Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes
Klinik für Unfall-, Hand- und Wiederherstellungschirurgie
Leitung: Prof. Dr. Tim Pohlemann
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Kuhn P, Bubel M, Jennewein M, Guthörl S, Pohlemann T, Oberringer M: Dose-dependent dominance: How cell densities design stromal cell functions during soft tissue healing. Cell Biochemistry and Function 40:439-450 (2022)

Später T, Marschall JE, Brücker LK, Nickels RM, Metzger W, Menger MD, Laschke MW:

Vascularization of Microvascular Fragment Isolates from Visceral and Subcutaneous Adipose Tissue of Mice. Tissue Eng Regen Med. 19: 161-175

doi: 10.1007/s13770-021-00391-8 (2022)

Metzger W, Rösch B, Sossong D, Bubel M, Pohlemann T:

Flow cytometric quantification of apoptotic and proliferating cells applying an improved method for dissociation of spheroids. Cell Biol Int. 45: 1633-1643

doi: 10.1002/cbin.11618 (2021)

Klingele M, Carstens M, Baerens L, Laschke MW, Metzger W, Fliser D, Meier CM:

A material stress test study on occurrence of leakage and material failure of peritoneal dialysis (PD) catheters. Sci Rep. 11: 10212

doi: 10.1038/s41598-021-89643-0 (2021)


Nalbach L, Müller D, Wrublewsky S, Metzger W, Menger MD, Laschke MW, Ampofo E:

Microvascular fragment spheroids: Three-dimensional vascularization units for tissue engineering and regeneration. J Tissue Eng. 12: 20417314211035593

doi: 10.1177/20417314211035593 (2021)

Später T, Marschall JE, Brücker LK, Nickels RM, Metzger W, Mai AS, Menger MD, Laschke MW:

Adipose Tissue-Derived Microvascular Fragments From Male and Female Fat Donors Exhibit a Comparable Vascularization Capacity. Front Bioeng Biotechnol.

9: 777687

doi: 10.3389/fbioe.2021.777687 (2021)

Fritz T, Ducommun P, Pohlemann T, Calcagni M, Tschernig T, Menger MD, Metzger W, Frueh FS:

Flexor tendon grafts for pulley reconstruction - Morphological aspects. Ann Anat. 231:151550. doi: 10.1016/j.aanat.2020.151550 (2020)

Nalbach L , Roma LP, Schmitt BM, Becker V, Körbel C, Wrublewsky S, Pack M, Später T, Metzger W, Menger MM, Frueh FS, Götz C, Lin H, Fox JE, MacDonald PE, Menger MD, Laschke MW, Ampofo E: Improvement of islet transplantation by the fusion of islet cells with functional blood vessels. EMBO Mol Med e12616. doi: 10.15252/emmm.202012616 (2020)

Bachmann S, Jennewein M, Bubel M, Guthörl S, Pohlemann T, Oberringer M: Interacting adipose-derived stem cells and microvascular endothelial cells provide a beneficial milieu for soft tissue healing. Mol Biol Rep 47: 111-122 (2020)

Aktas OC, Metzger W, Haidar A, Açil Y, Gülses A, Wiltfang J, Sacramento CM, Nothdurft FP: Enhancing adhesion and alignment of human gingival fibroblasts on dental implants. J Cranio Maxill Surg 47: 661-667 (2019)

Aktas OC, Metzger W, Mees L, Martinez MM, Haidar A, Oberringer M, Wennemuth G, Pütz N, Ghori MZ, Pohlemann T, Veith M: Controlling fibroblast adhesion and proliferation by 1D Al2O3 nanostructures. IET Nanobiotechnol 13: 621-625 (2019)

Laschke MW, Seifert MS, Scheuer C, Kontaxi E, Metzger W, Menger MD: High glucose exposure promotes proliferation and in vivo network formation of adipose-tissue-derived microvascular fragments. Eur Cells Mater 38: 188-200 (2019)

