Publications
Drittmittel AG Fassbender
EU (Koordinator, Participant)
DFG
BMBF
Thyssen Stiftung
Else Kröne Stiftung
Deutsch Stiftung, Breuer Stiftung
Industriemittel
PUBLICATIONS
Liu Y, Hao W, Dawson A, Liu S, Fassbender K. Expression of ALS-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2. J Biol Chem. 2008 Dec 17. [Epub ahead of print].
Martinez-Torres F, Menon S,? Fassbender K?. et al., Protocol for German trial of Acyclovir and corticosteroids in Herpes-simplex-virus-encephalitis (GACHE): a multicenter, multinational, randomized, double-blind, placebo-controlled German, Austrian and Dutch trial.. BMC Neurol. 2008; 29;8:40
Ludwig N, Keller A, Comtesse N, Rheinheimer S, Pallasch C, Fischer U, Fassbender K, Steudel WI, Lenhof HP, Meese E. Pattern of serum autoantibodies allows accurate distinction between a tumor and pathologies of the same organ. Clin Cancer Res 2008;14:4767-74.
Bose A, Henkes H, Alfke K, Reith W, Mayer TE, Berlis A, Branca V, Sit SP; Henkes H, Lowens S, Jansen O, Alfke K, Reith W, Fassbender K, Grunwald I, Osterhage J, Papanagiotou P, Orberk E, Mayer TE, Muller-Schunk S, Wiesmann M, Bruckmann H, Seelos K, Fesl G, Holtmannspotter M, Dichgans M, Mewald Y, Berlis A, Schumacher M, Niesen WD, Hetzel A, Branca V. The Penumbra System: a mechanical device for the treatment of acute stroke due to thromboembolism. AJNR Am J Neuroradiol. 2008;29:1409-13.Epub 2008 May 22.
Walter S, Letiembre M, Liu Y, Heine H, Penke B, Hao W, Bode B, Manietta N, Walter J, Schulz-Schäffer W, Fassbender K. Role of the Toll-like receptor 4 in neuroinflammation in Alzheimer?s disease. Cell Physiol Biochem 2007; 20(6):947-956.
van den Kommer TN, Dik MG, Comijys HC, Fassbender K, Lüthjohann D, Jonker C. Total colesterol and oxysterols: Early markers for cognitive decline in elderly? Neurobiol Aging 2008, in print.
Letiembre M, Walter S, Liu Y, Fassbender K. Systematic analysis of innate immune receptors in neurodegeneration: Common expression profiles in different neurodegenerative diseases: Neurobiol Ageing 2007; 146(1): 248-54.
Liu Y, Hao W, Letiembre M, Walter S, Kulanga M, Neumann H, Fassbender K. Suppression of microglial proinflammatory activity by myelin phagocytosis: role of reactive oxygen species generation via p47-PHOX. J Neurosci. 2006 Dec 13;26(50):12904-13.
Spiegel J, Hellwig D, Jost WH, Farmakis G, Samnick S, Fassbender K, Kirsch CM, Dillmann U. Cerebral and Extracranial Neurodegeneration are Strongly Coupled in Parkinson's Disease. Open Neurol J. 2007;1:1-4. Epub 2007 Aug 22.
Spiegel J, Hellwig D, Farmakis G, Jost WH, Samnick S, Fassbender K, Kirsch CM, Dillmann U. Myocardial sympathetic degeneration correlates with clinical phenotype of Parkinson's disease. Mov Disord. 2007; 22:1004-8.
Obeid R, Kasoha M, Knapp JP, Kostopoulos P, Becker G, Fassbender K, Herrmann W. Folate and Methylation Status in Relation to Phosphorylated Tau Protein(181P) and {beta}-Amyloid(1-42) in Cerebrospinal Fluid. Clin Chem. 2007; 53: 1129-36.
Zieker J, Zieker D, Jatzko A, Dietzsch J, Nieselt K, Schmitt A, Bertsch T, Fassbender K, Spanagel R, Northoff H, Gebicke-Haerter PJ. Differential gene expression in peripheral blood of patients suffering from post-traumatic stress disorder. Mol Psychiatry. 2007; 12:116-8.
