Medizinische Fakultät der Universität des Saarlandes
Biophysik
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Dr. E. Schwarz

 

Publications 2018 :

 

Quantity, quality, and functionality of peripheral blood cells derived from residual blood of different apheresis kits.

Knörck A, Marx S, Friedmann KS, Zöphel S, Lieblang L, Hässig C, Müller I, Pilch J, Sester U, Hoth M, Eichler H, Sester M, Schwarz EC.

Transfusion. 2018 Jun;58(6):1516-1526. doi: 10.1111/trf.14616. Epub 2018 May 6.

 

A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity.

Zhou X, Friedmann KS, Lyrmann H, Zhou Y, Schoppmeyer R, Knörck A, Mang S, Hoxha C, Angenendt A, Backes CS, Mangerich C, Zhao R, Cappello S, Schwär G, Hässig C, Neef M, Bufe B, Zufall F, Kruse K, Niemeyer BA, Lis A, Qu B, Kummerow C, Schwarz EC, Hoth M.

J Physiol. 2018 Jan 25. doi: 10.1113/JP274964. [Epub ahead of print]

 


 

Publications 2017 :

 

Human profilin 1 is a negativ regulator of CTL mediated cell-killing and migration.

Schoppmeyer R, Zhao R, Cheng H, Hamed M, Liu C, Zhou X, Schwarz EC, Zhou Y, Knörck A, Schwär G, Ji S, Liu L, Long J, Helms V, Hoth M, Yu X, Qu B.

Eur J Immunol. 2017;47:1562-1572. Epub ahead of print.

 

Bystander cells enhance NK cytotoxic efficiency by reducing search time.

Zhou X, Zhao R, Schwarz K, Mangeat M, Schwarz EC, Hamed M, Bogeski I, Helms V, Rieger H, Qu B.

Scientific Reports. 2017 Mar 13;7(44357)

 

The extracellular adherence protein (Eap) of Staphylococcus aureus acts as a proliferation and migration repressing factor that alters the cell morphology of keratinocytes.

Eisenbeis J, Peisker H, Backes CS, Bur S, Hölters S, Thewes N, Greiner M, Junker C, Schwarz EC, Hoth M, Junker K, Preissner KT, Jacobs K, Herrmann M, Bischoff M.

Int J Med Microbiol. 2017 Jan 18. pii: S1438-4221(17)30026-7. doi: 10.1016/j.ijmm.2017.01.002. [Epub ahead of print]

 


 

Publications 2016 :

 

Syntaxin 8 is required for efficient lytic granule trafficking in cytotoxic T lymphocytes.

Bhat SS,Friedmann KS, Knörck, Hoxha C, Leidinger P, Backes C, Meese E, Keller A, Rettig J, Hoth M, Qu B, Schwarz EC.

Biochim Biophys Acta - Molecular Cell Research. 2016 Jul;Vol. 1863, Issue 7 Part A:pp 1653-1664

 

A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+ channels.

Saul S, Gibhardt CS, Schmidt B, Lis A, Pasieka B, Conrad D, Jung P, Gaupp R, Wonnenberg B, Diler E, Stanisz H, Vogt T, Schwarz EC, Bischoff M, Herrmann M, Tschernig T, Kappl R, Rieger H, Niemeyer BA, Bogeski I.

Sci Signal. 2016 Mar 8;9(418):ra26.

 

Deep characterization of blood cell miRNomes by NGS.

Schwarz EC, Backes C, Knörck A, Ludwig N, Leidinger P, Hoxha C, Schwär G, Grossmann T, Müller SC, Hart M, Haas J, Galata V, Müller I, Fehlmann T, Eichler H, Franke A, Meder B, Meese E, Hoth M, Keller A.

Cell Mol Life Sci. 2016 Feb 13. [Epub ahead of print]

 


 

Publications 2014 :

 

A simple, economic, time-resolved killing assay.

Kummerow C, Schwarz EC, Bufe B, Zufall F, Hoth M, Qu B.

Eur J Immunol. 2014 Jun;44(6):1870-2. doi: 10.1002/eji.201444518. Epub 2014 Apr 13.

 

How ORAI and TRP channels interfere with each other: interaction models and examples from the immune system and the skin.

Saul S, Stanisz H, Backes CS, Schwarz EC, Hoth M.

Eur J Pharmacol. 2014 Sep 15;739:49-59. doi: 10.1016/j.ejphar.2013.10.071. Epub 2013 Nov 28.

 

Syntaxin11 serves as a t-SNARE for the fusion of lytic granules in human cytotoxic T lymphocytes.

Halimani M, Pattu V, Marshall MR, Chang HF, Matti U, Jung M, Becherer U, Krause E, Hoth M, Schwarz EC, Rettig J.

Eur J Immunol. 2014 Feb;44(2):573-84. doi: 10.1002/eji.201344011. Epub 2013 Dec 16.

 


 

Publications 2013 :

 

Holzmann C, Kilch T, Kappel S, Armbrüster A, Jung V, Stöckle M, Bogeski I, Schwarz EC, Peinelt C.

ICRAC controls the rapid androgen response in human primary prostate epithelial cells and is altered in prostate cancer.

Oncotarget. 2013 Nov;4(11):2096-107.

 

Schwarz EC, Qu B, Hoth M.

Calcium, cancer and killing: the role of calcium in killing cancer cells by cytotoxic T lymphocytes and natural killer cells.

Biochim Biophys Acta. 2013 Jul;1833(7):1603-11. Epub 2012 Dec 3. Review.

 


 

Publications 2012 :

 

Stanisz H, Stark A, Kilch T, Schwarz EC, Müller CS, Peinelt C, Hoth M, Niemeyer BA, Vogt T, Bogeski I.

