Selected Publications
2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 before 2000
2022
Eriksson, H., Roessler, O.G. and Thiel, G. (2022) Tyrosine hydroxylase gene promoter activity is upregulated in female catecholaminergic neuroblastoma cells following activation of a Gαq-coupled designer receptor. Neurochem. Int. 105407
Thiel, G. and Rössler, O.G. (2022) Expression of the C-terminal domain of phospholipase Cbeta3 of inhibits signaling via Gαq-coupled receptors and transient receptor potential channels. Int. J. Mol. Sci. article #1859317
Thiel, G. and Rössler, O.G. (2022) TRPM3-induced gene transcription is under epigenetic control. Pharmaceuticals 15, 846, https://doi.org/10.3390/ph15070846
Dahlhäusser, A.K., Rössler, O.G. and Thiel (2022) Regulation of c-Fos gene transcription by stimulus-responsive protein kinases. Gene 821, 146284, https://pubmed.ncbi.nlm.nih.gov/35143939
Backes, T.M., Rössler, O.G. and Thiel, G. (2022) Nobelpreis: Somatosensorik und Ionenkanäle. Biologie in unserer Zeit 52, 18-19, https://www.biuz.de/index.php/biuz/article/view/5185
2021
- Thiel, G., Guethlein, L.A. and Rössler, O.G. (2021) Insulin-responsive transcription factors. Biomolecules 11, 1886. https://doi.org/10.3390/biom11121886
- Thiel, G., Backes, T.M., Guethlein, L.A. and Rössler, O.G. (2021) Critical protein-protein interactions determine the biological activity of Elk-1, a master regulator of stimulus-induced gene transcription. Molecules 26, 6125. https://doi.org/10.3390/molecules26206125
- Backes, T.M., Langfermann, D.S., Wolf, A., Rössler, O.G., Laschke, M.W., Vinson, C. and Thiel, G. (2021) Regulation and function of AP-1 in insulinoma cells and pancreatic beta-cells. Biochem. Pharmacol. 193:114748
- Thiel, G., Wagner, L., Ulrich, M. and Rössler, O.G. (2021) Immediate-early transcriptional response to insulin receptor stimulation. Biochem. Pharmacol. 192, 114696
- Thiel, G., Schmidt, T. and Rössler, O.G. (2021) Ca2+ microdomains, calcineurin, and the regulation of gene transcription. Cells 10, 875, https://doi.org/10.3390/cells10040875
- Thiel, G., Backes, T.M., Guethlein, L.A. and Rössler, O.G. (2021) Chromatin-embedded reporter genes: Quantification of stimulus-induced gene transcription. Gene 787, 145645, doi: 10.1016/j.gene.2021.145645
2020
Loviscach, L., Backes, T.M., Langfermann, D.S., Ulrich, M. and Thiel, G. (2020) Zn2+ ions inhibit gene transcription following stimulation of the Ca2+ channels Cav1.2 and TRPM3. Metallomics 12, 1735-1747
Scheuble, J., Roessler, O.G., Ulrich, M., Thiel, G. (2020) Pharmacological and genetic inhibition of TRPC6-induced gene transcription. Euro. J. Pharmacol., 159, 104983
Lesch, A., Backes, T.M., Langfermann, D.S., Roessler, O.G., Laschke, M.W., Thiel, G. (2020) Ternary complex factor regulates pancreatic islet size and blood Glucose homeostasis in transgenic mice. Pharmacol. Res. 159:104983,
https://www.sciencedirect.com/science/article/abs/pii/S1043661820312913
Ulrich, M., Wissenbach, U., Thiel, G. (2020) The super-cooling compound icilin stimulates c-Fos and Egr-1 expression and activity involving TRPM8 channel activation, Ca2+ ion Influx and acitvation of the ternary comlex factor Elk-1. Biochem. Pharmacol., 177, 113936
Thiel, G., Ulrich, M., Mukaida, N. Roessler, O.G. (2020) Regulation of stimulus-induced interleukin-8 gene transcription in human adrenocortical carcinoma cells - role of AP-1 and NF-kB. Cytokine 126:154862, https://www.sciencedirect.com/science/article/abs/pii/S1043466619302911
Thiel, G., Backes, T.M., Roessler, O.G. (2020) Some like it hot - and spicy: Chili und der Capsaicin-Rezeptor TRPV1. Biologie in unserer Zeit, 50, 246-252

2019
Langfermann, D.S., Schmidt, T., Rössler O.G., Thiel, G. (2019) Calcineurin controls gene transcription following stimulation of a Gαq-coupled designer receptor. Exp. Cell Res. 383, 111553, www.sciencedirect.com/science/article/abs/pii/S0014482719304057
Thiel, G., Backes, T.M., Welck, J., Steinhausen, S., Fischer, A.-L., Langfermann, D.S., Ulrich, M., Wissenbach, U., Rössler, O.G. (2019) Pharmacological Inhibition of TRPM8-induced gene transcription. Biochem. Pharmacol. 170:113678, www.sciencedirect.com/science/article/abs/pii/S0006295219303776
