Saarland University Faculty of Medicine

Selected Publications

2022  2021  2020  2019  2018  2017  2016  2015  2014  2013  2012  2011  2010  2009  2008  2007  2006  2005  2004  2003  2002  2001  before 2000


Eriksson, H., Roessler, O.G. and Thiel, G. (2022) Tyrosine hydroxylase gene promoter activity is upregulated in female catecholaminergic neuroblastoma cells following activation of a Gαq-coupled designer receptor. Neurochem. Int. 105407


Thiel, G. and Rössler, O.G. (2022) Expression of the C-terminal domain of phospholipase  Cbeta3 of inhibits signaling via Gαq-coupled receptors and transient receptor potential channels. Int. J. Mol. Sci. article #1859317


Thiel, G. and Rössler, O.G. (2022) TRPM3-induced gene transcription is under epigenetic control. Pharmaceuticals 15, 846,                                                                                                                                                                                                                                                                                                                                  

Dahlhäusser, A.K., Rössler, O.G. and Thiel (2022)  Regulation of c-Fos gene transcription by stimulus-responsive protein kinases. Gene 821, 146284,


Backes, T.M., Rössler, O.G. and Thiel, G. (2022) Nobelpreis: Somatosensorik und Ionenkanäle. Biologie in unserer Zeit 52, 18-19,


  • Thiel, G., Guethlein, L.A. and Rössler, O.G. (2021) Insulin-responsive transcription factors. Biomolecules 11, 1886.
  • Thiel, G., Backes, T.M., Guethlein, L.A. and Rössler, O.G. (2021) Critical protein-protein interactions determine the biological activity of Elk-1, a master regulator of stimulus-induced gene transcription. Molecules 26, 6125.
  • Backes, T.M., Langfermann, D.S., Wolf, A., Rössler, O.G., Laschke, M.W., Vinson, C. and Thiel, G. (2021) Regulation and function of AP-1 in insulinoma cells and pancreatic beta-cells. Biochem. Pharmacol. 193:114748
  • Thiel, G., Wagner, L., Ulrich, M. and Rössler, O.G. (2021) Immediate-early transcriptional response to insulin receptor stimulation. Biochem. Pharmacol. 192, 114696
  • Thiel, G., Schmidt, T. and Rössler, O.G. (2021) Ca2+  microdomains, calcineurin, and the regulation of gene transcription. Cells 10, 875,
  • Thiel, G., Backes, T.M., Guethlein, L.A. and Rössler, O.G. (2021) Chromatin-embedded reporter genes: Quantification of stimulus-induced gene transcription. Gene 787, 145645, doi: 10.1016/j.gene.2021.145645


Loviscach, L., Backes, T.M., Langfermann, D.S., Ulrich, M. and Thiel, G. (2020) Zn2+ ions inhibit gene transcription following stimulation of the Ca2+ channels Cav1.2 and TRPM3. Metallomics 12, 1735-1747


Scheuble, J., Roessler, O.G., Ulrich, M., Thiel, G. (2020) Pharmacological and genetic inhibition of TRPC6-induced gene transcription. Euro. J. Pharmacol., 159, 104983


Lesch, A., Backes, T.M., Langfermann, D.S., Roessler, O.G., Laschke, M.W., Thiel, G. (2020) Ternary complex factor regulates pancreatic islet size and blood Glucose homeostasis in transgenic mice. Pharmacol. Res. 159:104983,


Ulrich, M., Wissenbach, U., Thiel, G. (2020) The super-cooling compound icilin stimulates c-Fos and Egr-1 expression and activity involving TRPM8 channel activation, Ca2+ ion Influx and acitvation of the ternary comlex factor Elk-1. Biochem. Pharmacol., 177, 113936


Thiel, G., Ulrich, M., Mukaida, N. Roessler, O.G. (2020) Regulation of stimulus-induced interleukin-8 gene transcription in human adrenocortical carcinoma cells - role of AP-1 and NF-kB. Cytokine 126:154862,

Thiel, G., Backes, T.M., Roessler, O.G. (2020) Some like it hot - and spicy: Chili und der Capsaicin-Rezeptor TRPV1. Biologie in unserer Zeit, 50, 246-252


Langfermann, D.S., Schmidt, T., Rössler O.G., Thiel, G. (2019) Calcineurin controls gene transcription following stimulation of a Gαq-coupled designer receptor. Exp. Cell Res. 383, 111553,


Thiel, G., Backes, T.M., Welck, J., Steinhausen, S., Fischer, A.-L., Langfermann, D.S., Ulrich, M., Wissenbach, U., Rössler, O.G. (2019) Pharmacological Inhibition of TRPM8-induced gene transcription. Biochem. Pharmacol. 170:113678,


Thiel, G., Welck, J., Wissenbach, U. and Rössler, O.G. (2019) Dihydrotestosterone activates AP-1 in LNCaP prostate cancer cells. Int. J. Biochem. Cell Biol. 110, 9-20,


