Structural Biology
Prof. Dr. C. Roy D. Lancaster

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Lancaster, C.R.D. (2010)
The superfamily of succinate:quinone oxidoreductases and its implications for the cyanobacterial enzymes.
In:
Bioenergetic Processes of Cyanobacteria (Peschek, G.A., Obinger, C., Renger, G., eds.), Springer, Dordrecht, NL, submitted.


Lancaster, C.R.D. (2010)
142. Respiratory Chain Complex II and Succinate: Quinone Oxidoreductases.
In:
Encyclopedia of Biological Chemistry 2nd Edition (Lennarz, W.J., Lane, M.D., eds.), Elsevier, Oxford, U.K., submitted.



Lancaster, C.R.D. (2010)
148. Purple Bacteria: Photosynthetic Reaction Centers.
In:
Encyclopedia of Biological Chemistry 2nd Edition (Lennarz, W.J., Lane, M.D., eds.), Elsevier, Oxford, U.K., submitted.


Madej, M.G., Müller, F.G., Ploch, J., Lancaster, C.R.D.(2009)
Limited reversibility of transmembrane proton transfer assisting transmembrane electron transfer in a dihaem-containing succinate:quinone oxidoreductase.
Biochim Biophys Acta
- Bioenergetics 1787,  593-600


Nasiri, H.R., Panisch, R., Madej, M.G., Bats, J.W., Lancaster, .C.R.D., Schwalbe, H. (2009)
The correlation of cathodic peak potentials of vitamin K(3) derivatives and their calculated electron affinities The role of hydrogen bonding and conformational changes.
Biochim. Biophys. Acta - Bioenergetics 1787,  601-608


Juhnke, H.D., Hiltscher, H., Nasiri, H. R., Schwalbe, H., Lancaster, C.R.D. (2009)
Production, Characterization, and Determination of the Real Catalytic Properties of the Putative 'Succinate Dehydrogenase' from Wolinella succinogenes.
Mol. Microbiol. 71, 1088-1101


Sreeramulu,S., Jonker, H.R.A., Langer,T., Richter,C., Lancaster,C.R.D. and Schwalbe. H. (2009)
The Human Cdc37·Hsp90 Complex Studied by Heteronuclear NMR Spectroscopy.
J. Biol. Chem. 284, 3885-3896


Lancaster,  C.R.D., Herzog, E., Juhnke, H.D, Madej, M.G., Müller, F.G., Paul, R., Schleidt, P.G. (2008)

Electroneutral and electrogenic catalysis by dihaem-containing succinate:quinone oxidoreductases.

Biochem. Soc. Trans. 36, 996-1000



Kozlova, M.A., Juhnke, H.D., Cherepanov, D.A., Lancaster, C.R.D., Mulkidjanian, A.Y. (2008)
Proton transfer in the photosynthetic reaction center of Blastochloris viridis.
FEBS Lett. 582, 238-242.


Lancaster, C.R.D. (2007)
Structures of Reaction Centers in Anoxygenic Bacteria.
In: Primary Processes of Photosynthesis. Principles and Apparatus. Part 2: Reaction Centers/Photosystems, Electron Transport Chains, Photophosphorylation and Evolution (Renger, G., Ed.), Royal Society of Chemistry, Cambridge, pp. 5-56.


Lancaster, C. R. D., Hunte, C., Kelley III, J., Trumpower, B.L., Ditchfield, R. (2007)
A comparison of stigmatellin conformations, free and bound to the photosynthetic reaction center and the cytochrome bc1 complex.
J. Mol. Biol. 368, 197-208.


Madej, M.G., Nasiri, H.R., Hilgendorff, N.S., Schwalbe H., Unden, G., Lancaster, C.R.D. (2006)
Experimental evidence for proton-motive force-dependent catalysis by the diheme-containing succinate:menaquinone oxidoreductase from the Gram-positive bacterium Bacillus licheniformis.
Biochemistry 45, 15049-15055.


Nasiri, H.R., Madej, M.G., Lancaster, C.R.D., Schwalbe H., Bolte M. (2006)
2-Hydroxy-2-3-(3-oxobutyl)naphtalene-1,4-dione.
Acta Crystallogr., Sect C 62 , 0671-0673.


