Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes
Institut für Klinisch-Experimentelle Chirurgie
Leitung: Prof. Dr. med. Michael D. Menger
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Publikationen 2017

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Abdelsamie AS, van Koppen CJ, Bey E, Salah M, Börger C, Siebenbürger L, Laschke MW, Menger MD, Frotscher M

Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17β-HSD1 inhibitor with sub-nanomolar IC50 for a proof-of-principle study.

Eur J Med Chem 2017 127: 944-957

 

Ampofo E, Lachnitt N, Rudzitis-Auth J, Schmitt BM, Menger MD, Laschke MW

Indole-3-carbinol is a potent inhibitor of ischemia-reperfusion-induced inflammation.

J Surg Res 2017 215:34-46

 

Ampofo E, Schmitt BM, Menger MD, Laschke MW

The regulatory mechanisms of NG2/CSPG4 expression.

Cell Mol Biol Lett 2017 22:4

 

Danielczok JG, Terriac E, Hertz L, Petkova-Kirova P, Lautenschläger F, Laschke MW, Kaestner L

Red Blood Cell Passage of Small Capillaries Is Associated with Transient Ca2+-mediated Adaptations.

Front Physiol 2017 5;8:979

 

Deichelbohrer M, Wu MF, Seitz B, Hüttenberger D, Laschke MW, Foth HJ, Wonnenberg B, Wagenpfeil S, Meier C, Bischoff M, Tschernig T

Bacterial keratitis: Photodynamic inactivation reduced experimental inflammation.

Exp Ther Med 2017 14:4509-4514

 

Emmerich J, van Koppen CJ, Burkhart JL, Hu Q, Siebenbürger L, Boerger C, Scheuer C, Laschke MW, Menger MD, Hartmann RW

Lead optimization generates CYP11B1 inhibitors of pyridylmethyl isoxazole type with improved pharmacological profile for the treatment of Cushing's disease.

J Med Chem 60:5086-5098

 

Frueh FS, Menger MD, Lindenblatt N, Giovanoli P, Laschke MW

Current and emerging vascularization strategies in skin tissue engineering.

Crit Rev Biotechnol 2017 37: 613-625

 

Frueh FS, Später T, Lindenblatt N, Calcagni M, Giovanoli P, Scheuer C, Menger MD, Laschke MW

Adipose tissue-derived microvascular fragments improve vascularization, lymphangiogenesis, and integration of dermal skin substitutes.

J Invest Dermatol 2017 137: 217-227

 

Frueh FS, Später T, Scheuer C, Menger MD, Laschke MW

Isolation of murine adipose tissue-derived microvascular fragments as vascularization units for tissue engineering.

J Vis Exp 2017 Apr 30;(122). doi: 10.3791/55721.

 

Gu Y, Ampofo E, Menger MD, Laschke MW

miR-191 suppresses angiogenesis by activation of NF-κB signaling.

FASEB J 2017 31:3321-3333

 

Jungnickel C, Schmidt LH, Bittigkoffer L, Wolf L, Wolf A, Ritzmann F, Kamyschnikow A, Herr C, Menger MD, Spieker T, Wiewrodt R, Bals R, Beisswenger C

IL-17C mediates the recruitment of tumor-associated neutrophils and lung tumor growth.

Oncogene 2017 36:4182-4190

 

Klein M, Laschke MW, Holstein JH, Histing T, Pohlemann T, Menger M, Garcia P

Mechanical and biological characterization of alkaline substituted orthophosphate bone substitutes containing meta- and diphosphates.

Biomed Mater 2017 12: 055007

 

Koenen K, Knepper I, Klodt M, Osterberg A, Stratos I, Mittlmeier T, Histing T, Menger MD, Vollmar B, Bruhn S, Müller-Hilke B

Sprint Interval Training Induces A Sexual Dimorphism but does not Improve Peak Bone Mass in Young and Healthy Mice.

Sci Rep 2017 7: 44047

 

Laschke MW, Menger MD

Life is 3D: Boosting spheroid function for tissue engineering.

Trends Biotechnol 2017 35: 133-144

 

Laschke MW, Menger MD

Spheroids as vascularization units: From angiogenesis research to tissue engineering applications.