Thiel, G., Welck, J., Wissenbach, U. and Rössler, O.G. (2019) Dihydrotestosterone activates AP-1 in LNCaP prostate cancer cells. Int. J. Biochem. Cell Biol. 110, 9-20, https://www.ncbi.nlm.nih.gov/pubmed/?term=Thiel+G%2C+Welck+J%2C+Wissenbach+U
Rubil, S. and Thiel, G. (2019) Stimulation of TRPM3 channels increases the transcriptional activation potential of Elk-1 involving cytosolic Ca2+, extracellular signal-regulated protein kinase, and calcineurin. European Journal of Pharmacology 844, 225-230, https://www.ncbi.nlm.nih.gov/pubmed/30552902
2018
Thiel, G., Ulrich, M., Mukaida, N. and Roessler, O.G. (2018) Resveratrol stimulation induces interleukin-8 gene transcription via NF-κB. Pharmacol. Res. 134, 238-245, https://www.sciencedirect.com/science/article/abs/pii/S104366181830714X
Thiel, G. (2018) The ingredient of chili peppers changes the gene expression pattern of cells. Science Trends, https://sciencetrends.com/the-ingredient-of-chili-peppers-changes-the-gene-expression-pattern-of-cells/
Thiel, G. and Rössler, O.G. (2018) Resveratrol stimulates c-Fos gene transcription via activation of ERK1/2 involving multiple genetic elements. Gene 658, 70-75, https://www.sciencedirect.com/science/article/pii/S0378111918302348?via%3Dihub
Backes, T.M., Roessler, O.G., Hui, X., Grötzinger, C., Lipp, P. and Thiel, G. (2018) Stimulation of TRPV1 channels activates the AP-1 transcription factor. Biochem. Pharmacol. 150, 160-169, https://www.sciencedirect.com/science/article/abs/pii/S0006295218300650
Langfermann, D.S., Roessler, O.G. and Thiel, G. (2018) Stimulation of B-Raf increases c-Jun and c-Fos expression and upregulates AP-1-regulated gene transcription in insulinoma cells. Mol. Cell. Endocrinol. 472, 126-139,
https://www.sciencedirect.com/science/article/pii/S0303720717306317?via%3Dihub
Rubil, S., Lesch, A., Mukaida, N. and Thiel, G. (2018) Stimulation of transient receptor potential M3 (TRPM3) channels increases Interleukin-8 Promotor activity involving AP-1 and extracullular signal-regulated Protein kinase. Cytokine 103, 133-141, https://www.sciencedirect.com/science/article/abs/pii/S1043466617302776
Thiel, G., Lesch, A., Rubil, S., Backes, T.M. and Roessler, O.G. (2018) Regulation of gene transcription following stimulation of transient receptor potential (TRP) channels. Int. Rev. Cell. Mol. Biol. 335, 167-189, https://www.sciencedirect.com/science/article/pii/S1937644817300850?via%3Dihub
Schmitt, B.M., Laschke, M.W., Roessler, O.G., Huang, W., Scheller, A., Menger, M.D., Ampofo, E. (2018) Nerve/glial antigen (NG) 2 is a crucial regulator of intercellular adhesion molecule (ICAM)-1 expression. BBA Molecular Cell Research 1865, 57-66
2017
Lesch, A., Rössler, O.G. and Thiel, G. (2017) Extracellular signal-regulated protein kinase, c-Jun N-terminal protein kinase and calcineurin regulate transient receptor potential M3 (TRPM3) induced activation of AP-1. J. Cell. Biochem. 118, 2409-2419
Thiel, G. and Rössler, O.G. (2017) Resveratrol regulates gene transcription via activation of stimulus-responsive transcription factors. Pharmacol. Res. 117, 166-176
Rössler O.G. and Thiel, G. (2017) Specificity of stress-responsive transcription factors Nrf2, ATF4 and AP-1. J. Cell. Biochem. 118, 127-140
Thiel, G. and Rössler, O.G. (2017) Hyperforin activates gene transcription involving transient receptor potential C6 channels. Biochem. Pharmacol. 129, 96-107
Rubil, S. and Thiel, G. (2017) Activation of gene transcription via CIM0216, a synthetic ligand of transient receptor potential melastatin-3 (TRPM3) channels. Channels 11, 79 - 83
Thiel, G., Rubil, S., Lesch, A., Guethlein, L., Roessler, O.G. (2017) Transient receptor potential TRPM3 channels: pharmacology, signaling, and biological functions. Pharmacol. Res. 124, 92-99
2016
Rössler, O.G., Lesch, A. and Thiel, G. (2016) Combining fibroblast isolation with lentiviral gene transfer to validate transgene expression in mice following pronucleus injection. Transgenic Res. 25, 839-846