Rubil, S. and Thiel, G. (2019) Stimulation of TRPM3 channels increases the transcriptional activation potential of Elk-1 involving cytosolic Ca2+, extracellular signal-regulated protein kinase, and calcineurin. European Journal of Pharmacology 844, 225-230,


Thiel, G., Ulrich, M., Mukaida, N. and Roessler, O.G. (2018) Resveratrol stimulation induces interleukin-8 gene transcription via NF-κB. Pharmacol. Res. 134, 238-245,


Thiel, G. (2018) The ingredient of chili peppers changes the gene expression pattern of cells. Science Trends,


Thiel, G. and Rössler, O.G. (2018) Resveratrol stimulates c-Fos gene transcription via activation of ERK1/2 involving multiple genetic elements. Gene 658, 70-75,


Backes, T.M., Roessler, O.G., Hui, X., Grötzinger, C., Lipp, P. and Thiel, G. (2018) Stimulation of TRPV1 channels activates the AP-1 transcription factor. Biochem. Pharmacol. 150, 160-169,


Langfermann, D.S., Roessler, O.G. and Thiel, G. (2018) Stimulation of B-Raf increases c-Jun and c-Fos expression and upregulates AP-1-regulated gene transcription in insulinoma cells. Mol. Cell. Endocrinol. 472, 126-139,


Rubil, S., Lesch, A., Mukaida, N. and Thiel, G. (2018) Stimulation of transient receptor potential M3 (TRPM3) channels increases Interleukin-8 Promotor activity involving AP-1 and extracullular signal-regulated Protein kinase. Cytokine 103, 133-141,


Thiel, G., Lesch, A., Rubil, S., Backes, T.M. and Roessler, O.G. (2018) Regulation of gene transcription following stimulation of transient receptor potential (TRP) channels. Int. Rev. Cell. Mol. Biol. 335, 167-189,


Schmitt, B.M., Laschke, M.W., Roessler, O.G., Huang, W., Scheller, A., Menger, M.D., Ampofo, E. (2018) Nerve/glial antigen (NG) 2 is a crucial regulator of intercellular adhesion molecule (ICAM)-1 expression. BBA Molecular Cell Research 1865, 57-66


Lesch, A., Rössler, O.G. and Thiel, G. (2017) Extracellular signal-regulated protein kinase, c-Jun N-terminal protein kinase and calcineurin regulate transient receptor potential M3 (TRPM3) induced activation of AP-1. J. Cell. Biochem. 118, 2409-2419


Thiel, G. and Rössler, O.G. (2017) Resveratrol regulates gene transcription via activation of stimulus-responsive transcription factors. Pharmacol. Res. 117, 166-176


Rössler O.G. and Thiel, G. (2017) Specificity of  stress-responsive transcription factors Nrf2, ATF4 and AP-1. J. Cell. Biochem. 118, 127-140


Thiel, G. and Rössler, O.G. (2017) Hyperforin activates gene transcription involving transient receptor potential C6 channels. Biochem. Pharmacol. 129, 96-107


Rubil, S. and Thiel, G. (2017) Activation of gene transcription via CIM0216, a synthetic ligand of transient receptor potential melastatin-3 (TRPM3) channels. Channels 11, 79 - 83


Thiel, G., Rubil, S., Lesch, A., Guethlein, L., Roessler, O.G. (2017) Transient receptor potential TRPM3 channels: pharmacology, signaling, and biological functions. Pharmacol. Res. 124, 92-99


Rössler, O.G., Lesch, A. and Thiel, G. (2016) Combining fibroblast isolation with lentiviral gene transfer to validate transgene expression in mice following pronucleus injection. Transgenic Res. 25, 839-846


Thiel, G. and Rössler, O.G. (2016) Resveratrol stimulates cyclic AMP response element-mediated gene transcription. Mol. Nutr. Food Res. 60, 256-265


Rubil, S., Rössler, O.G., and Thiel, G. (2016) CREB, AP-1, ternary complex factors and MAP kinases connect transient receptor potential melastatin-3 (TRPM3) channel stimulation with increased c-Fos expression. Brit. J. Pharmacol. 173, 305-318


Ampofo E., Rudzitis-Auth J., Dahmke I.N., Rössler O.G., Thiel G., Montenarh M., Menger M.D., Laschke M.W. (2015) Inhibition of protein kinase CK2 suppresses tumor necrosis factor (TNF)-alpha induced leukocyte-endothelial cell interaction. Biochim. Biophys. Acta 1852, 2123-2136


Rössler, O.G., Glatzel, D. and Thiel, G. (2015) Resveratrol upregulates Egr-1 expression and activity involving extracellular signal-regulated protein kinase and ternary complex factors. Exp. Cell Res. 332, 116-127

