Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes
Klinische Chemie und Laboratoriumsmedizin - Zentrallabor
Leitung: Prof. Dr. med Jürgen Geisel, M.A.
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Forschung

Ansprechpartnerin: Prof (apl.) Rima Obeid

Tel: 06841-1630711, E-Mail: rima.obeid @uks.eu

Bachelor-, Master- und Doktorarbeiten werden regelmäßig vergeben (je nach Kapazität). Wir freuen uns auf Ihre Bewerbung!

Aktuelle Themen (Stand September 2018):

  • Laboranalysen rund um das Thema Nährstoffe & Stoffwechsel Interaktion, Nährstoffe & epigenetische Veränderungen, Entwicklung, Messung und Anwendung von Biomarker (z.B. im Blut oder Urin) in klinische Studien.
  • Systematische Review/Metaanalysen im Bereich Biomarker-Ernährung-und Gesundheit. Die Sys. Review ist eine strukturierte Literatur Recherche und ggf. Auswertung. Eine sehr gute English Sprachkenntnisse ist erforderlich. Weiterhin, brauchen Sie bestimmte persönliche Eigenschaften um die Arbeit erfolgreich abzuschließen (z.B. Geduld, eigen Motivation, Organisation, Genauigkeit, etc). Zu der Methodik und Ablauf werden Sie eingeleitet.

General topics

  • Maternal-child nutrient gradients
  • Food-, single nutrient-, and drug-induced metabolomic changes
  • Interaction between nutrients and gut bacteria
  • Maternal nutrition status and child health outcome
  • Method development, validation, and utility of nutritional biomarkers in clinical studies
  • Post-prandial metabolomics in diagnosing lifestyle diseases
  • Personalized nutritional supplementation recommendations
  • Intervention studies with single nutrient or multinutritional supplements – and the effect on metabolism, epigenetics, or clinical endpoints
  • Diagnosis and treatment of aquired or inherited disorders in C1-metabolism

 

Research methods

Chromatography: GCMS, LCMS/MS, HPLC, immunological assays; metaanalyses; clinical trials; cost-effectiveness studies in the fields mentioned above

Research group / current theses

Open topic

The association between maternal and child vitamin D from birth to the age of 6 years: Systematic review and metaanalysis

Sandra Tillmann (Aarhus, DK)

Effects of probiotics on metabolic and behavioral traits in the host: experimental studies in animals with and without simultaneous dietary modifications

Christian Körber

The association between maternal and child vitamin B12 from birth to the age of 6 years: Systematic review and metaanalysis

Jonas Hans

The association between folate-containing supplements during pregnancy and outcomes other than neural tube defects: congenital heart defects and cleft lip: Systematic review and metaanalysis

Johannes Stein

The association between B-vitamins and pain/neuropathic pain: Systematic review and metaanalysis

N.N. (topic reserved)

Epigenetic DNA methylation in prediction of future disease outcome in patients with renal diseases

N.N. (topic reserved)

Vascular and soluble risk factors as determinants of epigenetic DNA methylation in patients with renal disorders

Astrid Knell

Choline and TMAO in relation to lipids metabolism, hormones, and glucose metabolism

Regina Tukuhole Shivute

Folate status and intake & MTHFR, metaanalysis

Tom Przibilla

Plasma and urine biomarkers & disease outcome in renal diseases

Johannes Preiß

Choline metabolism in patients with non-alcoholic liver steatosis

Abgeschlossene Promotion Arbeiten

Hussain Awwad, Nicole Klein, Vera Kruse, Kathrin Heucke, Susanne Kirsch, Yannick Rabagny, Kouris Ninios, Jennifer Schlundt, Mariz Kasoha, Achim Schadt, Eva Raabe.

 

Abgeschlossene Bachelor Arbeiten

Shalin Zenk, Sarah Dielmann, Cosima Klein, Frank Hoffmann

 

Ehemalige Stipendiaten:

Ranwa Al-Sayed (Damaskus Universität - DAAD Stipendium- 3 Monate)

Post Doc. Dr. Batool Shannan (Alexander von Humboldt)

Dr. Rasul Aziz (Post.Doc. University of Hawler, Iraq)

 

Publication (since 2016)

Book

Obeid R. Editor of the book “Vitamin B12: advances and insights”, CRC Press, Taylor & Francis Group, LLC. https://www.crcpress.com/Vitamin-B12-Advances-and-Insights/Obeid/p/book/9781498706995. ISBN 9781498706995. Published in January 2017.

