Medizinische Fakultät der Universität des Saarlandes
Biophysik
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Dr. R. Kappl

 

Publications 2017 :

 

Electrochemical quantification of extracellular local H2O2 kinetics originating from single cells.

Bozem M, Knapp P, Mirceski V, Slowik EJ, Bogeski I, Kappl R, Heinemann C, Hoth M.

Anitoxid Redox Signal. 2017 May 15; [Epub ahead of print].

 

Low STAT3 expression sensitizes to toxic effects of β-adrenergic receptor stimulation in peripartum cardiomyopathy.

Stapel B, Kohlhaas M, Ricke-Hoch M, Haghikia A, Erschow S, Knuuti J, Silvola JM, Roivainen A, Saraste A, Nickel AG, Saar JA, Sieve I, Pietzsch S, Müller M, Bogeski I, Kappl R, Jauhiainen M, Thackeray JT, Scherr M, Bengel FM, Hagl C, Tudorache I, Bauersachs J, Maack C, Hilfiker-Kleiner D.

Eur Heart J. 2017 Feb 1;38(5):349-361.

 


 

Publications 2016 :

 

New insights into the chemistry of Coenzyme Q-0: A voltammetric and spectroscopic study.

Gulaboski R, Bogeski I, Kokoskarova P, Haeri HH, Mitrev S, Stefova M, Stanoeva JP, Markovski V, Mirceski V, Hoth M, Kappl R.

Bioelectrochemistry. 2016 Oct;111:100-108.

 

An EPR and DFT study on the primary radical formed in hydroxylation reactions of 2,6-dimethoxy-1,4-benzoquinone.

Haeri H, Bogeski I, Gulaboski R, Mirceski V, Hoth M, Kappl R.

Mol Phys. 2016, March 17 online

 

A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+ channels.

Saul S, Gibhardt CS, Schmidt B, Lis A, Pasieka B, Conrad D, Jung P, Gaupp R, Wonnenberg B, Diler E, Stanisz H, Vogt T, Schwarz EC, Bischoff M, Herrmann M, Tschernig T, Kappl R, Rieger H, Niemeyer BA, Bogeski I.

Sci Signal. 2016 Mar 8;9(418):ra26.

 


 

Publications 2015 :

 

Reversal of mitochondrial transhydrogenase causes oxidative stress in heart failure.

Nickel A, Hardenberg A, Hohl A, Löffler J, Kohlhaas M, Becker J, Reil J, Kazakov A, Bonnekoh J, Stadelmaier M, Puhl S, Wagner M, Bogeski I, Cortassa S, Kappl R, Pasieka B, Lafontaine M, Lancaster R, Blacker T, Hall A, Duchen M, Kästner L, Lipp P, Zeller T, Müller C, Knopp A, Laufs U, Böhm U, Hoth M, Maack C.

Cell Metabolism. 2015 Sep 1; 22(3):472-84.

 

Recognition of Bacterial Signal Peptides by Mammalian Formyl Peptide Receptors: A New Mechanism for Sensing Pathogens.
Bufe B, Schumann T, Kappl R, Bogeski I, Kummerow C, Podgorska M, Smola S, Hoth M, Zufall F.
Journal of Biological Chemistry. 2015; 20;290(12):7369-87.

 

A natural heme-signature variant of CYP267A1 from Sorangium cellulosum So ce56 executes diverse ω-hydroxylation.

Khatri Y, Hannemann F, Girhard M, Kappl R, Hutter M, Urlacher VB, Bernhardt R.

FEBS J. 2015 Oct 10. doi: 10.1111/febs.13104.

 


 

Publications 2014 :

 

Inverse regulation of melanoma growth and migration by Orai1/STIM2-dependent calcium entry.

Stanisz H, Saul S, Müller CS, Kappl R, Niemeyer BA, Vogt T, Hoth M, Roesch A, Bogeski I.

Pigment Cell Melanoma Res. 2014 May;27(3):442-53. doi: 10.1111/pcmr.12222. Epub 2014 Mar 7.