Lesch, A., Hui, X., Lipp, P. and Thiel, G. (2015) Transient receptor potential melastatin-3 (TRPM3)-induced activation of AP-1 requires Ca2+ ions and the transcription factors c-Jun, ATF2, and ternary complex factor. Mol. Pharmacol. 87, 617-628


Thiel, G., Ekici, M. and Rössler, O.G. (2015) RE-1 silencing transcription factor (REST): a regulator of neuronal development and neuronal / endocrine function. Cell Tissue Res. 359, 99-109


Gozdecka, M., Lyons, S., Kondo, S., Taylor, J., Li, Y., Walczynski, J., Thiel, G., Breitwieser, W., Jones, N. (2014) JNK suppresses tumor formation via a gene-expression program mediated by ATF2. Cell Rep. 9, 1361-1374


Thiel, G., Kaufmann, A. and Roessler, O.G. (2014) G-Protein-gekoppelte Designerrezeptoren. BIOSpektrum 3/2014, 20. Jahrgang, 259-262


Kaufmann, A., Rössler, O.G. and Thiel, G. (2014) Expression of the transcription factor Egr-1 in pancreatic acinar cells following stimulation of cholecystokinin or G-alpha-q-coupled designer receptors. Cell. Physiol. Biochem. 33, 1411-1425


Thiel, G., Müller, I. and Rössler, O.G. (2014) Expression, signaling and function of Egr transcription factors in pancreatic beta cells and insulin-responsive tissues. Mol. Cell. Endocrinol. 388, 10-19


Thiel, G. and Rössler, O.G. (2014) Resveratrol stimulates AP-1 regulated gene transcription. Mol. Nutr. Food Res. 58, 1402-1413


Lesch, A., Rubil, S. and Thiel, G. (2014) Activation and ihibition of transient receptor potential TRPM3 induced gene transcription. Brit. J. Pharmacol. 171, 2645-2658


Gorbatenko, A., Olesen, C.W., Mørup, N., Thiel, G., Kallunki, T., Valen, E. and Pedersen, S.F. (2014) ErbB2 upregulates the Na+,HCO3(-)-cotransporter NBCn1/SLC4A7 in human breast cancer cells via Akt, ERK, Src, and Kruppel-like factor 4. FASEB J. 28, 350-363


Thiel, G., Kaufmann, A., Rössler, O.G. (2013) G-protein coupled designer receptors - new chemical-genetic tools for signal transduction research. Biol. Chem. 394, 1615-1622


Thiel, G., Müller, I., Rössler O.G. (2013) Signal transduction via TRPM3 channels in pancreatic beta-cells. J. Mol. Endocrinol. 50, R75-83


Thiel, G. (2013) How Sox2 maintains neural stem cell identity. Biochem. J. 450, e1-2


Hohl, M., Wagner, M., Reil, J.-C., Müller, S.-A., Taucnitz, M., Zimmer A. M., Lehmann, L. H., Thiel, G., Böhm, M., Backs, J. and Maack, C. (2013) Histone deacetylase 4 controls histone methylation in response to cardiac load. J. Clin. Invest. 123, 1359-1370

Kaufmann, A., Keim, A., and Thiel, G. (2013) Regulation of immediate-early gene transcription following activation of Gaq-coupled designer receptors. J. Cell. Biochem. 114, 681-696


Thiel, G., Lesch, A. and Keim, A. (2012) Transcriptional response to calcium-sensing receptor stimulation. Endocrinology, 153, 4716-4728


Müller, I., Rössler, O.G., Wittig, C., Menger, M.D. and Thiel, G. (2012) Critical role of Egr transcription factors in regulating insulin biosynthesis, blood glucose homeostasis, and islet size. Endocrinology, 153, 3040-3053


Müller, I., Lipp, P. and Thiel, G. (2012) Ca2+ signaling and gene transcription in glucose-stimulated insulinoma cells. Cell Calcium, 52, 137-151


Ekici, M., Keim, A., Rössler, O.G., Hohl, M. and Thiel, G. (2012) Chromatin structure and expression of the AMPA receptor subunit GluR2 in human glioma cells: major regulatory of REST and Sp1. J. Cell. Biochem., 133, 528-543


Keim, A., Rössler, O.G., Rothhaar, T.L. and Thiel, G. (2012) Arsenite-induced apoptosis of human neuroblastoma cells requires p53 but occurs independently of c-Jun. Neuroscience, 206, 25-38


Keim, A., Müller, I. and Thiel, G. (2012) Efficient genetic manipulation of 1321N1 astrocytoma cells using lentiviral gene transfer. J. Neurosci. Methods, 206, 138-142


Mayer, S.I., Müller, I., Mannebach, S., Endo, T. and Thiel, G. (2011) Signal transduction of pregnenolone sulfate in insulinoma cells - activation of EGR-1 expression involving TRPM3, voltage-gated calcium channels, ERK, and ternary complex factors. J. Biol. Chem., 286, 10084-10096