Obeid R, Kostopoulos P, Knapp JP, Kasoha M, Becker G, Fassbender K, Herrmann W. Biomarkers of folate and vitamin B12 are related in blood and cerebrospinal fluid. Clin Chem. 2007; 53:326-33.
Letiembre, M, Hao, W, Liu Y, Mihaljevic I, Rivest S, Fassbender K. Innate immune receptor expression in normal brain ageing. Neuroscience 2007 146:248-54.
Fassbender K, Lutjohann D, Dik MG, Bremmer M, Konig J, Walter S, Liu Y, Letiembre M, von Bergmann K, Jonker C. Moderately elevated plant sterol levels are associated with reduced cardiovascular risk ? The LASA study. Atherosclerosis. 2006 Nov 28; [Epub ahead of print].
Spiegel J, Hellwig D, Samnick S, Jost W, Mollers MO, Fassbender K, Kirsch CM, Dillmann U. Striatal FP-CIT uptake differs in the subtypes of early Parkinson's disease. J Neural Transm. 2006 May 24; [Epub ahead of print]
Ahlhelm FJ, Naumann N, Haass A, Grunwald I, Schulte-Altedorneburg G, Fassbender K, Reith W. Radiologie. 2006:46:905-918
Stroick M, Fatar M, Ragoschke-Schumm A, Fassbender K, Bertsch T, Hennerici MG. Protein S-100B--a prognostic marker for cerebral damage. Curr Med Chem. 2006;13(25):3053-60.
Walter S, Doering A, Letiembre M, Liu Y, Hao W, Diem R, Bernreuther C, Glatzel M, Engelhardt B, Fassbender K. The LPS Receptor, CD14 in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis. Cell Physiol Biochem 2006;17:167-172.
Walter A, Korth U, Hilgert M, Hartmann J, Weichel O, Hilgert M, Fassbender K, Schmitt A, Klein J. Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients. Neurobiol Aging. 2004 Nov-Dec;25(10):1299-303.
Liu Y, Walter S, Stagi M. Cherny D, Letiembre M, Schulz-Schaeffer W, Heine J, Penke B, Neumann H, Fassbender K. LPS receptor (CD14): a receptor for phagocytosis of Alzheimer´s amyloid peptide. Brain 2005 128:1778-89.
Spiegel J, Hellwig D, Mollers MO, Behnke S, Jost W, Fassbender K, Samnick S, Dillmann U, Becker G, Kirsch CM. Transcranial sonography and [123I]FP-CIT SPECT disclose complementary aspects of Parkinson's. disease. Brain 2006 Mar 2; [Epub ahead of print]
Lutjohann D, Stroick M, Bertsch T, Kuhl S, Lindenthal B, Thelen K, Andersson U, Bjorkhem I, Bergmann Kv K, Fassbender K. High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs. Steroids. 2004;69:431-8.
Lingor P, Boetticher D, Baehr M, Fassbender K. Paraneoplastic polymyosits in recurring adrenal gland carcinoma. Lancet Neurology 2003;2:435-436.
Fassbender K, Walter S, Kühl S, Landmann R, Ishi K, Bertsch T, Stalder AK, Muehlhauser F, Liu Y, Ulmer AJ, Rivest S, Lentschat A, Gulbins E, Jucker M, Staufenbiel M, Brechtel K, Walter J, Multhaup G, Penke B, Adach Y, Hartmann T, Beyreuther K. The LPS Receptor (CD14) links Innate Immunity with Alzheimer`s Disease. FASEB J 2004 18:203-5.
Bettina Schreiner, Meral Esen, Heike Grassme, Klaus Fassbender, Erich Gulbins. Acid sphingomyelinase is involved in internalisation of Staphylococcus aureus into human endothelial cells. Biochem. Biophys. Res. Commun in print.