 

Substrate-assisted O2 activation in a cofactor-independent dioxygenase.

Thierbach S, Bui N, Zapp J, Chhabra SR, Kappl R, Fetzner S.

Chem Biol. 2014 Feb 20;21(2):217-25. doi: 10.1016/j.chembiol.2013.11.013. Epub 2014 Jan 2.

 


 

Publications 2013 :

 

Square-Wave Voltammetry: A Review on the Recent Progress.

Mirceski V, Gulaboski R, Lovric M, Bogeski I, Kappl R, Hoth M.

Electroanalysis. 2013 Nov;25(11):2411-2422.

 

Heme impairs the ball-and-chain inactivation of potassium channels.

Sahoo N, Goradia N, Ohlenschläger O, Schönherr R, Friedrich M, Plass W, Kappl R, Hoshi T, Heinemann SH.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):E4036-44. doi: 10.1073/pnas.1313247110. Epub 2013 Sep 30.

 

Hydroxylated derivatives of dimethoxy-1,4-benzoquinone as redox switchable earth-alkaline metal ligands and radical scavengers.

Gulaboski R, Bogeski I, Mirčeski V, Saul S, Pasieka B, Haeri HH, Stefova M, Stanoeva JP, Mitrev S, Hoth M, Kappl R.

Sci Rep. 2013;3:1865. doi: 10.1038/srep01865.

 

Novel family members of CYP109 from Sorangium cellulosum So ce56 exhibit characteristic biochemical and biophysical properties.

Khatri Y, Hannemann F, Girhard M, Kappl R, Même A, Ringle M, Janocha S, Leize-Wagner E, Urlacher VB, Bernhardt R.

Biotechnol Appl Biochem. 2013 Jan-Feb;60(1):18-29. doi: 10.1002/bab.1087.

 


 

Publications 2012 :

 

Heart-rate reduction by If-channel inhibition with ivabradine restores collateral artery growth in hypercholesterolemic atherosclerosis.

Schirmer SH, Degen A, Baumhakel M, Custodis F, Schuh L, Kohlhaas M, Friedrich E, Bahlmann F, Kappl R, Maack C, Bohm M, Laufs U.

Eur Heart J. 2012 May;33(10):1223-31.

 


 

Publications 2011 :

 

Determination of copper(II) ion concentration by lifetime measurements of green fluorescent protein.

Hotzer B, Ivanov R, Altmeier S, Kappl R, Jung G.

J Fluoresc. 2011 Nov;21(6):2143-53.

 

Redox regulation of calcium ion channels: chemical and physiological aspects.

Bogeski I, Kappl R, Kummerow C, Gulaboski R, Hoth M, Niemeyer BA.

Cell Calcium. 2011 Nov;50(5):407-23. doi: 10.1016/j.ceca.2011.07.006. Epub 2011 Sep 17. Review.

 

ISC-like [2Fe-2S] ferredoxin (FdxB) dimer from Pseudomonas putida JCM 20004: structural and electron-nuclear double resonance characterization.

Iwasaki T, Kappl R, Bracic G, Shimizu N, Ohmori D, Kumasaka T.

J Biol Inorg Chem. 2011 Aug;16(6):923-35. doi: 10.1007/s00775-011-0793-8. Epub 2011 Jun 7.

 

Calcium binding and transport by coenzyme Q.

Bogeski I, Gulaboski R, Kappl R, Mirceski V, Stefova M, Petreska J, Hoth M.

J Am Chem Soc. 2011 Jun 22;133(24):9293-303. doi: 10.1021/ja110190t. Epub 2011 May 24.

 

Structural and thermodynamic characterization of the adrenodoxin-like domain of the electron-transfer protein Etp1 from Schizosaccharomyces pombe.

Müller JJ, Hannemann F, Schiffler B, Ewen KM, Kappl R, Heinemann U, Bernhardt R.

J Inorg Biochem. 2011 Jul;105(7):957-65. doi: 10.1016/j.jinorgbio.2011.04.001. Epub 2011 Apr 9.

