Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes
Klinische Chemie und Laboratoriumsmedizin - Zentrallabor
Leitung: Prof. Dr. med Jürgen Geisel, M.A.
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Bei Interesse an Doktorarbeiten wenden Sie sich bitte an: 06841-1630711 oder rima.obeid @uks.eu.

 

Beispiel aktuelle Themen zu vergeben (für medizinische Doktorranden) – Stand April 2017:

  • Systematische Review/Metaanalysen im Bereich Biomarker-Ernährung-und Gesundheit. Mehr zu den Themen erfahren Sie im persönlichen Gespräch. Die Sys. Review ist eine strukturierte Literatur Recherche und ggf. Auswertung. Eine sehr gute English Sprachkenntnisse ist erforderlich. Weiterhin, brauchen Sie bestimmte persönliche Eigenschaften um die Arbeit erfolgreich abzuschließen (z.B. Geduld, eigen Motivation, Organisation, Genauigkeit, etc). Zu der Methodik und Ablauf werden Sie ausführlich eingeleitet.
  • Ein Thema im Bereich ´Social-Determinans of Health´. Für die Arbeit brauchen Sie Vorkenntnisse in der Biometrie und Erfahrung in SPSS, SAS, oder STATA.

Interesse an Master oder Bachelor arbeiten? Hier haben wir auch Themen.

 

General Research topics

  1. Food-, single nutrient-, and drug-induced metabolomic changes
  2. Interaction between nutrients and gut bacteria
  3. Method development and validation of nutritional biomarkers
  4. Post-prandial metabolomics in diagnosing lifestyle diseases
  5. Personalized nutritional supplementation recommendations
  6. Intervention studies with single nutrient or multinutritional supplements – and the effect on metabolism, epigenetics, or clinical endpoints
  7. Diagnosis and treatment of aquired or inherited disorders in C1-metabolism

 

Research methods

Chromatography: GCMS, LCMS/MS, HPLC, immunological assays.

Metaanalysis

Clinical trials

Cost-effectiveness studies

 

Research group / current topics

Astrid Knell: choline and TMAO in relation to lipids metabolism

Regina Tukuhole Shivute: Folate & MTHFR, metaanalysis

Tom Przibilla: Plasma and urine biomarkers & disease outcome in renal diseases

Johannes Preiß: Choline metabolism in patients with non-alcoholic liver steatosis

Alexander Jost: Choline metabolism in patients with alcoholic liver diseases

 

Abgeschlossene Promotion Arbeiten

Hussain Awwad, Nicole Klein, Vera Kruse, Kathrin Heucke, Susanne Kirsch, Yannick Rabagny, Kouris Ninios, Jennifer Schlundt, Mariz Kasoha, Achim Schadt, Eva Raabe.

 

Abgeschlossene Bachelor Arbeiten

Shalin Zenk, Sarah Dielmann, Cosima Klein, Frank Hoffmann

 

Ehemalige Stipendiaten:

Ranwa Al-Sayed (Damaskus Universität - DAAD Stipendium- 3 Monate)

Post Doc. Dr. Batool Shannan (Alexander von Humboldt)

Dr. Rasul Aziz (Post.Doc. University of Hawler, Iraq)

 

Publication (since 2014)

Obeid R. Editor of the book “Vitamin B12: advances and insights”, CRC Press, Taylor & Francis Group, LLC. ISBN 9781498706995. Published in January 2017. https://www.crcpress.com/Vitamin-B12-Advances-and-Insights/Obeid/p/book/9781498706995

 

A) Original Papers

1. Pilz S, Hahn A, Schoen C, Wilhelm M, Obeid R. Effect of two different multi-micronutrient supplements on vitamin D status in women of childbearing age: a randomized trial. Nutrient 2017, in Press.
2. Siebert AK*, Obeid R*, Weder S, Awwad HM, Sputtek A, Geisel J, Keller M. Vitamin B-12 fortified toothpaste improves vitamin status in vegans: a 12-week randomized placebo-controlled study. Am J Clin Nutr 2017. DOI: 10.3945/ajcn.116.141978.* Shared first authorship.
3. Awwad HM, Geisel J, Obeid R. Determination of trimethylamine, trimethylamine N-oxide, and taurine in human plasma and urine by UHPLC-MS/MS technique. J Chromatogr B Analyt Technol Biomed Life Sci 2017; DOI: 10.1016/j.jchromb.2016
4. Obeid R, Awwad MH, Keller M, Geisel J. Trimethylamine-N-oxide and its biological variations in vegetarians. Eur J Nutr. 2016. DOI: 10.1007/s00394-016-1295-9.
5. Obeid R, Awwad MH, Kisch SH, Waldura C, Herrmann W, Graeber S, Geisel J. Plasma trimethylamine-N-oxide following supplementation with vitamin D or D plus B-vitamins. Mol Nutr & Food Res. 2016. DOI: 10.1002/mnfr.201600358.
6. Obeid R, Hübner U, Bodis M, Geisel J. Plasma Amyloid Beta 1-42 and DNA Methylation Pattern Predict Accelerated Aging in Young Subjects with Down Syndrome. Neuromolecular Med 2016: 18:593-601.
7. Abuyaman O, Torring N, Obeid R, Nexo E. First trimester serum levels of the soluble transcobalamin receptor, holo-transcobalamin, and total transcobalamin in relation to preeclampsia risk. Scand J Clin Lab Invest 2016;76:641-644.
8. Obeid R, Awwad MH, Rabagny Y, Graeber S, Herrmann W, Geisel J. Plasma trimethylamine N-oxide concentration is associated with choline, phospholipid, and methyl metabolism. Am J Clin Nutr 2016;103:703-11.
9. Awwad MH, Ohlmann CH, Stoeckle M, Aziz R, Geisel J, Obeid R. Disturbed choline-phospholipids inter-conversion in elderly patients with prostate cancer. Biochimie 2016;126:108-14.

