Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes
Strahlenschutz
Strahlenschutzbevollmächtigte Dr. Yvonne Lorat
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Lorat Y, Reindl J, Isermann A, Rübe C, Friedl A, Rübe CE.

Focused ion microbeam irradiation induces clustering of DNA double-strand breaks in heterochromatin visualized by nanoscale-resolution electron microskopy.

Int. J. Mol. Sci. 2021, 22, 7638.

https://doi.org/10.3390/ijms22147638

 

Lorat Y, Fleckenstein J, Görlinger P, Rübe C, Rübe CE.

Assessment of DNA damage by 53PB1 and pKu70 detection in peripheral blood lymphocytes by immunofluorescence and
high-resolution transmission electron microscopy.

Strahlenther Onkol. 2020 Jan 31. doi: 10.1007/s00066-020-01576-1

PMID: 32006067

 

Schuler N, Palm J, Schmitz S, Lorat Y, Rübe CE.

Increasing genomic instability during cancer therapy in a patient with Li-Fraumeni syndrome.
Clin Transl Radiat Oncol. 2017 Nov 2;7:71-78. doi: 10.1016/j.ctro.2017.10.004. eCollection 2017 Dec.

PMID: 29594232

 

Timm S, Lorat Y, Jakob B, Taucher-Scholz G, Rübe CE.

Clustered DNA damage concentrated in particle trajectories causes persistent large-scale rearrangements in chromatin architecture.
Radiother Oncol. 2018 Dec;129(3):600-610. doi: 10.1016/j.radonc.2018.07.003. Epub 2018 Jul 23.

PMID: 30049456

 

Lorat Y, Schanz S, Rübe CE.

Ultrastructural insights into Biological Significance of Persisting DNA Damage Foci after Low Doses of Ionizing Radiation.
Clinical Cancer Research. 2016 Nov. 1; 22(21): 5300-5311.
PMID: 27199493

Lorat Y, Timm S, Jakob B, Taucher-Scholz G, Rübe CE.
Clustered double-strand breaks in heterochromatin perturb DNA repair after high linear energy Transfer Irradiation.
Radiotherapy and Oncology, 2016 Oct; 121(1): 154-161. doi: 10.1016/j.radonc.2016.08.028.
PMID: 27637859

 

Lorat Y, Brunner CU, Schanz S, Jakob B, Taucher-Scholz G, Rübe CE.

Nanoscale analysis of clustered DNA damage after high-LET irradiation by quantitative electron microscopy - The heavy burden to repair.

DNA Repair (Amst). 2015 Apr;28:93-106. doi: 10.1016/j.dnarep.2015.01.007. Epub 2015 Jan 28.
PMID: 25659339


Schanz S, Schuler N, Lorat Y, Fan L, Kaestner L, Wennemuth G, Rübe C,Rübe CE.

Accumulation of DNA damage in complex normal tissues after protracted low-dose radiation. DNA Repair

DNA Repair (Amst). 2012 Oct 1;11(10):823-32. doi: 10.1016/j.dnarep.2012.07.005. Epub 2012 Sep 1.
PMID: 22947398

 

Lorat Y, Schanz S, Schuler N, Wennemuth G, Rübe C, Rübe CE.

Beyond repair foci: DNA double-strand break repair in euchromatic and heterochromatic compartments analyzed by transmission electron microscopy.
PLoS One. 2012;7(5):e38165. Epub 2012 May 30.
NCBI-PubMed: 22666473

 

Rübe CE, Lorat Y, Schuler N, Schanz S, Wennemuth G, Rübe C
DNA repair in the context of chromatin: New molecular insights by the nanoscale detection of DNA repair complexes using transmission electron microscopy
DNA Repair (Amst.) 2011 Apr 3;10(4):427-37. Epub 2011 Feb 20 ;
NCBI-PubMed: 21342792