Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes
Lehrstuhl für Experimentelle Orthopädie und Arthroseforschung
Univ.-Prof. Dr. Henning Madry
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Publikationen (seit 2000)

 

 

 

 

Gao, L., Orth, P., Cucchiarini, M., Madry, H. Autologous Matrix-induced Chondrogenesis - A Systematic Review of the Clinical Evidence, Am J Sports Med, 2017, accepted. Impact-Faktor: 5,673

 

Rey-Rico, A., Venkatesan, J.K., Schmitt, G., Concheiro, A., Madry, H., Alvarez-Lorenzo, C., Cucchiarini, M. rAAV-mediated overexpression of TGF-β via vector delivery in polymeric micelles stimulates the biological and reparative activities of human articular chondrocytes in vitro and in a human osteochondral defect model. International Journal of Nanomedicine, 2017, 12:6985-6996. Impact-Faktor: 4,3

 

Fickert, S. Aurich, M., Albrecht, D., Angele, P., Büchler, L., Dienst, M., Erggelet, C., Fitz, J., Gebhart, C., Gollwitzer, H., Kindler, M., Lampert, C., Madry, H., Möckel, G., Niemeyer, P., Schröder, J., Sobau, C., Spahn, G., Zinser, W., Landgraeber, S. Biologische Rekonstruktion lokallisiert vollschichtiger Knorpelschäden des Hüftgelenks: Empfehlungen der Arbeitsgemeinschaft „Klinische Geweberegeneration“ der DGOU und des Hüftkomitees der AGA, Z Orthop Unfall, 2017, DOI 10.1055/s-0043-116218. Impact-Faktor:  0,618

 

Goebel, L., Reinhard, J., Madry, H. Meniscal lesion: A pre-osteoarthritic condition of the knee joint. Der Orthopäde, 2017, doi: 10.1007/s00132-017-3462-y. Impact-Faktor:  0,629

 

Gao, L., Orth, P., Cucchiarini, M., Madry, H. Effects of solid acellular Type-I/III collagen biomaterials on in vitro and in vivo chondrogenesis of mesenchymal stem cells. Expert Rev Med Devices, 2017,  doi: 10.1080/17434440.2017.1368386. Impact-Faktor: 2,228

 

Ikeda, Y., Sakaue, M., Chijimatsu, R., Hart, D.A., Otsubo, H., Shimomura, K., Madry, H., Suzuki, T., Yoshikawa, H., Yamashita, T., Nakamura, N. IGF-1 Gene Transfer to Human Synovial MSCs Promotes Their Chondrogenic Differentiation Potential without Induction of the Hypertrophic Phenotype. Stem Cells Int. 2017, 2017:5804147. doi: 10.1155/2017/5804147. Impact-Faktor: 3,54

 

Rey-Rico, A., Babicz, H., Madry, H., Concheiro, A., Alvarez-Lorenzo, C., Cucchiarini, M. Supramolecular polypseudorotaxane gels for controlled delivery of rAAV vectors in human mesenchymal stem cells for regenerative medicine. Int J Pharm, 2017, doi: 10.1016/j.ijpharm.2017.05.050. Impact-Faktor: 3,994

 

Rey-Rico, A., Cucchiarini, M. Smart and controllable rAAV gene delivery carriers in progenitor cells for human musculoskeletal regenerative medicine with a focus on the articular cartilage. Curr Gene Ther, 2017, doi: 10.2174/ 1566523217666170510162459. Impact-Faktor: 2,738

 

Friedman, J.M., Sennett, M.L., Bonadio, M.B., Orji, K.O., Neuwirth, A.L., Keah, N., Carey, J.L., Moutos, F.T., Estes, B.T., Guilak, F., Madry, H., Mauck, R.L., Dodge, G.R. Comparison of Fixation Techniques of 3D-Woven Poly(ε-caprolactone) Scaffolds for Cartilage Repair in a Weight-Bearing Porcine Large Animal Model, Cartilage, 2017, accepted. Impact-Faktor: 1,127

 

Madry, H., Gao, L., Eichler, H., Orth, P., Cucchiarini, M. Bone Marrow Aspirate Concentrate-Enhanced Marrow Stimulation of Chondral Defects, Stem Cells Int, 2017, 2017:1609685. doi: 10.1155/2017/1609685. Impact-Faktor: 3,54

 

Almarza, D., Cucchiarini, M., Loughlin, J. Genome editing for human osteoarthritis - a perspective. Osteoarthritis and Cartilage, 2017, doi: 10.1016/j.joca.2017.05.003. Impact-Faktor: 4,535

 

Venkatesan, J.K., Frisch, J., Rey-Rico, A., Schmitt, G., Madry, H., Cucchiarini, M. Impact of mechanical stimulation on the chondrogenic processes in human bone marrow aspirates modified to overexpress sox9 via rAAV vectors, J Exp Orthop, 2017, 4(1):22.

 

Frisch, J., Orth, P., Rey-Rico, A., Venkatesan, J.K., Schmitt, G., Madry, H., Kohn, D., Cucchiarini M. Peripheral blood aspirates overexpressing IGF-I via rAAV gene transfer undergo enhanced chondrogenic differentiation processes. J Cell Mol Med, 2017, doi: 10.1111/jcmm.13190. Impact-Faktor: 4,938

 

Gao, L., Orth, P., Müller-Brandt, K., Goebel, L., Cucchiarini, M., Madry, H. Early loss of subchondral bone following microfracture is counteracted by bone marrow aspirate in a translational model of osteochondral repair, Scientific Reports, 7, 45189, doi: 10.1038/srep45189 (2017). Impact-Faktor: 5,228

 

Bonadio, M.B., Friedman, J.M., Sennett, M.L., Mauck, R.L., Dodge, G.R., Madry, H. A retinaculum-sparing surgical approach preserves porcine stifle joint cartilage in an experimental animal model of cartilage repair, J Exp Orthop, 2017, 4(1):11.

 

Cucchiarini, M. New cell engineering approaches for cartilage regenerative medicine, Biomed Mater Eng, 2017, 28(s1):S201-S207. Impact-Faktor: 0,7

 

Abat, F., Alfredson, H., Cucchiarini, M., Madry, H., Marmotti, A., Mouton, C., Oliveira, J.M., Pereira, H., Peretti, G.M., Romero-Rodriguez, D., Spang, C., Stephen, J., van Bergen, C.J.A., de Girolamo, L. Current trends in tendinopathy: consensus of the ESSKA basic science committee. Part I: biology, biomechanics, anatomy and an exercise-based approach. J Exp Orthop, 2017, 4(1):18.

 

Frisch, J., Orth, P., Venkatesan, J.K., Rey-Rico, A., Schmitt, G., Kohn, D., Madry, H., Cucchiarini, M. Genetic Modification of Human Peripheral Blood Aspirates Using Recombinant Adeno-Associated Viral Vectors for Articular Cartilage Repair with a Focus on Chondrogenic Transforming Growth Factor-β Gene Delivery. Stem Cells Translational Medicine, 2017, 6(1): 249-260. Impact-Faktor: 4,247

 

Tao, K., Rey-Rico, A., Frisch, J., Venkatesan, J.K., Schmitt, G., Madry, H., Lin, J., Cucchiarini, M. Effects of combined rAAV-mediated TGF-β and sox9 gene transfer and overexpression on the metabolic and chondrogenic activities in human bone marrow aspirates. Journal of Experimental Orthopaedics, 2017, 4(1): 4.

 

Rey-Rico A, Cucchiarini M, Madry H. Hydrogels for precision meniscus tissue engineering: a comprehensive review. Connective Tissue Research, 2017, 4:1-12. Impact-Faktor: 1,411

 

Goebel, L., Kohn, D., Madry, H. Biological Reconstruction of the Osteochondral Unit After Failed Focal Resurfacing of a Chondral Defect in the Knee. Am J Sports Med, 2016, 44(11):2911-2916. Impact-Faktor: 5,673

 

Minas, T., Biant, L., Brittberg, M., Cole, B., Erggelet, C., Farr, J., Gobbi, A., Gomoll, A.H., Kon, E., Lattermann, C., Madry, H., Nakamura, N., Nehrer, S., Peterson, L., Saris, D., Zaslav, K. ICRS Commentary on the Study by Knutsen et al. Journal of Bone and Joint Surgery (Am), 14 November 2016, jbjs.org/content/98/16/1332.eLetters

 

Gao, L.,  Orth, P., Goebel, L., Cucchiarini, M., Madry, H. A novel algorithm for a precise analysis of subchondral bone alterations. Scientific Reports, 2016, 6, 32982. Impact-Faktor: 5,228

 

Cucchiarini, M., de Girolamo, L., Filardo, G., Oliveira, J.M., Orth, P., Pape, D., Reboul, P. Basic science of osteoarthritis, J Exp Orthop, 2016, 3(1):22.