Thiel, G. and Rössler, O.G. (2016) Resveratrol stimulates cyclic AMP response element-mediated gene transcription. Mol. Nutr. Food Res. 60, 256-265
Rubil, S., Rössler, O.G., and Thiel, G. (2016) CREB, AP-1, ternary complex factors and MAP kinases connect transient receptor potential melastatin-3 (TRPM3) channel stimulation with increased c-Fos expression. Brit. J. Pharmacol. 173, 305-318
2015
Ampofo E., Rudzitis-Auth J., Dahmke I.N., Rössler O.G., Thiel G., Montenarh M., Menger M.D., Laschke M.W. (2015) Inhibition of protein kinase CK2 suppresses tumor necrosis factor (TNF)-alpha induced leukocyte-endothelial cell interaction. Biochim. Biophys. Acta 1852, 2123-2136
Rössler, O.G., Glatzel, D. and Thiel, G. (2015) Resveratrol upregulates Egr-1 expression and activity involving extracellular signal-regulated protein kinase and ternary complex factors. Exp. Cell Res. 332, 116-127
Lesch, A., Hui, X., Lipp, P. and Thiel, G. (2015) Transient receptor potential melastatin-3 (TRPM3)-induced activation of AP-1 requires Ca2+ ions and the transcription factors c-Jun, ATF2, and ternary complex factor. Mol. Pharmacol. 87, 617-628
Thiel, G., Ekici, M. and Rössler, O.G. (2015) RE-1 silencing transcription factor (REST): a regulator of neuronal development and neuronal / endocrine function. Cell Tissue Res. 359, 99-109
2014
Gozdecka, M., Lyons, S., Kondo, S., Taylor, J., Li, Y., Walczynski, J., Thiel, G., Breitwieser, W., Jones, N. (2014) JNK suppresses tumor formation via a gene-expression program mediated by ATF2. Cell Rep. 9, 1361-1374
Thiel, G., Kaufmann, A. and Roessler, O.G. (2014) G-Protein-gekoppelte Designerrezeptoren. BIOSpektrum 3/2014, 20. Jahrgang, 259-262
Kaufmann, A., Rössler, O.G. and Thiel, G. (2014) Expression of the transcription factor Egr-1 in pancreatic acinar cells following stimulation of cholecystokinin or G-alpha-q-coupled designer receptors. Cell. Physiol. Biochem. 33, 1411-1425
Thiel, G., Müller, I. and Rössler, O.G. (2014) Expression, signaling and function of Egr transcription factors in pancreatic beta cells and insulin-responsive tissues. Mol. Cell. Endocrinol. 388, 10-19
Thiel, G. and Rössler, O.G. (2014) Resveratrol stimulates AP-1 regulated gene transcription. Mol. Nutr. Food Res. 58, 1402-1413
Lesch, A., Rubil, S. and Thiel, G. (2014) Activation and ihibition of transient receptor potential TRPM3 induced gene transcription. Brit. J. Pharmacol. 171, 2645-2658
Gorbatenko, A., Olesen, C.W., Mørup, N., Thiel, G., Kallunki, T., Valen, E. and Pedersen, S.F. (2014) ErbB2 upregulates the Na+,HCO3(-)-cotransporter NBCn1/SLC4A7 in human breast cancer cells via Akt, ERK, Src, and Kruppel-like factor 4. FASEB J. 28, 350-363
2013
Thiel, G., Kaufmann, A., Rössler, O.G. (2013) G-protein coupled designer receptors - new chemical-genetic tools for signal transduction research. Biol. Chem. 394, 1615-1622
Thiel, G., Müller, I., Rössler O.G. (2013) Signal transduction via TRPM3 channels in pancreatic beta-cells. J. Mol. Endocrinol. 50, R75-83
Thiel, G. (2013) How Sox2 maintains neural stem cell identity. Biochem. J. 450, e1-2
Hohl, M., Wagner, M., Reil, J.-C., Müller, S.-A., Taucnitz, M., Zimmer A. M., Lehmann, L. H., Thiel, G., Böhm, M., Backs, J. and Maack, C. (2013) Histone deacetylase 4 controls histone methylation in response to cardiac load. J. Clin. Invest. 123, 1359-1370
Kaufmann, A., Keim, A., and Thiel, G. (2013) Regulation of immediate-early gene transcription following activation of Gaq-coupled designer receptors. J. Cell. Biochem. 114, 681-696
2012
Thiel, G., Lesch, A. and Keim, A. (2012) Transcriptional response to calcium-sensing receptor stimulation. Endocrinology, 153, 4716-4728
Müller, I., Rössler, O.G., Wittig, C., Menger, M.D. and Thiel, G. (2012) Critical role of Egr transcription factors in regulating insulin biosynthesis, blood glucose homeostasis, and islet size. Endocrinology, 153, 3040-3053
Müller, I., Lipp, P. and Thiel, G. (2012) Ca2+ signaling and gene transcription in glucose-stimulated insulinoma cells. Cell Calcium, 52, 137-151
Ekici, M., Keim, A., Rössler, O.G., Hohl, M. and Thiel, G. (2012) Chromatin structure and expression of the AMPA receptor subunit GluR2 in human glioma cells: major regulatory of REST and Sp1. J. Cell. Biochem., 133, 528-543
