Saarland University Faculty of Medicine
Abteilung Engel


Wadle, S. L. , Schmitt, T.T.X., Engel, J., Kurt, S., Hirtz, J.J.
"Altered population activity and local tuning heterogeneity in auditory cortex of Cacna2d3-deficient mice"
Biol Chem, , , (2022). DOI:10.1515/hsz-2022-0269., Pubmed-ID: 36342370

Bracic, G., Hegmann, K., Engel, J., Kurt, S.
"Impaired Subcortical Processing of Amplitude-Modulated Tones in Mice Deficient for Cacna2d3, a Risk Gene for Autism Spectrum Disorders in Humans"
eNeuro9, ENEURO.0118-22.2022, (2022). DOI:10.1523/ENEURO.0118-22.2022., Pubmed-ID: 35410870

Marchetta, P., Möhrle, D., Eckert, P., Reimann, K., Wolter, S., Tolone, A., Lang, I., Wolters, M., Feil, R., Engel, J., Paquet-Durand, F., Kuhn, M., Knipper, M., Rüttiger, L.
"Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss"
Front Aging Neurosci12, 83-XX, (2020). DOI:10.3389/fnagi.2020.00083., Pubmed-ID: 32327991

Schade-Mann, T., Münkner, S., Eckrich, T., Engel, J.
"Calcium signaling in interdental cells during the critical developmental period of the mouse cochlea"
Hear Res389, 107913-XXXXXX, (2020). DOI:10.1016/j.heares.2020.107913., Pubmed-ID: 32120242

Ortner, N. J. , Pinggera, A., Hofer, N.T., Siller, A., Brandt, N., Raffeiner, A., Vilusic, K., Lang, I., Blum, K., Obermair, G.J., Stefan, E., Engel, J., Striessnig, J.
"RBP2 stabilizes slow Cav1.3 Ca2+ channel inactivation properties of cochlear inner hair cells"
Pflugers Arch472, 3-25, (2020). DOI:10.1007/s00424-019-02338-4., Pubmed-ID: 31848688

Beggs, M. R. , Lee, J.J., Busch, K., Raza, A., Dimke, H., Weissgerber, P., Engel, J., Flockerzi, V., Alexander, R.T.
"TRPV6 and Cav1.3 Mediate Distal Small Intestine Calcium Absorption Before Weaning"
Cell Mol Gastroenterol Hepatol8, 625-642, (2019). DOI:10.1016/j.jcmgh.2019.07.005., Pubmed-ID: 31398491

Lang, I., Jung, M., Niemeyer, B.A., Ruth, P., Engel, J.
"Expression of the LRRC52 γ subunit (γ2) may provide Ca2+-independent activation of BK currents in mouse inner hair cells"
FASEB J33, 11721-11734, (2019). DOI:10.1096/fj.201900701RR., Pubmed-ID: 31348683

Stephani, F., Scheuer, V., Eckrich, T., Blum, K., Wang, W., Obermair, G.J., Engel, J.
"Deletion of the Ca2+ Channel Subunit α2δ3 Differentially Affects Cav2.1 and Cav2.2 Currents in Cultured Spiral Ganglion Neurons Before and After the Onset of Hearing"
Front Cell Neurosci13, 278-XXX, (2019). DOI:10.3389/fncel.2019.00278., Pubmed-ID: 31293392

Eckrich, S., Hecker, D., Sorg, K., Blum, K., Fischer, K., Münkner, S., Wenzel, G., Schick, B., Engel, J.
"Cochlea-Specific Deletion of Cav1.3 Calcium Channels Arrests Inner Hair Cell Differentiation and Unravels Pitfalls of Conditional Mouse Models"
Front Cell Neurosci13, 225-XXX, (2019). DOI:10.3389/fncel.2019.00225., Pubmed-ID: 31178698

Ceriani, F., Hendry, A., Jeng, J., Johnson, S.L., Stephani, F., Olt, J., Holley, M.C., Mammano, F., Engel, J., Kros, C.J., Simmons, D.D., Marcotti, W.
"Coordinated calcium signalling in cochlear sensory and non-sensory cells refines afferent innervation of outer hair cells"
EMBO J38, e99839, (2019). DOI:10.15252/embj.201899839., Pubmed-ID: 30804003

Sonntag, M., Blosa, M., Schmidt, S., Reimann, K., Blum, K., Eckrich, T., Seeger, G., Hecker, D., Schick, B., Arendt, T., Engel, J., Morawski, M.
"Synaptic coupling of inner ear sensory cells is controlled by brevican-based extracellular matrix baskets resembling perineuronal nets"
BMC Biol16, 99-XX, (2018). DOI:10.1186/s12915-018-0566-8., Pubmed-ID: 30253762