Other Publications

  1. 1. Obeid R, Awwad HM, Knell AI, Hübner U, Geisel J. Glucose and Fat Tolerance Tests Induce Differential Responses in Plasma Choline Metabolites in Healthy Subjects. Nutrients 2018, 10(9), 1209; https://doi.org/10.3390/nu10091209.
  2. 2. Obeid R, Pietrzik K. Neuralrohrdefekte: Das Veto gegen Folsäure im Mehl sollte überdacht werden. Dtsch Arztebl 2018; 115(27-28): A-1329 / B-1123 / C-1115. https://www.aerzteblatt.de/pdf.asp?id=198957.
  3. 3. Obeid R. Aktuelle Bewertung von Homocystein als Risikofaktor für Demenz. Ernährung & Medizin 2018; 33(01): 13-19. DOI: 10.1055/s-0044-101058. https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0044-101058.pdf
  4. 4. Obeid R, Schön C, Wilhelm W, Pietrzik K, Pilz S. Dietary and lifestyle predictors of folate insufficiency in non-supplemented German women. International Journal of Food Science and Nutrition: 2018 https://doi.org/10.1080/09637486.2018.1511686.
  5. 5. Pilz S, Obeid R, Schwetz V, Trummer C, et al., Hormonal Contraceptive Use Is Associated With Higher Total but Unaltered Free 25-Hydroxyvitamin D Serum Concentrations. J Clin Endocrinol Metab. 2018;103:2385-2391
  6. 6. Awwad HM, Ohlmann CH, Stoeckle M, Geisel J, Obeid R. Serum concentrations of folate vitamers in patients with a newly diagnosed prostate cancer or hyperplasia. Clin Biochem. 2018;56:41-46
  7. 7. Obeid R, Hübner U, Bodis M, Graeber S, Geisel J. Effect of adding B-vitamins to vitamin D and calcium supplementation on CpG methylation of epigenetic aging markers. Nutr Metab Cardiovasc Dis. 2018;28:411-417.
  8. 8. Smith AD, Refsum H, Bottiglieri T, Fenech M, Hooshmand B, McCaddon A , Miller JW, Rosenberg IH, Obeid R. Homocysteine and Dementia:An International Consensus Statement. J Alzheimer Disease. J Alzheimers Dis. 2018;62:561-570.
  9. 9. Obeid R, Schoen C, Wilhelm M, Pilz S, Pietrik K. Response of red blood cell folate to supplementation in non-pregnant women is predictable: a proposal for personalized supplementation. Mol Nutr Food Res. 2018;62(4).
  10. 10. Speckmann B, Schulz S, Hiller F, Hesse D, Schumacher F, Kleuser B, Geisel J, Obeid R, et al., Selenium increases hepatic DNA methylation and modulates one-carbon metabolism in the liver of mice. J Nutr Biochem; 48:112-119.
  11. 11. Obeid R, Schoen C, Wilhelm M, Pietrzik K, Pilz S. The effectiveness of daily supplementation with 400 or 800 µg folate in reaching protective red blood cell folate concentrations in non-pregnant women; a randomized trial. Eur J Nutr. 2018;57(5):1771-1780.
  12. 12. Pilz S, Hahn A, Schoen C, Wilhelm M, Obeid R. Effect of two different multimicronutrient supplements on vitamin D status in women of childbearing age: a randomized trial. Nutrient 2017, Doi: 10.3390/nu9010030.
  13. 13. Siebert AK*, Obeid R*, Weder S, Awwad HM, Sputtek A, Geisel J, Keller M. Vitamin B-12 fortified toothpaste improves vitamin status in vegans: a 12-week randomized placebo-controlled study. Am J Clin Nutr 2017:105:618-625. * Shared first authorship
  14. 14. Awwad HM, Geisel J, Obeid R. Determination of trimethylamine, trimethylamine N-oxide, and taurine in human plasma and urine by UHPLC-MS/MS technique. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Dec 1;1038:12-18.
