Publikationen
Dittrich A, Ramesh G, Jung M, Schmitz F (2023)
Rabconnectin-3α/DMXL2 Is Locally Enriched at the Synaptic Ribbon of Rod Photoreceptor Synapses
Cells 12(12), 1665.
https://www.mdpi.com/2073-4409/12/12/1665
Schwarz K, Schmitz F (2023)
The Disease Protein Tulp1 Is Essential for Periactive Zone Endocytosis in Photoreceptor Ribbon Synapses
Journal of Neuroscience 36(8): 2473-2493; doi: 10.1523/JNEUROSCI.2275-15.2016
* equal contributions
http://www.jneurosci.org/content/36/8/2473.short
Leon Lagnado and Frank Schmitz (2015)
Ribbon synapses and visual processing in the retina
Annual Review of Vision Science 1, 235-262.
Katiyar R*, Weissgerber P*, Roth E*, Dörr J, Sothilingam V, Garcia Garrido M, Beck SC, Seeliger M, Beck A, Schmitz F§, Flockerzi V§ (2015)
Influence of the β2-subunit of L-type voltage-gated Cav channels on the structural and functional development of photoreceptor ribbon synapses
*,§ equal contributions
Invest Ophthalmol Vis Sci. 2015 Mar 12. pii: IOVS-15-16654. doi: 10.1167/iovs.15-16654.
http://www.ncbi.nlm.nih.gov/pubmed/25766584
Anjum R, Ajoubian H, Schmitz F (2014)
Differential synaptic distribution of the scaffold proteins Cask and Caskin1 in the bovine retina
Mol Cell Neurosci 62, 19-29.
http://www.ncbi.nlm.nih.gov/pubmed/25123431
Mayur Dembla, Silke Wahl, Rashmi Katiyar, and Frank Schmitz
ArfGAP3 is a component of the photoreceptor synaptic ribbon complex and forms a NAD(H)-regulated, redox-sensitive complex with RIBEYE that is important for endocytosis
The Journal of Neuroscience,April 9, 2014.34(15):5245-5260
Silke Wahl, Rashmi Katiyar and Frank Schmitz.
Fairless R, Williams SK, Hoffmann DB, Stojic A, Hochmeister S, Schmitz F, Storch MK, Diem R.
Preclinical retinal neurodegeneration in a model of multiple sclerosis.
J Neurosci. 2012 Apr 18;32(16):5585-97.
http://www.ncbi.nlm.nih.gov/pubmed/22393316
Grabner CP, Gandini MA, Rehak R, Le Y, Zamponi GW, Schmitz F.
RIM1/2-mediated facilitation of Cav1.4 channel opening is required for Ca2+-stimulated release in mouse rod photoreceptors.
J Neurosci. 2015 Sep 23;35(38):13133-13147
http://www.ncbi.nlm.nih.gov/pubmed/26400943
Schauer C, Tong T, Petitjean H, Blum T, Peron S, Mai O, Schmitz F, Boehm U, Leinders-Zufall T (2015)
Hypothalamic gonadotropin releasing hormone (GnRH) receptor neurons fire in synchrony with the female reproductive cycle.
J Neurophysiol Jun 10:jn.00357.2015. doi: 10.1152/jn.00357.2015.
Schmitz F. (2014)
Presynaptic [Ca2+] and GCAPs: aspects on the structure and function of photoreceptor ribbon synapses.
Front. Mol. Neurosci., 06 February 2014 Volume 7 - 2014
http://www.frontiersin.org/molecular_neuroscience/10.3389/fnmol.2014.00003/abstract
Silke Wahl, Rashmi Katiyar and Frank Schmitz.
A Local, Periactive Zone Endocytic Machinery at Photoreceptor Synapses in Close Vicinity to Synaptic Ribbons.
The Journal of Neuroscience,2013 June 19;33(25)10278-10300April 9, 2014.34(15):5245-5260
http://www.jneurosci.org/content/33/25/10278.full.pdf+html
Matti U, Pattu V, Halimani M, Schirra C, Krause E, Liu Y, Weins L, Fang Chang H, Guzman R, Olausson J,Freichel M, Schmitz F, Pasche M, Becherer U, Bruns D, Rettig J.
Synaptobrevin2 is the v-SNARE required for cytotoxic T-lymphocyte lytic granule fusion.
Nat Commun. 2013 Feb 5;4:1439. doi: 10.1038/ncomms2467
http://www.nature.com/ncomms/journal/v4/n2/full/ncomms2467.html
Elena Alvarez-Baron1,*, Katrin Michel1,*,Tobias Mittelstaedt1, Thoralf Opitz2,3, Frank Schmitz5,Heinz Beck2,3, Dirk Dietrich4, Albert J. Becker1, and Susanne Schoch1
RIM3γ and RIM4γ Are Key Regulators of Neuronal Arborization.