Eckrich, T., Blum, K., Milenkovic, I., Engel, J.
"Fast Ca2+ Transients of Inner Hair Cells Arise Coupled and Uncoupled to Ca2+ Waves of Inner Supporting Cells in the Developing Mouse Cochlea"
Front Mol Neurosci11, 264-XXX, (2018). DOI:10.3389/fnmol.2018.00264., Pubmed-ID: 30104958

Fell, B., Eckrich, S., Blum, K., Eckrich, T., Hecker, D., Obermair, G.J., Münkner, S., Flockerzi, V., Schick, B., Engel, J.
"α2δ2 Controls the Function and Trans-Synaptic Coupling of Cav1.3 Channels in Mouse Inner Hair Cells and Is Essential for Normal Hearing"
J Neurosci36, 11024-11036, (2016). DOI:10.1523/JNEUROSCI.3468-14.2016., Pubmed-ID: 27798183

Scharinger, A., Eckrich, S., Vandael, D.H., Schönig, K., Koschak, A., Hecker, D., Kaur, G., Lee, A., Sah, A., Bartsch, D., Benedetti, B., Lieb, A., Schick, B., Singewald, N., Sinnegger-Brauns, M.J., Carbone, E., Engel, J., Striessnig, J.
"Cell-type-specific tuning of Cav1.3 Ca(2+)-channels by a C-terminal automodulatory domain"
Front Cell Neurosci9, 309-XXX, (2015). DOI:10.3389/fncel.2015.00309., Pubmed-ID: 26379493

Pirone, A., Kurt, S., Zuccotti, A., Rüttiger, L., Pilz, P., Brown, D.H., Franz, C., Schweizer, M., Rust, M.B., Rübsamen, R., Friauf, E., Knipper, M., Engel, J.
"α2δ3 is essential for normal structure and function of auditory nerve synapses and is a novel candidate for auditory processing disorders"
J Neurosci34, 434-445, (2014). DOI:10.1523/JNEUROSCI.3085-13.2014., Pubmed-ID: 24403143

Nothwang, H., Engel, J., Knipper, M., Friauf, E.
"L-type calcium channels in the auditory system"
e-Neuroforum, 5, 60-66 (2014). DOI: doi:10.1007/s13295-014-0059-3

Dettling, J., Franz, C., Zimmermann, U., Lee, S.C., Bress, A., Brandt, N., Feil, R., Pfister, M., Engel, J., Flamant, F., Rüttiger, L., Knipper, M.
"Autonomous functions of murine thyroid hormone receptor TRα and TRβ in cochlear hair cells"
Mol Cell Endocrinol382, 26-37, (2014). DOI:10.1016/j.mce.2013.08.025., Pubmed-ID: 24012852

Duncker, S. V. , Franz, C., Kuhn, S., Schulte, U., Campanelli, D., Brandt, N., Hirt, B., Fakler, B., Blin, N., Ruth, P., Engel, J., Marcotti, W., Zimmermann, U., Knipper, M.
"Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells"
J Neurosci33, 9508-9519, (2013). DOI:10.1523/JNEUROSCI.5689-12.2013., Pubmed-ID: 23719817

Kurt, S., Sausbier, M., Rüttiger, L., Brandt, N., Moeller, C.K., Kindler, J., Sausbier, U., Zimmermann, U., van Straaten, H., Neuhuber, W., Engel, J., Knipper, M., Ruth, P., Schulze, H.
"Critical role for cochlear hair cell BK channels for coding the temporal structure and dynamic range of auditory information for central auditory processing"
FASEB J26, 3834-3843, (2012). DOI:10.1096/fj.11-200535., Pubmed-ID: 22691916

Jaumann, M., Dettling, J., Gubelt, M., Zimmermann, U., Gerling, A., Paquet-Durand, F., Feil, S., Wolpert, S., Franz, C., Varakina, K., Xiong, H., Brandt, N., Kuhn, S., Geisler, H., Rohbock, K., Ruth, P., Schlossmann, J., Hütter, J., Sandner, P., Feil, R., Engel, J., Knipper, M., Rüttiger, L.
"cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function"
Nat Med18, 252-259, (2012). DOI:10.1038/nm.2634., Pubmed-ID: 22270721