Zingler VC, Krumm B, Bertsch T, Fassbender K, Pohlmann-Eden B. Early prediction of neurological outcome after cardiopulmonary resuscitation: a multimodal approach combining neurobiochemical and electrophysiological investigations may provide high prognostic certainty in patients after cardiac arrest. Eur Neurol 2003;49:79-84.
Fassbender K, Walter S, Liu Y, Muehlhauser F, Ragoschke A, Kühl S, Mielke O. Mobile stroke unit for hyperacute stroke treatment. Stroke 2003;34:epub44.
Fassbender K, Walter S, Gulbins E, Rieschel M, Herten M, Bertsch T, Engelhardt B. Glycosylation processing inhibition by castanospermine prevents experimental autoimmune encephalomyelitis by interference with IL-2 receptor signal transduction. J Neuroimmunol 2002;132:1-10.
Fassbender K, Stroick M, Bertsch T, Ragoschke A, Kühl S, Walter S, Walter J, Brechtel K, Muehlhauser F, von Bergmann K, Lütjohann D. Effects of statins on human cerebral cholesterol metabolism and secretion of Alzheimer amyloid peptide. Neurology 2002;59:1257-8.
Fassbender K, Ragoschke A, Kühl S, Fatar M, Back W, Bertsch T, Kreisel S, Hennerici M. Inflammatory leukocyte infiltration in focal cerebral ischemia: unrelated to infarct size. Cerebrovasc Dis 2002;13:198-203.
Lindenthal B, Bertsch T, Fassbender K, Stroick M, Kühl S, Lütjohann D, Von Bergmann K. Influence of simvastatin, pravastatin and BM 15.766 on neutral sterols in liver and testis of guinea pigs. Metabolism 2002;51:492-9.
Aufenanger J, Samman M, Quintel M, Fassbender K, Zimmer W, Bertsch T. Pancreatic phospholipase A2 activity in acute pancreatitis: a prognostic marker for early identification of patients at risk. Clin Chem Lab Med 2002;40:293-7.
Bertsch T, Zimmer W, Casarin W, Denz C, Quintel M, Fassbender K. Real-time PCR assay with fluorescent hybridization probes for rapid interleukin-6 promotor (-174G-->C) genotyping. Clin Chem 2001;47:1873-74.
Fassbender K, Simons M, Bergmann C, Stroick M, Lütjohann D, Keller P, Runz H, Kühl S, von Bergmann K, Hennerici M, Beyreuther K, Hartmann T. Simvastatin strongly reduces Alzheimer`s disease A?42 and A?40 levels in vitro and in vivo. Proc Natl Acad Sci USA 2001;98:5856-5861.
Bertsch T, Mielke O, Holy S, Zimmer W, Casarin W, Aufenanger J, Walter S, Muehlhauser F, Kühl S, Ragoschke A, Fassbender K. Homocysteine in cerebrovascular disease: an independent risk factor for subcortical vascular encephalopathy. Clin Chem Lab Med 2001;39:721-4.
Esen M, Schreiner B, Jendrossek V, Lang F, Fassbender K, Grassme H, Gulbins E. Mechanisms of Staphylococcus aureus induced apoptosis of human endothelial cells. Apoptosis 2001;6:431-9.
Muehlhauser F, Liebl U, Kuehl S, Walter S, Bertsch T, Fassbender K. Aggregation-dependent interaction of the Alzheimer`s beta-amyloid and microglia. Clin Chem Lab Med 2001;39:313-316.
Bertsch T, Casarin W, Kretschmar M, Zimmer W, Walter S, Sommer C, Muehlhauser F, Ragoschke A, Kühl S, Schmidt R, Eden BP, Nichterlein T, Nassabi C, Fassbender K. Protein S100 B: a serum marker for ischemic and infectious injury of cerebral tissue. Clin Chem Lab Med 2001;39:313-316.
Bertsch T, Denz C, Janke C, Weiss M, Fassbender K, Luiz T, Ellinger K, Krieter H. Hypertonic-hyperosmotic solutions decrease cardiac troponin I concentrations in peripheral blood in a porcine ischemia-reperfusion model. Exp Toxicol Pathol 2001;53:153-156.