Keim, A., Rössler, O.G., Rothhaar, T.L. and Thiel, G. (2012) Arsenite-induced apoptosis of human neuroblastoma cells requires p53 but occurs independently of c-Jun. Neuroscience, 206, 25-38
Keim, A., Müller, I. and Thiel, G. (2012) Efficient genetic manipulation of 1321N1 astrocytoma cells using lentiviral gene transfer. J. Neurosci. Methods, 206, 138-142
2011
Mayer, S.I., Müller, I., Mannebach, S., Endo, T. and Thiel, G. (2011) Signal transduction of pregnenolone sulfate in insulinoma cells - activation of EGR-1 expression involving TRPM3, voltage-gated calcium channels, ERK, and ternary complex factors. J. Biol. Chem., 286, 10084-10096
Xie, B., Wang, C., Zheng, Z., Song, B., Ma, C., Thiel, G. and Li, M. (2011) Egr-1 Transactivates Bim Gene Expression to Promote Neuronal Apoptosis. J. Neurosci., 31, 5032-5044
Chbicheb, S., Yao, X., Rodeau, J.L., Salamone, S., Boisbrun, M., Thiel, G., Spohn, D., Grillier-Vuissoz, I., Chapleur, Y., Flament, S. and Mazerbourg, S. (2011) EGR1 expression: a calcium and ERK1/2 mediated PPAR(γ)-independent event involved in the antiproliferative effect of 15-deoxy-(12, 14-prostaglandin J2 and Thiazolidinediones in breast cancer cells. Biochem. Pharmacol., 81, 1087-1097
Müller, I., Rössler, O.G. and Thiel, G. (2011) Pregnenolone Sulfate Activates Basic Region Leucine Zipper Transcription Factors in Insulinoma Cells - Role of Voltage Gated Ca2+ Channels and Transient Receptor Potential TRPM3 Channels. Mol Pharmacol., 80, 1179-1189
Thiel, G. and Rössler, O.G. (2011) Immediate-Early Transcriptional Response to Angiotensin II in Human Adrenocortical Cells. Endocrinology, 152, 4211-4223
2010
Spohn, D., Roessler, O.G., Philipp, S.E., Raubuch, M., Kitajima, S., Griesemer, D., Hoth, M. and Thiel, G. (2010) Thapsigargin induces expression of ATF3 in human keratinocytes involving Ca2+ ions and c-Jun N-terminal protein kinase. Mol. Pharmacol., 78, 865-76
Thiel, G., Mayer, S.I., Müller, I., Stefano, L. and Rössler, O.G. (2010) Egr-1 - A Ca(2+)-regulated transcription factor. Cell Calcium, 47, 397-403
Müller, I., Endo, T. and Thiel, G. (2010) Regulation of AP-1 activity in glucose-stimulated insulinoma cells. J. Cell. Biochem., 110, 1481-1494
Meng, R., Al-Quobaili, F., Müller, I., Götz, C., Thiel, G. and Montenarh, M. (2010) CK2 phosphorylation of Pdx-1 regulates its transcription factor activity. Cell. Mol. Life Sci., 67, 2481-2489
2009
Yuan, Z., Gong, S., Luo, J., Zheng, Z., Song, B., Ma, S., Guo, J., Hu, C., Thiel, G., Vinson, C., Hu, C.D., Wang, Y. and Li, M. (2009) Opposing roles for ATF2 and c-Fos in c-Jun-mediated neuronal apoptosis. Mol. Cell. Biol., 29, 2431-2442
Mayer, S.I. and Thiel, G. (2009) Calcium influx into MIN6 insulinoma cells induces expression of Egr-1 involving extracellular signal-regulated protein kinase and the transcription factors Elk-1 and CREB. Eur. J. Cell. Biol., 88, 19-33
Rössler, O.G. and Thiel, G. (2009) Thrombin induces Egr-1 expression in fibroblasts involving elevation of the intracellular Ca2+ concentration, phosporylation of ERK and activation of ternary complex factor. BMC Mol. Biol., 10:40
Mayer, S.I., Rössler, O.G., Endo, T., Charnay, P. and Thiel, G. (2009) Epidermal growth factor-induced proliferation of astrocytes requires Egr transcription factors. J. Cell. Sci., 122, 3340-3350
Colecchia, F., Kottwitz, D., Wagner, M., Pfenninger, C.V., Thiel, G., Tamm, I., Peterson, C. and Nuber, U.A. (2009) Tissue-specific regulatory network extractor (TS-REX): a database and software resource for the tissue and cell type-specific investigation of transcription factor-gene networks. Nucl. Acids Res., 37, e82
Thiel, G., Ekici, M. and Rössler, O.G. (2009) Regulation of cellular proliferation, differentiation and cell death by activated Raf. Cell Commun. Signal., 7:8
Friedrich, K., Lindquist, J.A., Entschladen, F., Serfling, E., Thiel, G., Kieser, A., Giehl, K., Ehrhardt, C., Feller, S.M., Ullrich, O., Schaper, F., Janssen, O. and Hass, R. (2009) Signal Transduction in the Footsteps of Goethe and Schiller. Cell Commun. Signal. 7:2
