Publications 2023 :
Identification of molecular candidates which regulate calcium-dependent CD8+ T-cell cytotoxicity.
Mol Immunol. 2023 May;157:202-213. doi: 10.1016/j.molimm.2023.04.002. Epub 2023 Apr 17.
Publications 2022 :
B-cell receptors of EBV-negative Burkitt lymphoma bind modified isoforms of autoantigens.
Bock T, Bewarder M, Cetin O, Fadle N, Regitz E, Schwarz EC, Held J, Roth S, Lohse S, Pfuhl T, Wagener R, Smola S, Becker SL, Bohle RM, Trumper L, Siebert R, Hansmann ML, Pfreundschuh M, Drexler HG, Hoth M, Kubuschok B, Roemer K, Preuss KD, Hartmann S, Thurner L.
(2022). EJHaem 3, 739-747. doi.org/10.1002/jha2.475.
Friedmann KS, Kaschek L, Knörck A, Cappello S, Lünsmann N, Küchler N, Hoxha C, Schäfer G, Iden S, Bogeski I, Kummerow C, Schwarz EC, Hoth M.
J Physiol. 2022 Dec;600(23):5027-5054. doi: 10.1113/JP283667. Epub 2022 Nov 3.
Cytotoxic Efficiency of Human CD8(+) T Cell Memory Subtypes.
Knorck A, Schafer G, Alansary D, Richter J, Thurner L, Hoth M, Schwarz EC.
Front. Immunol., 13 April 2022
Sec.T Cell Biology
Unspecific CTL Killing Is Enhanced by High Glucose via TNF-Related Apoptosis-Inducing Ligand.
Yang W, Denger A, Diener C, Kuppers F, Soriano-Baguet L, Schafer G, Yanamandra AK, Zhao R, Knorck A, Schwarz EC, Hart M, Lammert F, Roma LP, Brenner D, Christidis G, Helms V, Meese E, Hoth M, Qu B.
Front. Immunol., 21 February 2022
Sec.T Cell Biology
Publications 2021 :
Targeting the Microtubule-Network Rescues CTL Killing Efficiency in Dense 3D Matrices.
Zhao R, Zhou X, Khan ES, Alansary D, Friedmann KS, Yang W, Schwarz EC, Del Campo A, Hoth M, Qu B.
Front. Immunol., 17 August 2021
Sec.T Cell Biology
High Glucose Enhances Cytotoxic T Lymphocyte-Mediated Cytotoxicity.
Zhu J, Yang W, Zhou X, Zöphel D, Soriano-Baguet L, Dolgener D, Carlein C, Hof C, Zhao R, Ye S, Schwarz EC, Brenner D, Prates Roma L, Qu B.
Front Immunol. 2021 Jun 25;12:689337. doi: 10.3389/fimmu.2021.689337. eCollection 2021. PMID: 34248978 Free PMC article.
Publications 2020 :
Zou H, Yang W, Schwär G, Zhao R, Alansary D, Yin D, Schwarz EC, Niemeyer BA, Qu B.
Eur J Immunol. 2020 Dec;50(12):2095-2098. doi: 10.1002/eji.202048577. Epub 2020 Aug 1
Zhou Y, Zhao R, Schwarz EC, Akbar R, Kaba M, Pattu V, Helms V, Rieger H, Nunes-Hasler P, Qu B.
J Immunol. 2020 Dec 1;205(11):2988-3000. doi: 10.4049/jimmunol.2000195. Epub 2020 Oct 26
Publications 2019 :
Macrophage Polarization is Deregulated in Haemophilia.
Knowles LM, Kagiri D, Bernard M, Schwarz EC, Eichler H, Pilch J.
Thromb Haemost. 2019 Feb;119(2):234-245. doi: 10.1055/s-0038-1676796. Epub 2019 Jan 16
Leisegang MS, Gu L, Preussner J, Günther S, Hitzel J, Ratiu C, Weigert A, Chen W, Schwarz EC, Looso M, Fork C, Brandes RP.
Febs Letters. 2019 Feb 13; 539(5):487-498. doi: 10.1002/1873-3468.13337
miR-34a: a new player in the regulation of T cell function by modulation of NF-κB signaling.
Hart M, Walch-Rückheim B, Friedmann KS, Rheinheimer S, Tänzer T, Glombitza B, Sester M, Lenhof HP, Hoth M, Schwarz EC, Keller A, Meese E.
Cell Death Dis. 2019 Jan 18;10(2):46. doi: 10.1038/s41419-018-1295-1.
Publications 2018 :
Knörck A, Marx S, Friedmann KS, Zöphel S, Lieblang L, Hässig C, Müller I, Pilch J, Sester U, Hoth M, Eichler H, Sester M, Schwarz EC.
