Prof. Dr. M.Hoth

	1991	1992	1993	1994	1995	1996	1997	1998	1999
2000	2001	2002	2003	2004	2005	2006	2007	2008	2009
2010	2011

 

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Publications 2011 :

 

Pattu V, Qu B, Schwarz EC, Strauβ B, Weins L, Bhat SS, Halimani M, Marshall M, Rettig J, Hoth M.

SNARE protein expression and localization in human cytotoxic T lymphocytes.

Eur J Immunol. 2011 Nov 25. doi: 10.1002/eji.201141915. [Epub ahead of print]

 

Niemeyer BA, Hoth M.

Excitable T cells: Ca(v)1.4 channel contributions and controversies.

Immunity. 2011 Sep 23;35(3):315-7.

Bogeski I, Kappl R, Kummerow C, Gulaboski R, Hoth M, Niemeyer BA.

Redox regulation of calcium ion channels: chemical and physiological aspects.

Cell Calcium. 2011 Nov;50(5):407-23. doi: 10.1016/j.ceca.2011.07.006. Epub 2011 Sep 17.

 

Quintana A, Pasche M, Junker C, Al-Ansary D, Rieger H, Kummerow C, Nuñez L, Villalobos C, Meraner P, Becherer U, Rettig J, Niemeyer BA, Hoth M.

Calcium microdomains at the immunological synapse: how ORAI channels, mitochondria and calcium pumps generate local calcium signals for efficient T-cell activation.

The EMBO Journal advance online publication 16 August 2011; doi:10.1038/emboj.2011.289 Published online: 16 August 2011

 

Pattu V, Qu B, Marshall M, Becherer U, Junker C, Matti U, Schwarz EC, Krause E, Hoth M, Rettig J.

Syntaxin7 is required for lytic granule release from cytotoxic T lymphocytes.

 

Bogeski I, Gulaboski R, Kappl R, Mirceski V, Stefova M, Petreska J, Hoth M.

Calcium binding and transport by coenzyme q.

 

Qu B, Pattu V, Junker C, Schwarz EC, Bhat SS, Kummerow C, Marshall M, Matti U, Neumann F, Pfreundschuh M, Becherer U, Rieger H, Rettig J, Hoth M.

Docking of Lytic Granules at the Immunological Synapse in Human CTL Requires Vti1b-Dependent Pairing with CD3 Endosomes.

 

Qu B, Al-Ansary D, Kummerow C, Hoth M, Schwarz EC.

ORAI-mediated calcium influx in T cell proliferation, apoptosis and tolerance.

 

Muñoz E, Valero RA, Quintana A, Hoth M, Núñez L, Villalobos C.

Nonsteroidal Anti-inflammatory Drugs Inhibit Vascular Smooth Muscle Cell Proliferation by Enabling the Ca2+-dependent Inactivation of Calcium Release-activated Calcium/Orai Channels Normally Prevented by Mitochondria.

 

Junker C, Hoth M.

Immune synapses: mitochondrial morphology matters.

 

Wenning AS, Neblung K, Strauß B, Wolfs MJ, Sappok A, Hoth M, Schwarz EC.

TRP expression pattern and the functional importance of TRPC3 in primary human T-cells.

Biochim Biophys Acta. (2011 Mar);1813(3):412-23. Epub 2011 Jan 4.

 

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Publications 2010 :

 

Spohn D, Rössler OG, Philipp SE, Raubuch M, Kitajima S, Griesemer D, Hoth M, Thiel G.

Thapsigargin induces expression of activating transcription factor 3 in human keratinocytes involving Ca2+ ions and c-Jun N-terminal protein kinase.

Mol Pharmacol. (2010 Nov);78(5):865-76. Epub 2010 Aug 16.

 

Bogeski I, Al-Ansary D, Qu B, Niemeyer BA, Hoth M, Peinelt C.

Pharmacology of ORAI channels as a tool to understand their physiological functions.

Expert Review of Clinical Pharmacology (2010 May);3 (3):291-303.

 

Bogeski I, Kummerov C, Al-Ansary D, Schwarz EC, Koehler R, Kozai D, Takahashi N, Peinelt C, Griesemer D, Bozem M, Mori Y, Hoth M, Niemeyer BA.

Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling.

Sci Signal. (2010 Mar 30);3 (115):ra24.

 

Schwindling C, Quintana A, Krause E, Hoth M.

Mitochondria positioning controls local calcium influx in T cells.