Madej, M.G., Nasiri, H.R., Hilgendorff, N.S., Schwalbe H., Lancaster, C.R.D. (2006)
Evidence for transmembrane proton transfer in a dihaem-containing membrane protein complex.
EMBO J. 25, 4963-4970.


Lancaster, C.R.D., Haas, A.H., Madej, M.G., Mileni, M. (2006)
Recent progress on obtaining theoretical and experimental support for the "E-pathway hypothesis" of coupled transmembrane electron and proton transfer in dihaem-containing quinol:fumarate reductase.
(Special Issue: Proton Transfer Reactions) Biochim. Biophys. Acta, Bioenerg. 1757: 988-995.


Herzog, E., Frigato, T., Helms V., Lancaster, C.R.D. (2006)
Energy barriers of proton transfer reactions between amino acid side chain analogs and water from ab initio calculations.
J. Comput. Chem. 27: 1534-1547.


Mileni, M., MacMillan, F., Tziatzios, C. Zwicker, K., Haas, A.H., Mäntele, W., Simon, J., Lancaster, C.R.D.(2006)
Heterologous production in Wolinella succinogenes and characterisation of the quinol:fumarate reductase enzymes from Helicobacter pylori and Campylobacter jejuni.
Biochem. J. 395: 191-201.


Mileni, M., Haas, A.H., Mäntele, W., Simon, J., Lancaster, C.R.D.(2005)
Probing Heme Propionate Involvement in Transmembrane Proton Transfer Coupled to Electron Transfer in Dihemic Quinol:Fumarate Reductase by 13C-Labeling and FTIR Difference Spectroscopy.
Biochemistry 44: 16718 - 16728.


Lancaster, C.R.D., Sauer, U.S., Groß, R., Haas, A.H., Graf, J., Schwalbe, H., Mäntele, W., Simon, J., Madej, M.G.(2005)
Experimental support for the "E-pathway hypothesis" of coupled transmembrane e- and H+ transfer in dihemic quinol:fumarate reductase.
Proc. Natl. Acad. Sci. U.S.A. 102: 18860 - 18865.


Haas, A.H., Sauer, U.S., Groß, R., Simon, J., Mäntele, W., Lancaster, C.R.D. (2005)
FTIR Difference Spectra of Wolinella succinogenes quinol:fumarate reductase support a key role of Glu C180 within the "E-Pathway Hypothesis" of Coupled Transmembrane Electron and Proton Transfer.
Biochemistry 44: 13949 - 13961.


Fufezan, C., Drepper, F., Juhnke, H.D., Lancaster, C.R.D., Un, S., Rutherford, A.W., and Krieger-Liszkay, A. (2005)
Herbicide-induced changes in charge recombination and redox potential of QA in the T4 mutant of Blastochloris viridis.
Biochemistry 44: 5931-5939.


Haas, A.H., Lancaster, C.R.D. (2004)
Calculated Coupling of Transmembrane Electron and Proton Transfer in Dihemic Quinol:Fumarate Reductase.
Biophys J. 87: 4298-4315.


Lancaster, C.R.D. (2004)
Ion pump in the movies.
Nature 432: 286-287.


Lancaster, C.R.D. (2004)
Respiratory Chain Complex II and Succinate:Quinone Oxidoreductases.
In: Encyclopedia of Biological Chemistry (Lennarz, W.J., Lane, M.D., eds.), Elsevier, Oxford, U.K.,
Vol. 3, 681-687.


Lancaster, C.R.D. (2004)
Purple Bacteria: Photosynthetic Reaction Centers.
In: Encyclopedia of Biological Chemistry (Lennarz, W.J., Lane, M.D., eds.), Elsevier, Oxford, U.K., Vol. 3, 586-594.


Lancaster, C.R.D. (2004)
Structure and function of succinate:quinone oxidoreductases and the role of quinol:fumarate reductases in fumarate respiration.
In: Zannoni, D. (Ed.) Respiration in Archaea and Bacteria Volume 1: Diversity of Prokaryotic Electron Transport Carriers. Kluwer Scientific, Dordrecht, The Netherlands, pp. 57-85.


