Forschung

Bei Interesse an Doktorarbeiten melden Sie sich bitte bei Fr. Obeid Tel: 16-30711.

Zurzeit bieten wir 2 offene Themen (Zusammenarbeit zwischen Klinik/Labor), Start im Juli, August 2012.

Schwerpunkte der Forschung

• Klinische und experimentelle Modelle über den Zusammenhang und Einfluss vom Methylierungs-Status auf neurodegenerative Prozesse.
• Weitere Mechanismen, wie Methylierung, die biochemischen Funktionen in der Zelle beeinflussen können.
• Wechselwirkung zwischen Genen und Nahrungsstoffen.
• Methylierung in Zusammenhang mit verschiedenen neurologischen Erkrankungen, Knochengesundheit, Schwangerschaftskomplikationen und Polyneuropathie.
• Methodenentwicklung für "Methyl-Donors" wie Betaine und Choline, sowie methylierte und nicht-methylierte Substrate.
• Folat und dessen Formen im Zusammenhang mit genetischen Polymorphismen, Supplementation und Krankheiten.
• Vitamin B12 Mangel (Diagnostik und biologische Konsequenzen).

Forschungsgruppe von Fr. Jun. Prof. Dr. Rima Obeid

Dipl. Biologin Frau Susanne Kirsch

Dipl. Biologe Herr Yannick Rabagny

Hussain AWAD (Damaskus Universität – Stipendium)

Externe Studenten/ medizinische Dissertationen

Ranwa Al-Sayed (Damaskus Universität - DAAD Stipendium- 3 Monate)

Panagiotis Kostopoulos

Kouris Ninios

Kathrin Hartmuth

Nicole Klein

John Yung

Julia Falk

Kathrin Heucke

Vera Kruse

Abgeschlossene Promotion Arbeiten

Jennifer Schlundt

Mariz Kasoha

Achim Schadt

Eva Raabe

Abgeschlossene Bachelor Arbeiten

Sarah Dielmann

Cosima Klein

Frank Hoffmann

Ehemalige Stipendiaten

Post Doc. Dr. Batool Shannan (Alexander von Humboldt)

Veranstaltung:

International Conference on “Advances and Controversies in B-vitamins and Choline”

5-8 March 2012 University of Leipzig, Germany

http://www.b-vitamins-conference.de

Collaboration

Prof. Ebba Nexo, Department of Clinical Biochemistry, University of Aahrus, Denmark

• Cobalamin analogus in maternal blood and cord blood at birth.
• Trifoil Peptides (TFF) in amniotic fluids.

Prof. Reichrat, Department of Dermatology, University of Saarland, Germany

• The role of UVB/UVA treatment in altering folate forms in blood.

Prof. Fassbender, Department of Neurology, University of Saarland, Germany

• “Cobalamin resistance hypothesis” Intracellular cobalamin deficiency in patients with type II diabetes and polyneuropathy.

Prof. Gortner, Dr. Rohrer, Prof. Dockter, Department of Paediatrics, University of Saarland, Germany

• Methylation and neurodegeneration in children with Down syndrome: the role of B-vitamins, choline and betaine.
• The relationship between bone metabolism and D- and B-vitamins in children with malabsorption disorders: nutritional intake and metabolic assessments.

Prof. Seitz, Department of Ophthalmology, University of Saarland, Germany

• The role of methylation, AGEs and neurodegeneration in age-related macular degeneration.

Prof. Flisser and Dr. Klingele, Department of Internal Medicine, Dialysis Unit, University of Saarland, Germany

• Persistent increase of concentrations of S-adenosylhomocysteine in patients on chronic peritoneal dialysis is related to betaine depletion during the dialysis process. Quantitative assessment of betaine, choline and B-vitamin lose during the dialysis.

Prof. Jouma, Department of Pharmacy, University of Damascus, Syria

• The role of deficiency of glycation, cobalamin, folate, vitamins B1- and D in congenital heart defects.

Bücher

Editted by Herrmann W & Obeid R: Vitamins in the prevention of human diseases (ISBN 978-3-11-021448-2) Copyright © by Walter de Gruyter GmbH & Co. KG. Publishing date January 2011. http://www.degruyter.com/cont/fb/me/detailEn.cfm?isbn=978-3-11-021449-9.