Transfusion. 2018 Jun;58(6):1516-1526. doi: 10.1111/trf.14616. Epub 2018 May 6.
A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity.
Zhou X, Friedmann KS, Lyrmann H, Zhou Y, Schoppmeyer R, Knörck A, Mang S, Hoxha C, Angenendt A, Backes CS, Mangerich C, Zhao R, Cappello S, Schwär G, Hässig C, Neef M, Bufe B, Zufall F, Kruse K, Niemeyer BA, Lis A, Qu B, Kummerow C, Schwarz EC, Hoth M.
J Physiol. 2018 Jan 25. doi: 10.1113/JP274964. [Epub ahead of print]
Publications 2017 :
Human profilin 1 is a negativ regulator of CTL mediated cell-killing and migration.
Schoppmeyer R, Zhao R, Cheng H, Hamed M, Liu C, Zhou X, Schwarz EC, Zhou Y, Knörck A, Schwär G, Ji S, Liu L, Long J, Helms V, Hoth M, Yu X, Qu B.
Eur J Immunol. 2017;47:1562-1572. Epub ahead of print.
Bystander cells enhance NK cytotoxic efficiency by reducing search time.
Zhou X, Zhao R, Schwarz K, Mangeat M, Schwarz EC, Hamed M, Bogeski I, Helms V, Rieger H, Qu B.
Scientific Reports. 2017 Mar 13;7(44357)
Eisenbeis J, Peisker H, Backes CS, Bur S, Hölters S, Thewes N, Greiner M, Junker C, Schwarz EC, Hoth M, Junker K, Preissner KT, Jacobs K, Herrmann M, Bischoff M.
Int J Med Microbiol. 2017 Jan 18. pii: S1438-4221(17)30026-7. doi: 10.1016/j.ijmm.2017.01.002. [Epub ahead of print]
Publications 2016 :
Syntaxin 8 is required for efficient lytic granule trafficking in cytotoxic T lymphocytes.
Bhat SS,Friedmann KS, Knörck, Hoxha C, Leidinger P, Backes C, Meese E, Keller A, Rettig J, Hoth M, Qu B, Schwarz EC.
Biochim Biophys Acta - Molecular Cell Research. 2016 Jul;Vol. 1863, Issue 7 Part A:pp 1653-1664
Saul S, Gibhardt CS, Schmidt B, Lis A, Pasieka B, Conrad D, Jung P, Gaupp R, Wonnenberg B, Diler E, Stanisz H, Vogt T, Schwarz EC, Bischoff M, Herrmann M, Tschernig T, Kappl R, Rieger H, Niemeyer BA, Bogeski I.
Sci Signal. 2016 Mar 8;9(418):ra26.
Deep characterization of blood cell miRNomes by NGS.
Publications 2014 :
A simple, economic, time-resolved killing assay.
Kummerow C, Schwarz EC, Bufe B, Zufall F, Hoth M, Qu B.
Eur J Immunol. 2014 Jun;44(6):1870-2. doi: 10.1002/eji.201444518. Epub 2014 Apr 13.
Saul S, Stanisz H, Backes CS, Schwarz EC, Hoth M.
Eur J Pharmacol. 2014 Sep 15;739:49-59. doi: 10.1016/j.ejphar.2013.10.071. Epub 2013 Nov 28.
Syntaxin11 serves as a t-SNARE for the fusion of lytic granules in human cytotoxic T lymphocytes.
Halimani M, Pattu V, Marshall MR, Chang HF, Matti U, Jung M, Becherer U, Krause E, Hoth M, Schwarz EC, Rettig J.
Eur J Immunol. 2014 Feb;44(2):573-84. doi: 10.1002/eji.201344011. Epub 2013 Dec 16.
Publications 2013 :
Holzmann C, Kilch T, Kappel S, Armbrüster A, Jung V, Stöckle M, Bogeski I, Schwarz EC, Peinelt C.
Oncotarget. 2013 Nov;4(11):2096-107.
Schwarz EC, Qu B, Hoth M.
Biochim Biophys Acta. 2013 Jul;1833(7):1603-11. Epub 2012 Dec 3. Review.
Publications 2012 :
Stanisz H, Stark A, Kilch T, Schwarz EC, Müller CS, Peinelt C, Hoth M, Niemeyer BA, Vogt T, Bogeski I.
Journal of Investigative Dermatology. 2012 May; 132(5): 1443–1451.
Pattu V, Qu B, Schwarz EC, Strauβ B, Weins L, Bhat SS, Halimani M, Marshall M, Rettig J, Hoth M.
SNARE protein expression and localization in human cytotoxic T lymphocytes.