 


 

Publications 2010 :

 

Paramagnetic centres in oxidised coal.

Najder-Kozdrowska L, Samoilova RI, Kappl R, Huttermann J, Wieckowski AB.

Acta Physica Polonica A. 2010;118:475-479.

 


 

Publications 2009 :

 

Probing structural and electronic parameters in randomly oriented metalloproteins by orientation-selective ENDOR spectroscopy.

Kappl R, Bracic G, Hüttermann J.

High Resolution EPR, Biological Magnetic Resonance. 2009;28:63-104. doi:10.1007/978-0-387-84856-3_3

 

Genome mining in Sorangium cellulosum So ce56: identification and characterization of the homologous electron transfer proteins of a myxobacterial cytochrome P450.

Ewen KM, Hannemann F, Khatri Y, Perlova O, Kappl R, Krug D, Hüttermann J, Müller R, Bernhardt R.

J Biol Chem. 2009 Oct 16;284(42):28590-8. doi: 10.1074/jbc.M109.021717. Epub 2009 Aug 20.

 

The reduced [2Fe-2S] clusters in adrenodoxin and Arthrospira platensis ferredoxin share spin density with protein nitrogens, probed using 2D ESEEM.

Dikanov SA, Samoilova RI, Kappl R, Crofts AR, Hüttermann J.

Phys Chem Chem Phys. 2009 Aug 21;11(31):6807-19. doi: 10.1039/b904597j. Epub 2009 Jul 1.

 


 

Publications 2008 :

Merkens H, Kappl R, Jakob RP, Schmid FX, Fetzner S
Quercetinase QueD of Streptomyces sp FLA, a Monocupin Dioxygenase with a Preference for Nickel and Cobalt.
Biochemistry. 2008 Nov 12;47(46):12185-12196.

 


 

Publications 2007 :

Kappl R, Eltis LD, Caspersen MB, Christensen HEM, Hüttermann J.
Site-specific oxidation of the [Fe4S4] cubanes in high-potential iron sulfur proteins as probed by EPR and orientation-selective proton ENDOR spectroscopy: Ectothiorhodospira halophila I versus Rhodocyclus tenuis.
Applied Magnetic Resonance. 2007;31(3-4):483-507.

Collnot EM, Baldes C, Wempe MF, Kappl R, Hüttermann J, Hyatt JA, Edgar KJ, Schäfer UF, Lehr CM.
Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS: Influence on ATPase activity and membrane fluidity.
Molecular Pharmaceutics. 2007 May-Jun;4(3):465-474.

 


 

Publications 2006 :

Kappl R, Ebelshäuser M, Hannemann F, Berhardt R, Hüttermann J
Probing electronic and structural properties of the reduced [2Fe-2S] cluster by orientation-selective H-1 ENDOR spectroscopy: Adrenodoxin versus Rieske iron-sulfur protein.
Applied Magnetic Resonance. 2006;30(3-4):427-459.

Kappl R, Sielker S, Ranguelova K, Wegner J, .Parschat K, Hüttermann J, Fetzner S
Spectroscopic and biochemical studies on protein variants of quinaldine 4-oxidase: Role of E736 in catalysis and effects of serine ligands on the FeSI and FeSII clusters.
Biochemistry. 2006 Dec 12;45(49):14853-14868.

 


 

Publications 2005 :

Kappl R, Ranguelova K, Koch B, Duboc C, Hüttermann J.
Multi-frequency high-field EPR studies on metal-substituted xylose isomerase.
Magnetic Resonance in Chemistry. 2005 Nov;43(Sp. Iss. SI):S65-S73.

 


 

Publications 2004 :

Frerichs-Deeken U, Ranguelova K, Kappl R, Hüttermann J, Fetzner S.
Dioxygenases without requirement for cofactors and their chemical model reaction:Compulsory order ternary complex mechanism of 1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase involving general base catalysis by histidine 251 and single-electron oxidation of the substrate dianion.
Biochemistry. 2004 Nov 16;43(45):14485-14499.