Grässer U, Bubel M, Sossong D, Oberringer M, Pohlemann T, Metzger W: Dissociation of mono- and co-culture spheroids into single cells for subsequent flow cytometric analysis. Annals of Anatomy 216: 1-8 (2018)

Laschke MW, Karschnia P, Scheuer C, Heß A, Metzger W, Menger MD: Effects of cryopreservation on adipose tissue-derived microvascular fragments. J Tissue Eng Regen Med 12(4): 1020-1030 (2018)

Oberringer M, Bubel M, Jennewein M, Guthörl S, Morsch T, Bachmann S, Metzger W, Pohlemann T: The role of adipose-derived stem cells in a self-organizing 3D model with regard to human soft tissue healing. Mol Cell Biochem (2018)

Später T, Frueh FS, Metzger W, Menger MD, Laschke MW: In vivo biocompatibility, vascularization, and incorporation of Integra® dermal regenerative template and flowable wound matrix. J Biomed Mater Res B Appl Biomater 106(1): 52-60 (2018)

Atak BH, Buyuk B, Huysal M, Isik S, Senel M, Metzger W, Cetin G: Preparation and characterization of amine functional nano-hydroxyapatite/chitosan bionanocomposite for bone tissue engineering applications. Carbohydr Polym 164: 200-213 (2017)

Metzger W, Rother S, Pohlemann T, Möller S, Schnabelrauch M, Hintze V, Scharnweber D: Evaluation of cell-surface interaction using a 3D spheroid cell culture model on artificial extracellular matrices. Mater Sci Eng C 73: 310-318 (2017)

Brauer A, Pohlemann T, Metzger W: Osteogenic differentiation of immature osteoblasts: Interplay of cell culture media and supplements. Biotech Histochem 91(3): 161-169 (2016)

Jennewein M, Bubel M, Guthörl S, Metzger W, Weigert M, Pohlemann T, Oberringer M: Two- and three-dimensional co-culture models of soft tissue healing: pericyte-endothelial cell interaction. Cell Tissue Res 365: 279-293 (2016)

Laschke MW, Augustin VA, Sahin F, Anschütz D, Metzger W, Scheuer C, Bischoff M, Aktas C, Menger MD: Surface modification by plasma etching impairs early vascularization and tissue incorporation of porous polyethylene (Medpor®) implants. J Biomed Mater Res Part B 104(8): 1738-1748 (2015)

Schneider G, Bubel M, Pohlemann T, Oberringer M: Response of endothelial cells and pericytes to hypoxia and erythropoietin in a co-culture assay dedicated to soft tissue repair. Mol Cell Biochem 407: 29-40 (2015)

Dorst N, Oberringer M, Grässer U, Pohlemann T, Metzger W: Analysis of cellular composition of co-culture spheroids. Annals of Anatomy 196(5): 303-311 (2014)

Metzger W, Schwab B, Miro MM, Grad S, Simpson A, Zaporojtchenko V, Veith M, Wennemuth G, Verrier S, Hayes JS, Bubel M, Pohlemann T, Oberringer M, Aktas C: Induction of osteogenic differentiation by nanostructured alumina surfaces. J Biomed Nanotechnol 10(5): 831-845 (2014)

Aichele K, Bubel M, Deubel G, Pohlemann T, Oberringer M: Bromelain down-regulates myofibroblast differentiation in an in vitro wound healing assay. Naunyn Schmiedebergs Arch Pharmacol. 386(10): 853-863 (2013)

WalserR, MetzgerW, Görg A, PohlemannT, MengerM,  LaschkeMW: Generation of co-culture spheroids as vascularization units for bone tissue engineering. European Cells and Materials 26: 222-223 (2013)

Laschke MW, Schank TE, Scheuer C, Kleer S, Schuler S, Metzger W, Eglin D, Alini M, Menger MD: Three-dimensional spheroids of adipose-derived mesenchymal stem cells are potent initiators of blood vessel formation in porous polyurethane scaffolds. Acta Biomater 9(6): 6876-6884 (2013)