J Immunol (2010 Jan);184(1):184-90. Epub 2009 Nov 30.

 

Thiel M, Wolfs M-J, Bauer S, Wenning AS, Burckhart T, Schwarz EC, Scott AM, Renner C, Hoth M.

Efficiency of T-cell co-stimulation by CD80 and CD86 cross-linking correlates with calcium entry.

Immunology (2010 Jan);129(1):28-40. Epub 2009 Oct 12.

 

Al-Ansary D, Bogeski I, Disteldorf BM, Becherer U, Niemeyer BA.

ATP modulates Ca2+ uptake by TRPV6 and is counteracted by isoform-specific phosphorylation.

FASEB J. (2010 Feb);24(2):425-35. Epub 2009 Oct 5.

 

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Publications 2009 :

 

Kummerow C, Junker C, Kruse K, Rieger H, Quintana A, Hoth M.

The immunological synapse controls local and global calcium signals in T lymphocytes.

Immunol. Rev. (2009 Sep);231(1):132-147

 

Quintana A, Kummerow C, Junker C, Becherer U, Hoth M.

Morphological changes of T cells following formation of immunological synapse modulate intracellular calcium signals.

Cell calcium (2009 Feb);45(2):109-122

 

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Publications 2008 :

Gulaboski R, Lovric M, Mirceski V, Bogeski I, Hoth M.

A new rapid and simple method to determine the kinetics of electrode reactions of biologically relevant compounds from half-peak width of the square-wave voltammograms.

Biophys. Chem. (2008 Dec);138(3):130-137

 

Gulaboski R, Lovric M, Mirceski V, Bogeski I, Hoth M.

Protein-film voltammetry: A theoretical study of the temperature effect using square-wave voltammetry.

Biophys. Chem. (2008 Sep);137(1):49-55

 

Gulaboski R, Pereira CM, Cordeiro MN, Silva AF, Hoth M, Bogeski I.

Redox properties of the calcium chelator Fura-2 in mimetic biomembranes.

Cell Calcium (2008 June);43(2):615-621

 

Bogeski I, Mirceski V, Hoth M.

Probing the redox activity of T-lymphocytes deposited at electrode surfaces with voltammetric methods.

Clin. Chem. Lab. Med. (2008 Feb);46(2):197-203

 

Five chapters of the Duale Reihe "Physiologie", Allgemeine Einführung, Neurophysiologie, Blut, Immunsystem, Herz.

(2008 in press)

 

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Publications 2007 :

Schwarz EC, Kummerow C, Wennings AS, Wagner K, Waggershauser K, Griesemer D, Staruß B, Wolfs M-J, Quintana A, Hoth M.

Calcium dependence of T-cell proliferation following focal stimulation.

Eur. J. Immunol. (2007 Sep 26);37(10):2723-2733

 

Quintana A, Schwindling C, Wenning AS, Becherer U, Rettig J, Schwarz EC, Hoth M.

T cell activation requires mitochondrial translocation to the immunological synapse.

Proc. Natl. Acad. Sci. USA. (2007 Sep 4);104(36):14418-14423

 

Mueller P, Quintana A, Griesemer D, Hoth M, Pieters J.

Disruption of the cortical actin cytoskeleton does not affect store operated Ca²⁺ channels in human T-cells.

FEBS lett. (2007 July 24);581(18):3557-3562

 

Stefano L, Rössler OG, Griesemer D, Hoth M, Thiel G.

P2X(7) receptor stimulation upregulates Egr-1 biosynthesis involving a cytosolic Ca²⁺ rise, transactivation of the EGF receptor and phosphorylation of ERK and Elk-1.

J. Cell. Physiol. (2007 May 1);213(1):36-44

 

Mirceski V, Gulaboski R, Bogeski I, Hoth M.

Redox chemistry of Ca-transporter 2-palmitoylhydroquinone in an artificial thin organic film membrane.

J. Phys. Chem. (2007 Mar 29);111(16):6068-6076

 

Schwarz EC, Wolfs MJ, Tonner S, Wenning A, Quintana A, Griesemer D, Hoth M.

TRP channels in lymphocytes.

Handb. Exp. Pharmacol. (2007 Feb);179:445-456

 

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Publications 2006 :

Quintana A, Schwarz EC, Schwindling C, Lipp P, Kaestner L, Hoth M.

Sustained activity of CRAC channels requires translocation of mitochondria to the plasma membrane.