Entschladen, F., Lindquist, J.A., Serfling, E., Thiel, G., Kieser, A., Giehl, K., Ehrhardt, C., Feller, S.M., Ullrich, O., Schaper, F., Janssen, O., Hass, R. and Friedrich, K. (2009) Signal transduction-receptors, mediators, and genes. Sci. Signal. 2(63):mr3
Müller, I., Mayer, S.I., Keim, A. and Thiel, G. (2009) Lentiviraler Gentransfer: Analyse von transkriptioneller Aktivierung und DNA-Bindung. BIOSpektrum 15, 52-53
2008
Abramovitz, L., Shapira, T., Ben-Dror, I., Dror, V., Granot, L., Rousso, T., Landoy, E., Blau, L., Thiel, G. and Vardimon, L.(2008) Dual role of NRSF/REST in activation and repression of the glucocorticoid response. J. Biol. Chem., 283, 110-119
Ekici, M., Hohl, M., Schuit, F., Martinez-Serrano, A. and Thiel, G. (2008) Transcription of genes encoding synaptic vesicle proteins in human neural stem cells: Chromatin accessibility, histone methylation pattern and essential role of REST. J. Biol. Chem., 283, 9257-9268
Ekici, M., Schmitz, F., Hohl., M., Seigel, G.M., and Thiel, G. (2008) Chromatin structure and expression of synapsin I and synaptophysin in retinal precursor cells. Neurochem. Int., 53, 165-172
Thiel, G. and Schuit, F. (2008) No REST for healthy beta cells. Diabetologia, 51, 1343-1346
Rössler, O.G., Henß, I. and Thiel, G. (2008) Transcriptional response to muscarinic acetyl-choline receptor stimulation: Regulation of Egr-1 biosynthesis by Elk-1, ERK, MKP-1 and calcineurin in carbachol stimulated human neuroblastoma cells. Arch. Biochem. Biophys., 470, 93-102
Mungunsukh, O., Marquez, A.P., Lee, Y.H., Thiel, G. and Day, R.M. (2008) Characterization of the Bovine Angiotensin Converting Enzyme Promoter: Essential roles of Egr-1, ATF-2 and Ets-1 in the regulation by phorbol ester. Gene, 421, 81-88
Franko, A., Mayer, S., Thiel, G., Mercy, L., Arnould, T., Hornig-Do, H.T., Wiesner, R.J. and Goffert, S. (2008) CREB-1a is recruited to and mediates upregulation of the Cytochrome c promoter during enhanced mitochondrial biogenesis accompanying skeletal muscle differentiation. Mol. Cell. Biol., 28, 2446-2459
Ceyhan, G.O., Demir, I.E., Altintas, B., Rauch, U., Thiel, G., Müller, M.W., Giese, N.E,, Friess, H., and Schäfer, K.H. (2008) Neural invasion in pancreatic cancer: A mutual tropism between neurons and cancer cells. Biochem. Biophys. Res. Commun., 374, 442-447
Mayer, S.I., Willars, G.B., Nishida, E. and Thiel, G. (2008) Elk-1, CREB and MKP-1 regulate Egr-1 expression in gonadotropin-releasing hormone stimulated gonadotrophs. J. Cell. Biochem., 105, 1267-1278
Mayer, S.I., Dexheimer, V., Nishida, E., Kitajima, S. and Thiel,G. (2008) Expression of the transcriptional repressor ATF3 in gonadotrophs is regulated by Egr-1, CREB and ATF2 after gonadotropin-releasing hormone receptor stimulation. Endocrinology, 149, 6311-6325
2007
Bauer, I., Al Sarraj, J., Vinson, C., Larsen, R. and Thiel, G. (2007) Interleukin-1 beta and tetradecanoylphorbol acetate-induced biosynthesis of tumor necrosis factor alpha in human hepatoma cells involves the transcription factors ATF2 and c-Jun and stress-activated protein kinases. J. Cell. Biochem., 100, 242-255
Stefano, L., Rössler, O.G., Griesemer, D., Hoth, M. and Thiel, G. (2007) P2X(7) receptor stimulation upregulates Egr-1 biosynthesis involving a cytosolic Ca(2+) rise, transactivation of the EGF receptor and phosphorylation of ERK and Elk-1. J. Cell. Physiol., 213, 36-44
Thiel, G. and Rössler, O.G. (2007) Wie aus einem Retrovirus ein Gentransfer-Vektor entsteht: Viren als Werkzeuge der Gentherapie. Biologie in unserer Zeit, 37, 241-248
2006

Thiel, G. and Hohl, M. (2006) RE-1 silencing transcription factor (REST) - Regulation of neuronal gene expression via modification of the chromatin structure. In: Transcription factors in the nervous system – Development, Brain Function and Disease (G. Thiel, Editor), Wiley-VCH, Weinheim, Germany, pp 113-128
Rössler, O.G., Stefano, L., Bauer, I. and Thiel, G. (2006) Stimulus-transcription coupling in the nervous system –the zinc finger protein Egr-1. In: Transcription factors in the nervous system – Development, Brain Function and Disease (G. Thiel, Editor), Wiley-VCH Verlag GmbH & Co.KGaA, Weinheim, Germany, pp 379-395