Buerbank, S., Becker, K., Becker, C., Brandt, N., Engel, J., Knipper, M., Schick, B., Dlugaiczyk, J.
"Developmental regulation of glycine receptors at efferent synapses of the murine cochlea"
Histochem Cell Biol136, 387-398, (2011). DOI:10.1007/s00418-011-0855-6., Pubmed-ID: 21850450

El Ouardi, A., Streckert, J., Bitz, A., Münkner, S., Engel, J., Hansen, V.
"New fin-line devices for radiofrequency exposure of small biological samples in vitro allowing whole-cell patch clamp recordings"
Bioelectromagnetics32, 102-112, (2011). DOI:10.1002/bem.20621., Pubmed-ID: 21225887

Baig, S. M. , Koschak, A., Lieb, A., Gebhart, M., Dafinger, C., Nürnberg, G., Ali, A., Ahmad, I., Sinnegger-Brauns, M.J., Brandt, N., Engel, J., Mangoni, M.E., Farooq, M., Khan, H.U., Nürnberg, P., Striessnig, J., Bolz, H.J.
"Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness"
Nat Neurosci14, 77-84, (2011). DOI:10.1038/nn.2694., Pubmed-ID: 21131953

Gebhart, M., Juhasz-Vedres, G., Zuccotti, A., Brandt, N., Engel, J., Trockenbacher, A., Kaur, G., Obermair, G.J., Knipper, M., Koschak, A., Striessnig, J.
"Modulation of Cav1.3 Ca2+ channel gating by Rab3 interacting molecule"
Mol Cell Neurosci44, 246-259, (2010). DOI:10.1016/j.mcn.2010.03.011., Pubmed-ID: 20363327

Johnson, S. L. , Franz, C., Kuhn, S., Furness, D.N., Rüttiger, L., Münkner, S., Rivolta, M.N., Seward, E.P., Herschman, H.R., Engel, J., Knipper, M., Marcotti, W.
"Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses"
Nat Neurosci13, 45-52, (2010). DOI:10.1038/nn.2456., Pubmed-ID: 20010821

Zampini, V., Johnson, S.L., Franz, C., Lawrence, N.D., Münkner, S., Engel, J., Knipper, M., Magistretti, J., Masetto, S., Marcotti, W.
"Elementary properties of CaV1.3 Ca(2+) channels expressed in mouse cochlear inner hair cells"
J Physiol588, 187-199, (2010). DOI:10.1113/jphysiol.2009.181917., Pubmed-ID: 19917569

Kuhn, S., Knirsch, M., Rüttiger, L., Kasperek, S., Winter, H., Freichel, M., Flockerzi, V., Knipper, M., Engel, J.
"Ba2+ currents in inner and outer hair cells of mice lacking the voltage-dependent Ca2+ channel subunits beta3 or beta4"
Channels (Austin)3, 366-376, (2009). DOI:10.4161/chan.3.5.9774., Pubmed-ID: 19755851

Heidrych, P., Zimmermann, U., Kuhn, S., Franz, C., Engel, J., Duncker, S.V., Hirt, B., Pusch, C.M., Ruth, P., Pfister, M., Marcotti, W., Blin, N., Knipper, M.
"Otoferlin interacts with myosin VI: implications for maintenance of the basolateral synaptic structure of the inner hair cell"
Hum Mol Genet18, 2779-2790, (2009). DOI:10.1093/hmg/ddp213., Pubmed-ID: 19417007

Winter, H., Rüttiger, L., Müller, M., Kuhn, S., Brandt, N., Zimmermann, U., Hirt, B., Bress, A., Sausbier, M., Conscience, A., Flamant, F., Tian, Y., Zuo, J., Pfister, M., Ruth, P., Löwenheim, H., Samarut, J., Engel, J., Knipper, M.
"Deafness in TRbeta mutants is caused by malformation of the tectorial membrane"
J Neurosci29, 2581-2587, (2009). DOI:10.1523/JNEUROSCI.3557-08.2009., Pubmed-ID: 19244534

Johnson, S. L. , Forge, A., Knipper, M., Münkner, S., Marcotti, W.
"Tonotopic variation in the calcium dependence of neurotransmitter release and vesicle pool replenishment at mammalian auditory ribbon synapses"
J Neurosci28, 7670-7678, (2008). DOI:10.1523/JNEUROSCI.0785-08.2008., Pubmed-ID: 18650343

Engel, J.
"Gerbils can tune in"
J Physiol586, 919-XXX, (2008). DOI:10.1113/jphysiol.2007.150409., Pubmed-ID: 18287384