J. Biol. Chem. (2006 Dec 29);281:40302-40309

 

Griesemer D, Löffler B, Kummerow C, Quintana A, Schwarz EC, Hoth M.

CRAC calcium channels as signal transducers in T-cells.

Signal Transduction (2006 July 11);6(4):233-239

 

Schwarz EC, Wissenbach U, Niemeyer BA, Strauß B, Philipp SE, Flockerzi V, Hoth M.

TRPV6 potentiates calcium-dependent cell proliferation.

Cell Calcium (2006 Feb);39(2):163-173

 

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Publications 2005 :

Quintana A, Griesemer D, Schwarz EC, Hoth M.

Calcium-dependent activation of T-lymphoctes.

Eur. J. Physiol. Pflügers Arch. (2005 April);450(1):1-12

 

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Publications 2004 :

Tutsch E, Griesemer D, Schwarz A, Stallmach A, Hoth M.

Two-photon analysis of calcium signals in T-lymphocytes of intact human intestine.

Eur. J. Immunol. (2004 Sep 20);34(12):3477-3484

 

Quintana A, Hoth M.

Apparent cytosolic calcium gradients in T-lymphocytes and other cell types due to fura-2 accumulation in mitochondra.

Cell Calcium (2004 Aug);36(2):99-109

 

Zitt C, Strauß B, Schwarz EC, Spaeth N, Hatzelmann A, Hoth M.

Potent inhibition of CRAC channels and T-lymphocyte activation by the pyrazole derivative BTP2.

J. Biol. Chem. (2004 Mar 26);279:12427-12437

 

Schwarz A, Tutsch E, Ludwig B, Schwarz EC, Stallmach A, Hoth M.

Ca²⁺ signaling in identified lymphocytes from human intestine: relation to hyporeactivity, proliferation and inflammatory bowel disease.

J. Biol. Chem. (2004 Feb 13);279:5641-5647

 

Griesemer D, Quintana A, Mery L, Schwarz E, Hoth M.

Calcium transport in T-lymphocytes.

Nova Acta Leopoldina (2004);89(336):75-80

 

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Publications 2003 :

Philipp S, Strauß B, Hirnet D, Mery L, Wissenbach U, Flockerzi V, Hoth M.

TRPC3 mediates T-cell receptor-dependent calcium entry in human T-lymphocytes.

J. Biol. Chem. (2003 July 18);278:26629-26638

 

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Publications 2002 :

Bautista DM, Hoth M, Lewis RS.

Enhancement of calcium signalling dynamics and stability by delayed modulation of the plasma-membrane calcium-ATPase in human T-cells.

J Physiol. (2002 June 15);541(3):877-894

 

Mery L, Strauß B, Dufour JF, Krause KH, Hoth M.

The PDZ-interacting domain of TRPC4 controls its localization and surface expression in HEK293 cells.

J. Cell Science (2002 June 14);115:3497-3508

 

Held B, Freise D, Freichel M, Hoth M, Flockerzi V.

Skeletal muscle L-type ca²⁺ current modulation in γ1-deficient and wildtype murine myotubes by the γ1 subunit and cAMP.

J Physiol. (2002 Jan 11);539(2):459-468

 

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Publications 2001 :

Niemeyer BA, Mery L, Zawar C, Suckow A, Monje F, Pardo LA, Stühmer W, Flockerzi V, Hoth M.

Ion channels in health and disease.

EMBO Reports (2001);2(7):568-573

 

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Publications 2000 :

Hoth M, Button DC, Lewis RS.

Mitochondrial control of calcium-channel gating: A mechanism for sustained signaling and transcriptional activation in T lymphocytes.

Proc. Natl. Acad. Sci. USA. 2000 Sep 12;97(19):10607-10612

 

Philipp S, Trost C, Warnat J, Rautmann J, Himmerkus N, Schroth G, Kretz O, Nastainczyk W, Cavalie A, Hoth M, Flockerzi V.

TRP4 (CCE1)protein is part of native calcium release-activated Ca²⁺-like channels in adrenal cells.

J. Biol. Chem. 2000 May 17;275:23965-23972

 

Freise D, Held B, Wissenbach U, Pfeifer A, Trost C, Himmerkus N, Schweig U, Freichel M, Biel M, Hofmann F, Hoth M, Flockerzi V.

Absence of the γ subunit of the skeletal muscle dihydropyridine receptor increases L-type Ca²⁺ currents and alters channel inactivation properties.