Lee J, Miró MM, Akkan CK, Haidar A, Metzger W, Schwarz LK, Zaporojtchenko V, Schäfer KH, Abdul-Khaliq A, Veith M, Aktas C: Development of multi scale structured Al/Al2O3 nanowires for controlled cell guidance. J Biomed Nanotechnol 9(2):295-298 (2013)

Oberringer M, Akman E, Lee J, Metzger W, Akkan CK, Demir A, Abdul-Khaliq H, Pütz N, Wennemuth G, Pohlemann T, Veith M, Aktas C: Reduced myofibroblast differentiation on femtosecond laser treated 316LS stainless steel. Materials Science and Engineering C 33 (2): 901-908 (2013)

Schwarz F, Jennewein M, Bubel M, Holstein JH, Pohlemann T, Oberringer M: Soft tissue fibroblasts from well healing and chronic human wounds show different rates of myofibroblasts in vitro. Mol Biol Rep 40:1721-1733 (2013)

Metzger W, Schimmelpfennig L, Schwab B, Sossong D, Dorst N, Bubel M, Görg A, Pütz N, Wennemuth G, Pohlemann T, Oberringer M: Expansion and differentiation of human primary osteoblasts in 2D and 3D culture. Biotechnic & Histochemistry 88(2):86-102 (2013)

Histing T, Stenger D, Scheuer C, Metzger W, Garcia P, Holstein JH, Klein M, Pohlemann T, Menger MD:

Pantoprazole, a proton pump inhibitor, delays fracture healing in mice. Calcified Tissue International 90(6):507-514 (2012)

Aktas, C, Dörrschuck E, Schuh C, Lee J, Martinez Miró M, Pütz N, Wennemuth G, Metzger W, Oberringer M, Veith M, Abdul-Khaliq H. Micro- and nanostructured Al2O3 surfaces for controlled vascular endothelial and smooth muscle cell adhesion and proliferation. Materials Science and Engineering C 32 (5): 1017-1024 (2012)

Breit S, Bubel M, Pohlemann T, Oberringer M: Erythropoietin ameliorates the reduced migration of human fibroblasts during in vitro hypoxia. J Physiol Biochem 67: 1-13 (2011)


Schmitz K, Jennewein M, Pohlemann T, Seekamp A, Oberringer M: Reoxygenation attenuates the adhesion of neutrophils to microvascular endothelial cells. Angiology 62: 155-162 (2011)


Metzger W, Sossong D, Bächle A, Pütz N, Wennemuth G, Pohlemann T, Oberringer M: The liquid overlay technique is the key to the formation of co-culture spheroids consisting of primary osteoblasts, fibroblasts and endothelial cells. Cytotherapy 13 (8): 1000-1012 (2011)


Veith M, Aktas OC, Metzger W, Sossong D, Wazir H, Grobelsek I, Pütz N, Wennemuth G, Pohlemann T, Oberringer M: Adhesion of fibroblasts on micro- and nanostructured surfaces prepared by chemical vapor deposition and pulsed laser treatment. Biofabrication 2 (3): (2010)


Veith M, Aktas C, Metzger W, Oberringer M, Pohlemann T, Müller M, Gerbes S: Chemical Vapour Deposition of Aluminium Based Micro- and Nano Structured Surfaces of Biological Applications. Mater Lett 62: 3842-3845 (2008)

LINK zum Artikel

Oberringer M, Meins C, Bubel M, Pohlemann T: In vitro wounding: Effects of hypoxia and transforming growth factor β1 on proliferation, migration and myofibroblastic differentiation in an endothelial cell-fibroblast co-culture model. J Mol Histol 39: 37-47 (2008)



Metzger W, Grenner N, Motsch SE, Strehlow R, Pohlemann T, Oberringer M: Induction of myofibroblastic differentiation in vitro by covalently immobilized transforming growth factor-b1. Tissue Eng 13(11): 2751-2760 (2007)



Oberringer M, Meins C, Bubel M, Pohlemann T: A new in vitro wound model based on the co-culture of human dermal microvascular endothelial cells and human dermal fibroblasts. Biol Cell 99 (4): 197-207 (2007)