 


 

Publications 2003 :

Parschat K, Hauer B, Kappl R, Kraft R, Hüttermann J, Fetzner S.
Gene cluster of Arthrobacter ilicis Ru61a involved in the degradation of quinaldine to anthranilate.
Journal of Biological Chemistry. 2003 Jul 25;278(30):27483-27494.

Frerichs-Deeken U, Goldenstedt B, Gahl-Jannsen R, Kappl R, Hüttermann J, Fetzner S.
Functional expression of the quinoline 2-oxidoreductase genes (qorMSL) in Pseudomonas putida KT2440 pUF1 and in P-putida 86-1 Delta qor pUF1 and analysis of the Qor proteins.
European Journal of Biochemistry. 2003 Apr;270(7):1567-1577.

 


 

Publications 2002 :

Kappl R, Hüttermann J, Fetzner S.
The molybdenum-containing hydroxylases of quinoline, isoquinoline and qualdine.
Met Ions Biol Syst. 2002;39:481-537.

 

Kunz T, Stephan A, Methner FJ, Kappl R, Hüttermann J.
Fundamentals on electron spin resonance spectroscopy (ESR) and research about the correlation between oxidative beer stability and sulphite content.
Monatsschrift für Brauwissenschaft. 2002 Aug;55(7-8):140-153.

 

Müller A, Tscherny I, Kappl R, Hatchikian EC, Hüttermann J, Cammack R.
Hydrogenases in the "active" state: determination of g-matrix axes and electron spin distribution at the active site by H-1 ENDOR pectroscopy.
Journal of Biological Inorganic Chemistry. 2002 Jan;7(1-2):177-194.

 

Mai C, Schormann W, Hüttermann A, Kappl R, Hüttermann J.
The influence of laccase on the chemo-enzymatic synthesis of lignin graft-copolymers.
Enzyme and Microbial Technology. 2002 Jan 8;30(1):66-72.

 


 

Publications 2001 :

Schmidt PP, Kappl R, Hüttermann J.
On the mode of hexacoordinated NO-Binding to myo- and hemoglobin: Variable-temperature EPR studies at multiple microwave frequencies.
Applied Magnetic Resonance. 2001;21(3-4):423-440.

 

Hüttermann J, Kappl R.
Characterization of structural, dynamic and electronic properties of metal centers in proteins by high-resolution EPR techniques: iron sulfur proteins.
Journal of Inorganic Biochemistry. 2001 Aug;86(1):273-273.

 

Parschat K, Canne C, Kappl R, Hüttermann J, Fetzner S.
Xanthine dehydrogenase from Pseudomonas putida 86: specificity, oxidation-reduction potentials of its redoxe-active centers, and first EPR characterization.
Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 2001 Jan 12;1544(1-2):151-165.

 


 

Publications 2000 :

Bogumil, Kappl R, Hüttermann J.
Role of the binuclear manganese(II) site in xylose isomerase.
Metal Ions in Biological Systems. 2000;37:365-405.

Canne C, Ebelshäuser M, Gay E, Shergill JK, Cammack R, Kappl R, Hüttermann J.
Probing magnetic properties of the reduced [Fe2-S2] cluster of the ferrodoxin from Arthrospira platensis by H-1 ENDOR spectroscopy.
Journal of Biological Inorganic Chemistry. 2000 Aug;5(4):514-526.

 


 

Publications 1999 :

Canne C, Lowe DJ, Fetner S, Adams B, Smith AT, Kappl R, Bray RC, Hüttermann J.
Kinetics and interactions of molybdenum and iron-sulfur centers in bacterial enzymes of the xanthine oxidase family: Mechanistic implications.
Biochemistry. 1999 Oct 19;38(42):14077-14087.

 

Hund HK, Breuer J, Lingens F, Hüttermann J, Kappl R, Fetzner S.
Flavonol 2,4-dioxygenase from Aspergillus niger DSM 821, a type 2 Cu-II-containing glycoprotein.
European Jornal of Biochemistry. 1999 Aug;263(3):871-878.