  15. 15. Obeid R, Awwas HM, Keller M, Geisel J. Trimethylamine-N-oxide and its biological variations in vegetarians. Eur J Nutr 2017;56:2599-2609.
  16. 16. Obeid R, Awwad MH, Kisch SH, Waldura C, Herrmann W, Graeber S, Geisel J. Plasma trimethylamine-N-oxide following supplementation with vitamin D or D plus B-vitamins. Mol Nutr & Food Res. 2016. DOI: 10.1002/mnfr.201600358.
  17. 17. Obeid R, Hübner U, Bodis M, Geisel J. Plasma Amyloid Beta 1-42 and DNA Methylation Pattern Predict Accelerated Aging in Young Subjects with Down Syndrome. Neuromolecular Med 2016;18:593-601.
  18. 18. Abuyaman O, Torring N, Obeid R, Nexo E. First trimester serum levels of the soluble transcobalamin receptor, holo-transcobalamin, and total transcobalamin in relation to preeclampsia risk. The Scandinavian Journal of Clinical & Laboratory Investigation 2016;76:641-644.
  19. 19. Obeid R, Awwad MH, Rabagny Y, Graeber S, Herrmann W, Geisel J. Plasma trimethylamine N-oxide concentration is associated with choline, phospholipid, and methyl metabolism. Am J Clin Nutr 2016;103:703-11.
  20. 20. Awwad MH, Ohlmann CH, Stoeckle M, Aziz R, Geisel J, Obeid R. Disturbed choline-phospholipids inter-conversion in elderly patients with prostate cancer. Biochimie 2016;126:108-14.
  21. 21. Weinhold A, Obeid R, Vogt T, Reichrath J. Prospective Investigation of 25(OH)D3 serum concentrations following UVB narrow band phootherapy in patients with psoriasis and atopic dermatitis. Anticancer Res 2016;36:1439-44.
  22. 22. Zawada AM, Schneider JS, Michel AI, Rogacev KS, Hummel B, Krezdorn N, Müller S, Rotter B, Winter P, Obeid R, et al. DNA methylation profiling reveals differences in the three human monocyte subsets and identifies uremia to induce DNA methylation changes during differentiation. Epigenetics 2016; 11:259-72.
  23. 23. Nillson T, Hurtig-Wennloef A, Sjoestroem M, Herrmann W, Obeid R, Owen JR, Zeisel S. Plasma 1-carbon metabolites and academic achievement in 15-year-old Swedish adolescents. FASEB 2016;30:1683-8.
  24. 24. Obeid R, Kirsch SH, Dilmann S, Klein C, Eckert R, et al. Folic acid causes higher prevalence of detectable unmetabolized folic acid in serum than B-complex: a randomized trial. Eur J Nutr 2016;55:1021-28.

B) Review articles /comments

  1. 25. Obeid R, Pietrzik K. Smoking, B Vitamins, and Lung cancer: The chicken or the egg causality dilemma. Journal of Clinical Oncology 2017 DOI: 10.1200/JCO.2017.75.9472. Letter to the editor to: Brasky et al. Long-Term, Supplemental, One-Carbon Metabolism-Related Vitamin B Use in Relation to Lung Cancer Risk in the Vitamins and Lifestyle (VITAL) Cohort. J Clin Oncol 2017. doi: 10.1200/JCO.2017.72.7735.
  2. 26. Obeid R, Murphy M, Sole-Navais P, Yajnik C. Cobalamin status from pregnancy to early childhood; lessons from global experience. Adv Nutr 2017;8:1–9; doi: https://doi.org/10.3945/an.117.015628.
  3. 27. Obeid R, Pietrzik K. Serum Concentrations of Folate and Vitamin B12 and the Risk of Prostate Cancer According to Pooled Data: The Devil Is in the Detail. European Urology 2016; 70:e133-e134. Letter to the Editor.
    1. 28. Obeid R, Oexle K, Rißmann A, Pietrzik K, Koletzko B. Folate status and health: challenges and opportunities. J Perinat Med 2016; 44:281-8.