ORAI1 Ca(2+) channels control endothelin-1-induced mitogenesis and melanogenesis in primary human melanocytes.

Journal of Investigative Dermatology. 2012 May; 132(5): 1443–1451.

 

Pattu V, Qu B, Schwarz EC, Strauβ B, Weins L, Bhat SS, Halimani M, Marshall M, Rettig J, Hoth M.

SNARE protein expression and localization in human cytotoxic T lymphocytes.

Eur J Immunol. 2012 Feb;42(2):470-5. doi: 10.1002/eji.201141915. Epub 2012 Jan 5.

 


 

Publications 2011 :

 

Pattu V, Qu B, Marshall M, Becherer U, Junker C, Matti U, Schwarz EC, Krause E, Hoth M, Rettig J.

Syntaxin7 is required for lytic granule release from cytotoxic T lymphocytes.

Traffic. 2011 Jul;12(7):890-901. doi: 10.1111/j.1600-0854.2011.01193.x. Epub 2011 Apr 21.

 

Qu B, Pattu V, Junker C, Schwarz EC, Bhat SS, Kummerow C, Marshall M, Matti U, Neumann F, Pfreundschuh M, Becherer U, Rieger H, Rettig J, Hoth M.

Docking of Lytic Granules at the Immunological Synapse in Human CTL Requires Vti1b-Dependent Pairing with CD3 Endosomes.

J Immunol. 2011 Jun 15;186(12):6894-904. Epub 2011 May 11.

 

Qu B, Al-Ansary D, Kummerow C, Hoth M, Schwarz EC.

ORAI-mediated calcium influx in T cell proliferation, apoptosis and tolerance.

Cell Calcium. 2011 Jun 10. [Epub ahead of print]

 

Wenning AS, Neblung K, Strauß B, Wolfs MJ, Sappok A, Hoth M, Schwarz EC.

TRP expression pattern and the functional importance of TRPC3 in primary human T-cells.

Biochim Biophys Acta. (2011 Mar);1813(3):412-23. Epub 2011 Jan 4.

 


 

Publications 2010 :

 

A myosin IK-Abp1-PakB circuit acts as a switch to regulate phagocytosis efficiency.

Dieckmann R, Von Heyden Y, Kistler C, Gopaldass N, Hausherr S, Crawley SW, Schwarz EC, Diensthuber RP, Côté GP, Tsiavaliaris G, Soldati T.

Mol. Biol. Cell. 2010 May 1. 21(9):1505-1518

 

Bogeski I, Kummerov C, Al-Ansary D, Schwarz EC, Koehler R, Kozai D, Takahashi N, Peinelt C, Griesemer D, Bozem M, Mori Y, Hoth M, Niemeyer BA.

Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling.

Sci Signal. (2010 Mar 30);3 (115):ra24.

 

Thiel M, Wolfs M-J, Bauer S, Wenning AS, Burckhart T, Schwarz EC, Scott AM, Renner C, Hoth M.

Efficiency of T-cell co-stimulation by CD80 and CD86 cross-linking correlates with calcium entry.

Immunology (2010 Jan);129(1):28-40. Epub 2009 Oct 12.

 


 

Publications 2007 :

 

Schwarz EC, Kummerow C, Wennings AS, Wagner K, Waggershauser K, Griesemer D, Staruß B, Wolfs M-J, Quintana A, Hoth M.

Calcium dependence of T-cell proliferation following focal stimulation.

Eur. J. Immunol. (2007 Sep 26);37(10):2723-2733

 

Quintana A, Schwindling C, Wenning AS, Becherer U, Rettig J, Schwarz EC, Hoth M.

T cell activation requires mitochondrial translocation to the immunological synapse.

Proc. Natl. Acad. Sci. USA. (2007 Sep 4);104(36):14418-14423

 

Schwarz EC, Wolfs MJ, Tonner S, Wenning A, Quintana A, Griesemer D, Hoth M.

TRP channels in lymphocytes.

Handb. Exp. Pharmacol. (2007 Feb);179:445-456

 


 

Publications 2006 :

 

Quintana A, Schwarz EC, Schwindling C, Lipp P, Kaestner L, Hoth M.

Sustained activity of CRAC channels requires translocation of mitochondria to the plasma membrane.

J. Biol. Chem. (2006 Dec 29);281:40302-40309

 

Griesemer D, Löffler B, Kummerow C, Quintana A, Schwarz EC, Hoth M.

CRAC calcium channels as signal transducers in T-cells.

Signal Transduction (2006 July 11);6(4):233-239

 

Schwarz EC, Wissenbach U, Niemeyer BA, Strauß B, Philipp SE, Flockerzi V, Hoth M.

TRPV6 potentiates calcium-dependent cell proliferation.

Cell Calcium (2006 Feb);39(2):163-173

 


 

Publications 2005 :

 

Quintana A, Griesemer D, Schwarz EC, Hoth M.

Calcium-dependent activation of T-lymphoctes.

Eur. J. Physiol. Pflügers Arch. (2005 April);450(1):1-12

 


 

Publications 2004 :

 

Zitt C, Strauß B, Schwarz EC, Spaeth N, Hatzelmann A, Hoth M.

Potent inhibition of CRAC channels and T-lymphocyte activation by the pyrazole derivative BTP2.

J. Biol. Chem. (2004 Mar 26);279:12427-12437

 

Schwarz A, Tutsch E, Ludwig B, Schwarz EC, Stallmach A, Hoth M.

Ca2+ signaling in identified lymphocytes from human intestine: relation to hyporeactivity, proliferation and inflammatory bowel disease.

J. Biol. Chem. (2004 Feb 13);279:5641-5647