Bertsch T, Kuehl S, Muehlhauser F, Walter S, Hodapp B, Rossol S, Schmeck J, Ragoschke A, Schütt S, Frizinger M, Horn P, Vajkoczy P, Wellner MW, Fassbender K. Source of endothelin-1 in subarachnoid hemorrhage. Clin Chem Lab Med 2001;39:341-345.
Esen M, Grassmé H, Riethmueller J, Riehle A, Fassbender K, Gulbins E. Invasion of human epithelial cells by Pseudomonas aeruginosa involves Src-like tyrosine kinases p60Src and p59Fyn. Immun Infect 2001;69:281-287.
Fassbender K, Hodapp B, Rossol S, Bertsch T, Schmeck J, Schütt S, Fritzinger M, Horn P, Vajkoczy P, Brunner J, Schmiedeck P, Hennerici M. Inflammatory cytokines in subarachnoid hemorrhage: association with abnormal blood flow velocities in basal cerebral arteries. J Neurol Neuropsych Neurosurg 2001;70:534-537.
Fassbender K, Hodapp B, Rossol S, Bertsch T, Schmeck J, Schütt S, Fritzinger M, Horn P, Vajkoczy P, Wendel-Wellner M, Brunner J, Schürer L, Schmiedeck P, Hennerici M. Endothelin-1 in Subarachnoid Hemorrhage: an Acute-Phase Reactant Produced by CSF-Leukocytes. Stroke 2000;31:2971-2975.
Ishii K, Muelhauser F, Liebl U, Picard M., Penke B, Bayer T, Hennerici M, Hartmann T, Beyreuther, K, Fassbender K. Subacute NO-generation induced by Alzheimer's ?-amyloid in the living brain: reversal by inhibition of the inducible NO synthase. FASEB J 2000;14:1485-1489.
Fassbender K, Fatar M, Ragoschke A, Picard A, Hennerici M. Subacute but not acute generation of nitric oxide in focal cerebral ischemia. A microdialysis study. Stroke 2000;31:2208-2211.
Wildgruber D, Kischka U, Fassbender K, Ettlin TM. A frontal lobe score: evaluation of its clinical validity. Clin Rehabil 2000;14:272-278.
Fassbender K, Masters C, Beyreuther K. Alzheimer?s disease: An inflammatory disease? Neurobiol Aging 2000;21:433-436, discussion 451-453.
Fassbender K, Schneider S, Bertsch T, Schlueter D, Fatar M, Ragoschke A, Kuehl S, Kischka U, Hennerici M. Temporal profile of release of interleukin-1? in neurotrauma: an in vivo microdialysis study. Neurosci Lett 2000;284:135-138.
Fassbender K, Mielke O, Bertsch T, Hennerici M. Homocysteine and cerebrovascular disease. Stroke 1999;30:2238-2248.
Fassbender K, Dempfle CE, Mielke O, Schwartz A, Daffertshofer M, Eschenfelder C, Dollman M, Hennerici M. Changes in markers of coagulation and fibrinolysis in acute ischemic stroke treated with recombinant tissue-type plasminogen activator (rt-PA). Stroke 1999; 30:2101-2104.
Fassbender K, Mielke O, Bertsch T, Hennerici M. Homocysteine in cerebral microangiopathy. Lancet 1999;354:1029-1030.
Fassbender K, Mielke O, Bertsch T, Nafe B, Fröschen S, Hennerici M. Homocysteine in cerebral macro- and micro-angiopathy. Lancet 1999;353:1586-1587. (Research Letter).
Fassbender K, Mielke O, Bertsch T, Muehlhauser F, Hennerici M, Kurimoto M, Rossol S. Interferon-?-inducing factor/IL-18 and interferon- ? in inflammatory CNS diseases. Neurology 1999;53:1104-1106.
Fassbender K, Bertsch T, Mielke O, Mühlhauser F, Hennerici M. Adhesion molecules in cerebrovascular diseases: Evidence for an inflammatory endothelial activation in cerebral large- and small-vessel disease. Stroke 1999;30:1647-1650.