Xie, B., Wang, C., Zheng, Z., Song, B., Ma, C., Thiel, G. and Li, M. (2011) Egr-1 Transactivates Bim Gene Expression to Promote Neuronal Apoptosis. J. Neurosci., 31, 5032-5044


Chbicheb, S., Yao, X., Rodeau, J.L., Salamone, S., Boisbrun, M., Thiel, G., Spohn, D., Grillier-Vuissoz, I., Chapleur, Y., Flament, S. and Mazerbourg, S. (2011) EGR1 expression: a calcium and ERK1/2 mediated PPAR(γ)-independent event involved in the antiproliferative effect of 15-deoxy-(12, 14-prostaglandin J2 and Thiazolidinediones in breast cancer cells. Biochem. Pharmacol., 81, 1087-1097


Müller, I., Rössler, O.G. and Thiel, G. (2011) Pregnenolone Sulfate Activates Basic Region Leucine Zipper Transcription Factors in Insulinoma Cells - Role of Voltage Gated Ca2+ Channels and Transient Receptor Potential TRPM3 Channels. Mol Pharmacol., 80, 1179-1189


Thiel, G. and Rössler, O.G. (2011) Immediate-Early Transcriptional Response to Angiotensin II in Human Adrenocortical Cells. Endocrinology, 152, 4211-4223


Spohn, D., Roessler, O.G., Philipp, S.E., Raubuch, M., Kitajima, S., Griesemer, D., Hoth, M. and Thiel, G. (2010) Thapsigargin induces expression of ATF3 in human keratinocytes involving Ca2+ ions and c-Jun N-terminal protein kinase. Mol. Pharmacol., 78, 865-76


Thiel, G., Mayer, S.I., Müller, I., Stefano, L. and Rössler, O.G. (2010) Egr-1 - A Ca(2+)-regulated transcription factor. Cell Calcium, 47, 397-403


Müller, I., Endo, T. and Thiel, G. (2010) Regulation of AP-1 activity in glucose-stimulated insulinoma cells. J. Cell. Biochem., 110, 1481-1494


Meng, R., Al-Quobaili, F., Müller, I., Götz, C., Thiel, G. and Montenarh, M. (2010) CK2 phosphorylation of Pdx-1 regulates its transcription factor activity. Cell. Mol. Life Sci., 67, 2481-2489


Yuan, Z., Gong, S., Luo, J., Zheng, Z., Song, B., Ma, S., Guo, J., Hu, C., Thiel, G., Vinson, C., Hu, C.D., Wang, Y. and Li, M. (2009) Opposing roles for ATF2 and c-Fos in c-Jun-mediated neuronal apoptosis. Mol. Cell. Biol., 29, 2431-2442


Mayer, S.I. and Thiel, G. (2009) Calcium influx into MIN6 insulinoma cells induces expression of Egr-1 involving extracellular signal-regulated protein kinase and the transcription factors Elk-1 and CREB. Eur. J. Cell. Biol., 88, 19-33


Rössler, O.G. and Thiel, G. (2009) Thrombin induces Egr-1 expression in fibroblasts involving elevation of the intracellular Ca2+ concentration, phosporylation of ERK and activation of ternary complex factor. BMC Mol. Biol., 10:40


Mayer, S.I., Rössler, O.G., Endo, T., Charnay, P. and Thiel, G. (2009) Epidermal growth factor-induced proliferation of astrocytes requires Egr transcription factors. J. Cell. Sci., 122, 3340-3350


Colecchia, F., Kottwitz, D., Wagner, M., Pfenninger, C.V., Thiel, G., Tamm, I., Peterson, C. and Nuber, U.A. (2009) Tissue-specific regulatory network extractor (TS-REX): a database and software resource for the tissue and cell type-specific investigation of transcription factor-gene networks. Nucl. Acids Res., 37, e82


Thiel, G., Ekici, M. and Rössler, O.G. (2009) Regulation of cellular proliferation, differentiation and cell death by activated Raf. Cell Commun. Signal., 7:8


Friedrich, K., Lindquist, J.A., Entschladen, F., Serfling, E., Thiel, G., Kieser, A., Giehl, K., Ehrhardt, C., Feller, S.M., Ullrich, O., Schaper, F., Janssen, O. and Hass, R. (2009) Signal Transduction in the Footsteps of Goethe and Schiller. Cell Commun. Signal. 7:2


Entschladen, F., Lindquist, J.A., Serfling, E., Thiel, G., Kieser, A., Giehl, K., Ehrhardt, C., Feller, S.M., Ullrich, O., Schaper, F., Janssen, O., Hass, R. and Friedrich, K. (2009) Signal transduction-receptors, mediators, and genes. Sci. Signal. 2(63):mr3


Müller, I., Mayer, S.I., Keim, A. and Thiel, G. (2009) Lentiviraler Gentransfer: Analyse von transkriptioneller Aktivierung und DNA-Bindung. BIOSpektrum 15, 52-53

top ...


