Saarland University Faculty of Medicine
Medizinische Biochemie und Molekularbiologie

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You are here: >> Startseite >> Einrichtungen >> Fachrichtungen Theoretische und Klinische Medizin >> Biochemie >> AG Prof. Dr. Claudia Götz >> Publikationen

AG Prof. Dr. Claudia Götz

Publikationen

  1. Reinhard,B.,  Götz, C., and Faillard, H.: Synthesis of N-Acetyl-9-O-acetylneuraminic acid a-p-aminophenylthioketoside and its application as ligand in the affinity chromatography of a lectin with preferential affinity to O-acetylated sialic acids. Biol.Chem. Hoppe-Seyler 373: 1243 – 1248, 1992.
  2. Götz,C. and Montenarh,M.  p53: DNA-damage, DNA repair and apoptosis.  Rev. Physiol. Biochem. Pharmacol.   127:  65-95,   1995
  3. Götz,C. and Montenarh,M.  p53 and its implication in apoptosis.  Int. J. Oncol.   6:  1129-1135,   1995
  4. Götz,C., Koenig,M.G., Issinger,O.-G. and Montenarh,M.  A protein kinase CK2 related kinase is tightly associated with SV40 large T antigen.  Eur. J. Biochem.   233:  327-334,   1995.
  5. Götz,C., Wagner,P., Issinger,O.-G. and Montenarh,M.  p21WAF1/CIP1 interacts with protein kinase CK2.  Oncogene   13:  391-398,   1996.
  6. Götz,C., Scholtes,P. and Montenarh,M.  Characterization of the interaction between protein kinase CK2 and the C-terminus of p53.  Eur. J. Cell Biol.   72:  209 1997.
  7. Guerra,B., Götz,C., Wagner,P., Montenarh,M. and Issinger,O.-G.  The carboxy terminus of p53 mimicks the polylysine effect of protein kinase CK2-catalyzed MDM2 phosphorylation.  Oncogene   14:  2683-2688,   1997.
  8. Montenarh,M. and Götz,C.  p53 autoantibodies and human malignancies.  Cancer Molec. Biol.   4:  991-1010,   1997.
  9. Montenarh,M. and Götz,C.  p53 Autoantikörper bei Tumorerkrankungen: Wegweisende Marker.  Münch. med. Wschr.   139:  673-674,   1997.
  10. Götz,C., Kartarius,S., Scholtes,P. and Montenarh,M.  In vivo studies of the interaction between protein kinase CK2 and p21WAF1/CIP1.  Cancer Molec. Biol.   5:  1189-1205,   1998.
  11. Rief,N., Waschow,C., Nastainczyk,W., Montenarh,M. and Götz,C.  Production and characterization of a rabbit monoclonal antibody against human CDC25C phosphatase.  Hybridoma   17:  389-394,   1998.
  12. Wagner,P., Fuchs,A., Nastainczyk,W., Götz,C. and Montenarh,M.  Fine mapping and regulation of the association of p53 and p34cdc2.  Oncogene   16:  105-111,   1998.
  13. Götz,C., Kartarius,S., Scholtes,P., Nastainczyk,W. and Montenarh,M.  Identification of a CK2 phosphorylation site in mdm2.  Eur. J. Biochem.   266:  493-501,   1999.
  14. Götz,C., Scholtes,P., Schuster,N., Prowald,A., Nastainczyk,W. and Montenarh,M.  Protein kinase CK2 binds to a multi-protein binding domain of the growth suppressor protein p53.  Mol. Cell. Biochem.   191:  111-120,   1999.
  15. Götz,C., Kartarius,S., Scholtes,P. and Montenarh,M.  Binding domain of p21WAF1/CIP1 on the polypeptide chain of the protein kinase CK2 b- subunit.  Biochem. Biophys. Res. Commun.   268:  882-885,   2000.
  16. Rief,N., Herges,H., Prowald,A., Götz,C. and Montenarh,M.  Binding of the growth suppressor p53 protein to the cell cycle regulator phosphatase cdc25C.  Int. J. Oncol.   17:  189-195,   2000.
  17. Ababneh,M., Götz,C. and Montenarh,M.  Downregulation of the cdc2/cyclin B protein kinase activity by binding of p53 to p34cdc2.  Biochem. Biophys. Res. Commun.   283:  507-512,   2001.
  18. Schuster,N., Götz,C., Faust,M., Schneider,E., Prowald,A., Jungbluth,A. and Montenarh,M.  Wild-type p53 inhibits protein kinase CK2 activity.  J. Cell. Biochem.   81:  172-181,   2001.
  19. Lensch,R., Götz,C., Andres,C., Bex,A., Lehmann,J., Zwergel,T., Unteregger,G., Kamradt,J., Stoeckle,M. and Wullich,B.  Comprehensive genotypic analysis of human prostate cancer cell lines and sublines derived from metastases after orthotopic implantation in nude mice.  Int. J. Oncol.   21:  695-706,   2002.
  20. Faust,M., Günther,J., Morgenstern,E., Montenarh,M. and Götz,C.  Specific localization of the catalytic subunits of protein kinase CK2 at the centrosomes.  Cell. Mol. Life Sci.   59:  2155-2164,   2002.
  21. Hessenauer,A., Montenarh,M. and Götz,C.  Inhibition of CK2 activity provokes different responses in hormone-sensitive and hormone-refractory prostate cancer cells.  Int. J. Oncol.   22:  1263-1270,   2003.