 

Goebel, L., Orth, P., Cucchiarini, M., Pape, D., Madry, H. Macroscopic cartilage repair scoring of defect fill, integration and total points correlate with corresponding items in histological scoring systems - a study in adult sheep. Osteoarthritis and Cartilage, 2016, 25(4):581-588. Impact-Faktor: 4,535

 

Rey-Rico, A., Madry, H., Cucchiarini, M. Hydrogel-Based Controlled Delivery Systems for Articular Cartilage Repair. Biomed Research International, 2016, 2016:1215263. Impact-Faktor: 2,134

 

Cucchiarini, M. Human gene therapy: novel approaches to improve the current gene delivery systems. Discovery Medicine, 2016, 21 (118):495-506. Impact-Faktor: 3,426

 

Frisch, J., Venkatesan, J.K., Rey-Rico, A., Zawada, A.M., Schmitt, G., Madry, H., Cucchiarini, M. Effects of rAAV-mediated FGF-2 gene transfer and overexpression upon the chondrogenic differentiation processes in human bone marrow aspirates. Journal of Experimental Orthopaedics, 2016, 3(1):16.

 

Orth, P., Madry, H. Knorpeldefekte - Natürlicher Verlauf und autologes Reparaturpotenzial. Arthroskopie, 2016, 29(2): 68-74.

 

Rey-Rico, A., Frisch, J., Venkatesan, J.K., Schmitt, G., Rial-Hermida, I., Taboada, P., Concheiro, A., Madry, H., Alvarez-Lorenzo, C., Cucchiarini, M. PEO-PPO-PEO carriers for rAAV-mediated transduction of human articular chondrocytes in vitro and in a human osteochondral defect model. ACS Applied Materials & Interfaces, 2016, 8(32): 20600-13. Impact-Faktor: 7,145

 

Rey-Rico, A., Klich, A., Cucchiarini, M., Madry, H. Biomedical-grade, high mannuronic acid content (BioMVM) alginate enhances the proteoglycan production of primary human meniscal fibrochondrocytes in a 3-D microenvironment. Scientific Reports, 2016, 6: 28170. Impact-Faktor: 5,228

 

Rey-Rico, A., Cucchiarini, M. Controlled release strategies for rAAV-mediated gene delivery. Acta Biomaterialia, 2016, 29: 1-10. Impact-Faktor: 6,025

 

Madry, H., Orth, P., Cucchiarini, M. Role of the Subchondral Bone in Articular Cartilage Degeneration and Repair. Journal of the American Academy of Orthopaedic Surgeons, 2016, 24(4): e45-6. Impact-Faktor: 2,527

 

Cucchiarini, M., McNulty, A.L., Mauck, R.L., Setton, L.A., Guilak, F., Madry, H. Advances in combining gene therapy with cell and tissue engineering-based approaches to enhance healing of the meniscus. Osteoarthritis and Cartilage, 2016, 24(8): 1330-9. Impact-Faktor: 4,165


Madry, H., Goebel, L., Hoffmann, A., Dück, K., Gerich, T., Seil, R., Tschernig, T., Pape, D. Surgical anatomy of medial open-wedge high tibial osteotomy: crucial steps and pitfalls. Knee Surgery, Sports Traumatology, Arthroscopy, 2016, in press, Impact-Faktor: 3,053

 

Angele, P., Madry, H., Kon, E. Early OA: point of no return or a chance for regenerative approaches. Knee Surgery, Sports Traumatology, Arthroscopy, 2016, 24(6): 1741-2. Impact-Faktor: 3,097


Angele, P., Niemeyer, P., Steinwachs, M., Filardo, G., Gomoll, A.H., Kon, E., Zellner, J., Madry, H. Chondral and osteochondral operative treatment in early osteoarthritis. Knee Surgery, Sports Traumatology, Arthroscopy, 2016, 24(6): 1743-52. Impact-Faktor: 3,097

 

Madry, H., Kon, E., Condello, V., Peretti, G.M., Steinwachs, M., Seil, R., Berruto, M., Engebretsen, L., Filardo, G., Angele, P. Early osteoarthritis of the knee. Knee Surgery, Sports Traumatology, Arthroscopy, 2016, 24(6): 1753-62. Impact-Faktor: 3,097

 

Verdonk, R., Madry, H., Shabshin, N., Dirisamer, F., Peretti, G.M., Pujol, N., Spalding, T., Verdonk, P., Seil, R., Condello, V., Di Matteo, B., Zellner, J., Angele, P. The role of meniscal tissue in joint protection in early osteoarthritis. Knee Surgery, Sports Traumatology, Arthroscopy, 2016, 24(6): 1763-74. Impact-Faktor: 3,097

 

Filardo, G., Kon, E., Longo, U.G., Madry, H., Marchettini, P., Marmotti, A., Van Assche, D., Zanon, G., Peretti, G.M. Non-surgical treatments for the management of early osteoarthritis. Knee Surgery, Sports Traumatology, Arthroscopy, 2016, 24(6): 1775-85. Impact-Faktor: 3,097

 

Kon, E., Ronga, M., Filardo, G., Farr, J., Madry, H., Milano, G., Andriolo, L., Shabshin, N. Bone marrow lesions and subchondral bone pathology of the knee. Knee Surgery, Sports Traumatology, Arthroscopy, 2016, 24(6):1797-814. Impact-Faktor: 3,097

 

Gomoll, A.H., Angele, P., Condello, V., Madonna, V., Madry, H., Randelli, P., Shabshin, N., Verdonk, P., Verdonk, R. Load distribution in early osteoarthritis. Knee Surgery, Sports Traumatology, Arthroscopy, 2016, 24(6): 1815-25. Impact-Faktor: 3,097

 

de Girolamo, L., Kon, E., Filardo, G., Marmotti, A.G., Soler, F., Peretti, G.M., Vannini, F., Madry, H., Chubinskaya, S. Regenerative approaches for the treatment of early OA. Knee Surgery, Sports Traumatology, Arthroscopy, 2016, 24(6): 1826-35. Impact-Faktor: 3,097

 

Felka, T., Rothdiener, M., Bast, S., Uynuk-Ool, T., Zouhair, S., Ochs, B.G., De Zwart, P., Stoeckle, U., Aicher, W.K., Hart, M.L., Shiozawa, T., Grodzinsky, A.J., Schenke-Layland, K., Venkatesan, J.K., Cucchiarini, M., Madry, H., Kurz, B., Rolauffs, B. Loss of spatial organization and destruction of the pericellular matrix in early osteoarthritis in vivo and in a novel in vitro methodology. Osteoarthritis and Cartilage, 2016, 24(7): 1200-9. Impact-Faktor: 4,535

 

Frisch J., Cucchiarini M. Gene- and Stem Cell-Based Approaches to Regulate Hypertrophic Differentiation in Articular Cartilage Disorders. Stem Cells and Development, 2016, accepted. Impact-Faktor: 3,727

 

Niemeyer, P., Albrecht, D., Andereya, S., Angele, P., Ateschrang, A., Aurich, M., Baumann, M., Bosch, U., Erggelet, C., Fickert, S., Gebhard, H., Gelse, K., Günther, D., Hoburg, A., Kasten, P., Kolombe, T., Madry, H., Marlovits, S., Meenen, N.M., Müller, P.E., Nöth, U., Petersen, J.P., Pietschmann, M., Richter, W., Rolauffs, B., Rhunau, K., Schewe, B., Steinert, A., Steinwachs, M.R., Welsch, G.H., Zinser, W., Fritz, J. Autologous chondrocyte implantation (ACI) for cartilage defects of the knee: A guideline by the working group "Clinical Tissue Regeneration" of the German Society of Orthopaedics and Trauma (DGOU). The Knee, 2016, 23(3): 426-35. Impact-Faktor: 1,446

 

Seil, R., Madry, H. The Development of Experimental Orthopedics. German Journal of Sports Medicine, 2016, 67: 101-102. Impact-Faktor: 0,575

 

Rey-Rico, A., Cucchiarini, M. Recent tissue engineering-based advances for effective rAAV-mediated gene transfer in the musculoskeletal system. Bioengineered, 2016, 24: 0, doi: 10.1080/21655979.2016.1187347. Impact-Faktor: 1,676


Tao, K., Rey-Rico, A., Frisch, J., Venkatesan, J. K., Schmitt, G., Madry, H., Lin, J., Cucchiarini, M. rAAV-mediated combined gene transfer and overexpression of TGF-β and SOX9 remodels human osteoarthritic articular cartilage. Journal of Orthopaedic Research, 2016, doi: 10.1002/jor.23228. Impact-Faktor: 2,986

 

Madry H. Translating orthopaedic basic science into clinical relevance. Journal of Experimental Orthopaedics. 2014, 1(1): 5.