J. Biol. Chem. 2000 May 12;275:14476-14481

 

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Publications 1999 :

Hoth M, Lewis RS.

Monitoring intra-mitochondrial calcium concentration with rhod-2.

In "Imaging Neurones", eds. Yuste R, LAnni F, Konnerth A, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, (1999);pp 39.1-39.14

 

Zweifach A, Hoth M, Lewis RS.

Simultanous measurements of membrane current and intracellular calcium.

In "Advanced Imaging Techniques", eds. Fasolato C, Rizzuto R, Springer Verlag, Hamburg, (1999)

 

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Publications 1998 :

Hoth M.

The fate of calcium ions entering a cell.

In "Integrative Aspects of Calcium Signaling", eds. Verkhratsky A & Toescu E, Plenum Press, New York, (1998);pp 23-33

 

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Publications 1997 :

Hoth M, Fanger CM, Lewis RS.

Mitochondrial regulation of store-operated calcium signaling in T lymphocytes.

J Cell Biol. 1997 May 5;137(3):633-648

 

Suda N, Franzius D, Fleig A, Nishimura S, Bödding M, Hoth M, Takeshima H, Penner R.

Ca²⁺-induced Ca²⁺ release in Chinese hamster ovary (CHO) cells co-expressing dihydropyridine and ryanodine receptors.

J Gen Physiol. 1997 May 1;109(5):619-631

 

Fanger CM, Zweifach A, Dolmetsch RE, Hoth M, Lewis RS.

Function follows form: The role of store-operated calcium channels in T cell activation.

Cell. Physiol. Biochem. (1997);7(3-4):203-218

 

Niemeyer B, Fanger CM, Hoth S, Hoth M.

Diversity of calcium entry mechanisms and their roles in cell signaling.

Futura (1997);12(1):11-19

 

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Publications 1996 :

Hoth M.

Depletion of intracellular calcium stores activates an outward potassium current in mast and RBL-1 cells that is correlated with CRAC channel activation.

FEBS letters 390 (1996) 285-288

 

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Publications 1995 :

Fanger CM, Hoth M, Crabtree GR, Lewis RS.

Characterization of T cells mutants with defects in capacitative calcium entry:genetic evidence for the physiological roles of CRAC channels.

J Cell Biol. 1995 Nov;131(3):655-667

 

Hoth M.

Calcium and barium permeation through calcium release-activated calcium (CRAC) channels.

Pflugers Arch. Eur. J. Physiol. (1995 July). 430:315-322

 

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Publications 1994 :

Franzius D, Hoth M, Penner R.

Non-specific effects of calcium entry antagonists in mast cells.

Pflugers Arch. Eur. J. Physiol. (1994 June). 428:433-438

 

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Publications 1993 :

Hoth M, Fasolato C, Penner R.

Ion channels and calcium signaling in mast cells.

Ann. NY Acad. Sci. (1993 Dec 20);707:198-209

Fasolato C, Hoth M, Penner R.

A GTP-dependent step in the activation mechanism of capacitative calcium influx.

J. Biol. Chem. 1993 Oct 5;268(28):20737-40

 

Penner R, Fasolato C, Hoth M.

Calcium influx and its control by calcium release.

Cur. Opin. Neurobil. (1993 June);3(3):368-374

 

Hoth M, Penner R.

Calcium release-activated calcium current in rat mast cells.

J Physiol. (June 1, 1993), 465, 359-386

 

Fasolato C, Hoth M, Penner R.

Multiple mechanisms of manganese-induced quenching of fura-2 fluorescence in rat mast cells.

Pflugers Arch. Eur. J. Physiol. (1993 May). 423:225-231

 

Fasolato C, Hoth M, Matthews G, Penner R.

Calcium and manganese influx through receptor-mediated activation of non-specific cation channels in mast cells.

Proc. Natl. Acad. Sci. USA. 1993 Apr 1;90(7):3068-72

 

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Publications 1992 :

Hoth M, Penner R.

Depletion of intracellular calcium stores activates a calcium current in mast cells.

Nature 355,353-356 (23 January 1992).

 

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Publications 1991 :

Stocker M, Pongs O, Hoth M, Heinemann SH, Stühmer W, Schröter K-H & Ruppersberg JP.

Swapping of functional domains in voltage-gated K⁺ channels.

Proc. Biol. Sci. 1991 Aug 22;245(1313):101-7.