Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes
Innere Medizin IV - Nieren- und Hochdruckkrankheiten
Leitung: Prof. Dr. Danilo Fliser
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AG 3 - Vascular Biology and Lipoprotein Metabolism

Team members

Prof. Dr. med. Danilo Fliser Principal Investigator 06841/16-23526
Dr. med. Dr. sc. nat. Timo Speer Group Leader

06841/16-21501 oder 15001

Fax: 06841/16-1721503

Scientific Staff

Mira Klug
M. Sc. 06841/16-23542
Dr. Ioannis Petrakis Postdoc 06841/16-23542
Dr. David Schmit
Postdoc 06841/16-23542
Dr. Stefan Schunk
Postdoc 06841/16-23542
Dr. med. Stephen Zewinger Postdoc 06841/16-21503
Sarah Triem M. Sc. 06841/16-23542

Technical Staff

Sophia Klahm Technician 06841/16-23542
Claudia Noll Technician 06841/16-23512

Doctoral Students

Felix Frenzel
cand. med.

Tobias Herter cand. med.

Andreas Jung
cand. med.

Marlene Lehmann cand. med., B.Sc.

Anna Paschen cand. med.
Julia Riffel cand. med.

Gabriel Wernicke cand. med.

Research Topics

  • Regulation of vascular function and regeneration by lipoproteins (high-density lipoproteins, HDL and low-density lipoproteins, LDL)
  • Effects of Chronic Kidney Disease (CKD) on metabolism and vascular function of HDL and LDL
  • Modulation of innate immunity by lipoproteins
  • Remodeling of lipoproteins (lipid and protein modifications) in patients with CKD
  • Regulation of vascular calcification in patients with CKD

External Collaboration

  • University Hospital Zurich, Cardiovascular Center, Cardiology, Zurich, Switzerland
    Prof. Dr. T. F. Lüscher, Prof. Dr. Landmesser
  • University Hospital Zurich, Institute of Clinical Chemistry, Zurich, Switzerland
    Prof. Dr. A. von Eckardstein, Dr. L. Rohrer
  • University Zurich, Institute of Physiology, Zurich, Switzerland
    Prof. Dr. O. Devuyst
  • Great Ormond Street Hospital for Children, London, Great Britain
    Dr. R. Shroff
  • Great Ormond Street Hospital for Children, London, Great Britain
    Prof. Dr. J. Deanfield
  • University Hospital Mannheim, Mannheim Institute of Public Health, Mannheim, Germany
    Prof. Dr. W. März

Internal Collaboration (Saarland University Hospital)

  • Department of Internal Medicine, Cardiology
    Prof. Dr. M. Böhm, Prof. Dr. U. Laufs, Dr. F. Mahfoud
  • Institute of Clinical Chemistry
    Prof. Dr. J. Geisel
  • Institute of Transplantation Immunology
    Prof. Dr. M. Sester
  • Department of Internal Medicine, Pneumology
    Prof. Dr. R. Bahls, Dr. P. Lepper
  • Institute of Biophysics
    Dr. R. Kappl
  • Department of Anaesthesiology
    Prof. Dr. T. Volk, Dr. T. Fink

Experimental techniques

  • Transgenic mouse models, conditional knock-out
  • Small animal models of acute kidney injury and chronic kidney disease
  • In vitro and in vivo modulation of gene expression
  • RT-PCR methods, molecular cloning
  • Metabolic studies of small animals: metabolic cages, special diets
  • Electron-spin resonance spectroscopy (ESR)
  • Immortalized cell lines and primary cell culture models
  • Immunoblotting, immunoprecipitation
  • Immunohistochemistry, cytochemistry
  • Biochemical analyses in rodent samples