J Neurosci. 2013 Jan 9;33(2):824-39
http://www.jneurosci.org/content/33/2/824.full
Schmitz F, Natarajan S, Venkatesan JK, Wahl S, Schwarz K, Grabner CP.
EF hand-mediated Ca and cGMP signaling in photoreceptor synaptic terminals.
Front Mol Neurosci., 2012;5:26. Epub 2012 Feb 29.
http://www.ncbi.nlm.nih.gov/pubmed?term=22514320[uid]
Schwarz K*, Natarajan S*, Kassas N, Vitale N, Schmitz F
The Synaptic Ribbon Is a Site of Phosphatidic Acid Generation in Ribbon Synapses.
J. Neurosci., 2011 Nov 2; 31(44): 15996-16011. * gleichberechtigte Erstautoren.
http://www.jneurosci.org/content/31/44/15996.full
Ritter LM, Khattree N, Tam B, Moritz OL, Schmitz F, Goldberg AF.
In Situ Visualization of Protein Interactions in Sensory Neurons: Glutamic Acid-Rich Proteins (GARPs) Play Differential Roles for Photoreceptor Outer Segment Scaffolding.
J. Neurosci., 2011 Aug 3;31(31):11231-43.
http://www.jneurosci.org/content/31/31/11231.long
Venkatesan J.K.*, Natarajan S.*, Schwarz K.*, Mayer S.I., Alpadi K., Magupalli V.G. Sung C.-H., Schmitz F. (2010) NAD(H)-dependent binding of the neuronal Ca2+-sensor protein GCAP2 to photoreceptor synaptic ribbons.
J. Neurosci., 2010 May 12;30(19):6559-76.* gleichberechtigte Erstautoren.
http://www.ncbi.nlm.nih.gov/pubmed/20463219
Schmitz F. (2009) The making of synaptic ribbons: how they are built and what they do.
The Neuroscientist 15, 611-624.
http://www.ncbi.nlm.nih.gov/pubmed/19700740
Sorg H., Krueger C., Schulz T., Menger M.D., Schmitz F., Vollmar B. (2009) Effects of erythropoietin in skin wound healing are dose related.
FASEB J. 23, 3049-3058.
http://www.ncbi.nlm.nih.gov/pubmed/19403513
Schmitz, F., Fernandez-Chacon, R. (2009) Cysteine-string proteins.
The New Encyclopedia of Neuroscience3, 285-292.
Alpadi, K., Magupalli, V.G., Käppel, S., Köblitz, L., Schwarz, K., Seigel, G.M., Sung, C.H., Schmitz, F. (2008) RIBEYE recruits Munc119, the mammalian ortholog of the Caenorhabditis elegans protein unc119 to synaptic ribbons of photoreceptor synapses.
J. Biol. Chem. 283, 26461-26467.
http://www.ncbi.nlm.nih.gov/pubmed/18664567
Magupalli, V.G., Schwarz, K., Alpadi, K., Natarajan, S., Seigel, G.M., Schmitz, F. (2008) Multiple RIBEYE - RIBEYE interactions create a dynamic scaffold for the formation of synaptic ribbons.
J. Neurosci. 28, 7954-7967 (2008).
http://www.ncbi.nlm.nih.gov/pubmed/18685021
Ekici, M., Schmitz, F., Hohl, M., Seigel, G.M., Thiel, G. (2008) Chromatin structure and expression of synapsin I and synaptophysin in retinal precursor cells.
Neurochem. Int. 53, 165-172.
http://www.ncbi.nlm.nih.gov/pubmed/18692536
Wei C., Möller C.C., Altintas M.M., Li J., Schwarz K., Zacchigna S., Xie L., Heuger A., Schmid H., Rastaldi M.P., Cowan P., Kretzler M., Parilla R., Bendayan M., Gupta V., Nikolic B., Kalluri R., Carmeliet P., Mundel P., Reiser J. (2008) Modification of kidney barrier function by the urokinase receptor.
Nature Medicine 14, 55-63.
http://www.ncbi.nlm.nih.gov/pubmed/18084301
Vennekens, R., Olausson, J., Meissner, M., Bloch, W., Mathar, I., Philipp, S.E., Schmitz, F., Weissgerber, P., Nilius, B., Flockerzi, V., Freichel, M. (2007) Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4.
Nature Immunol. 3, 312-320.
http://www.ncbi.nlm.nih.gov/pubmed/17293867
Schoch, S., Mittelstaedt., T., Kaeser, P., Padgett, D., Feldman, N., Chevalevre V., Castillo, P.E., Hammer, R.E., Han,W., Schmitz, F., Lin, W., Südhof, T.C. (2006) Redundant functions of RIM1alpha and RIM2alpha in Ca2+-triggered neurotransmitter release.