Tao, K., Frisch, J., Rey-Rico, A., Venkatesan, J. K., Schmitt, G., Madry, H., Lin, J., Cucchiarini, M. Co-overexpression of TGF-β and SOX9 via rAAV gene transfer modulates the metabolic and chondrogenic activities of human bone marrow-derived mesenchymal stem cells. Stem Cell Research & Therapy, 2016, 7: 20. Impact-Faktor: 3,368

 

Frisch, J., Rey-Rico, A., Venkatesan, J.K., Schmitt, G., Madry, H., Cucchiarini, M. TGF-β gene transfer and overexpression via rAAV vectors stimulates chondrogenic events in human bone marrow aspirates. Journal of Cellular and Molecular Medicine, 2016, 20 (3): 430-440, Impact-Faktor:  4,014

 

Madry, H., Cucchiarini, M. Gene therapy for human osteoarthritis: principles and clinical translation. Expert Opinion On Biological Therapy, 2016, 16 (3): 331-46. Impact-Faktor: 3,743

 

Cucchiarini M., Madry H. The potential of gene transfer for the treatment of osteoarthritis. Regenerative Medicine. 2014, 9(1): 5-8. Impact-Faktor: 2,602

 

Joshi Y, Sória MG, Quadrato G, Inak G, Zhou L, Hervera A, Rathore KI, Elnaggar M, Cucchiarini M, Marine JC, Puttagunta R, Di Giovanni S. The MDM4/MDM2-p53-IGF1 axis controls axonal regeneration, sprouting and functional recovery after CNS injury. Brain. 2015; 138 (Pt 7): 1843-62. Impact-Faktor: 10.226

 

Orth, P., Peifer, C., Goebel, l., Cucchiarini, M., Madry, H. Comprehensive analysis of translational osteochondral repair: Focus on the histological assessment. Progress in Histochemistry and Cytochemistry. 2015, 50(3):19-36. Impact-Faktor: 5,909

 

Orth, P., Duffner, J., Zurakowski, D., Cucchiarini, M., Madry, H. Small-Diameter Awls Improve Articular Cartilage Repair After Microfracture Treatment in a Translational Animal Model. American Journal of Sports Medicine, 2015, 44(1): 209-19. Impact-Faktor: 4,699

 

Díaz-Rodríguez, P., Rey-Rico, A., Madry, H., Landin, M., Cucchiarini, M. Effective genetic modification and differentiation of hMSCs upon controlled release of rAAV vectors using alginate/poloxamer composite systems. International Journal of Pharmaceutics, 2015, 496(2): 614-26. Impact-Faktor: 3,650

 

Frisch, J., Rey-Rico, A., Venkatesan, J.K., Schmitt, G., Madry, H., Cucchiarini, M. rAAV-mediated overexpression of sox9, TGF-β and IGF-I in minipig bone marrow aspirates to enhance the chondrogenic processes for cartilage repair. Gene Therapy, 2015, 23(3): 247-55. Impact-Faktor 3,104

 

Rey-Rico, A., Venkatesan, J. K., Frisch, J., Rial-Hermida, I., Schmitt, G., Concheiro, A., Madry, H., Alvarez-Lorenzo, C., Cucchiarini, M. PEO-PPO-PEO micelles as effective rAAV-mediated gene delivery systems to target human mesenchymal stem cells without altering their differentiation potency. Acta Biomaterialia, 2015, 27: 42-52. Impact-Faktor: 6,025

 

Willie, B.M., Pap, T., Perka, C., Schmidt, C.O., Eckstein, F., Arampatzis, A., Hege, H.C., Madry, H., Vortkamp, A., Duda, G.N. OVERLOAD of joints and its role in osteoarthritis. Towards understanding and preventing progression of primary osteoarthritis. Zeitschrift für Rheumatologie, 2015, 74(7): 618-21. Impact-Faktor: 0,613

 

Frisch, J., Rey-Rico, A., Venkatesan, J.K., Schmitt, G., Madry, H., Cucchiarini, M. Chondrogenic Differentiation Processes in Human Bone Marrow Aspirates upon rAAV-Mediated Gene Transfer and Overexpression of the Insulin-Like Growth Factor I. Tissue Engineering Part A, 2015, 21(17-18): 2460-71. Impact-Faktor: 4,254

 

Orth, P., Madry, H. Advancement of the Subchondral Bone Plate in Translational Models of Osteochondral Repair: Implications for Tissue Engineering Approaches. Tissue Engineering Part B: Reviews, 2015, 21(6): 504-20. Impact-Faktor: 4,254

 

Goebel, L., Müller, A., Bücker, A., Madry, H. High resolution MRI imaging at 9.4 Tesla of the osteochondral unit in a translational model of articular cartilage repair. BMC Musculoskeletal Disorders, 2015, 16:91. Impact-Faktor: 1,717

 

Orth, P., Madry, H. Complex and elementary histological scoring systems for articular cartilage repair. Histology and Histopathology, 2015, 30(8): 911-9. Impact-Faktor: 2,096

 

Madry, H., Ochi, M., Cucchiarini, M., Pape, D., Seil, R. Large animal models in experimental knee sports surgery: focus on clinical translation. Journal of Experimental Orthopaedics, 2015, 2:9.

 

Cucchiarini M, Henrionnet C, Mainard D, Pinzano A, Madry H. New trends in articular cartilage repair. Journal of Experimental Orthopaedics, 2015, 2:8.

 

Niemeyer, P., Uhl, M., Salzmann, G.M., Morscheid, Y.P., Südkamp, N.P., Madry, H. Evaluation and analysis of graft hypertrophy by means of arthroscopy, biochemical MRI and osteochondral biopsies in a patient following autologous chondrocyte implantation for treatment of a full-thickness-cartilage defect of the knee. Archives of Orthopaedic and Trauma Surgery, 2015, 135(6):819-30. Impact-Faktor: 1,597

 

Rey-Rico, A., Venkatesan, J.K., Frisch, J., Schmitt, G., Monge-Marcet, A., Lopez-Chicon, P., Mata, A., Semino, C., Madry, H., Cucchiarini, M. Effective and durable genetic modification of human mesenchymal stem cells via controlled release of rAAV vectors from self-assembling peptide hydrogels with a maintained differentiation potency. Acta Biomaterialia, 2015, 18:118-27. Impact-Faktor: 6,025

 

Cucchiarini, M., Schmidt, K., Frisch, J., Kohn, D., Madry, H. Overexpression of TGF-β via rAAV-Mediated Gene Transfer Promotes the Healing of Human Meniscal Lesions Ex Vivo on Explanted Menisci. American Journal of Sports Medicine, 2015, 43(5):1197-205. Impact-Faktor: 4,362

 

Frisch, J., Venkatesan, J.K., Rey-Rico, A., Schmitt, G., Madry, H., Cucchiarini, M. Determination of the chondrogenic differentiation processes in human bone marrow-derived mesenchymal stem cells genetically modified to overexpress transforming growth factor-β via recombinant adeno-associated viral vectors. Human Gene Therapy, 2014, 25(12):1050-60. Impact-Faktor: 3,755

 

Pape, D., van Heerwaarden, R., Haag, M., Seil, R., Madry, H. Osteotomy techniques close to the knee. Effect on wedge volume and bony contact surface. Der Orthopade, 2014, 43(11):966-75.

 

Cucchiarini, M., Madry, H. Overexpression of human IGF-I via direct rAAV-mediated gene transfer improves the early repair of articular cartilage defects in vivo. Gene Therapy, 2014, 21(9): 811-9. Impact-Faktor: 5,6

 

Goebel, L., Zurakowski, D., Müller, A., Pape, D., Cucchiarini, M., Madry, H.  2D and 3D MOCART scoring systems assessed by 9.4 T high-field MRI correlate with elementary and complex histological scoring systems in a translational model of osteochondral repair. Osteoarthritis and Cartilage, 2014. 22(10): 1386-95. Impact-Faktor: 4,7

 

Rey-Rico, A., Frisch, J., Venkatesan, J.K., Schmitt, G., Madry, H., Cucchiarini, M. Determination of effective rAAV-mediated gene transfer conditions to support chondrogenic differentiation processes in human primary bone marrow aspirates. Gene Therapy, 2014, 22(1): 50-7. Impact-Faktor: 5,6


Frisch, J., Venkatesan, J.K., Rey-Rico, A., Madry, H., Cucchiarini, M. Current progress in stem cell-based gene therapy for articular cartilage repair. Current Stem Cell Research & Therapy, 2014, 10(2): 121-31. Impact-Faktor: 2,861

 

Eldracher, M., Orth, P., Cucchiarini, M., Pape, D., Madry, H. Small subchondral drill holes improve marrow stimulation of articular cartilage defects. American Journal of Sports Medicine, 2014, 42(11): 2741-50. Impact-Faktor: 4,7

 

Frisch, J., Venkatesan, J.K., Rey-Rico, A., Schmitt, G., Madry, H., Cucchiarini M. Influence of insulin-like growth factor I overexpression via recombinant adeno-associated vector gene transfer upon the biological activities and differentiation potential of human bone marrow-derived mesenchymal stem cells. Stem Cell Research & Therapy, 2014, 5(4):103-14. Impact-Faktor: 3,210

 

Madry, H., Cucchiarini, M. Tissue-engineering strategies to repair joint tissue in osteoarthritis: nonviral gene-transfer approaches. Curr Rheum Rep, 2014, 16(10): 450. Impact-Faktor: 2,454

 

Cucchiarini, M., Madry, H. Use of tissue engineering strategies to repair joint tissues in osteoarthritis: viral gene transfer approaches. Curr Rheum Rep, 2014, 16(10): 449. Impact-Faktor: 2,454

 

Madry, H., Ziegler, R., Pape, D., Cucchiarini, M. Structural changes in the lateral tibiofemoral compartment after high tibial osteotomy. Der Orthopäde, 2014, 43 (11): 958-65. Impact-Faktor: 0,665

 