Stefano, L., Al Sarraj, J., Rössler, O.G., Vinson, C. and Thiel, G. (2006) Upregulation of tyrosine hydroxylase gene transcription by tetradecanoylphorbol acetate is mediated by the transcription factors Ets-like protein-1 (Elk-1) and Egr-1. J. Neurochem., 97, 92-104
Zhou, Y., Zhang F., Abidi, P., Lin, M., Thiel, G. and Liu, J. (2006) Blockage of oncostatin M-induced LDL receptor gene transcription by a dominant- negative mutant of c/EBPß. Biochem. J., 397, 101-108
Sobke, A.c., Selimovic, D., Orlova, V., Hassan, M., Chavakis, T., Athanasopoulos, A.N., Schubert, U., Hussain, M., Thiel, G., Preissner, K.T. and Herrmann, M. (2006) The extracellular adherence protein from Staphylococcus aureus abrogates angiogenic responses of endothelial cells by blocking Ras activation. FASEB J., 20, 2621-2623
2005
Thiel, G., Al Sarraj, J. and Stefano, L. (2005) cAMP response element binding protein (CREB) activates transcription via two distinct genetic elements of the human glucose-6-phosphatase gene. BMC Molecular Biology, 6:2
Thiel, G., Al Sarraj, J., Vinson, C., Stefano, L. and Bach, K. (2005) Role of basic region leucine zipper transcription factors cyclic AMP response element binding protein (CREB), CREB2, activation transcription factor 2 and CAAT/enhancer binding protein a in cyclic AMP response element-mediated transcription. J. Neurochem., 92, 321-336
Al Sarraj, J., Vinson, C., Han, J. and Thiel, G. (2005) Regulation of GTP cyclohydrolase I gene transcription by basic region leucine zipper transcription factors. J. Cell. Biochem., 96, 1003-1020
Al Sarraj, J., Vinson, C. and Thiel, G. (2005) Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP. Biol. Chem., 386, 873-879
Al-Sarraj, A., Day, R.M. and Thiel, G. (2005) Specificity of transcriptional regulation by the zinc finger transcription factors Sp1, Sp3 and Egr-1. J. Cell. Biochem., 94, 153-167
Bauer, I., Hohl, M., Al-Sarraj, A., Vinson, C. and Thiel, G. (2005) Transcriptional activation of the Egr-1 gene mediated by tetradecanoylphorbol acetate and extracellular signal-regulated protein kinase. Arch. Biochem. Biophys., 438, 36-52
Thiel, G. and Rössler, O.G. (2005) Signaltransduktion: Rezeptor-Tyrosinkinasen und intrazelluläre Signalkaskaden. Biologie in unserer Zeit 35, 312-319
Thiel, G., Bauer, I. and Rössler, O.G. (2005) Role of extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase in neuronal cell death and survival. Signal Transduction, 6, 322-333
Hohl, M. and Thiel, G. (2005) Cell type-specific regulation of RE-1 silencing transcription factor (REST) target genes. Eur. J. Neurosci., 22, 2216-2230
Lahiri, D.K., Ge, Y.-W., Maloney, B., Thiel, G., Zawia, N.H., Greig, N.H. and Sambamurti, K. (2005) Functional and structural domains of the 5´-flanking regions of the BACE1 gene promoter: Implications in Alzheimer´s Disease. New Trends in Alzheimer and Parkinson related disorder 2005, 7-14
2004
Rössler, O.G., Giehl, K.M. & Thiel, G. (2004) Neuroprotection of immortalized hippocampal neurons by brain-derived neurotrophic factor and Raf-1 protein kinase: Role of extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase. J. Neurochem. 88, 1240-1252
Rössler, O.G., Bauer, I., Chung, H.-Y. & Thiel, G. (2004) Glutamate-induced cell death of immortalized hippocampal neurons: Neuroprotective activity of heme oxygenase-1, heat shock protein 70, and sodium selenite. Neurosci. Lett. 362, 253-257
Rössler, O.G. & Thiel, G. (2004) Brain-derived neurotrophic factor, epidermal growth factor, or A-Raf induced growth of HaCaT keratinocytes requires extracellular signal-regulated kinase. Am.J. Physiol - Cell. Physiol. 286, C1118-C1129
Averous, J., Bruhat, A., Jousse, C., Carraro, V., Thiel, G. & Fafournoux, P. (2004) Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation. J. Biol. Chem. 279, 5288-5297
Day, R.M., Thiel, G., Lum, J., ChŽvere, R.D., Yang, Y., Stevens, J., Sibert, L. & Fanburg, B.L. (2004) Hepatocyte growth factor regulates angiotensin converting enzyme expression. J. Biol. Chem. 279, 8792-8801