Fassbender K, Kaptur S, Becker P, Gröschel J, Schmidt R, Hennerici M. Inverse association between glucocorticoid secretion and L-selectin (CD62L) expression in trauma patients: indications for a negative feed-back control of Inflammatory leukocyte recruitment. Life Sci 1999;65:2471-2480.
Fassbender K, Kaptur S, Becker P, Gröschel J, Hennerici M. Adhesion molecules in tissue injury: Kinetics of expression and shedding and association with cytokine release in humans. Clin Immunol Immunopathol 1998;89:545-60.
Fassbender K, Eschenfelder C, Hennerici M. Fas (Apo-1/Cd95) in inflammatory CNS diseases: intrathecal release in bacterial meningitis. J Neuroimmunol 1999;93:122-125.
Knauber J, Kischka U, Roth M, Schmidt WJ, Hennerici M, and Fassbender K. NMDA receptor-mediated acethylcholine release in the rat striatum: an in vivo microdialysis study. J Neural Transmiss 1999;106:35-40.
Sobieska M, Fassbender K, Aeschlimann A, Bourgeois P, Mackiewicz S, Muller W. Still`s disease in children and adults: a distinct pattern of acute-phase proteins. Clin Rheumatol 1998;17:258-260.
Fassbender K, Ragoschke A, Rossol S, Schwartz A, Mielke O, Paulig A, Hennerici M. Increased release of interleukin-12p40 in multiple sclerosis: association to intracerebral inflammation. Neurology 1998;51:753-758.
Fassbender K, Schmidt R, Mößner R, Kischka U, Kühnen J, Schwartz A, Hennerici M. Mood disorders and dysfunction of the hypothalamic-pituitary-adrenal- (HPA-) axis in multiple sclerosis: association with cerebral inflammation. Arch Neurol 1998;55:66-72.
Fassbender K, Dempfle CE, Mielke O, Rossol S, Schneider S, Dollman M, Hennerici M. Proinflammatory cytokines: indicators of infections in high risk patients. J Lab Clin Med 1997;130:535-539.
Fassbender K, Schminke U, Ries S, Ragoschke A. Hennerici M. Endothelial-derived adhesion molecules in bacterial meningitis: association to cytokine release and intrathecal leukocyte-recruitment. J Neuroimmunol 1997;74:130-134.
Fassbender K, Schmidt R, Fatar M, Mühlhauser F, Hennerici M. Leakage of brain-originated proteins in peripheral blood: temporal profile and diagnostic value in early ischemic stroke?. J Neurol Sci 1997;148:101-105.
Fassbender K, Samborsky W, Kellner M, Müller W, Lautenbacher S. Tender points, depressive and functional symptoms. Comparision between fibromyalgia and major depression. Clin Rheumatol 1997;16:76-79.
Ries S, Schminke U, Fassbender K, Daffertshofer M, Steinke W, Hennerici M. Cerebrovascular involvement in the acute phase of bacterial meningitis. J Neurol 1997:244:51-55.
Mößner R, Fassbender K, Kühnen J, Schwartz A, Hennerici M. Circulating L-selectin in multiple sclerosis patients with active, gadolinium-enhancing brain plaques. J Neuroimmunol 1996;65:61-65
Mößner R, Fassbender K, Kühnen J, Schwartz A, Hennerici M. Vascular cell adhesion molecules - an new approach to detect endothelial cell activation in MS and in encephalitis in vivo. Acta Neurol Scand 1996;93: 118-122.
Fassbender K, Ries S, Schminke U, Schneider S, Hennerici M. Inflammatory cytokines in CSF in bacterial meningitis: association with altered blood flow velocities in basal cerebral arteries. 1996;61:57-61.
Fassbender K, Mößner R, Motsch L, Kischka U, Grau A, Hennerici M. Circulating selectin- and immunoglobulin-type adhesion molecules in acute ischemic stroke. Stroke 1995;26:1361-1364. (selected for ?Atherosclerosis Current Review?, Synergy Int. Inc., Japan)
Fassbender K, Fassbender M, Schaberg T, Sobieska M, Müller W. Glycosylation of alpha-1 acid glycoprotein in bacterial lung infections. Distinct pattern in tuberculosis. Clin Chem 1995:41:472-473.