Ziegler, R., Goebel, L., Seidel, R., Cucchiarini, M., Pape, D., Madry, H. Effect of open wedge high tibial osteotomy on the lateral tibiofemoral compartment in sheep. Part III: Analysis of the microstructure of the subchondral bone and correlations with the articular cartilage and meniscus. Knee Surgery, Sports Traumatology, Arthroscopy, 2014, 23(9): 2704-14. Impact-Faktor: 2,676

 

Lopa, S., Madry, H. Bioinspired scaffolds for osteochondral regeneration. Tissue Engineering Part A, 2014, 20(15-16): 2052-76. Impact-Faktor: 4,636

 

Lee, H. P., Kaul, G., Cucchiarini, M., Madry, H. Nonviral gene transfer to human meniscal cells. Part I: Transfection analyses and cell transplantation to meniscus explants. International Orthopaedics, 2014. 38(9): 1923-30. Impact-Faktor: 2,32

 

Lee, H. P., Rey-Rico, A., Cucchiarini, M., Madry, H. Nonviral gene transfer into human meniscal cells. Part II: Effect of three-dimensional environment and overexpression of human fibroblast growth factor 2. International Orthopaedics, 2014, 38(9): 1931-6. Impact-Faktor: 2,32

 

Orth, P., Cucchiarini, M., Wagenpfeil, S., Menger, M.D., Madry, H. PTH [1-34]-induced alterations of the subchondral bone provoke early osteoarthritis. Osteoarthritis and Cartilage, 2014, 22(6): 813-21. Impact-Faktor: 4,26

 

Rey-Rico, A., Venkatesan, J. K., Sohier, J., Moroni, L., Cucchiarini, M., Madry, H. Adapted chondrogenic differentiation of human mesenchymal stem cells via controlled release of TGF-β1 from poly(ethylene oxide)-terephtalate/poly(butylene terepthalate) multiblock scaffolds. J Biomed Mater Res A., 2014, 103(1): 371-83. Impact-Factor: 2.834.

 

Madry, H., Alini, M., Stoddart, M.J., Evans, C., Miclau, T., Steiner, S. Barriers and strategies for the clinical translation of advanced orthopaedic tissue engineering protocols. European Cells and Materials, 2014, 27: 17-21. Impact-Faktor: 4,558

 

Madry, H., Rey Rico, A., Venkatesan, J.K., Johnstone, B., Cucchiarini, M. Transforming growth factor Beta-releasing scaffolds for cartilage tissue engineering. Tissue Engineering Part B Reviews, 2014, 20(2): 106-25, Impact-Faktor: 4,636

 

Kiss, A., Cucchiarini, M., Menger, M.,   Kohn D, Hannig, M., Madry H. Enamel matrix derivative inhibits   proteoglycan production and articular cartilage repair, delays the   restoration of the subchondral bone, and induces changes of the synovial   membrane in a lapine osteochondral defect model in vivo. Journal of Tissue Engineering and Regenerative Medicine, 2014, 8 (1):41-9. Impact-Faktor: 5,199

 

Madry, H., Cucchiarini, M. Advances and challenges in gene-based approaches for osteoarthritis. Journal of Gene Medicine, 2013, 15(10):343-55. Impact-Faktor: 2,16

 

Cucchiarini, M., Madry, H., Guilak, F., Saris, D.B., Stoddart, M.J., Koon Wong, M., Roughley, P. A vision on the future of articular cartilage repair. European Cells and Materials, 2014; 27:12-16. Impact-Faktor: 4,558

 

Orth, P., Rey-Rico, A., Venkatesan, J.K., Madry, H., Cucchiarini, M. Current perspectives in stem cell research for knee cartilage repair. Stem Cells and Cloning: Advances and Applications 2014, 7:1-17. Impact-Factor: 2.66

 

M. Cucchiarini, M., Madry, H., Terwilliger, E. F. Enhanced expression of the central Survival of Motor Neuron (SMN) protein during the pathogenesis of osteoarthritis. Journal of Cellular and Molecular Medicine, 2014, 18(1): 115-24. Impact Factor: 4.753

 

Veith, N.T., Tschernig, T., Histing, T., Madry, H. Plantar Fibromatosis - Topical Review. Foot Ankle Int. 2013 Sep 16. Impact-Faktor: 1,474

 

Venkatesan, J.K., Rey-Rico, A., Schmitt, G., Wezel, A., Madry, H., Cucchiarini, M. rAAV-mediated overexpression of TGF-β stably restructures human osteoarthritic articular cartilage in situ. Journal of Translational Medicine, 2013, 13;11(1):211. Impact-Faktor: 3,46

 

Orth, P., Cucchiarini, M., Kohn, D., Madry, H. Alterations of the subchondral bone in osteochondral repair – translational data and clinical evidence. Eur Cell Mater, 2013, 25:299-316; discussion 314-6. Impact-Faktor: 4,558

 

Orth, P., Meyer, H.L., Goebel, L., Eldracher, M., Ong, M.F., Cucchiarini, M., Madry, H. Improved repair of chondral and osteochondral defects in the ovine trochlea compared with the medial condyle. Journal of Orthopaedic Research, 2013, 31 (11):1772-9. Impact-Faktor: 2,976

 

*Johnstone, B., *Alini, M., *Cucchiarini, M., *Dodge, G. R., *Eglin, D., *Guilak, F., *Madry, H., *Mata, A., *Mauck, R., *Semino, C. E., *Stoddart, M. J. Tissue engineering for articular cartilage repair - the state of the art. Eur Cell Mater, 2013, 25: 248-267. Impact-Faktor: 4,558

 

Orth, P., Zurakowski, D., Alini, M., Cucchiarini, M., Madry, H. Reduction of sample size requirements by bilateral versus unilateral research designs in animal models for cartilage tissue engineering. Tissue Eng Part C, 2013, 19 (11):885-91. Impact-Faktor: 4,636

 

Madry, H., Kaul, G., Zurakowski, D., Vunjak-Novakovic, G., Cucchiarini, M. Cartilage constructs engineered from chondrocytes overexpressing IGF-I improve the repair of osteochondral defects in a rabbit model. Eur Cell Mater, 2013, 25:229-47. Impact-Faktor: 4,558

 

Orth, P., Cucchiarini, M., Zurakowski, D., Menger, M., Kohn D, Madry, H. Parathyroid hormone [1-34] improves articular cartilage surface architecture and integration and subchondral bone reconstitution in osteochondral defects in vivo. Osteoarthritis and Cartilage, 2013, 21 (4):614-24. Impact-Faktor: 4.262

 

Niemeyer P, Andereya S, Angele P, Ateschrang A, Aurich M, Baumann M, Behrens P, Bosch U, Erggelet C, Fickert S, Fritz J, Gebhard H, Gelse K, Günther D, Hoburg A, Kasten P, Kolombe T, Madry H, Marlovits S, Meenen NM, Müller PE, Nöth U, Petersen JP, Pietschmann M, Richter W, Rolauffs B, Rhunau K, Schewe B, Steinert A, Steinwachs MR, Welsch GH, Zinser W, Albrecht D. Autologous Chondrocyte Implantation (ACI) for Cartilage Defects of the Knee: A Guideline by the Working Group "Tissue Regeneration" of the German Society of Orthopaedic Surgery and Traumatology (DGOU). Zeitschrift für Orthopädie und Unfallchirurgie. 2013, 151(1):38-47. Impact-Faktor: 0,522

 

Ziegler, R., Goebel, L., Cucchiarini, M., Pape, D., Madry, H. Effect of open wedge high tibial osteotomy on the lateral tibiofemoral compartment in sheep. Part II: Standard and overcorrection do not cause articular cartilage degeneration. Knee Surgery, Sports Traumatology, Arthroscopy, 2013, 22 (7):1666-77. Impact-Faktor: 2,209

 

Orth, P., Madry, H. A low morbidity surgical approach to the sheep femoral trochlea. BMC Musculoskeletal Disorders, 2013, 14:5. DOI: 10.1186/1471-2474-14-5. Impact-Faktor: 1,58

 

Cucchiarini, M., Orth, P., Madry, H. Direct rAAV SOX9 administration for durable articular cartilage repair with delayed terminal differentiation and hypertrophy in vivo. Journal of Molecular Medicine, 2012, 91(5):625-36. Impact-Faktor: 4,668

 

Madry, H., Kohn, D., Cucchiarini, M. Direct FGF-2 gene transfer via recombinant adeno-associated virus vectors stimulates cell proliferation, collagen production, and the repair of experimental lesions in the human ACL. American Journal of Sports Medicine, 2012, 41 (1):194-202. Impact-Faktor: 3,821

 

Filardo, G., Madry, H., Jelic, M., Roffi, A., Cucchiarini, M., Kon, E. Mesenchymal stem cells for the treatment of cartilage lesions: from preclinical findings to clinical application in orthopaedics. Knee Surgery, Sports Traumatology, Arthroscopy. 2012, 21 (8):1717-29. Impact-Faktor: 2,209

 

Orth, P., Anagnostakos, K., Fritsch, E., Kohn, D., Madry, H. Static winging of the scapula caused by osteochondroma in adults - a case series. Journal of Medical Case Reports, 2012, 6(1):363.