 

Gay E, Kappl R, Canne C, Hüttermann J, Chatelet C, Meyer J, Shergill J, Cammack R.
Proton ENDOR studies of the majoe classes of [Fe2S2] proteins.
Journal of Inorganic Biochemistry. 1999 Apr;74(1-4):137-137.

 

Müller A, Hatchikian EC, Hüttermann J, Kappl R, Cammack R
Hydrogen interaction with the active site of a [NiFe] hydrogenase studied by ENDOR techniques.
Journal of Inorganic Biochemistry. 1999 Apr 30;74(1-4):240.

 

Durmus A, Eicken C, Sift BH, Kratel A, Kappl R, Hüttermann J, Krebs B.
The active site of purple acid phosphatase of sweet potatoes (lpomoea batatas) - Metal content ans spectroscopic characterization.
European Jornal of Biochemistry. 1999 Mar;260(3):709-716.

 

Kappl R, Ciurli S, Luchinat C, Hüttermann J.
Probing structural and electronic properties of the oxidized [Fe4S4](3+) cluster of Ectothiorhodospira halophila iso-II high-potential iron-sulfur protein by ENDOR spectroscopy.
Journal Of The American Chemical Society. 1999 Mar 10;121(9):1925-1935.

 


 

Publications 1998 :

Griepenburg U, Blasczyk K, Kappl R, Hüttermann J, Auling G.
A divalent metal site in the small subunit of the manganese-dependent ribonucleotide reductase of Corynebacterium ammoniagenes.
Biochemistry. 1998 Jun 2;37(22):7992-7996.

 

Fetzner S, Tshisuaka B, Lingens F, Kappl R, Hüttermann J.
Bacterial degradation of quinoline and derivatives - Pathways and their biocatalysts.
Angewandte Chemie - International Edition. 1998 Mar 16;37(5):576-597.

 

Neese F, Kappl R, Hüttermann J, Zumft WG, Kroneck PMH.
Probing the ground state of the purple mixed valance Cu-A center in nitrous oxide reductase: a CW ENDOR (X-band) study of the Cu-65, N-15-histidine labeled enzyme and interpretation of hyperfine couplings by molecular orbital calculations.
Journal of Biological Inorganic Chemistry. 1998 Feb;3(1):53-67.

 

Kulzer R, Pils T, Kappl R, Hüttermann J, Knappe J.
Reconstitution and characterization of the polynuclear iron-sulfur cluster in pyruvate formate-lyase-activating enzyme - Molecular properties of the holoenzyme form.
Journal of Biological Chemistry. 1998 Feb 27;273(9):4897-4903.

 


 

Publications 1997 :

Canne C, Stephan I, Finsterbusch J, Lingens F, Kappl R, Fetzner S, Hüttermann J.
Comparative EPR and redox studies of three prokaryotic enzymes of the xanthine oxidase family: Quinoline 2-oxireductase, quinaldine 4-oxidase, and isoquinoline 1-oxidoreductase.
Biochemistry. 1997 Aug 12;36(32):9780-9790.

Bogumil R, Kappl R, Hüttermann J, Witzel H.
Electron paramagnetic resonance of D-xylose isomerase : Evidence for metal ion movement induced by binding of cyclic substrates and inhibitors.
Biochemistry. 1997 Mar 4;36(9):2345-2352.

 


 

Publications 1996 :

Iakovleva O, Parak F, Rimke T, Meier B, Hüttermann J, Kapp R.
The active center of superoxide dismutase from propionibacterium shermanii.
Nuovo Cimento della Societa Italiana di Fiscia d-condensated matter atomic molecular and chemical physics fluids plasmas biophysics. 1996 Feb-Mar;18(2-3):199-212.

 


 

Publications 1995 :

Iakovleva O, Parak F, Rimke T, Meier B, Hüttermann J, Kappl R.
An interpretation of EPR-spectra of azide ligated superoxide-dismutase from propionibacterium - shermanii.
European Biophysics Journal. 1995 Oct;24(2):65-68.