10. Weinhold A, Obeid R, Vogt T, Reichrath J. Prospective Investigation of 25(OH)D3 serum concentrations following UVB narrow band phootherapy in patients with psoriasis and atopic dermatitis. Anticancer Res 2016;36:1439-44.

11. Zawada AM, Schneider JS, Michel AI, Rogacev KS, Hummel B, Krezdorn N, Müller S, Rotter B, Winter P, Obeid R, et al. DNA methylation profiling reveals differences in the three human monocyte subsets and identifies uremia to induce DNA methylation changes during differentiation. Epigenetics 2016; 11:259-72.

12. Nillson T, Hurtig-Wennloef A, Sjoestroem M, Herrmann W, Obeid R, Owen JR, Zeisel S. Plasma 1-carbon metabolites and academic achievement in 15-year-old Swedish adolescents. FASEB 2016;30:1683-8.

13. Obeid R, Kirsch SH, Dilmann S, Klein C, Eckert R, et al. Folic acid causes higher prevalence of detectable unmetabolized folic acid in serum than B-complex: a randomized trial. Eur J Nutr 2016;55:1021-28.

14. Obeid R, Geisel J, Herrmann W. Comparison of two methods for measuring methylmalonic acid as a marker for vitamin B12 deficiency. Diagnosis 2015. DOI: 10.1515/dx-2014-0030.

15. Nix WA, Zirwes R, Bangert V, Kaiser RP, Schilling M, Hostalek U, Obeid R. Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy. Diab Res & Clin Pract 2015;107:157-65.

16. Kirsch SH, Herrmann W, Kruse V, Eckert R, Graeber S, Geisel J, Obeid R. One year B-vitamins increases serum and whole blood folate forms and lowers plasma homocysteine in older German. Clin Chem Lab Med 2015;53:445-52.

17. Obeid R, Pietrzik K, Oakley G, Kancherla V, Holzgreve W, Wieser S. Preventable spina bifida and anencephaly in Europe. J Birth Defects Res A 2015:103:763-71.

18. Awwad H, Kirsch HS, Geisel J, Obeid R. Measurement of concentrations of whole blood levels of choline, betaine, and dimethylglycine and their relations to plasma levels. Journal of Chromatography B 2014; 957: 41-5.

19. Zawada A, Rogacev KS, Hummel B, Berg JT, Friedrich A, Roth HJ, Obeid R, et al., S-adenosylhomocysteine is associated with subclinical atherosclerosis and renal function in a cardiovascular low-risk population Atherosclerosis. Atherosclerosis 2014;234:17-22.

20. Dahlhoff C, Worsch S, Sailer M, Hummel BA, Fiamoncini J, Uebel K, Obeid R, et al., Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels. Mol Metab 2014;3:565-80.

B) Other Publications

21. Obeid R, Pietrzik K. Serum Concentrations of Folate and Vitamin B12 and the Risk of Prostate Cancer According to Pooled Data: The Devil Is in the Detail. European Urology 2016. doi: 10.1016/j.eururo.2016.05.024. Letter to the Editor.

22. Obeid R, Oexle K, Rißmann A, Pietrzik K, Koletzko B. Folate status and health: challenges and opportunities. J Perinat Med 2016; 44:281-8.

23. Obeid R, Fedosov S, Nexo E. Cobalamin coenzyme forms are not likely to be superior to cyano- and hydroxyl-cobalamin in prevention or treatment of cobalamin deficiency. Mol Nutr Food Res 2015;59:1364-72.

24. Obeid R. Serum unmetabolized folic acid: the straw that broke the dihydrofolate reductase’s back? J Nutr 2015; 145: 387-90. Invited comment.

25. Obeid R, Koletzko B, Pietrzik K. The unresolved debate on lowering the recommended dietary intake for folate. Clin Nutr 2014;33: 731-2.

26. Obeid R, Koletzko B, Pietrzik K. Critical evaluation of lowering the recommended dietary intake of folate. Clin Nutr 2014;33: 252-9.

27. Obeid R. Metformin causing vitamin B12 deficiency: a guilty verdict without sufficient evidence. Diabetes Care: 2014:37:e22-23.

28. Péter S, Eggersdorfer M, van Asselt D, Buskens E, Detzel P, Freijer K, Koletzko B, Kraemer K, Kuipers F, Neufeld L, Obeid R, et al. Selected nutrients and their implications for health and disease across the lifespan: a roadmap. Nutrient 2014;6:6076-94.