 

Madry, H., Ziegler, R., Orth, P., Goebel, L., Ong, M.F., Kohn, D., Cucchiarini, M., Pape, D. Effect of open wedge high tibial osteotomy on the lateral compartment in sheep. Part I: Analysis of the lateral meniscus. Knee Surgery, Sports Traumatology, Arthroscopy, 2012, 21 (1):39-48. Impact-Faktor: 2,209

 

Cucchiarini, M., Venkatesan, J. K., Ekici, M., Schmitt, G., Madry, H. Human mesenchymal stem cells overexpressing therapeutic genes: from basic science to clinical applications for articular cartilage repair. Bio-Medical Materials and Engineering, 2012, 22 (4):197-208. Impact-Faktor: 1,225

 

Pape, D., Madry, H. The preclinical sheep model of high tibial osteotomy relating basic science to the clinics: standards, techniques and pitfalls. Knee Surgery, Sports Traumatology, Arthroscopy, 2012, 21 (1):228-36. Impact-Faktor: 2,209

 

Orth, P., Cucchiarini, M., Kaul, G., Ong, M.F., Gräber, S., Kohn, D., Madry, H. Temporal and spatial migration pattern of the subchondral bone plate in a rabbit osteochondral defect model. Osteoarthritis and Cartilage, 2012, 20 (10):1161-9. Impact-Faktor: 4,262

 

van Heerwaarden R, Najfeld M, Brinkman M, Seil R, Madry H, Pape D. Wedge volume and osteotomy surface depend on surgical technique for distal femoral osteotomy. Knee Surgery, Sports Traumatology, Arthroscopy, 2012, 21 (1):206-12. Impact-Faktor: 2,209

 

Elsler, D., Schetting, S., Schmitt, G., Kohn, D., *Madry, H., *Cucchiarini, M. Effective, safe nonviral gene transfer to preserve the chondrogenic differentiation potential of human mesenchymal stem cells. Journal of Gene Medicine, 2012, 14 (7):501-11. Impact-Faktor: 3,079

 

*Venkatesan, J.K., *Ekici, M., Madry, H., Schmitt, G., Kohn, D., Cucchiarini, M. SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells. Stem Cell Research & Therapy, 2012, 3 (3):22. Impact-Fakor: 3.210. Editor´s pick.

 

Goebel, L., Orth, P., Müller, A., Zurakowski, D., Bücker, A., Cucchiarini, M., Pape, D., Madry, H. Experimental scoring systems for macroscopic articular cartilage repair correlate with the MOCART score assessed by a high-field MRI at 9.4 T -- comparative evaluation of five macroscopic scoring systems in a large animal cartilage defect model. Osteoarthritis and Cartilage, 2012, 20 (9):1046-55. Impact-Faktor: 4.262

 

*Madry, H., *Venkatesan, J.K., Schmitt, G., Schetting, S., Ekici, M., Kohn, D., Cucchiarini, M. rAAV Vectors as Safe and Efficient Tools for the Stable Delivery of Genes to Primary Human Chondrosarcoma Cells in Vitro and in Situ. Sarcoma, 2012, 2012:347417.

 

Pape, D., Dueck, K., Haag, M., Lorbach, O., Seil, R., Madry, H. Wedge volume and osteotomy surface depend on surgical technique for high tibial osteotomy. Knee Surgery, Sports Traumatology, Arthroscopy, 2012, 21 (1):127-33. Impact-Faktor: 2.209

 

Weimer, A., Madry, H., Venkatesan, J.K., Schmitt, G., Frisch, J., Wezel, A., Jung, J., Kohn, D., Terwilliger, E.F., Trippel, S.B., Cucchiarini, M. Benefits of rAAV-Mediated IGF-I Overexpression for the Long-Term Reconstruction of Human Osteoarthritic Cartilage by Modulation of the IGF-I Axis. Molecular Medicine. 2011 Dec 9. doi: 10.2119/molmed.2011.00371. Impact-Faktor: 5,908

 

Kaul, G., Cucchiarini, M., Remberger, K., Kohn, D., Madry H., Failed cartilage repair for early osteoarthritis defects: a biochemical, histological and immunohistochemical analysis of the repair tissue after treatment with marrow stimulation techniques. Knee Surgery, Sports Traumatology, Arthroscopy, 2011, 20(11):2315-24. Impact-Faktor: 2.209

 

Orth, P., Zurakowski, D., Wincheringer, D., Madry, H. Reliability, reproducibility and validation of five major histological scoring systems for experimental articular cartilage repair in the rabbit model. Tissue Engineering Part C Methods, 18(5):329-39. Impact-Faktor: 4,636

 

Madry, H., Grün, U., Knutsen, G. Cartilage Repair and Joint Preservation: Medical and Surgical Treatment Options. Deutsches Aerzteblatt International 2011; 108(40): 669-77. Impact-Faktor: 2.92

 

Kon, E., Filardo, G., Drobnic, M., Madry, H., Jelic, M., van Dijk, N., Della Villa, S. Non-surgical management of early knee osteoarthritis, Knee Surgery, Sports Traumatology, Arthroscopy. 2011 Oct 25. Impact-Faktor: 2.209

 

Heijink, A., Gomoll, A.H., Madry, H., Drobnič, M., Filardo, G., Espregueira-Mendes, J., Van Dijk, C.N. Biomechanical considerations in the pathogenesis of osteoarthritis of the knee. Knee Surgery, Sports Traumatology, Arthroscopy. 2011 Dec 16. Impact-Faktor: 2.209

 

Orth, P., Goebel, L., Wolfram, U., Ong, M.F., Gräber, S., Kohn, D., Cucchiarini, M., Ignatius, A., Pape, D., Madry, H. Effect of subchondral drilling on the microarchitecture of subchondral bone: analysis in a large animal model at 6 months. American Journal of Sports Medicine, 2011, 40(4):828-36. Impact-Faktor: 3,821

 

Madry, H., Luyten, F., Facchini, A. Biological aspects of early osteoarthritis. Knee Surgery, Sports Traumatology, Arthroscopy, 2011, 20(3):407-22. Impact-Faktor: 2.209

 

Madry, H., Orth, P., Cucchiarini, M. Gene therapy for cartilage repair. Cartilage, 2011, 2(3):201-25.

 

Stratos I, *Madry H, Rotter R, Weimer A, Graff J, Cucchiarini M, Mittlmeier T, Vollmar B. Fibroblast Growth Factor-2-Overexpressing Myoblasts Encapsulated in Alginate Spheres Increase Proliferation, Reduce Apoptosis, Induce Adipogenesis, and Enhance Regeneration Following Skeletal Muscle Injury in Rats. Tissue Eng Part A. 2011, 17(21-22):2867-77. Impact-Faktor: 4,582

 

Madry, H., Cucchiarini, M. Clinical potential and challenges of using genetically modified cells for articular cartilage repair. CMJ, 2011, 52(3):245-61. Impact-Faktor: 1.796

 

Heiligenstein S, Cucchiarini M, Laschke MW, Bohle RM, Kohn D, Menger M, Madry H. In vitro and in vivo characterization of non-biomedical and biomedical grade alginates for articular chondrocyte transplantation. Tissue Eng Part C Methods, 2011, Apr 2. Impact-Faktor: 4,582


Cucchiarini, M., Ekici, M., Schetting, S., Kohn, D., Madry, H. Metabolic activities and chondrogenic differentiation of human mesenchymal stem cells following rAAV-mediated gene transfer and overexpression of fibroblast growth factor 2. Tissue Eng Part A, 2011 Mar 18. Impact-Faktor: 4,582

Heiligenstein, S., Cucchiarini, M., Laschke, M., Bohle, R.M., Kohn, D., Menger, M.D., Madry, H. Evaluation of non-biomedical and biomedical grade alginates for the transplantation of genetically modified articular chondrocytes to cartilage defects in a large animal model in vivo. Journal of Gene Medicine, 2011, 13(4):230-42. Impact-Faktor: 3,079


Orth, P., Kaul, G., Cucchiarini, M., Zurakowski, D., Menger, M.D., Kohn, D., Madry, H. Transplanted articular chondrocytes co-overexpressing IGF-I and FGF-2 stimulate cartilage repair in vivo. Knee Surgery, Sports Traumatology, Arthroscopy, 2011, 2011 Feb 25. Impact-Faktor: 2.209

 

Rübe, C.E., Fricke, A., Widmann, T.A., Fürst, T., Madry, H., Pfreundschuh, M., Rübe, C. Accumulation of DNA Damage in Hematopoietic Stem and Progenitor Cells during Human Aging. PLoS One. 2011; 6(3): e17487. Impact-Faktor: 4,35

 

Cucchiarini, M., Madry, H. Genetic modification of mesenchymal stem cells for cartilage repair. Bio-Medical Materials and Engineering, 2010, 1–9, 1, DOI 10.3233/BME-2010-0625 Impact-Faktor: 1.225

Madry, H., Orth, P., Kaul, G., Zurakowski, D., Menger, M.D., Kohn, D., Cucchiarini, M. Acceleration of articular cartilage repair by combined gene transfer of human insulin-like growth factor I and fibroblast growth factor-2 in vivo. Archives of Orthopaedic and Trauma Surgery, 2010, DOI: 10.1007/s00402-010-1130-3

 

Madry, H., van Dijk, C.N., Mueller-Gerbl, M. The basic science of the subchondral bone. Knee Surgery, Sports Traumatology, Arthroscopy, 2010, 18(4): 419-433. Impact-Faktor: 2.209