Abramovitz, L., Shapira, T., Ben-Dror, I., Dror, V., Granot, L., Rousso, T., Landoy, E., Blau, L., Thiel, G. and Vardimon, L.(2008) Dual role of NRSF/REST in activation and repression of the glucocorticoid response. J. Biol. Chem., 283, 110-119


Ekici, M., Hohl, M., Schuit, F., Martinez-Serrano, A. and Thiel, G. (2008) Transcription of genes encoding synaptic vesicle proteins in human neural stem cells: Chromatin accessibility, histone methylation pattern and essential role of REST. J. Biol. Chem., 283, 9257-9268


Ekici, M., Schmitz, F., Hohl., M., Seigel, G.M., and Thiel, G. (2008) Chromatin structure and expression of synapsin I and synaptophysin in retinal precursor cells. Neurochem. Int., 53, 165-172


Thiel, G. and Schuit, F. (2008) No REST for healthy beta cells. Diabetologia, 51, 1343-1346


Rössler, O.G., Henß, I. and Thiel, G. (2008) Transcriptional response to muscarinic acetyl-choline receptor stimulation: Regulation of Egr-1 biosynthesis by Elk-1, ERK, MKP-1 and calcineurin in carbachol stimulated human neuroblastoma cells. Arch. Biochem. Biophys., 470, 93-102


Mungunsukh, O., Marquez, A.P., Lee, Y.H., Thiel, G. and Day, R.M. (2008) Characterization of the Bovine Angiotensin Converting Enzyme Promoter: Essential roles of Egr-1, ATF-2 and Ets-1 in the regulation by phorbol ester. Gene, 421, 81-88


Franko, A., Mayer, S., Thiel, G., Mercy, L., Arnould, T., Hornig-Do, H.T., Wiesner, R.J. and Goffert, S. (2008) CREB-1a is recruited to and mediates upregulation of the Cytochrome c promoter during enhanced mitochondrial biogenesis accompanying skeletal muscle differentiation. Mol. Cell. Biol., 28, 2446-2459


Ceyhan, G.O., Demir, I.E., Altintas, B., Rauch, U., Thiel, G., Müller, M.W., Giese, N.E,, Friess, H., and Schäfer, K.H. (2008) Neural invasion in pancreatic cancer: A mutual tropism between neurons and cancer cells. Biochem. Biophys. Res. Commun., 374, 442-447


Mayer, S.I., Willars, G.B., Nishida, E. and Thiel, G. (2008) Elk-1, CREB and MKP-1 regulate Egr-1 expression in gonadotropin-releasing hormone stimulated gonadotrophs. J. Cell. Biochem., 105, 1267-1278


Mayer, S.I., Dexheimer, V., Nishida, E., Kitajima, S. and Thiel,G. (2008) Expression of the transcriptional repressor ATF3 in gonadotrophs is regulated by Egr-1, CREB and ATF2 after gonadotropin-releasing hormone receptor stimulation. Endocrinology, 149, 6311-6325


Bauer, I., Al Sarraj, J., Vinson, C., Larsen, R. and Thiel, G. (2007) Interleukin-1 beta and tetradecanoylphorbol acetate-induced biosynthesis of tumor necrosis factor alpha in human hepatoma cells involves the transcription factors ATF2 and c-Jun and stress-activated protein kinases. J. Cell. Biochem., 100, 242-255


Stefano, L., Rössler, O.G., Griesemer, D., Hoth, M. and Thiel, G. (2007) P2X(7) receptor stimulation upregulates Egr-1 biosynthesis involving a cytosolic Ca(2+) rise, transactivation of the EGF receptor and phosphorylation of ERK and Elk-1. J. Cell. Physiol., 213, 36-44


Thiel, G. and Rössler, O.G. (2007) Wie aus einem Retrovirus ein Gentransfer-Vektor entsteht: Viren als Werkzeuge der Gentherapie. Biologie in unserer Zeit, 37, 241-248

top ...


Thiel, G. and Hohl, M. (2006) RE-1 silencing transcription factor (REST) - Regulation of neuronal gene expression via modification of the chromatin structure. In: Transcription factors in the nervous system – Development, Brain Function and Disease (G. Thiel, Editor), Wiley-VCH, Weinheim, Germany, pp 113-128


Rössler, O.G., Stefano, L., Bauer, I. and Thiel, G. (2006) Stimulus-transcription coupling in the nervous system –the zinc finger protein Egr-1. In: Transcription factors in the nervous system – Development, Brain Function and Disease (G. Thiel, Editor), Wiley-VCH Verlag GmbH & Co.KGaA, Weinheim, Germany, pp 379-395