Biotechnol Adv 2017 35:782-791

 

Linxweiler J, Körbel C, Müller A, Jüngel E, Blaheta R, Heinzelmann J, Stöckle M, Junker K, Menger MD, Saar M

Experimental imaging in orthotopic renal cell carcinoma xenograft models: comparative evaluation of high-resolution 3D ultrasonography, in-vivo micro-CT and 9.4T MRI.

Sci Rep 2017 7:14249

 

Müller A, Fries P, Jelvani B, Lux F, Rübe CE, Kremp S, Giovanoli P, Buecker A, Menger MD, Laschke MW, Frueh FS

Magnetic resonance lymphography at 9.4 T using a Gadolinium-based nanoparticle in rats: Investigations in healthy animals and in a hindlimb lymphedema model.

Invest Radiol 2017 52:725-732

 

Nenicu A, Gu Y, Körbel C, Menger MD, Laschke MW

Combination therapy with telmisartan and parecoxib induces regression of endometriotic lesions.

Br J Pharmacol 2017 174:2623-2635

 

Orth M, Kruse NJ, Braun BJ, Scheuer C, Holstein JH, Khalil A, Yu X, Murphy WL, Pohlemann T, Laschke MW, Menger MD

BMP-2-coated mineral coated microparticles improve bone repair in atrophic non-unions.

Eur Cell Mater 2017 33: 1-12

 

Rollmann MF, Herath SC, Holstein JH, Pohlemann T, Menger MD, Histing T

Surgical treatment of pelvic ring fractures in the elderly now and then: a pelvic registry study.

Aging Clin Exp Res 2017 29:639-646

 

Rollmann MF, Herath SC, Kirchhoff F, Braun BJ, Holstein JH, Pohlemann T, Menger MD, Histing T

Pelvic ring fractures in the elderly now and then - a pelvic registry study.

Arch Gerontol Geriatr 2017 71: 83-88

 

Schaefer N, Helfer AG, Kettner M, Laschke MW, Schlote J, Ewald AH, Meyer MR, Menger MD, Maurer HH, Schmidt PH

Metabolic patterns of JWH-210, RCS-4, and THC in pig urine elucidated using LC-HR-MS/MS: Do they reflect patterns in humans?

Drug Test Anal 2017 9: 613-625

 

Schaefer N, Kettner M, Laschke MW, Schlote J, Ewald AH, Menger MD, Maurer HH, Schmidt PH

Distribution of synthetic cannabinoids JWH-210, RCS-4 and ∆ 9-tetrahydrocannabinol after intravenous administration to pigs.

Curr Neuropharmacol 2017 15:713-723

 

Senger S, Sperling J, Oberkircher B, Schilling MK, Kollmar O, Menger MD, Ziemann C

Portal branch ligation does not counteract the inhibiting effect of temsirolimus on extrahepatic colorectal metastatic growth.

Clin Exp Metastasis 2017 Jun;34(5):323-332

 

Später T, Frueh FS, Menger MD, Laschke MW

Potentials and limitations of Integra® flowable wound matrix seeded with adipose tissue-derived microvascular fragments.

Eur Cell Mater 2017 33:268-278

 

Später T, Körbel C, Frueh FS, Nickels RM, Menger MD, Laschke MW

Seeding density is a crucial determinant for the in vivo vascularisation capacity of adipose tissue-derived microvascular fragments.

Eur Cell Mater 2017 34: 55-69

 

Spohrer S, Groß R, Nalbach L, Schwind L, Stumpf H, Menger MD, Ampofo E, Montenarh M, Götz C

Functional interplay between the transcription factors USF1 and PDX-1 and protein kinase CK2 in pancreatic β-cells.

Sci Rep 2017 7:16367

 

Veith NT, Histing T, Menger MD, Pohlemann T, Tschernig T

Helping prometheus: liver protection in acute hemorrhagic shock.

Ann Transl Med 2017 5:206

 

Werner TV, Hart M, Nickels R, Kim YJ, Menger MD, Bohle RM, Keller A, Ludwig N, Meese E

MiR-34a-3p alters proliferation and apoptosis of meningioma cells in vitro and is directly targeting SMAD4, FRAT1 and BCL2.

Aging 2017 23;9(3):932-954

 

Wu MF, Deichelbohrer M, Tschernig T, Laschke MW, Szentmáry N, Hüttenberger D, Foth HJ, Seitz B, Bischoff M

Chlorin e6 mediated photodynamic inactivation for multidrug resistant Pseudomonas aeruginosa keratitis in mice in vivo.

Sci Rep 2017 15;7:44537