  22. Facchin,S., Lopreiato,R., Ruzzene,M., Marin,O., Götz,C., Sartori,G., Montenarh,M., Carignani,G. and Pinna,L.A.  Functional conservation within a primordal protein kinase family:yeast piD/Bud32 and human PRPK display interchangeable roles.  FEBS Lett.   549:  63-66,   2003.
  23. Schwindling,S.L., Noll,A., Montenarh,M. and Götz,C.  Mutation of a CK2 phosphorylation site in cdc25C impairs importin a/b binding and results in cytoplasmic retention.  Oncogene   23:  4155-4165,   2004.
  24. Götz,C., Kartarius,S., Schetting,S. and Montenarh,M.  Immunologically defined subclasses of the protein kinase CK2b-subunit in prostate carcinoma cell lines.  Mol. Cell. Biochem.   274:  181-187,   2005.
  25. Götz,C., Kartarius,S., Schwär,G. and Montenarh,M.  Phosphorylation of mdm2 at serine 269 impairs its interaction with the retinoblastoma protein.  Int. J. Oncol.   26:  801-808,   2005.
  26. Touma,R., Kartarius,S., Harlozinska,A., Götz,C. and Montenarh,M.  Growth inhibition and apoptosis induction in ovarian cancer cells.  Int. J. Oncol.   29:  481-488,   2006.
  27. Busch,C., Barton,O., Morgenstern,E., Günther,J., Noll,A., Götz,C. and Montenarh,M.  Protein phosphatase cdc25C is located within centrosomes.  Int. J. Biochem. Cell Biol.   39:  1707-1713,   2007.
  28. Götz,C., Bachmann,C. and Montenarh,M.  Inhibition of protein kinase CK2 leads to a modulation of androgen receptor dependent transcription in prostate cancer cells.  The Prostate   67:  125-134,   2007.
  29. Ölgen, S., Götz, C., and Jose, J.: Synthesis and biological evaluation of 3-(substituted-benzylidene)-1,3-dihydro-indolin derivatives as human protein kinase CK2 and p60(c-Src) tyrosine kinase inhibitors. Biol. Pharm. Bull. 30: 715 – 718,  2007.
  30. Ruppenthal,S.L., Noll,A., Götz,C. and Montenarh,M.  Interference between p53 and cdc25C in cell cycle regulation.  Int. J. Oncol.   31:  345-362,   2007.
  31. Dörr,J., Kartarius,S., Götz,C. and Montenarh,M.  Contribution of the individual subunits of protein kinase CK2 and of hPrp3p to the splicing process.  Mol. Cell Biochem.   316:  187-193,   2008.
  32. Lehnert,S., Götz,C. and Montenarh,M.  Protein kinase CK2 interacts with the splicing factor hPrp3p.  Oncogene   27:  2390-2400,   2008.
  33. Schäfer,B., Götz,C., Dudek,J., Hessenauer,A., Matti,U. and Montenarh,M.  KIF5C, a new binding partner for  protein kinase CK2 with a preference for CK2a'.  Cell Mol. Life Sci.   66:  339-349,   2008.
  34. Schäfer,B., Götz,C. and Montenarh,M.  The kinesin I family member KIF5C is a novel substrate for protein kinase CK2.  Biochem. Biophys. Res. Commun.   375:  179-183,   2008.
  35. Schneider,C.C., Hessenauer,A., Götz,C. and Montenarh,M.  DMAT:an inhibitor of protein kinase CK2 induces reactive oxygen species and DNA double strand breaks.  Oncol. Rep.   21:  1593-1597,   2008.
  36. Götz, C., Müller A., Montenarh, M., Zimmermann, R., and Dudek, J.: The ER-membrane resident Hsp40 Erj1 is a novel substrate for protein kinase CK2. Biochem. Biophys.Res. Comm. 388: 637 – 642, 2009.
  37. Schneider,C.C., Hessenauer,A., Montenarh,M. and Götz,C. p53 is dispensable for the induction of apoptosis after inhibition of protein kinase CK2.  Prostate   70:126-34 (2010).
  38. Gratz A, Götz C, José J. A FRET-based microplate assay for human protein kinase CK2, a target in neoplastic disease. J Enzyme Inhib. Med. Chem. 25:234-9 (2010)
  39. Gratz A., Götz C., and José J. A CE-based assay for human protein kinase CK2 activity measurement and inhibitor screening. Electrophoresis 31: 634 – 640 (2010).
  40. Meng R., Al-Quobaili F., Müller I., Götz C., Thiel G., and Montenarh M. CK2 phosphorylation of Pdx-1 regulates its transcription factor activity. Cell. Mol. Life Sci. 67(14):2481-9 (2010)
  41. Ampofo E., Kietzmann T., Zimmer A., Jakupovic M.,  Montenarh M. and Götz C.  Phosphorylation of the von Hippel-Lindau protein (VHL) by protein kinase CK2 reduces its protein stability and affects p53 and HIF-1a mediated transcription: Int.J.Biochem.Cell Biol. 42: 1729 – 1735 (2010)
  42. Hessenauer A., Schneider C.C., Götz C., and Montenarh M. CK2 inhibition induces apoptosis via the ER stress response. Cellular Signalling 23: 145 – 151 (2011).
  43. Meng R., Götz, C., and Montenarh M. The role of protein kinase CK2 in the regulation of the insulin production of pancreatic islet cells. Biochem. Biophys. Res. Comm.  401: 203 – 206 (2010).