Madry, H. The subchondral bone: a new frontier in articular cartilage repair. Knee Surgery, Sports Traumatology, Arthroscopy, 2010, 18(4): 417-418. Impact-Faktor: 2.209

 

Pape, D., Filardo, G., Kon, E., C. van Dijk, C.N., Madry, H. Disease-specific clinical problems associated with the subchondral bone. Knee Surgery, Sports Traumatology, Arthroscopy, 2010, 18(4): 448-462. Impact-Faktor: 2.209

 

Menetrey, J., Unno-Veith, F., Madry, H., van Breuseghem, I. Epidemiology and imaging of the subchondral bone in articular cartilage repair. Knee Surgery, Sports Traumatology, Arthroscopy, 2010, 18(4): 463-471. Impact-Faktor: 2.209

 

Gomoll, A., Madry, H., Knutsen, G., van Dijk, C.N., Seil, R., Brittberg, M., Kon, E. The subchondral bone in articular cartilage repair - Current problems in the surgical management. Knee Surgery, Sports Traumatology, Arthroscopy, 2010, 18(4): 434-447. Impact-Faktor: 2.209

 

Cucchiarini, M., Heiligenstein, S., Kohn, D., Madry, H. Molekulare Werkzeuge zur Wiederherstellung von arthrotischem Knorpel - Wachstumsfaktoren, Transkriptions­faktoren und Signalmoleküle. Der Orthopäde. 2009, 38(11):1063-70. Impact-Faktor: 0,6

 

Cucchiarini, M., Schetting, S., Terwilliger, E.F., Kohn, D., Madry, H. rAAV-mediated overexpression of FGF-2 promotes cell proliferation, survival, and a-SMA expression in human meniscal lesions. Gene Therapy, 2009, 16(11):1363-72. Impact-Faktor: 5,6

 

Cucchiarini, M., Terwilliger, E.F., Kohn, D., Madry, H. Remodelling of human ostaoarthritic cartilage by FGF-2, alone or combined with SOX9 via rAAV gene transfer. Journal of Cellular and Molecular Medicine, 2009, 13(8): 2476-2488. Impact-Faktor: 6.807

 

Madry, H., Molekulare Therapie von traumatischen Knorpeldefekten. Trauma und Berufskrankheit, 2009, 11(Suppl 1):55-59. Impact-Faktor: nicht gelistet

 

Anand AR, Cucchiarini M, Terwilliger EF, Ganju RK. The tyrosine kinase Pyk2 mediates lipopolysaccharide-induced IL-8 expression in human endothelial cells. Journal of Immunology, 2008;180(8):5636-44. Impact-Faktor: 6,0

 

Orth, P., Weimer, A., Kaul, G., Kohn, D., Cucchiarini, M., Madry, H. Analysis of novel nonviral gene transfer systems for gene delivery to cells of the musculoskeletal system. Molecular Biotechnology, 2008, 38 (2):137-144. Impact-Faktor: 1,9

 

Madry, H., Pape, D. Autologe Chondrozytentransplantation. Der Orthopäde, 2008, 37: 756-763. Impact-Faktor: 0,6

 

Madry, H. Autologe und allogene Bindegewebetransplantation - Aktueller Wissensstand. Der Orthopäde, 2008, 37: 733. Impact-Faktor: 0,6

 

Madry, H., Weimer, A., Kohn, D., Cucchiarini, M. Tissue Engineering zur Knorpelreparatur verbessert durch Gentransfer - Aktuelle Forschungsergebnisse und Literaturübersicht. Der Orthopäde, 2007, 36: 236-247.

 

Sohier, J., Hamann, D., Koenders, M., Cucchiarini, M., Madry, H., van Blitterswijk, C., de Groot, K., Bezemer, J.M. Tailored release of TGF-beta 1 from porous scaffolds and potential for cartilage tissue engineering. International Journal of Pharmaceutics, 2007, 6; 332(1-2): 80-89. Impact-Faktor: 2,156

 

Cucchiarini, M., Thurn, T., Weimer, A., Kohn, D., Terwilliger, E.F., Madry, H. Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor sox9. Arthritis and Rheumatism, 2007, 56 (1): 158 ?167. Impact-Faktor: 7,8

 

Madry, H., Prudlo, J., Grgic, A., Freyschmidt, J. Nasu-Hakola disease (PLOSL): Report of Five Cases and Review of the Literature (Review). Clinical Orthopaedics and Related Research, 2007, 454:262-269. Impact-Faktor: 2,161

 

Madry, H., Wilmes, P., Kohn, D., Cucchiarini, M. Gentherapie für traumatische Knorpeldefekte. Physikalische Medizin Rehabilitationsmedizin Kurortmedizin, 2007, 17: 12-19. Impact-Faktor: nicht gelistet

 

Trippel, S.B., Cucchiarini, M., Madry, H., Shi, S., Wang, C. Gene therapy for articular cartilage repair. Journal of Engineering in Medicine (Proc Inst Mech Eng), 2007, 221 (Part H): 451-459. Impact-Faktor: 0,556

 

Cucchiarini, M., Sohier, J., Mitosch, K., Kaul, G., Zurakowski, D., Bezemer, J.M., Kohn, D., Madry, H. Effect of transforming growth factor-ß1 (TGF-ß1) released from a scaffold on chondrogenesis in an osteochondral defect model in the rabbit. Central European Journal of Biology, 2006, 4 (1): 1-18. Impact-Faktor: 0,662

 

Kaul, G., Cucchiarini, M., Arntzen, D., Zurakowski, D., Menger, M.D., Kohn, D., Trippel, S.B., Madry, H. Local stimulation of articular cartilage repair by transplantation of encapsulated chondrocytes overexpressing human fibroblast growth factor 2 (FGF-2) in vivo. Journal of Gene Medicine, 2006, 8 (1): 100-111. Impact-Faktor: 4,6

 

Madry, H., Kohn, D., Cucchiarini, M. Gentherapie in der Orthopädie. Der Orthopäde, 2006, 35: 1193-1204. Impact-Faktor: 0,6

 

Heiligenstein S, Eisfeld K, Sendzik T, Jimenéz-Becker N, Breinig F, Schmitt MJ. Retrotranslocation of a viral A/B toxin from the yeast endoplasmic reticulum is independent of ubiquitination and ERAD. EMBO Journal. 2006;25(20):4717-27. Impact-Faktor: 12,46

 

Madry, H., Kaul, G., Cucchiarini, M., Stein, U., Zurakowski, D., Remberger, K. Menger, M.D., Kohn, D., Trippel, S.B. Enhanced repair of articular cartilage defects in vivo by transplanted chondrocytes overexpressing insulin-like growth factor I (IGF-I). Gene Therapy, 2005, 12 (14): 1171-1179. Impact-Faktor: 5,6

 

Cucchiarini, M., Madry, H., Ma, C., Thurn, T., Zurakowski, D., Menger, M.D., Kohn, D., Trippel, S.B., Terwilliger, E.F. Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2. Molecular Therapy, 2005, 12 (2): 229-238. Impact-Faktor: 7,4

 

Cucchiarini, M., Madry, H. Gene therapy for cartilage defects. Journal of Gene Medicine, 2005, 7 (12): 1495-1509. Impact-Faktor: 4,6

 

Lennerz, C., Madry, H., Ehlhardt, S., Venzke, T., Zang, K.D., Mehraein, Y. Parvovirus B19 related chronic monarthropathy: immunohistochemical detection of virus positive cells within the synovial tissue compartment. Two reported cases. Clinical Rheumatology, 2004, 23 (1): 59-62. Impact-Faktor: 1,0

 

Madry, H., Cucchiarini, M., Kaul, G., Kohn, D., Terwilliger, E.F., Trippel, S.B. Menisci are efficiently transduced by recombinant adeno-associated virus vectors in vitro and in vivo. American Journal of Sports Medicine, 2004, 32 (8): 1860-1865. Impact-Faktor: 3,4

 

Madry, H., Kohn, D. Konservative Therapie der Kniegelenksarthrose. Der Unfallchirurg, 2004, 107: 689-700. Impact-Faktor: 0,6

 

Madry, H. Gentransfer bei Knorpelschäden - aktueller Stand und Zukunftsvisionen. Orthopädische Praxis, 2004, 40 (10): 569-573. Impact-Faktor: nicht gelistet

 

Mehraein, Y., Lennerz, C., Ehlhardt, S., Zang, K.D., Madry, H. Replicative multivirus infection with cytomegalovirus (CMV)-, herpes simplex virus 1(HSV I) -, and parvovirus B19 -, and latent Epstein ? Barr - virus (EBV) - infection in the synovial tissue of a psoriatic arthritis patient. Journal of Clinical Virology, 2004, 31 (1): 25-31. Impact-Faktor: 2,6

 

Madry, H., Emkey, G., Zurakowski, D., Trippel, S.B. Overexpression of human fibroblast growth factor 2 stimulates cell proliferation in an ex vivo model of articular chondrocyte transplantation. Journal of Gene Medicine, 2004, 6 (6): 238-245. Impact-Faktor: 4,6

 