Al-Sarraj, A. & Thiel, G. (2004) The zinc finger transcription factor Egr-1 is upregulated in arsenite-treated human ker atinocytes. J. Mol. Med. 82, 530-538
Thiel, G., Lietz, M. & Hohl, M. (2004) How mammalian transcriptional repressors work. Eur. J. Biochem. 271, 2855-2862
2003
Lietz, M., Hohl, M. & Thiel, G. (2003) RE-1 silencing transcription factor (REST) regulates human synaptophysin gene transcription through an intronic sequence-specific DNA-binding site. Eur. J. Biochem. 270, 2-9
Steinmüller, L. & Thiel, G. (2003) Regulation of gene transcription by a constitutively active mutant of activating transcription factor 2 (ATF2). Biol. Chem. 384, 667-672
Schuster, N., Bender, H., Rössler, O.G.,Philippi, A., Dünker, N., Thiel, G. & Krieglstein, K. (2003) TGF-b and TNF-a cooperate to induce apoptosis in the oligodendroglial cell line OLI-neu. J. Neurosci. Res. 73, 324-333
Jin, Q., Van Eynde, A., Beullens, M., Roy, N., Thiel, G., Stalmans, W. & Bollen, M. (2003) The protein phosphatase-1 regulator NIPP1 interacts with the Polycomb-group protein EED and functions as a transcriptional repressor. J. Biol. Chem. 278, 30677-30685
Zhang, F., Lin, M., Abidi, P., Thiel, G. & Liu, J. (2003) Specific interaction of Egr1 and c/EBPbeta leads to the transcriptional activation of the human LDL receptor gene. J. Biol. Chem. 278, 44246-44252
2002
Thiel, G. & Cibelli, G. (2002) Regulation of life and death by the zinc finger transcription factor Egr-1. J. Cell. Physiol. 193, 287-292
Kaufmann, K. & Thiel, G. (2002) Epidermal growth factor and thrombin induced proliferation of immortalized human keratinocytes is coupled to the synthesis of Egr-1, a zinc finger transcriptional regulator. J. Cell. Biochem. 85, 381-391
Al-Sarraj, A. & Thiel, G. (2002) Substance P induced biosynthesis of the zinc finger transcription factor Egr-1 in human glioma cells requires activation of the EGF receptor and of extracellular signal-regulated protein kinase. Neurosci. Lett. 332, 111-114
Cibelli, G., Policastro, V., Rössler, O. & Thiel, G. (2002) Nitric oxide-induced programmed cell death in human neuroblastoma cells is accompanied by the synthesis of Egr-1, a zinc finger transcription factor. J. Neurosci. Res. 67, 450-460
Magin, A., Lietz, M., Cibelli, G. & Thiel, G. (2002)RE-1 silencing transcription factor-4 (REST4) is neither a transcriptional repressor nor a de-repressor. Neurochem. Int. 40, 193-200
Bartholomä, P., Erlandsson, N., Kaufmann, K., Rössler, O., Baumann, B., Wirth, T., Giehl, K.M. & Thiel, G. (2002) Neuronal cell death induced by antidepressants: lack of correlation with Egr-1, N F-kB and extracellular signal-regulated protein kinase activation. Biochem. Pharmacol. 63, 1507-1516
Erlandsson, N., Baumann, B., Rossler, O.G., Kaufmann, K., Giehl, K.M., Wirth, T. & Thiel, G. (2002) Lack of correlation between NF-kB activation and induction of programmed cell death in PC12 pheochromocytoma cells treated with 6-hydroxydopamine or the cannabinoid receptor 1-agonist CP55,940. Biochem. Pharmacol. 64, 487-495
Rössler, O.G., Steinmüller, L., Giehl K.M. & Thiel, G. (2002) Role of c-Jun concentration in neuronal cell death. J. Neurosci. Res. 70, 655-664
2001
Cibelli, G., Corsi, P., Diana, G., Vitiello, F. & Thiel, G. (2001) Corticotropin-releasing factor triggers neurite outgrowth of a catecholaminergic immortalized neuron involving c AMP and MAP kinase signaling pathways. Eur. J. Neurosci. 13, 1339-1348
Schoch, S., Cibelli, G. , Magin, A., Steinmüller, L. & Thiel, G. (2001) Modular structure of cAMP response element binding protein 2 (CREB2). Neurochem. Int. 38, 601-608
Thiel, G., Lietz, M., Bach, K., Guethlein, L. & Cibelli, G. (2001) Biological activity of mammalian transcriptional repressors. Biol. Chem. 382, 891-902
Lietz, M., Bach, K. & Thiel, G. (2001) Biological a ctivity of RE-1 silencing transcription factor (REST) towards distinct transcriptional activators. Eur. J. Neurosci. 14, 1303-1312
Kaufmann, K., Bach, K. & Thiel, G. (2001) Extracellular signal-regulated protein kinases Erk1/Erk2 stimulate expression and biological activity of the transcriptional regulator Egr-1. Biol. Chem. 382, 1077-1081