Eur J Immunol. 2012 Feb;42(2):470-5. doi: 10.1002/eji.201141915. Epub 2012 Jan 5.
Publications 2011 :
Pattu V, Qu B, Marshall M, Becherer U, Junker C, Matti U, Schwarz EC, Krause E, Hoth M, Rettig J.
Syntaxin7 is required for lytic granule release from cytotoxic T lymphocytes.
Traffic. 2011 Jul;12(7):890-901. doi: 10.1111/j.1600-0854.2011.01193.x. Epub 2011 Apr 21.
Qu B, Pattu V, Junker C, Schwarz EC, Bhat SS, Kummerow C, Marshall M, Matti U, Neumann F, Pfreundschuh M, Becherer U, Rieger H, Rettig J, Hoth M.
J Immunol. 2011 Jun 15;186(12):6894-904. Epub 2011 May 11.
Qu B, Al-Ansary D, Kummerow C, Hoth M, Schwarz EC.
ORAI-mediated calcium influx in T cell proliferation, apoptosis and tolerance.
Cell Calcium. 2011 Jun 10. [Epub ahead of print]
Wenning AS, Neblung K, Strauß B, Wolfs MJ, Sappok A, Hoth M, Schwarz EC.
TRP expression pattern and the functional importance of TRPC3 in primary human T-cells.
Biochim Biophys Acta. (2011 Mar);1813(3):412-23. Epub 2011 Jan 4.
Publications 2010 :
A myosin IK-Abp1-PakB circuit acts as a switch to regulate phagocytosis efficiency.
Dieckmann R, Von Heyden Y, Kistler C, Gopaldass N, Hausherr S, Crawley SW, Schwarz EC, Diensthuber RP, Côté GP, Tsiavaliaris G, Soldati T.
Mol. Biol. Cell. 2010 May 1. 21(9):1505-1518
Bogeski I, Kummerov C, Al-Ansary D, Schwarz EC, Koehler R, Kozai D, Takahashi N, Peinelt C, Griesemer D, Bozem M, Mori Y, Hoth M, Niemeyer BA.
Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling.
Sci Signal. (2010 Mar 30);3 (115):ra24.
Thiel M, Wolfs M-J, Bauer S, Wenning AS, Burckhart T, Schwarz EC, Scott AM, Renner C, Hoth M.
Efficiency of T-cell co-stimulation by CD80 and CD86 cross-linking correlates with calcium entry.
Immunology (2010 Jan);129(1):28-40. Epub 2009 Oct 12.
Publications 2007 :
Schwarz EC, Kummerow C, Wennings AS, Wagner K, Waggershauser K, Griesemer D, Staruß B, Wolfs M-J, Quintana A, Hoth M.
Calcium dependence of T-cell proliferation following focal stimulation.
Eur. J. Immunol. (2007 Sep 26);37(10):2723-2733
Quintana A, Schwindling C, Wenning AS, Becherer U, Rettig J, Schwarz EC, Hoth M.
T cell activation requires mitochondrial translocation to the immunological synapse.
Proc. Natl. Acad. Sci. USA. (2007 Sep 4);104(36):14418-14423
Schwarz EC, Wolfs MJ, Tonner S, Wenning A, Quintana A, Griesemer D, Hoth M.
Handb. Exp. Pharmacol. (2007 Feb);179:445-456
Publications 2006 :
Quintana A, Schwarz EC, Schwindling C, Lipp P, Kaestner L, Hoth M.
Sustained activity of CRAC channels requires translocation of mitochondria to the plasma membrane.
J. Biol. Chem. (2006 Dec 29);281:40302-40309
Griesemer D, Löffler B, Kummerow C, Quintana A, Schwarz EC, Hoth M.
CRAC calcium channels as signal transducers in T-cells.
Signal Transduction (2006 July 11);6(4):233-239
Schwarz EC, Wissenbach U, Niemeyer BA, Strauß B, Philipp SE, Flockerzi V, Hoth M.
TRPV6 potentiates calcium-dependent cell proliferation.
Cell Calcium (2006 Feb);39(2):163-173
Publications 2005 :
Quintana A, Griesemer D, Schwarz EC, Hoth M.
Calcium-dependent activation of T-lymphoctes.
Eur. J. Physiol. Pflügers Arch. (2005 April);450(1):1-12
Publications 2004 :
Zitt C, Strauß B, Schwarz EC, Spaeth N, Hatzelmann A, Hoth M.
Potent inhibition of CRAC channels and T-lymphocyte activation by the pyrazole derivative BTP2.
J. Biol. Chem. (2004 Mar 26);279:12427-12437
Schwarz A, Tutsch E, Ludwig B, Schwarz EC, Stallmach A, Hoth M.
J. Biol. Chem. (2004 Feb 13);279:5641-5647