Stefano, L., Al Sarraj, J., Rössler, O.G., Vinson, C. and Thiel, G. (2006) Upregulation of tyrosine hydroxylase gene transcription by tetradecanoylphorbol acetate is mediated by the transcription factors Ets-like protein-1 (Elk-1) and Egr-1. J. Neurochem., 97, 92-104


Zhou, Y., Zhang F., Abidi, P., Lin, M., Thiel, G. and Liu, J. (2006) Blockage of oncostatin M-induced LDL receptor gene transcription by a dominant- negative mutant of c/EBPß. Biochem. J., 397, 101-108


Sobke, A.c., Selimovic, D., Orlova, V., Hassan, M., Chavakis, T., Athanasopoulos, A.N., Schubert, U., Hussain, M., Thiel, G., Preissner, K.T. and Herrmann, M. (2006) The extracellular adherence protein from Staphylococcus aureus abrogates angiogenic responses of endothelial cells by blocking Ras activation. FASEB J., 20, 2621-2623

top ...


Thiel, G., Al Sarraj, J. and Stefano, L. (2005) cAMP response element binding protein (CREB) activates transcription via two distinct genetic elements of the human glucose-6-phosphatase gene. BMC Molecular Biology, 6:2


Thiel, G., Al Sarraj, J., Vinson, C., Stefano, L. and Bach, K. (2005) Role of basic region leucine zipper transcription factors cyclic AMP response element binding protein (CREB), CREB2, activation transcription factor 2 and CAAT/enhancer binding protein a in cyclic AMP response element-mediated transcription. J. Neurochem., 92, 321-336


Al Sarraj, J., Vinson, C., Han, J. and Thiel, G. (2005) Regulation of GTP cyclohydrolase I gene transcription by basic region leucine zipper transcription factors. J. Cell. Biochem., 96, 1003-1020


Al Sarraj, J., Vinson, C. and Thiel, G. (2005) Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP. Biol. Chem., 386, 873-879


Al-Sarraj, A., Day, R.M. and Thiel, G. (2005) Specificity of transcriptional regulation by the zinc finger transcription factors Sp1, Sp3 and Egr-1. J. Cell. Biochem., 94, 153-167


Bauer, I., Hohl, M., Al-Sarraj, A., Vinson, C. and Thiel, G. (2005) Transcriptional activation of the Egr-1 gene mediated by tetradecanoylphorbol acetate and extracellular signal-regulated protein kinase. Arch. Biochem. Biophys., 438, 36-52


Thiel, G. and Rössler, O.G. (2005) Signaltransduktion: Rezeptor-Tyrosinkinasen und intrazelluläre Signalkaskaden. Biologie in unserer Zeit 35, 312-319


Thiel, G., Bauer, I. and Rössler, O.G. (2005) Role of extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase in neuronal cell death and survival. Signal Transduction, 6, 322-333


Hohl, M. and Thiel, G. (2005) Cell type-specific regulation of RE-1 silencing transcription factor (REST) target genes. Eur. J. Neurosci., 22, 2216-2230


Lahiri, D.K., Ge, Y.-W., Maloney, B., Thiel, G., Zawia, N.H., Greig, N.H. and Sambamurti, K. (2005) Functional and structural domains of the 5´-flanking regions of the BACE1 gene promoter: Implications in Alzheimer´s Disease. New Trends in Alzheimer and Parkinson related disorder 2005, 7-14

top ...


Rössler, O.G., Giehl, K.M. & Thiel, G. (2004) Neuroprotection of immortalized hippocampal neurons by brain-derived neurotrophic factor and Raf-1 protein kinase: Role of extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase. J. Neurochem. 88, 1240-1252


Rössler, O.G., Bauer, I., Chung, H.-Y. & Thiel, G. (2004) Glutamate-induced cell death of immortalized hippocampal neurons: Neuroprotective activity of heme oxygenase-1, heat shock protein 70, and sodium selenite. Neurosci. Lett. 362, 253-257


Rössler, O.G. & Thiel, G. (2004) Brain-derived neurotrophic factor, epidermal growth factor, or A-Raf induced growth of HaCaT keratinocytes requires extracellular signal-regulated kinase. Am.J. Physiol - Cell. Physiol. 286, C1118-C1129


Averous, J., Bruhat, A., Jousse, C., Carraro, V., Thiel, G. & Fafournoux, P. (2004) Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation. J. Biol. Chem. 279, 5288-5297


Day, R.M., Thiel, G., Lum, J., ChŽvere, R.D., Yang, Y., Stevens, J., Sibert, L. & Fanburg, B.L. (2004) Hepatocyte growth factor regulates angiotensin converting enzyme expression. J. Biol. Chem. 279, 8792-8801


Al-Sarraj, A. & Thiel, G. (2004) The zinc finger transcription factor Egr-1 is upregulated in arsenite-treated human ker atinocytes. J. Mol. Med. 82, 530-538