Singh, A., Gebhart, M., Fritsch, R., Sinnegger-Brauns, M.J., Poggiani, C., Hoda, J., Engel, J., Romanin, C., Striessnig, J., Koschak, A.
"Modulation of voltage- and Ca2+-dependent gating of CaV1.3 L-type calcium channels by alternative splicing of a C-terminal regulatory domain"
J Biol Chem283, 20733-20744, (2008). DOI:10.1074/jbc.M802254200., Pubmed-ID: 18482979

Tarabova, B., Lacinova, L., Engel, J.
"Effects of phenylalkylamines and benzothiazepines on Ca(v)1.3-mediated Ca2+ currents in neonatal mouse inner hair cells"
Eur J Pharmacol573, 39-48, (2007). DOI:10.1016/j.ejphar.2007.06.050., Pubmed-ID: 17651721

Knirsch, M., Brandt, N., Braig, C., Kuhn, S., Hirt, B., Münkner, S., Knipper, M., Engel, J.
"Persistence of Ca(v)1.3 Ca2+ channels in mature outer hair cells supports outer hair cell afferent signaling"
J Neurosci27, 6442-6451, (2007). DOI:10.1523/JNEUROSCI.5364-06.2007., Pubmed-ID: 17567805

Winter, H., Braig, C., Zimmermann, U., Engel, J., Rohbock, K., Knipper, M.
"Thyroid hormone receptor alpha1 is a critical regulator for the expression of ion channels during final differentiation of outer hair cells"
Histochem Cell Biol128, 65-75, (2007). DOI:10.1007/s00418-007-0294-6., Pubmed-ID: 17520268

Brandt, N., Kuhn, S., Münkner, S., Braig, C., Winter, H., Blin, N., Vonthein, R., Knipper, M., Engel, J.
"Thyroid hormone deficiency affects postnatal spiking activity and expression of Ca2+ and K+ channels in rodent inner hair cells"
J Neurosci27, 3174-3186, (2007). DOI:10.1523/JNEUROSCI.3965-06.2007., Pubmed-ID: 17376979

Schug, N., Braig, C., Zimmermann, U., Engel, J., Winter, H., Ruth, P., Blin, N., Pfister, M., Kalbacher, H., Knipper, M.
"Differential expression of otoferlin in brain, vestibular system, immature and mature cochlea of the rat"
Eur J Neurosci24, 3372-3380, (2006). DOI:10.1111/j.1460-9568.2006.05225.x., Pubmed-ID: 17229086

Engel, J., Braig, C., Rüttiger, L., Kuhn, S., Zimmermann, U., Blin, N., Sausbier, M., Kalbacher, H., Münkner, S., Rohbock, K., Ruth, P., Winter, H., Knipper, M.
"Two classes of outer hair cells along the tonotopic axis of the cochlea"
Neuroscience143, 837-849, (2006). DOI:10.1016/j.neuroscience.2006.08.060., Pubmed-ID: 17074442

Strutz-Seebohm, N., Seebohm, G., Fedorenko, O., Baltaev, R., Engel, J., Knirsch, M., Lang, F.
"Functional coassembly of KCNQ4 with KCNE-beta- subunits in Xenopus oocytes"
Cell Physiol Biochem18, 57-66, (2006). DOI:10.1159/000095158., Pubmed-ID: 16914890

Winter, H., Braig, C., Zimmermann, U., Geisler, H., Fränzer, J., Weber, T., Ley, M., Engel, J., Knirsch, M., Bauer, K., Christ, S., Walsh, E.J., McGee, J., Köpschall, I., Rohbock, K., Knipper, M.
"Thyroid hormone receptors TRalpha1 and TRbeta differentially regulate gene expression of Kcnq4 and prestin during final differentiation of outer hair cells"
J Cell Sci119, 2975-2984, (2006). DOI:10.1242/jcs.03013., Pubmed-ID: 16803873

Rüttiger, L., Sausbier, M., Zimmermann, U., Winter, H., Braig, C., Engel, J., Knirsch, M., Arntz, C., Langer, P., Hirt, B., Müller, M., Köpschall, I., Pfister, M., Münkner, S., Rohbock, K., Pfaff, I., Rüsch, A., Ruth, P., Knipper, M.
"Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BKbeta1-subunit leads to progressive hearing loss"
Proc Natl Acad Sci U S A101, 12922-12927, (2004). DOI:10.1073/pnas.0402660101., Pubmed-ID: 15328414