 


 

Publications 1994 :

Hüttermann J, Burgard C, Kappl R.
Proton-ENDOR from randomly orientated NO-ligated hemoglobin - approaching the structural basis for the R-T transition.
Journal of the Chemical Society - Faraday Transactions. 1994 Oct 21;90(20):3077-3087.

Reinhard H, Kappl R, Hüttermann J, Viezzoli MS.
ENDOR of superoxide-dismutase-structure determination of the copper site from randomly orientated specimen.
Journal Of Physical Chemistry. 1994 Sep 1;98(35):8806-8812.

 


 

Publications 1993 :

Büchler JW, Eberle M, Hammerschmitt P, Hüttermann J, Kappl R.
Metal complexes with tetrapyrrol ligands. 65. Generation and ESR-spectra of the cation radicals of bis(octaethylporphyrinato)zirconium(IV) and bis (chelate)(octaethylporphyrinato)zirconium(IV) complexes.
Chemische Berichte. 1993 Dec;126(12):2619-2623.

 

Tshisuaka B, Kappl R, Hüttermann J, Lingens F.
Quinoline oxidoreductase from pseudomonas-putida-86 - an improved purification procedure and electron-paramegnetic-spectroscopy.
Biochemistry. 1993 Nov 30;32(47):12928-12934.

Bogumil R, Kappl R, Hüttermann J, Sudfeldt C, Witzel H.
X-Band and Q-Band EPR studies on the 2 Mn-2+-substituted metal-binding sites of D-xylose isomerase.
European Journal of Biochemistry. 1993 May 1;213(3):1185-1192.

 


 

Publications 1991 :

Davydov R, Kappl R, Hüttermann J, Peterson JA.
EPR-spectroscopy of reduced oxyferrous-P450cam.
FEBS Letters. 1991 Dec 16;295(1-3):113-115.

 

Korner M, Suerbaum H, Witzel H, Kappl R, Hüttermann J.
The binding of tetrahedral oxoanions to the activ-center of the violet phosphatase from red kidney beans as investigated by uv vis-spectroscopy and esr-spectroscopy.
Biological Chemistry Hoppe-Seyler. 1991 Sep;372(9):694.

Bogumil R, Hüttermann J, Kappl R, Stabler R, Sudfeldt C, Witzel H.
Visible EPR and Electron Nuclear Double-Resonance spectroscopic studies on the 2metal-binding sites of oxovanadium (IV)-substituted D-Xylose isomerase.
European Journal of Biochemistry. 1991 Mar 4;196(2):305-312.

 


 

Publications 1989 :

Kappl R, Hüttermann J.
An ENDOR study of nitrosyl myoglobin single-crystals.
Israel Journal Of Chemistry. 1989;29(1):73-84.

 


 

Publications 1988 :

Hüttermann J, Kappl R, Banci L; Bertini I.
An ENDOR study of human and bovine erythrocyte superoxide dismutase: 1H and 14N interactions.
Biochimica et Biophysica Acta. 1988 Sep 21;956(2):173-188.

 


 

Publications 1987 :

Banci L, Bertini I, Hüttermann J, Kappl R.
H-1 and N-14 ENDOR of erythrocyte superoxide-dismutase derivatives.
Recueil des Travaux Chimiques des Pays-Bas-Journal of the Royal Netherlands Chemical Society. 1987, Jun-Jul;106(6-7):361.

Hüttermann J, Kappl R.
ENDOR - Probing the coordination environment in metalloproteins.
Metal Ions in Biological Systems. 1987;22:1-80.

 


 

Publications 1985 :

Kappl R, Hohnberlage M, Hüttermann J, Bartlett N, Symons MCR.
Electron-Spin and Electron Nuclear Double-Resonance of the [FeO2]-center from irradiated oxyhemoglobin and oxymyoglobin.
Biochimica et Biophysica Acta. 1985;827(3):327-343.