Thiel, G., Lietz, M. & Hohl, M. (2004) How mammalian transcriptional repressors work. Eur. J. Biochem. 271, 2855-2862


Lietz, M., Hohl, M. & Thiel, G. (2003) RE-1 silencing transcription factor (REST) regulates human synaptophysin gene transcription through an intronic sequence-specific DNA-binding site. Eur. J. Biochem. 270, 2-9


Steinmüller, L. & Thiel, G. (2003) Regulation of gene transcription by a constitutively active mutant of activating transcription factor 2 (ATF2). Biol. Chem. 384, 667-672


Schuster, N., Bender, H., Rössler, O.G.,Philippi, A., Dünker, N., Thiel, G. & Krieglstein, K. (2003) TGF-b and TNF-a cooperate to induce apoptosis in the oligodendroglial cell line OLI-neu. J. Neurosci. Res. 73, 324-333


Jin, Q., Van Eynde, A., Beullens, M., Roy, N., Thiel, G., Stalmans, W. & Bollen, M. (2003) The protein phosphatase-1 regulator NIPP1 interacts with the Polycomb-group protein EED and functions as a transcriptional repressor. J. Biol. Chem. 278, 30677-30685


Zhang, F., Lin, M., Abidi, P., Thiel, G. & Liu, J. (2003) Specific interaction of Egr1 and c/EBPbeta leads to the transcriptional activation of the human LDL receptor gene. J. Biol. Chem. 278, 44246-44252

top ...


Thiel, G. & Cibelli, G. (2002) Regulation of life and death by the zinc finger transcription factor Egr-1. J. Cell. Physiol. 193, 287-292


Kaufmann, K. & Thiel, G. (2002) Epidermal growth factor and thrombin induced proliferation of immortalized human keratinocytes is coupled to the synthesis of Egr-1, a zinc finger transcriptional regulator. J. Cell. Biochem. 85, 381-391


Al-Sarraj, A. & Thiel, G. (2002) Substance P induced biosynthesis of the zinc finger transcription factor Egr-1 in human glioma cells requires activation of the EGF receptor and of extracellular signal-regulated protein kinase. Neurosci. Lett. 332, 111-114


Cibelli, G., Policastro, V., Rössler, O. & Thiel, G. (2002) Nitric oxide-induced programmed cell death in human neuroblastoma cells is accompanied by the synthesis of Egr-1, a zinc finger transcription factor. J. Neurosci. Res. 67, 450-460


Magin, A., Lietz, M., Cibelli, G. & Thiel, G. (2002)RE-1 silencing transcription factor-4 (REST4) is neither a transcriptional repressor nor a de-repressor. Neurochem. Int. 40, 193-200


Bartholomä, P., Erlandsson, N., Kaufmann, K., Rössler, O., Baumann, B., Wirth, T., Giehl, K.M. & Thiel, G. (2002) Neuronal cell death induced by antidepressants:  lack of correlation with Egr-1, N F-kB and extracellular signal-regulated protein kinase activation. Biochem. Pharmacol. 63, 1507-1516


Erlandsson, N., Baumann, B., Rossler, O.G., Kaufmann, K., Giehl, K.M., Wirth, T. & Thiel, G. (2002) Lack of correlation between NF-kB activation and induction of programmed cell death in PC12 pheochromocytoma cells treated with 6-hydroxydopamine or the cannabinoid receptor 1-agonist CP55,940. Biochem. Pharmacol. 64, 487-495


Rössler, O.G., Steinmüller, L., Giehl K.M. & Thiel, G. (2002) Role of c-Jun concentration in neuronal cell death. J. Neurosci. Res. 70, 655-664


Cibelli, G., Corsi, P., Diana, G., Vitiello, F.  & Thiel, G. (2001) Corticotropin-releasing factor triggers neurite outgrowth of a catecholaminergic  immortalized  neuron involving c AMP and MAP kinase signaling pathways. Eur. J. Neurosci. 13, 1339-1348


Schoch, S., Cibelli, G. , Magin, A., Steinmüller, L. & Thiel, G. (2001) Modular structure of cAMP response element binding protein 2 (CREB2). Neurochem. Int. 38, 601-608


Thiel, G., Lietz, M., Bach, K., Guethlein, L. & Cibelli, G. (2001) Biological activity of mammalian transcriptional repressors. Biol. Chem. 382, 891-902


Lietz, M., Bach, K. & Thiel, G. (2001) Biological a ctivity of RE-1 silencing transcription factor (REST) towards distinct transcriptional activators. Eur. J. Neurosci. 14, 1303-1312


Kaufmann, K., Bach, K. & Thiel, G. (2001) Extracellular signal-regulated protein kinases Erk1/Erk2 stimulate expression and biological activity of the transcriptional regulator Egr-1. Biol. Chem. 382, 1077-1081


Kaufmann, K. & Thiel, G. (2001) Epidermal growth factor and platelet-derived  growth factor induce expression of Egr-1, a zinc finger transcription factor, in human malignant glioma cells. J. Neurol. Sci. 189, 83-91