Oberringer M, Jennewein M, Motsch SE, Pohlemann T, Seekamp A: Different cell cycle responses of wound healing protagonists to transient in vitro hypoxia. Histochem Cell Biol 123 (6): 595-603 (2005)



Oberringer M, Heinz B, Englisch A, Gao H, Martin T, Hartmann U: Atomic force microscopy and scanning near-field microscopy studies on the characterization of human metaphase chromosomes. Eur Biophys J 32 (7): 620-627 (2003)



Lothschütz D, Jennewein M, Pahl S, Lausberg HF, Eichler A, Mutschler W, Hanselmann RG, Oberringer M: Polyploidization and centrosome hyperamplification in inflammatory bronchi. Inflamm Res 51 (8): 416-422 (2002)



Lauer NK, Maier SM, Oberringer M, Schulte M, Mutschler W, Hanselmann RG, Schartl M, Scherer SJ,  Wirbel RJ: Absence of telomerase activity in malignant bone tumors and soft-tissue sarcomas. Sarcoma 6 (1): 43-46 (2002)



Gao H, Oberringer M, Englisch A, Hanselmann RG, Hartmann U: The scanning near-field optical microscope as a tool for proteomics. Ultramicroscopy 86 (1-2): 145-150 (2001)



Englisch A, Gao H, Oberringer M, Hanselmann R, Hartmann U: Charakterisierung und Strukturierung menschlicher DNA mittels optischer Rasternahfeldmikroskopie. Schriftenreihe der Akademie der Wissenschaften und der Literatur; Biona-Report 14: 77-80 (2000)

Oberringer M, Lothschütz D, Jennewein M, Koschnick M, Mutschler W, Hanselmann RG: Centrosome-multiplication accompanies a transient clustering of tetraploid cells during tissue repair. Mol Cell Biol Res Commun 2 (3): 190-196 (1999)



Ermis A, Oberringer M, Wirbel R, Koschnick M, Mutschler W, Hanselmann RG: Tetraploidization is a physiological enhancer of wound healing; Eur Surg Res 30: 385-392 (1998)



Hanselmann R, Seybold U, Oberringer M,  Vollmar B,  Koschnick M, Mutschler W: Molekularbiologische Untersuchungen zur Rolle des Hitzeschockprotein 70 in der menschlichen Wunde; Unfallchirurg 257: 399-406 (1996)

Oberringer M, Baum HP, Jung V, Welter C, Frank J, Kuhlmann M, Mutschler W, Hanselmann RG: Differential expression of heat shock protein 70 in well healing and chronic human wound tissue; Biochem Biophys Res Co 214 (3): 1009-1914 (1995)



Jennewein M, Oberringer M: Zellwachstum zwischen Regeneration und Regulation am Beispiel der Wundheilung. Saarländisches Ärzteblatt Februar 2007: 36-39 (2007)


Metzger W, Oberringer M, Hu J, Li MQ, Hartmann U: Nanoscale analysis of biofunctional molecules and components. J Nanosci Nanotechnol 4 (5): 489-495 (2004)



Oberringer M, Jennewein M, Schmitz K, Motsch S, Seekamp A, Pohlemann T,  Bohn H, Ißle J, Hartmann U: Inflammation Research using Fluorescence and Atomic Force Microscopy. Imaging and Microscopy Vol.5, 4/03: 44-45 (2003)



Oberringer M, Metzger W, Hartmann U: Beispiele nanobiotechnologischer Ansätze in Grundlagenforschung und industrieller Anwendung. Magazin Forschung der Universität des Saarlandes 2/2002: 6-13 (2002)


Oberringer M, Hartmann U: Nanobiotechnologische Ansätze in der Zytogenetik. Bioforum 04/2002: 206-208 (2002)

Hanselmann RG und Oberringer M: Polyploidization: a Janus-faced mechanism. Med Hypotheses 56 (1): 58-64 (2001)