Kellner M, Fassbender K, Backmund H, Möller A. Familial persenile dementia with motor neuron disease. J Clin Psychiatry 1994;55:496-497
Lautenbacher S, Roscher S, Strian DM, Fassbender K, Krumrey K, Krieg JC. Pain perception in depression: relationship to symptomatology and naloxone-sensitive mechanisms. Psychosom Med 1994;56:345-352.
Fassbender K, Schmidt R, Mößner R, Daffertshofer M, Hennerici M. Activation of hypothalamic-pituitary-adrenal-axis in hyperacute stroke: Pattern of response and relation to clinical characteristics. Stroke1994;25: 1105-1108.
Fassbender K, Rossol S, Kammer T, Daffertshofer M, Wirth S, Hennerici M. Kinetics of proinflammatory cytokines following acute stroke: relation to extent of brain damage and disease. J Neurol Sci 1994;122:135-139.
Kellner M, Strian F, Fassbender K, Kennerknecht J, Klein R. Organic personality syndrome, pontocerebellar atrophy, and anti-CNS antibodies in DIDMOAD (Wolfram) syndrome. Br J Psychiatr 1994;164:132-133.
Pollmächer T, Schreiber W, Gudewill S, Vedder H, Fassbender K, Wiedemann K, Galanos C, Holsboer F. The influence of endotoxin on nocturnal sleep in male humans. Am J Physiol 1994, 264:R1077-1083.
Fassbender K, Gerber B, Karrer U, Sobieska M, Aeschlimann A, Müller W. Glycosylation of acute phase proteins and interleukins following hip arthroplasty. Acta Orthop Scand 1993;64:212-215. (selected for "Digest in Rheumatology and Orthopedics 1994").
Fassbender K, Parrger H, Müller W, Zimmerli W. Interleukin-6 and acute phase protein concentrations in surgical intensive care unit patients: Diagnostic signs in nosocomial infection. Crit Care Med 1993;21:1175-1180.
Schreiber W, Pollmächer T, Fassbender K, Gudewill S, Vedder H, Wiedemann K, Galanos C, Holsboer F. Endotoxin and corticotropin-releasing hormone (CRH)- induced release of ACTH and cortisol: A comparative study in human males. Neuroendocrinology 1992;517:1-6.
Gudewill S, Pollmächer T, Vedder H, Schreiber W, Fassbender K, Holsboer F. Nocturnal plasma levels of cytokines in healthy men. Eur Arch Psychiatry Clin Neurosci 1992;242:53-56.
Fassbender K, Michels H, Zepp F, Zimmerli W, Aeschlimann A, Mackiewicz A, Truckenbrodt H, Müller W. Distinct patterns of glycosylation of alpha1-acid glycoprotein in acute bacterial infection and systemic onset juvenile rheumatoid arthritis/Still's disease. J Rheumatol 1992;20:123-127.
Karrer U, Aeschlimann A, Fassbender K, Vogt P, Muller W. Interleukin-6, soluble interleukin-2 receptor and microheterogeneity of alpha-1 acid glycoprotein: new markers of the acute phase reaction. Schweiz Med Wochenschr 1992;122:233-236.
Aeschlimann A, Pawlowski T, Fassbender K, Mackiewicz SH, Muller W. Alpha-1 acid glycoprotein in differential diagnosis of rheumatic diseases. Med Klin 1991;86:491-7.
Fassbender K, Zimmerli W, Kissling R, Sobieska M, Aeschlimann A, Kellner M, Müller W. Glycosylation of alpha1-acid glycoprotein in relation to duration of disease in acute and chronic infection and inflammation. Clin Chim Acta 1991;203:315-328.
Thonar EJ, Feist S, Fassbender K, Lenz ME, Matijevitch BL, Kuettner KE. Quantification of hen egg white lysozyme in cartilage by an enzyme-linked immunosorbent assay. ConnTiss Res 1988;17:181-188.