Kaufmann, K. & Thiel, G. (2001) Epidermal growth factor and platelet-derived growth factor induce expression of Egr-1, a zinc finger transcription factor, in human malignant glioma cells. J. Neurol. Sci. 189, 83-91
Steinmüller, L., Cibelli, G., Moll, J.R., Vinson, C. & Thiel, G. (2001) Regulation and composition of activator protein 1 (AP-1) transcription factors controlling collagenase and c-Jun promoter activities. Biochem. J. 360, 599-607
Holzmann, C., Schmidt, T., Thiel, G., Epplen, J.T. & Riess, O. (2001) Functional characterization of the human Huntington's disease gene promoter. Mol. Brain Res. 92, 85-97
Wadle, A., Thiel, G., Mischo, A., Jung, V., Pfreundschuh, M. & Renner, C. (2001) Chromosomal localization and promoter analysis of the adenomatous polyposis coli binding protein RP1. Oncogene 20, 5920-5929
before 2000
Thiel, G., Kaufmann, K., Magin, A., Lietz, M., Bach, K. & Cramer, M. (2000) The human transcriptional repressor protein NAB1: expression and biological activity. Biochim. Biophys. Acta 1493, 289-301
Groot, Moxer, L. M. & Thiel, G. (2000) Nerve growth factor and epidermal growth factor regulated gene transcription in PC12 pheochromocytoma and INS-1 insulinoma cells. Eur. J. Cell Biol. 79, 924-935
Leichter, M. & Thiel, G. (1999) Transcriptional repression by the zinc finger protein REST is mediated by titratable nuclear factors. Eur. J. Neurosci. 11, 1937-1946
Thiel, G., Lietz, M. & Leichter, M. (1999) Regulation of neuronal gene expression. Naturwissenschaften 86, 1-7
Cibelli, G., Schoch, S. & Thiel, G. (1999) Nuclear targeting of cAMP-response element binding protein 2 (CREB2). Eur. J. Cell Biol. 78, 642-649
Thiel, G. & Cibelli G. (1999) Corticotropin-releasing factor and vasoactive intestinal polypeptide activate gene transcription through the cAMP signaling pathway in a catecholaminergic immortalized neuron. Neurochem. Int. 34, 183-191
Lietz, M., Cicchetti, P. & Thiel, G. (1998) Inverse expression pattern of REST and synapsin I in human neuroblastoma cells. Biol. Chem. 379, 1301-1304
Thiel, G., Lietz, M. & Cramer, M. (1998) Biological activity and modular structure of RE-1 silencing transcription factor (REST), a repressor of neuronal genes. J. Biol. Chem. 273, 26891-26899
Holzmann, C., Maueler, W., Petersohn, D., Schmidt, T., Thiel, G., Epplen, J.T. & Riess, O. (1998) Isolation and characterization of the rat huntingtin promoter. Biochem. J. 336, 227-234
Schoch, S., Cibelli, G. & Thiel, G. (1996) Neuron-specific gene expression of synapsin I: Major role of a negative regulatory mechanism. J. Biol. Chem. 271, 3317-3323
Cibelli, G., Jüngling, S., Schoch, S., Gerdes, H.-H. & Thiel, G. (1996) Identification of a functional cAMP response element in the secretogranin II gene. Eur. J. Biochem. 236, 171-179
Cibelli, G., Schoch, S., Pajunk, H., Brand, I. & Thiel, G. (1996) A (G+C)-rich motif in the aldolase C promoter functions as a constitutive transcriptional enhancer element. Eur. J. Biochem. 237, 311-317
Petersohn, D. & Thiel, G. (1996) Role of zinc finger proteins Sp1 and zif268/egr-1 in transcriptional regulation of the human synaptobrevin II gene. Eur. J. Biochem. 239, 827-834
Petersohn, D., Schoch, S., Brinkmann, D. R. & Thiel, G. (1995) The human synapsin II gene promoter - Possible role for the transcription factors zif268/egr-1, polyoma enhancer activator 3, and AP2. J. Biol. Chem. 270, 24361-24369
Thiel, G., Schoch, S. & Petersohn, D. (1994) Regulation of synapsin I gene expression by the zinc finger transcription factor zif268/egr-1. J. Biol. Chem. 269, 15294-15301
Jüngling, S., Cibelli, G., Czardybon, M., Gerdes, H.-H. & Thiel, G. (1994) Differential regulation of chromogranin B and synapsin I gene promoter activity by cyclic AMP and cyclic AMP-dependent protein kinase. Eur. J. Biochem. 226, 925-935
Siow, Y.L., Chilcote, T. J., Benfenati, F., Greengard, P. & Thiel, G. (1992) Synapsin IIa: Expression in insect cells, purification and characterization. Biochemistry 31, 4268-4275
Thiel, G., Greengard, P. & Südhof, T.C. (1991) Characterization of tissue-specific transcription by the human synapsin I promoter. Proc. Natl. Acad. Sci. USA 88, 3431-3435