Madry, H. Verbesserte Reparatur von Knorpeldefekten nach Gentransfer von humanem insulinartigen Wachstumsfaktor I (IGF-I) in vivo. Nova Acta Leopoldina (Neue Folge), 2004, 19: 128-131. Impact-Faktor: nicht gelistet

 

Madry, H., Cucchiarini, M., Stein, U., Remberger, K. Menger, M.D., Kohn, D., Trippel, S.B. Sustained transgene expression in cartilage defects in vivo after transplantation of articular chondrocytes modified by lipid-mediated gene transfer in a gel suspension delivery system. Journal of Gene Medicine, 2003, 5 (6): 502-509. Impact-Faktor: 4,6

 

Cucchiarini M, Ren XL, Perides G, Terwilliger EF. Selective gene expression in brain microglia mediated via adeno-associated virus type 2 and type 5 vectors. Gene Therapy. 2003; 10(8):657-67. Impact-Faktor: 5,6

 

Madry, H., Cucchiarini, M., Terwilliger, E.F., Trippel, S.B. Recombinant adeno-associated virus vectors efficiently and persistently transduce chondrocytes in normal and osteoarthritic human articular cartilage. Human Gene Therapy, 2003, 14 (4) 393-402. Impact-Faktor: 5,6

 

Madry, H., Padera, B., Seidel, J., Freed, L., Langer, R., Trippel, S.B., Vunjak-Novakovic, G. Gene transfer of a human insulin-like growth factor-I cDNA enhances tissue engineering of cartilage. Human Gene Therapy, 2002, 13 (13), 1621-1630. Impact-Faktor: 5,6

 

Madry, H., Gentransfer in der Kreuzbandchirurgie - Naturwissenschaftliche Grundlagen und klinische Anwendungsmöglichkeiten (Review). Der Orthopäde, 2002, 31: 799-809. Impact-Faktor: 0,6

 

Madry, H., Zurakowski, D., Trippel, S.B. Overexpression of human insulin-like growth factor-I promotes new tissue formation in an ex vivo model of articular chondrocyte transplantation. Gene Therapy, 2001, 8 (19): 1443-1449. Impact-Faktor: 5,6

 

Madry, H., Reszka, R., Bohlender, J., Wagner, J. Efficacy of cationic-liposome mediated gene transfer to mesangial cells in vitro and in vivo. Journal of Molecular Medicine, 2001, 79 (4), 184-189. Impact-Faktor: 3,3

 

Cucchiarini M, Kammer AR, Grabscheid B, Diepolder HM, Gerlach TJ, Grüner N, Santantonio T, Reichen J, Pape GR, Cerny A. Vigorous peripheral blood cytotoxic T cell response during the acute phase of hepatitis C virus infection. Cell Immunol. 2000;203(2):111-23. Impact-Faktor: 2,25

 

Grüner NH, Gerlach TJ, Jung MC, Diepolder HM, Schirren CA, Schraut WW, Hoffmann R, Zachoval R, Santantonio T, Cucchiarini M, Cerny A, Pape GR. Association of hepatitis C virus-specific CD8+ T cells with viral clearance in acute hepatitis C. J Infect Dis. 2000, 181(5):1528-36. Impact-Faktor: 6,035

 

Madry, H., Trippel, S.B. Efficient lipid-mediated gene transfer to articular chondrocytes. Gene Therapy, 2000, 7 (4): 286-291. Impact-Faktor: 5,6

 

Madry, H., Reszka, R., Bohlender, J., Wagner, J. Efficacy of cationic-liposome mediated gene transfer to mesangial cells in vitro and in vivo. Journal of Molecular Medicine, 2001, 79 (4), 184-189. Impact-Faktor: 3,3

 

Cucchiarini M, Kammer AR, Grabscheid B, Diepolder HM, Gerlach TJ, Grüner N, Santantonio T, Reichen J, Pape GR, Cerny A. Vigorous peripheral blood cytotoxic T cell response during the acute phase of hepatitis C virus infection. Cell Immunol. 2000;203(2):111-23. Impact-Faktor: 2,25

 

Grüner NH, Gerlach TJ, Jung MC, Diepolder HM, Schirren CA, Schraut WW, Hoffmann R, Zachoval R, Santantonio T, Cucchiarini M, Cerny A, Pape GR. Association of hepatitis C virus-specific CD8+ T cells with viral clearance in acute hepatitis C. J Infect Dis. 2000, 181(5):1528-36. Impact-Faktor: 6,035

 

Madry, H., Trippel, S.B. Efficient lipid-mediated gene transfer to articular chondrocytes. Gene Therapy, 2000, 7 (4): 286-291. Impact-Faktor: 5,6

 

 

 

 

* These authors contributed equally.

 

_______________________________________________________________________________________________________________________________________________________

 

 

 

 

 

Herausgeber von Büchern


 

“Regenerative therapy for the musculoskeletal system using recombinant adeno-associated viral vectors“

Herausgeber: Cucchiarini, M., Madry, H. Verlag: Research Signpost. Erscheinungsdatum: 2010. Kapitel:

 

  • Flotte, T. R. "Production of clinical-grade recombinant adeno-associated virus vectors"
  • Robbins, P. D. "Approaches for musculoskeletal gene therapy: an overview"
  • Evans, C. H. "Application of rAAV vectors in clinical trials"
  • Jorgensen, C. "Gene therapy for rheumatoid arthritis“
  • Cucchiarini, M. "Treatment of osteoarthritis via rAAV vectors"
  • Madry, H. "Development of gene-based therapies for articular cartilage defects"
  • Chen, Y. "Potential applications of gene therapy for bone healing"
  • Schwarz, E. M. "Advances in gene delivery for bone allografts"
  • Barry F. P. "Regenerative medicine and engineering using mesenchymal stem cells"
  • Ghivizzani, S. C. "Mesenchymal stem cells for regeneration of the musculoskeletal system"
  • Fu, F. H. "rAAV vectors for soft tissue reconstruction"
  • Kang, J. D. "Application of rAAV vectors for intervertebral disc degeneration"
  • Krebsbach, P. H. "Gene therapy approaches for craniofacial research using rAAV vectors"
  • Huard, J. "Gene therapy for the treatment of muscle disorders"
  • Siegal, G. P. "Therapeutic options using rAAV for orthopedic oncology"

 

 

 

 

“Current concepts on cartilage repair“

Herausgeber: Brittberg, M., Mandelbaum, B, Imhoff, A., Madry, H. Verlag: DJO Publishing / ESSKA. Erscheinungsdatum: 2010. Kapitel:

 

  • Peretti, G. „Basic science of articular cartilage repair“
  • Hannouche, D. „Cell requirements and culture conditions for articular cartilage repair“
  • Handl, M. “ Current status of biomechanical evaluation of articular cartilage repair ”
  • Madry, H. , Cucchiarini, M. “Gene therapy and stem cells used to improve the cartilage repair ”
  • Mainard, D. „Cartilage Tissue Engineering. From animal experiments to clinical use“
  • Richardson, J. „Subchondral bone repair“
  • Kon, E. „Scaffolds for articular cartilage repair“
  • Mandelbaum, B. „Cartilage repair treatment flow charts“
  • Drobnic, M. „Debridement of cartilage lesions“
  • Zaffagnini, S. „The treatment of large degenerative defects“
  • Brittberg, M. “Unloading of the repaired cartilage lesion. Why, when and how”
  • Imhoff, A. “ OATS and Mega OATS. Why, when and how“
  • Gobbi, A. „Platelet-rich plasma for cartilage repair“
  • Almqvist, F. „Allografts and allogeneic chondrocytes for cartilage repair“
  • Knutsen, G. „Microfractures and chondrocyte implantation; their place in the therapy“
  • Slynarski, K. „Bone marrow mesenchymal stem cells for cartilage repair“
  • Marlovitz, S.”How to perform a good MRI evaluation of articular cartilage repair“
  • Brittberg, M. “Failed articular cartilage repair”
  • Van Assche, D. „Rehabilitation after articular cartilage repair I“
  • Risberg, M. „Rehabilitation after articular cartilage repair II“
  • Gobbi, A., Madry, H., Peretti, G. „Future of Cartilage Treatment”

 

 

Buchbeiträge

 

 

 

Goebel, L. Gao, L., Madry, H. Animal Models in Cartilage Repair. In: Cartilage, Volume 3: Repair Strategies und Regeneration. Editor: Grässel, S., Aszódi, A. Publisher: Springer. 2017.

 

Angele, P., Hirschmann, M. T., Kopf, S., Madry, H., Niemeyer, P., Verdonk, P. ICL ESSKA Glasgow 2018 „Meniscus cartilage combined lesions“, 2017

 

Madry, H., Orth, P., Venkatesan, J.K., Tao, K., Goebel, L., Cucchiarini, M. Gene therapy. In: Bio-Orthopedics: a New Approach. Springer-Verlag, 2017

 

Cucchiarini, M., Madry, H. New gene delivery approaches in joint replacement research. In: From Materials towards Biomedical Devices: Joint Prostheses. Editor: Migonney, V. Publisher: World Scientific Publishers. 2016.