Gross, R., Pisa, R., Sänger, M., Lancaster, C.R.D., Simon, J. (2004)
Characterization of the menaquinone reduction site in the diheme cytochrome b membrane anchor of Wolinella succinogenes NiFe hydrogenase
J. Biol. Chem. 279: 274-281.


Lancaster, C.R.D. (2003)
Wolinella succinogenes quinol:fumarate reductase and its comparison to E. coli succinate:quinone reductase.
FEBS Lett. 555: 21-28.


Lancaster, C.R.D. (2003)
Crystallization of Wolinella succinogenes quinol:fumarate reductase in three crystal forms. 
Iwata, S. (Ed.) Methods and Results in Membrane Protein Crystallization. University Line, La Jolla, CA, U.S.A, pp. 177-19
2.


Lancaster, C.R.D. (2003)
The role of electrostatics in proton-conducting membrane protein complexes.
FEBS Lett. 545: 52-60.


Lancaster, C.R.D. (2003)
The structure of Wolinella succinogenes quinol:fumarate reductase and its relevance to the superfamily of succinate:quinone oxidoreductases.
Adv. Prot. Chem. 63: 131-149.


Lancaster, C.R.D. (2003)
Crystallization of Wolinella succinogenes quinol:fumarate reductase. 
In: Membrane Protein Purification and Crystallization. 2nd edition. Hunte, C., Schägger, H., von Jagow, G. (Eds.) Academic Press, San Diego, CA, U.S.A., pp. 219-228.


Lancaster, C.R.D. (2002)
Wolinella succinogenes quinol:fumarate reductase - 2.2 Å resolution crystal structure and the E-pathway hypothesis of coupled transmembrane proton and electron transfer
Biochim. Biophys. Acta Biomembranes 1565: 215-231.



Lancaster, C.R.D. (2002)
A P-type ion pump at work. 
Nature Struct. Biol. 9: 643-645.


Barquera, B., Hellwig, P., Zhou, W., Morgan, J.E., Häse, C.C., Gosink, K.K., Nilges, M., Bruesehoff, P.J., Roth, A., Lancaster, C.R.D., Gennis, R.B. (2002)
Purification and characterization of the recombinant Na+-translocating NADH:quinone oxidoreductase from Vibrio cholerae.

Biochemistry 41: 3781-3789.


Lancaster, C.R.D., Simon, J. (2002)

Succinate: quinone oxidoreductases from ε-proteobacteria.

Biochim. Biophys. Acta Bioenergetics 1553: 84-101



Kröger, A., Biel, S., Simon, J., Gross, R., Unden, G., Lancaster, C.R.D. (2002)
Fumarate respiration of Wolinella succinogenes: enzymology, energetics, and coupling mechanism.
Biochim. Biophys. Acta Bioenergetics 1553: 23-38.


Lancaster, C.R.D. (2002)
Succinate:quinone oxidoreductases - an overview (Editorial)
Biochim. Biophys. Acta Bioenergetics 1553: 1-6.


Lancaster, C.R.D. (2001)
Succinate:quinone oxidoreductases - What can we learn from Wolinella succinogenes quinol:fumarate reductase?
FEBS Lett. 504: 133-141.


Bartoschek, S., Johansson, M., Geierstanger, B.H., Okun, J.G., Lancaster, C.R.D., Humpfer, E., Yu, L., Yu, C.A., Griesinger, C., Brandt, U. (2001)
Three molecules of ubiquinone bind specifically to mitochondrial cytochrome bc1 complex
J. Biol. Chem. 276: 35231-35234


Lancaster, C.R.D. (2001)
Succinate:quinone oxidoreductases. 
In: Handbook of Metalloproteins (Wieghardt, K., Huber, R., Poulos, T., Messerschmidt, A., eds.), Volume 1, Wiley, Chichester, U.K., pp. 379-401.


Lancaster, C.R.D., Michel, H. (2001)
Photosynthetic reaction centres of purple bacteria. 
In: Handbook of Metalloproteins (Wieghardt, K., Huber, R., Poulos, T., Messerschmidt, A., eds.), Volume 1, Wiley, Chichester, U.K., pp. 119-135.