EMBO J. 25, 5852-5863.
http://www.ncbi.nlm.nih.gov/pubmed/17124501
Schmitz, F., Tabares, L., Khimich, D., Strenzke, N., de la Villa-Polo, P., Castellano-Munoz, M., Bulankina, A., Moser, T., Fernandez-Chacon, R.F., Südhof, T.C. (2006) CSPalpha deficiency causes massive and rapid photoreceptor degeneration.
Proc. Natl. Acad. Sci. USA 103, 2926-2931.
http://www.ncbi.nlm.nih.gov/pubmed/16477021
Tom Dieck, S., Schmitz, F., Brandstätter, J.H. (2005) CtBPs as synaptic proteins. In: G. Chinnadurai (Ed.) CtBP family proteins, Landes Bioscience,
New York, Springer Press, pp. 105-111.
Schlüter, O., Schmitz, F., Jahn, R., Südhof, T.C. (2004) A complete genetic analysis of neuronal Rab3 function.
J. Neurosci. 24, 6629-6637.
http://www.ncbi.nlm.nih.gov/pubmed/15269275
Fernandez-Chacon, R., Wölfel, M., Nishimune, H., Tabares, L., Schmitz, F., Castellano-Munoz, M., Rosenmund, C., Montesinos, M.L., Sanes, J.R., Schneggenburger, R., Südhof, T.C. (2004) The synaptic vesicle protein CSPalpha prevents presynaptic degeneration.
Neuron 42, 237-251.
http://www.ncbi.nlm.nih.gov/pubmed/15091340
von Kriegstein, K., Schmitz, F. (2003) Expression and assembly of synaptic membrane proteins in ribbon synapses of the developing mouse retina.
Cell Tiss. Res. 311, 159-173.
http://www.ncbi.nlm.nih.gov/pubmed/12596036
Schoch, S., Castillo, P., Jo, T., Mukhargee, K., Geppert, M., Wang, Y., Schmitz, F., Malenka, R.C., Südhof, T.C. (2002) RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone.
Nature 415, 321-326.
http://www.ncbi.nlm.nih.gov/pubmed/11797009
Castillo P, Schoch S, Schmitz F, Südhof T.C., Malenka R.C. (2002) Rim1a is required for presynaptic long-term potentiation.
Nature 415, 327-330.
http://www.ncbi.nlm.nih.gov/pubmed/11797010
Schmitz F. (2001) Immunological heterogeneity of synaptic and extrasynaptic forms of nonerythroid alpha-spectrin in the rat retina.
Neurosci. Lett. 313, 25-28.
http://www.ncbi.nlm.nih.gov/pubmed/11684331
Schmitz F. , Augustin, I., Brose, N. (2001) Absence of the synaptic vesicle priming protein Munc13-1 from tonically active ribbon synapses of the rat retina.
Brain Res. 895, 258-263.
http://www.ncbi.nlm.nih.gov/pubmed/11259787
Schmitz F,Königstorfer A, SüdhofT.C. (2000) RIBEYE, a component of ribbon synapses: A protein?s journey through evolution provides insight into synaptic ribbon function.
Neuron 28, 857-872.
http://www.ncbi.nlm.nih.gov/pubmed/11163272
Butz S, Fernandez-Chacon R, Schmitz F, Jahn R, Südhof T.C. (1999) Synaptotagmin III is concentrated in synapses but excluded from synaptic vesicles: a synaptic synaptotagmin absent from synaptic vesicles.
J. Biol. Chem. 274, 18290-18296.
http://www.ncbi.nlm.nih.gov/pubmed/10373432
von Kriegstein K, Schmitz F, Link E, Südhof T.C. (1999) Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of synapses.
Europ. J. Neurosci. 11, 1335-1348.
http://www.ncbi.nlm.nih.gov/pubmed/10103129
Kraemer J, Schmitz F, Drenckhahn D (1999) Cytoplasmic dynein and dynactin as likely candidates for microtubule-dependent apical targeting of pancreatic zymogen granules.
Europ. J. Cell Biol. 78, 265-277.
http://www.ncbi.nlm.nih.gov/pubmed/10350215
Wang Y, Okamoto M, Schmitz F, Hofmann K, Südhof T.C. (1997) RIM is a putative Rab3 effector in regulating synaptic - vesicle fusion.
Nature 388, 593-598.
http://www.ncbi.nlm.nih.gov/pubmed/9252191
Schmitz F , Bechmann M , Drenckhahn D (1996) Purification of synaptic ribbons, structural components of the active zone complex of photoreceptor synapses.
J. Neurosci. 16, 7109-7116.