Publikation (letzten 5 Jahre)

1. Quantification of Plasma Phospholipids by Ultra Performance Liquid chromatography Tandem Mass Spectrometry. Yannick Rabagny, Wolfgang Herrmann, Jürgen Geisel, Susanne H Kirsch, Rima Obeid. Anal Bioanal Chem. 2011;401(3):891-9
2. Advanced glycation end products overload might explain intracellular cobalamin deficiency in renal dysfunction, diabetes and aging.Obeid R, Shannan B, Herrmann W. Med Hypotheses. 2011;77(5):884-8.
3. Trefoil factor family peptides in the human foetus and at birth. Samson MH, Poulsen SS, Obeid R, Herrmann W, Nexo E. Eur J Clin Invest. 2011 Jul;41(7):785-92.
4. The mandatory fortification of staple foods with folic Acid: a current controversy in Germany. Herrmann W, Obeid R.Dtsch Arztebl Int. 2011 Apr;108(15):249-54.
5. Folate is related to phosphorylated neurofilament-H and P-tau (Ser396) in rat brain. Obeid R, Schlundt J, Umanskaya N, Herrmann W, Herrmann M. J Neurochem. 2011 Jun;117(6):1047-54.
6. Homocysteine: a biomarker in neurodegenerative diseases. Herrmann W, Obeid R.Clin Chem Lab Med. 2011 Mar;49(3):435-41.
7. Biomarkers of neurodegenerative diseases. Herrmann W, Obeid R. Clin Chem Lab Med. 2011 Mar;49(3):343-4.
8. Quantification of acetylcholine, choline, betaine, and dimethylglycine in human plasma and urine using stable-isotope dilution ultra performance liquid chromatography-tandem mass spectrometry. Kirsch SH, Herrmann W, Rabagny Y, Obeid R. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Dec 15;878(32):3338-44.
9. Concentrations of unmetabolized folic acid and primary folate forms in pregnant women at delivery and in umbilical cord blood. Obeid R, Kasoha M, Kirsch S, Munz W, Herrmann W. Am J Clin Nutr. 2010 Dec;92(6):1416-22.
10. Concentrations of unmetabolized folic acid and primary folate forms in plasma after folic acid treatment in older adults. Obeid R, Kirsch SH, Kasoha M, Eckert R, Herrmann W. Metabolism. 2011 May;60(5):673-80.
11. Homocysteine in SGA and non-SGA preterm neonates from mothers receiving folic acid supplementation. Gomes TS, Lindner U, Tennekoon, Karandagoda W, Gortner L, Obeid R. Clin Chem Lab Med. 2010 Aug;48(8):1157-61.
12. Deficiencies of folate and vitamin B12 do not affect fracture healing in mice. Holstein JH, Herrmann M, Schmalenbach J, Obeid R, Olkü I, Klein M, Garcia P, Histing T, Pohlemann T, Menger MD, Herrmann W, Claes L. Bone. 2010 Jul;47(1):151-5
13. Quantification of key folate forms in serum using stable-isotope dilution ultra performance liquid chromatography-tandem mass spectrometry. Kirsch SH, Knapp JP, Herrmann W, Obeid R. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jan 1;878(1):68-75.
14. Simultaneous quantification of S-adenosyl methionine and S-adenosyl homocysteine in human plasma by stable-isotope dilution ultra performance liquid chromatography tandem mass spectrometry. Kirsch SH, Knapp JP, Geisel J, Herrmann W, Obeid R. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Nov 15;877(30):3865-70.
15. Enhanced bone metabolism in vegetarians--the role of vitamin B12 deficiency. Herrmann W, Obeid R, Schorr H, Hübner U, Geisel J, Sand-Hill M, Ali N, Herrmann M. Clin Chem Lab Med. 2009;47(11):1381-7.
16. Methylation status and neurodegenerative markers in Parkinson disease. Obeid R, Schadt A, Dillmann U, Kostopoulos P, Fassbender K, Herrmann W. Clin Chem. 2009 Oct;55(10):1852-60.
17. Causes and early diagnosis of vitamin B12 deficiency. Herrmann W, Obeid R. Dtsch Arztebl Int. 2008 Oct;105(40):680-5.
18. Hyperhomocysteinemia is associated with impaired fracture healing in mice. Claes L, Schmalenbach J, Herrmann M, Olkü I, Garcia P, Histing T, Obeid R, Schorr H, Herrmann W, Pohlemann T, Menger MD, Holstein JH. Calcif Tissue Int. 2009 Jul;85(1):17-21.