Steinmüller, L., Cibelli, G., Moll, J.R., Vinson, C. & Thiel, G. (2001) Regulation and composition of activator protein 1 (AP-1) transcription factors controlling collagenase and c-Jun promoter activities. Biochem. J. 360, 599-607


Holzmann, C., Schmidt, T., Thiel, G., Epplen, J.T. & Riess, O. (2001) Functional characterization of the human Huntington's disease gene promoter. Mol. Brain Res. 92, 85-97


Wadle, A., Thiel, G., Mischo, A., Jung, V., Pfreundschuh, M. & Renner, C. (2001) Chromosomal localization and promoter analysis of the adenomatous polyposis coli binding protein RP1. Oncogene 20, 5920-5929

top ...

before 2000

Thiel, G., Kaufmann, K., Magin, A., Lietz, M., Bach, K. & Cramer, M. (2000) The human transcriptional repressor protein NAB1: expression and biological activity. Biochim. Biophys. Acta 1493, 289-301


Groot, Moxer, L. M. & Thiel, G. (2000) Nerve growth factor and epidermal growth factor regulated gene transcription in PC12 pheochromocytoma and INS-1 insulinoma cells. Eur. J. Cell Biol. 79, 924-935


Leichter, M. & Thiel, G. (1999) Transcriptional repression by the zinc finger protein REST is mediated by titratable nuclear factors. Eur. J. Neurosci. 11, 1937-1946


Thiel, G., Lietz, M. & Leichter, M. (1999) Regulation of neuronal gene expression. Naturwissenschaften 86, 1-7


Cibelli, G., Schoch, S. & Thiel, G. (1999) Nuclear targeting of cAMP-response element binding protein 2 (CREB2). Eur. J. Cell Biol. 78, 642-649


Thiel, G. & Cibelli G. (1999) Corticotropin-releasing  factor and vasoactive intestinal polypeptide activate gene transcription through the cAMP signaling pathway in a catecholaminergic immortalized neuron. Neurochem. Int. 34, 183-191


Lietz, M., Cicchetti, P. & Thiel, G. (1998) Inverse expression pattern of REST and synapsin I in human neuroblastoma cells. Biol. Chem. 379, 1301-1304


Thiel, G., Lietz, M. & Cramer, M. (1998) Biological activity and modular structure of RE-1 silencing transcription factor (REST), a repressor of neuronal genes. J. Biol. Chem. 273, 26891-26899


Holzmann, C., Maueler, W., Petersohn, D., Schmidt, T., Thiel, G., Epplen, J.T. & Riess, O. (1998) Isolation and characterization of the rat huntingtin promoter. Biochem. J. 336, 227-234


Schoch, S., Cibelli, G. & Thiel, G. (1996) Neuron-specific gene expression of synapsin I: Major role of a negative regulatory mechanism. J. Biol. Chem. 271, 3317-3323


Cibelli, G., Jüngling, S., Schoch, S., Gerdes, H.-H. & Thiel, G. (1996) Identification of a functional cAMP response element in the secretogranin II gene. Eur. J. Biochem. 236, 171-179


Cibelli, G., Schoch, S., Pajunk, H., Brand, I. & Thiel, G. (1996) A (G+C)-rich motif in the aldolase C promoter functions as a constitutive transcriptional enhancer element. Eur. J. Biochem. 237, 311-317


Petersohn, D. & Thiel, G. (1996) Role of zinc finger proteins Sp1 and zif268/egr-1 in transcriptional regulation of the human synaptobrevin II gene. Eur. J. Biochem. 239, 827-834


Petersohn, D., Schoch, S., Brinkmann, D. R. & Thiel, G. (1995) The human synapsin II gene promoter - Possible role for the transcription factors zif268/egr-1, polyoma enhancer activator 3, and AP2.  J. Biol. Chem. 270, 24361-24369


Thiel, G., Schoch, S. & Petersohn, D. (1994) Regulation of synapsin I gene expression by the zinc finger transcription factor zif268/egr-1. J. Biol. Chem. 269, 15294-15301


Jüngling, S., Cibelli, G., Czardybon, M., Gerdes, H.-H. & Thiel, G. (1994) Differential regulation of chromogranin B and synapsin I gene promoter activity by cyclic AMP and cyclic AMP-dependent protein kinase. Eur. J. Biochem. 226, 925-935


Siow, Y.L., Chilcote, T. J., Benfenati, F., Greengard, P. & Thiel, G. (1992) Synapsin IIa: Expression in insect cells, purification and characterization. Biochemistry 31, 4268-4275


Thiel, G., Greengard, P. & Südhof, T.C. (1991) Characterization of tissue-specific transcription by the human synapsin I promoter. Proc. Natl. Acad. Sci. USA 88, 3431-3435