 

Niemeyer, P., Steinwachs, M., Madry, H. Komplikationen und Revisionsstrategien nach knorpelregenerativen Eingriffen. In: „Knorpeltherapie“, Herausgeber: Fritz, J.; Albrecht, D., Niemeyer, P. Verlag De Gruyter, 2016

 

Goebel, L., Madry, H. Grundlagen und innovative Ansätze zur Arthrosetherapie. In: Degenerative Gelenkerkrankungen – Fortschritte in der Arthroseforschung. Reihe: Exzellenzforschung in der Medizin, Nr. 8, 12-19. forMED-Verlag 2016. Herausgeber: Windhagen, H., Aldinger, P.R.; Grußwort: Johanna Wanka, Bundesministerin für Bildung und Forschung.

 

Goebel, L., Madry, H. Anatomie der osteochondralen Einheit. In: „Knorpeltherapie“, Herausgeber: Fritz, J.; Albrecht, D., Niemeyer, P. Verlag De Gruyter, 2016

 

Madry, H. Translational aspects of marrow stimulation for cartilage repair. In “ESSKA Instructional Course Lecture 2016 - Recent advances in cartilage repair“, Herausgeber: Zaffagnini S. et al.; Springer-Verlag, 2016

 

Goebel, L., Madry, H. History of Arthroscopy. In “Arthroscopy”, Herausgeber: Dejour, D. et al.; Springer-Verlag, 2016

 

Orth, P., Madry, H. Cartilage repair: microfracture. In “Arthroscopy”, Herausgeber: Dejour D. et al.; Springer-Verlag, 2016

 

Goebel, L., Gao, L., Madry, H. Animal models in cartilage repair. In “Cartilage - Volume 3: Cartilage Repair”, Herausgeber: Grässel, S., Aszodi, A. Springer-Verlag, 2016

 

Zdanowicz, U., Śmigielski, R., Espejo-Reina, A., Espejo-Baena, A., Madry, H. Anatomy and vascularisation. In “European perspective on the meniscus”, Herausgeber: Hulet, C. et al.; Springer-Verlag, 2016

 

Cucchiarini, M., Madry, H. Gene Therapy for Meniscal Repair. In “European perspective on the meniscus”, Herausgeber: Hulet, C. Springer-Verlag, 2016

 

Zaffagnini, S., Cucchiarini, M., de Girolamo, L., Angele, P., Pereira, H., Reis, R.L., Madry, H. Orfei, Zellner, J., Filardo, G. Mesenchymal Cells. In “Surgery of the Meniscus”, Herausgeber: Hulet, C. Springer-Verlag, 2016

 

Verdonk, P., Madry, H. Basic Science on the Meniscus. In “European perspective on the meniscus”, Herausgeber: Hulet, C. Springer-Verlag, 2016

 

Madry, H., Cucchiarini, M. Signalling pathways in osteochondral defect regeneration. In: “A Tissue Regeneration Approach to Bone Repair”. Herausgeber: Zreiqat, H.; Rosen, V.; Dunstan, C. Springer-Verlag, 2015.

 

Kon, E., Menetrey, J., van Dijk, C. N., Filardo, G., Perdisa, F., Andriolo, L., Billières, J., Ruffieux, E., Orth, P., Marcacci, M., Goyal, A., Goyal, D., Madry, H. Subchondral bone and reason for surgery. Instructional Course Lecture 16, ESSKA Instructional Course Lectures. Springer-Verlag, 2014.

 

Madry, H. Kapitel 12: Arthrose. In “Expertise Knie“.Herausgeber: Kohn, D., Thieme-Verlag Stuttgart, 2014

 

Madry, H. Kniegelenk - Knorpeloperationen. In: „Spezielle Orthopädie“. 1. Auflage. Herausgeber: Kohn, D.; Günther, K.P.; Scharf H.P. Elsevier Verlag, München, Kapitel 6.4, 2013

 

Madry, H., Cucchiarini, M. Gentherapie. In: „Forschung in Orthopädie und Unfallchirurgie - Bestandsaufnahme und Ausblick. Weißbuch Forschung in Orthopädie und Unfallchirurgie“ Herausgeber: Deutsche Gesellschaft für Orthopädie und Unfallchirurgie e.V., 1. Auflage. Redaktion: Mittelmeier, W., Josten, C., Siebert, H.R. , Niethard, F.U., Marzi, I., Klüß, D. Deutsche Gesellschaft für Orthopädie und Unfallchirurgie e.V., 1. Auflage, 2013

 

Orth, P., Madry, H. Konservative Therapie der Arthrose. In “Orthopädie und Unfallchirurgie up2date“. (Zeitschriftenreihe zur Fortbildung im Fach Orthopädie und Unfallchirurgie). Herausgeber: Hoffmann, R., Zacher, J. Thieme-Verlag Stuttgart, 2013

 

Madry, H. Das Kniegelenk - Entzündliche Erkrankungen. „Praxis der Orthopädie und Unfallchirurgie“. 1. Auflage. Herausgeber: C.J. Wirth;  W. Mutschler; D. Kohn, T. Pohlemann. Thieme-Verlag Stuttgart, 3. Auflage, 2013

 

Madry, H. Das Kniegelenk - Entzündliche Erkrankungen. In: „Facharztprüfung Orthopädie und Unfallchirurgie, 1000 kommentierte Prüfungsfragen“. Herausgeber: C.J. Wirth und W. Mutschler. Thieme-Verlag Stuttgart, 3. Auflage, 2013

 

Nakamura, N., Rodeo, S., Alini, M., Maher, S., Madry, H., Erggelet, C. Physiology and Pathophysiology of Musculoskeletal Tissues” in: DeLee & Drez’s Orthopaedic Sports Medicine, 4th edition. Editor: Miller and Thompson, 2013

 

Rolauffs B, Albrecht, D. Madry, H., Felka, T. „Was gibt es Neues in der Knorpelchirurgie“. Jahresband „Was gibt es Neues in der Chirurgie? Berichte zur chirurgischen Weiter- und Fortbildung. Berufsverband der Deutschen Chirurgen e.V. in Zusammenarbeit mit der Deutschen Gesellschaft für Chirurgie, den in ihr vertretenen Fachgesellschaften und dem Berufsverband der Deutschen Chirurgen. Verlagsgruppe Hüthig Jehle Rehm GmbH, Unternehmensbereich ecomed Medizin.  Herausgeber: Jenne, J., Königs, Rainer, Südkamp, M., Schröder, W. Kapitel 1.2, Seite 35 – 48, 2013

 

Cucchiarini, M., Madry, H. Gene therapy for human osteoarthritis. In: Osteoarthritis/Book 2. Editor: Qian, C. Publisher: InTech. 2012.

 

Cucchiarini, M., Madry, H. Chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells. In: Regenerative medicine and cell therapy. Editor: Stoltz, J.-F. Publisher: IOS Amsterdam. 2012.

 

Madry, H., Cucchiarini, M. Gene therapy for osteochondral defects. In: Regenerative medicine and cell therapy. Editor: Stoltz, J.-F. Publisher: IOS Amsterdam. 2012.

 

Madry, H. "Development of gene-based therapies for articular cartilage defects" “Regenerative therapy for the musculoskeletal system using recombinant adeno-associated viral vectors“. Herausgeber: Cucchiarini, M., Madry, H. Verlag: Research Signpost

 

Madry, H., Kohn, D. "Pathophysiologie des Knorpels in: „Basisfacharzt Orthopädie / Unfallchirurgie“. Herausgeber: H. P. Scharf et al. Urban & Fischer Verlag, Elsevier GmbH, München, 2008, Kapitel 3

 

Madry, H., Kohn, D. Das Kniegelenk - Entzündliche Erkrankungen. In: Facharztprüfung Orthopädie und Unfallchirurgie. Herausgeber: C.J. Wirth und W. Mutschler. Thieme-Verlag Stuttgart, 2007, 626-631

 

Madry, H., Kohn, D. Das Kniegelenk - Entzündliche Erkrankungen. In: Facharztprüfung Orthopädie und Unfallchirurgie, 1000 kommentierte Prüfungsfragen. Herausgeber: C.J. Wirth und W. Mutschler. Thieme-Verlag Stuttgart, 2007, 149

 

Madry, H. Lipid - mediated gene transfer for cartilage tissue engineering. In: Culture of cells for orthopaedic tissue engineering. Culture of Specialized Cells. Herausgeber: I. Freshney und G. Vunjak-Novakovic. John Wiley & Sons, New York, 2006, 113-127

 

Vunjak-Novakovic, G., Obradovic B., Madry, H., Altman G. and Kaplan D. Bioreactors for Orthopaedic Tissue Engineering. In: Orthopaedic Tissue Engineering: Basic science and practice. Editors: A. I. Caplan and V. Goldberg, New York, NY: Marcel Dekker Inc., 2004, 123-147

 

Madry, H. Arthrose: Operative und rekonstruktive Behandlung. In: Orthopädie und Orthopädische Chirurgie: Knie. Reihenherausgeber: C.J. Wirth und L. Zichner. Bandherausgeber: D. Kohn. Thieme-Verlag Stuttgart, 2004, 367-379.

 

Madry, H., Kohn, D. Die Pridie-Bohrung. Arthrose – Neues über Genese und Therapie. Reihentitel: Münsteraner Streitgespräche. Herausgeber: S. Fuchs. Steinkopf-Verlag Darmstadt, 2004, 133-145.