Michna, M., Knirsch, M., Hoda, J., Muenkner, S., Langer, P., Platzer, J., Striessnig, J., Engel, J.
"Cav1.3 (alpha1D) Ca2+ currents in neonatal outer hair cells of mice"
J Physiol553, 747-758, (2003). DOI:10.1113/jphysiol.2003.053256., Pubmed-ID: 14514878

Waka, N., Knipper, M., Engel, J.
"Localization of the calcium channel subunits Cav1.2 (alpha1C) and Cav2.3 (alpha1E) in the mouse organ of Corti"
Histol Histopathol18, 1115-1123, (2003). DOI:10.14670/HH-18.1115., Pubmed-ID: 12973680

Engel, J., Michna, M., Platzer, J., Striessnig, J.
"Calcium channels in mouse hair cells: function, properties and pharmacology"
Adv Otorhinolaryngol59, 35-41, (2002). DOI:10.1159/000059243., Pubmed-ID: 11885659

Koschak, A., Reimer, D., Huber, I., Grabner, M., Glossmann, H., Engel, J., Striessnig, J.
"alpha 1D (Cav1.3) subunits can form l-type Ca2+ channels activating at negative voltages"
J Biol Chem276, 22100-22106, (2001). DOI:10.1074/jbc.M101469200., Pubmed-ID: 11285265

Platzer, J., Engel, J., Schrott-Fischer, A., Stephan, K., Bova, S., Chen, H., Zheng, H., Striessnig, J.
"Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca2+ channels"
Cell102, 89-97, (2000). DOI:10.1016/s0092-8674(00)00013-1., Pubmed-ID: 10929716

Engel, J., Schultens, H.A., Schild, D.
"Small conductance potassium channels cause an activity-dependent spike frequency adaptation and make the transfer function of neurons logarithmic"
Biophys J76, 1310-1319, (1999). DOI:10.1016/S0006-3495(99)77293-0., Pubmed-ID: 10049314

Althaus, H. H. , Hempel, R., Klöppner, S., Engel, J., Schmidt-Schultz, T., Kruska, L., Heumann, R.
"Nerve growth factor signal transduction in mature pig oligodendrocytes"
J Neurosci Res50, 729-742, (1997). DOI:10.1002/(SICI)1097-4547(19971201)50:5<729::AID-JNR10>3.0.CO;2-X., Pubmed-ID: 9418961

Engel, J., Rabba, J., Schild, D.
"A transient, RCK4-like K+ current in cultured Xenopus olfactory bulb neurons"
Pflugers Arch432, 845-852, (1996). DOI:10.1007/s004240050207., Pubmed-ID: 8772135

Jung, A., Lischka, F.W., Engel, J., Schild, D.
"Sodium/calcium exchanger in olfactory receptor neurones of Xenopus laevis"
Neuroreport5, 1741-1744, (1994). DOI:10.1097/00001756-199409080-00013., Pubmed-ID: 7827321

Engel, J., Althaus, H.H., Kristjansson, G.I.
"NGF increases [Ca2+]i in regenerating mature oligodendroglial cells"
Neuroreport5, 397-400, (1994). DOI:10.1097/00001756-199401120-00006., Pubmed-ID: 8003662

Engel, J., Donath, E.
"Osmotic lysis of chromaffin granules treated with the ionophores nigericin and A23187 in isotonic sucrose solution at low pH"
Biochim Biophys Acta1064, 155-161, (1991). DOI:10.1016/0005-2736(91)90422-5., Pubmed-ID: 2025634

Engel, J., Pastushenko, V.F., Richter, W., Donath, E.
"On the interaction between chromaffin granule membranes and intragranular vesicles--theory and analysis of freeze-fracture micrographs"
Biorheology28, 75-87, (1991). DOI:10.3233/bir-1991-281-208., Pubmed-ID: 2049534

Engel, J., Ermakov, Y.A., Richter, W., Donath, E.
"Two different types of lysis of chromaffin granules characterised by freeze-fracture electron microscopy and photon correlation spectroscopy"
Biochim Biophys Acta1028, 236-244, (1990). DOI:10.1016/0005-2736(90)90172-k., Pubmed-ID: 2223797

PubMed Engel, J., Donath, E., Ermakov, Y.A., Meyer, H.W., Richter, W.
"Hyperosmotic relaxation lysis of chromaffin granules is caused by interactions between the granular membrane and intragranular vesicles"
Biochim Biophys Acta985, 111-119, (1989). DOI:10.1016/0005-2736(89)90354-4.