, Thurner L, Borchmann P, Viardot A, Soekler M, Keller U, Schmidt C, Truemper L, Mahlberg R, Marks R, Hoeffkes HG, Metzner B, Dierlamm J, Frickhofen N, Haenel M, Neubauer A, Kneba M, Merli F, Tucci A, de Nully Brown P, Federico M, Lengfelder E, di Rocco A, Trappe R, Rosenwald A, Berdel C, Maisenhoelder M, Shpilberg O, Amam J, Christofyllakis K, Hartmann F, Murawski N, Stilgenbauer S, Nickelsen M, Wulf G, Glass B, Schmitz N, Altmann B, Loeffler M, Pfreundschuh M; FLYER Trial Investigators; German Lymphoma Alliance.

Lancet 2020 Dec 21;394(10216):2271-2281.

https://pubmed.ncbi.nlm.nih.gov/31868632/
 

LRPAP1 is a frequent proliferation-inducing antigen of BCRs of mantle cell lymphomas and can be used for specific therapeutic targeting.

Thurner L, Hartmann S, Fadle N, Kemele M, Bock T, Bewarder M, Regitz E, Neumann F, Nimmesgern A, von Müller L, Pott C, Kim YJ, Bohle RM, Wasik M, Schuster SJ, Hansmann ML, Preuss KD, Pfreundschuh M.

Leukemia 2019 Jan;33(1):148-158.

https://pubmed.ncbi.nlm.nih.gov/29955130/
 

Safety and feasibility of electrical muscle stimulation in patients undergoing autologous and allogeneic stem cell transplantation or intensive chemotherapy.

Bewarder M, Klostermann A, Ahlgrimm M, Bittenbring JT, Pfreundschuh M, Wagenpfeil S, Kaddu-Mulindwa D.

Support Care Cancer 2019 Mar;27(3):1013-1020. doi: 10.1007/s00520-018-4390-z. Epub 2018 Aug 9.

https://pubmed.ncbi.nlm.nih.gov/30094730/
 

Venetoclax and Obinutuzumab in Patients With CLL and Coexisting Conditions

Kirsten Fischer , Othman Al-Sawaf , Jasmin Bahlo , Anna-Maria Fink , Maneesh Tandon , Mark Dixon , Sandra Robrecht , Simon Warburton , Kathryn Humphrey , Olga Samoylova , Anna M Liberati , Javier Pinilla-Ibarz , Stephen Opat , Liliya Sivcheva , Katell Le Dû , Laura M Fogliatto , Carsten U Niemann , Robert Weinkove , Sue Robinson , Thomas J Kipps , Sebastian Boettcher , Eugen Tausch , Rod Humerickhouse , Barbara Eichhorst , Clemens-Martin Wendtner , Anton W Langerak , Karl-Anton Kreuzer , Matthias Ritgen , Valentin Goede , Stephan Stilgenbauer , Mehrdad Mobasher , Michael Hallek 

N Engl J Med 2019 Jun 6;380(23):2225-2236.

https://pubmed.ncbi.nlm.nih.gov/31166681/
 

Hyper-N-glycosylated SAMD14 and neurabin-I as driver autoantigens of primary central nervous system lymphoma.

Thurner L, Preuss KD, Bewarder M, Kemele M, Fadle N, Regitz E, Altmeyer S, Schormann C, Poeschel V, Ziepert M, Walter S, Roth P, Weller M, Szczepanowski M, Klapper W, Monoranu C, Rosenwald A, Möller P, Hartmann S, Hansmann ML, Mackensen A, Schäfer H, Schorb E, Illerhaus G, Buslei R, Bohle RM, Stilgenbauer S, Kim YJ, Pfreundschuh M.

Blood 2018 Dec 27;132(26):2744-2753.

https://pubmed.ncbi.nlm.nih.gov/30249786/
 

The riddle of lymphoma BCR-antigenes.

Thurner L, Hartmann S, Preuss KD, Bewarder M.

Oncotarget 2018 Nov 9;9(88):35805-35806.

https://pubmed.ncbi.nlm.nih.gov/30533194/