Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes
Strahlenschutzbevollmächtigte Dr. Yvonne Lorat
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Lorat Y, Reindl J, Isermann A, Rübe C, Friedl A, Rübe CE.

Focused ion microbeam irradiation induces clustering of DNA double-strand breaks in heterochromatin visualized by nanoscale-resolution electron microskopy.

Int. J. Mol. Sci. 2021, 22, 7638.



Lorat Y, Fleckenstein J, Görlinger P, Rübe C, Rübe CE.

Assessment of DNA damage by 53PB1 and pKu70 detection in peripheral blood lymphocytes by immunofluorescence and
high-resolution transmission electron microscopy.

Strahlenther Onkol. 2020 Jan 31. doi: 10.1007/s00066-020-01576-1

PMID: 32006067


Schuler N, Palm J, Schmitz S, Lorat Y, Rübe CE.

Increasing genomic instability during cancer therapy in a patient with Li-Fraumeni syndrome.
Clin Transl Radiat Oncol. 2017 Nov 2;7:71-78. doi: 10.1016/j.ctro.2017.10.004. eCollection 2017 Dec.

PMID: 29594232


Timm S, Lorat Y, Jakob B, Taucher-Scholz G, Rübe CE.

Clustered DNA damage concentrated in particle trajectories causes persistent large-scale rearrangements in chromatin architecture.
Radiother Oncol. 2018 Dec;129(3):600-610. doi: 10.1016/j.radonc.2018.07.003. Epub 2018 Jul 23.

PMID: 30049456


Lorat Y, Schanz S, Rübe CE.

Ultrastructural insights into Biological Significance of Persisting DNA Damage Foci after Low Doses of Ionizing Radiation.
Clinical Cancer Research. 2016 Nov. 1; 22(21): 5300-5311.
PMID: 27199493

Lorat Y, Timm S, Jakob B, Taucher-Scholz G, Rübe CE.
Clustered double-strand breaks in heterochromatin perturb DNA repair after high linear energy Transfer Irradiation.
Radiotherapy and Oncology, 2016 Oct; 121(1): 154-161. doi: 10.1016/j.radonc.2016.08.028.
PMID: 27637859


Lorat Y, Brunner CU, Schanz S, Jakob B, Taucher-Scholz G, Rübe CE.

Nanoscale analysis of clustered DNA damage after high-LET irradiation by quantitative electron microscopy - The heavy burden to repair.

DNA Repair (Amst). 2015 Apr;28:93-106. doi: 10.1016/j.dnarep.2015.01.007. Epub 2015 Jan 28.
PMID: 25659339

Schanz S, Schuler N, Lorat Y, Fan L, Kaestner L, Wennemuth G, Rübe C,Rübe CE.

Accumulation of DNA damage in complex normal tissues after protracted low-dose radiation. DNA Repair

DNA Repair (Amst). 2012 Oct 1;11(10):823-32. doi: 10.1016/j.dnarep.2012.07.005. Epub 2012 Sep 1.
PMID: 22947398


Lorat Y, Schanz S, Schuler N, Wennemuth G, Rübe C, Rübe CE.

Beyond repair foci: DNA double-strand break repair in euchromatic and heterochromatic compartments analyzed by transmission electron microscopy.
PLoS One. 2012;7(5):e38165. Epub 2012 May 30.
NCBI-PubMed: 22666473


Rübe CE, Lorat Y, Schuler N, Schanz S, Wennemuth G, Rübe C
DNA repair in the context of chromatin: New molecular insights by the nanoscale detection of DNA repair complexes using transmission electron microscopy
DNA Repair (Amst.) 2011 Apr 3;10(4):427-37. Epub 2011 Feb 20 ;
NCBI-PubMed: 21342792