19. Homocysteine and cholesterol: guilt by association? Obeid R, Herrmann W. Stroke. 2009 Jul;40(7):e516; author reply e517.
20. Homocysteine and lipids: S-adenosyl methionine as a key intermediate. Obeid R, Herrmann W. FEBS Lett. 2009 Apr 17;583(8):1215-25.
21. Hyperhomocysteinemia Is Associated with Impaired Fracture Healing in Mice. Claes L, Schmalenbach J, Herrmann M, Olkü I, Garcia P, Histing T, Obeid R, Schorr H, Herrmann W, Pohlemann T, Menger MD, Holstein JH. Calcif Tissue Int. 2009 Jun 17. [Epub ahead of print]
22. Holotranscobalamin in laboratory diagnosis of cobalamin deficiency compared to total cobalamin and methylmalonic acid. Obeid R, Herrmann W. Clin Chem Lab Med. 2007;45(12):1746-50.
23. The role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric diseases. Obeid R, McCaddon A, Herrmann W. Clin Chem Lab Med. 2007;45(12):1590-606.
24. Biomarkers of folate and vitamin B(12) status in cerebrospinal fluid. Herrmann W, Obeid R. Clin Chem Lab Med. 2007;45(12):1614-20.
25. [Review of the role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric disorders--current evidence and preliminary recommendations]. Herrmann W, Lorenzl S, Obeid R. Fortschr Neurol Psychiatr. 2007 Sep;75(9):515-27.
26. Priorities in the discovery of the implications of water channels in epilepsy and Duchenne muscular dystrophy. Obeid R, Herrmann W. Cell Mol Biol (Noisy-le-grand). 2006 Dec 31;52(5):16-20.
27. Clinical validation of a new blood collection tube for the accuracy of total homocysteine measurement by different methods. Bissé E, Epting T, Kögel G, Obeid R, Gempel K, Huzly D, Fuhrmann K, Rolinski B, Herrmann W, Wieland H. Clin Biochem. 2007 Jun;40(9-10):739-43.
28. Folate and methylation status in relation to phosphorylated tau protein(181P) and beta-amyloid(1-42) in cerebrospinal fluid. Obeid R, Kasoha M, Knapp JP, Kostopoulos P, Becker G, Fassbender K, Herrmann W. Clin Chem. 2007 Jun;53(6):1129-36.
29. Hyperhomocysteinaemia: a critical review of old and new aspects. Herrmann W, Herrmann M, Obeid R. Curr Drug Metab. 2007 Jan;8(1):17-31.
30. Biomarkers of folate and vitamin B12 are related in blood and cerebrospinal fluid. Obeid R, Kostopoulos P, Knapp JP, Kasoha M, Becker G, Fassbender K, Herrmann W. Clin Chem. 2007 Feb;53(2):326-33.
31. [Hyperhomocysteinemia and B-vitamin deficiency. Current clinical aspects]. Herrmann W, Herrmann M, Obeid R. Med Monatsschr Pharm. 2006 Aug;29(8):291-302.
32. Cerebrospinal fluid diagnostic markers correlate with lower plasma copper and ceruloplasmin in patients with Alzheimer's disease. Kessler H, Pajonk FG, Meisser P, Schneider-Axmann T, Hoffmann KH, Supprian T, Herrmann W, Obeid R, Multhaup G, Falkai P, Bayer TA. J Neural Transm. 2006 Nov;113(11):1763-9.
33. Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia. Obeid R, Herrmann W. FEBS Lett. 2006 May 29;580(13):2994-3005.
34. The cobalamin-binding proteins transcobalamin and haptocorrin in maternal and cord blood sera at birth. Obeid R, Morkbak AL, Munz W, Nexo E, Herrmann W. Clin Chem. 2006 Feb;52(2):263-9.
35. Altered vitamin B12 status in recreational endurance athletes. Herrmann M, Obeid R, Scharhag J, Kindermann W, Herrmann W. Int J Sport Nutr Exerc Metab. 2005 Aug;15(4):433-41.
36. The vegetarian lifestyle and DNA methylation. Geisel J, Schorr H, Bodis M, Isber S, Hübner U, Knapp JP, Obeid R, Herrmann W. Clin Chem Lab Med. 2005;43(10):1164-9.
37. Concentrations of homocysteine, related metabolites and asymmetric dimethylarginine in preeclamptic women with poor nutritional status. Herrmann W, Isber S, Obeid R, Herrmann M, Jouma M. Clin Chem Lab Med. 2005;43(10):1139-46.
38. Homocysteine, folic acid and vitamin B12 in relation to pre- and postnatal health aspects. Obeid R, Herrmann W. Clin Chem Lab Med. 2005;43(10):1052-7.