Zachariae, U., Lancaster, C.R.D. (2001)
Proton uptake associated with the reduction of the primary quinone QA influences the binding site of the secondary quinone QB in Rhodopseudomonas viridis photosynthetic reaction centres.
Biochim. Biophys. Acta Bioenergetics 1505: 280-290.


Lancaster, C.R.D., Groß, R., Simon, J. (2001)
A third crystal form of Wolinella succinogenes quinol:fumarate reductase reveals domain closure at the site of fumarate reduction.
Eur. J. Biochem. 268: 1820-1827.


Lancaster, C.R.D., Kröger, A. (2000) 
Succinate: quinone oxidoreductases: new insights from X-ray crystal structures.
Biochim. Biophys. Acta Bioenergetics 1459: 422-431.


Lancaster, C.R.D., Groß, R., Haas, A., Ritter M., Mäntele W., Simon, J., Kröger, A. (2000) 
Essential role of Glu-C66 for menaquinol oxidation indicates transmembrane electrochemical potential generation by Wolinella succinogenes fumarate reductase. Proc. Natl. Acad. Sci. U.S.A. 97: 13051-13056.


Lancaster, C.R.D., Bibikova, M.V., Sabatino, P., Oesterhelt, D., Michel, H. (2000)
Structural basis of the drastically increased initial electron transfer rate in the reaction center from a Rhodopseudomonas viridis mutant described at 2.00-Å resolution.
J. Biol. Chem. 275: 39364-39368 .


Lancaster, C.R.D., Kröger, A. (2000) 
Succinate: quinone oxidoreductases: new insights from X-ray crystal structures.
Biochim. Biophys. Acta Bioenergetics 1459: 422-431.


Lancaster, C.R.D., Kröger, A., Auer, M., Michel, H. (1999) Structure of fumarate reductase from Wolinella succinogenes at 2.2 Å resolution. Nature 402, 377-385 (1999).



Lancaster, C.R.D. (1999) 
Quinone-binding sites in membrane proteins: what can we learn from the Rhodopseudomonas viridis reaction centre? Biochem. Soc. Trans. 27: 591-596.


Lancaster, C.R.D., Michel, H. (1999) 
Refined Crystal Structures of Reaction Centres from Rhodopseudomonas viridis in Complexes with the Herbicide Atrazine and Two Chiral Atrazine Derivatives also Lead to a New Model of the Bound Carotenoid.
J. Mol. Biol. 286: 883-898


Gross, R., Simon, J., Lancaster, C.R.D., Kröger, A. (1998) 
Identification of histidine residues in Wolinella succinogenes hydrogenase that are essential for menaquinone reduction by H2. Mol. Microbiol. 30: 639-646.


Kannt, A., Lancaster, C.R.D., Michel, H. (1998) 
The role of electrostatic interactions for cytochrome c oxidase function.
J. Bioenerg. Biomembr. 30: 81-87


Kannt, A., Lancaster, C.R.D., Michel, H. (1998) 
The coupling of electron transfer and proton translocation: electrostatic calculations on Paracoccus denitrificans cytochrome c oxidase.
Biophys. J. 74: 708-721.


Lancaster, C.R.D. (1998) 
Ubiquinone reduction and protonation in photosynthetic reaction centres from Rhodopseudomonas viridis - X-ray structures and their functional implications. 
Biochim. Biophys. Acta Bioenergetics 1365: 143-150.



Lancaster, C.R.D., Michel, H. (1997) 
The coupling of light-induced electron transfer and proton uptake as derived from crystal structures of reaction centres from Rhodopseudomonas viridis modified at the binding site of the secondary quinone, QB.
Structure 5: 1339-1359.


Lancaster, C.R.D., Michel, H., Honig, B., Gunner, M.R. (1996) 
Calculated coupling of electron and proton transfer in the photosynthetic reaction center of Rhodopseudomonas viridis.
Biophys. J. 70: 2469-2492.


Lancaster, C.R.D., Michel, H. (1996) 
Three-dimensional structures of photosynthetic reaction centers (Minireview).
Photosynth. Res. 48: 65-74.

[Translate to Englisch:] Für eine Aufstellung der Publikationen von Prof. Dr. C. Roy D. Lancaster bei der  U.S. National Library of Medicine (PubMed), klicken Sie bitte  hier.