Medizinische Fakultät der Universität des Saarlandes
Humangenetik
Leitung: Prof. Dr. Eckart Meese
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2012

Shah AA, Leidinger P, Keller A, Wendschlag A, Meese E, Blin N.
Altered miRNA expression patterns in Tff2 knock-out mice correlate with cellular pathways of neoplastic development and caloric metabolism. Int J Mol Med. 2012 Apr;29(4):637-43. doi: 10.3892/ijmm.2012.881. Epub 2012 Jan 10.

 

Leidinger P, Keller A, Meese E.
MicroRNAs - Important Molecules in Lung Cancer Research. Front Genet. 2011;2:104. Epub 2012 Jan 23.

 

2011

Shah AA, Leidinger P, Keller A, Wendschlag A, Backes C, Baus-Loncar M, Meese E, Blin N.
The intestinal factor Tff3 and a miRNA network regulate murine caloric metabolism. RNA Biol. 2011 Jan 1;8(1). [Epub ahead of print]

 

Leidinger P, Keller A, Borries A, Huwer H, Rohling M, Huebers J, Lenhof HP, Meese E.
Specific peripheral miRNA profiles for distinguishing lung cancer from COPD. Lung Cancer. 2011 Mar 7. [Epub ahead of print]

 

Ehrhardt M, Leidinger P, Keller A, Baumert T, Díez J, Meese E, Meyerhans A.
Profound differences of microRNA expression patterns in hepatocytes and hepatoma cell lines commonly used in hepatitis C virus studies. Hepatology. 2011 Sep 2;54(3):1112-3. doi: 10.1002/hep.24366. Epub 2011 Jun 27. No abstract available.

 

Keller A, Leidinger P, Gislefoss R, Haugen A, Langseth H, Staehler P, Lenhof HP, Meese E.
Stable serum miRNA profiles as potential tool for non-invasive lung cancer diagnosis. RNA Biol. 2011 May-Jun;8(3):506-16. Epub 2011 May 1.

 

Keller A, Harz C, Matzas M, Meder B, Katus HA, Ludwig N, Fischer U, Meese E.
Identification of novel SNPs in glioblastoma using targeted resequencing. PLoS One. 2011;6(6):e18158. Epub 2011 Jun 10.

 

Backes C, Ludwig N, Leidinger P, Harz C, Hoffmann J, Keller A, Meese E, Lenhof HP.
Immunogenicity of autoantigens. BMC Genomics. 2011 Jul 4;12:340.

 

Olsen BB, Fischer U, Rasmussen TL, Montenarh M, Meese E, Fritz G, Issinger OG.
Lack of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is accompanied by increased CK2α' levels. Mol Cell Biochem. 2011 Oct;356(1-2):139-47. Epub 2011 Jul 13

 

Keller A, Leidinger P, Bauer A, Elsharawy A, Haas J, Backes C, Wendschlag A, Giese N, Tjaden C, Ott K, Werner J, Hackert T, Ruprecht K, Huwer H, Huebers J, Jacobs G, Rosenstiel P, Dommisch H, Schaefer A, Müller-Quernheim J, Wullich B, Keck B, Graf N, Reichrath J, Vogel B, Nebel A, Jager SU, Staehler P, Amarantos I, Boisguerin V, Staehler C, Beier M, Scheffler M, Büchler MW, Wischhusen J, Haeusler SF, Dietl J, Hofmann S, Lenhof HP, Schreiber S, Katus HA, Rottbauer W, Meder B, Hoheisel JD, Franke A, Meese E.
Toward the blood-borne miRNome of human diseases. Nat Methods. 2011 Sep 4;8(10):841-3. doi: 10.1038/nmeth.1682.

 

Schmitt J, Heisel S, Keller A, Leidinger P, Ludwig N, Habel N, Furtwängler R, Nourkami-Tutdibi N, Wegert J, Grundy P, Gessler M, Graf N, Lenhof HP, Meese E.
Multicenter study identified molecular blood-born protein signatures for Wilms Tumor. Int J Cancer. 2011 Sep 12. doi: 10.1002/ijc.26419. [Epub ahead of print]

 

Keller A, Backes C, Leidinger P, Kefer N, Boisguerin V, Barbacioru C, Vogel B, Matzas M, Huwer H, Katus HA, Stähler C, Meder B, Meese E.
Next-generation sequencing identifies novel microRNAs in peripheral blood of lung cancer patients. Mol Biosyst. 2011 Dec;7(12):3187-99. Epub 2011 Oct 25.

 

Schmitt J, Keller A, Nourkami-Tutdibi N, Heisel S, Habel N, Leidinger P, Ludwig N, Gessler M, Graf N, Berthold F, Lenhof HP, Meese E.
Autoantibody signature differentiates Wilms tumor patients from neuroblastoma patients. PLoS One. 2011;6(12):e28951. Epub 2011 Dec 16.

 

Backes C, Rurainski A, Klau GW, Müller O, Stöckel D, Gerasch A, Küntzer J, Maisel D, Ludwig N, Hein M, Keller A, Burtscher H, Kaufmann M, Meese E, Lenhof HP.
An integer linear programming approach for finding deregulated subgraphs in regulatory networks. Nucleic Acids Res. 2011 Dec 30. [Epub ahead of print]

 

 

2010

 

Backes C, Meese E, Lenhof HP, Keller A.
A dictionary on microRNAs and their putative target pathways. Nucleic Acids Res. 2010 Mar 18. [Epub ahead of print]

 

Leidinger P, Keller A, Heisel S, Ludwig N, Rheinheimer S, Klein V, Andres C, Staratschek-Jox A, Wolf J, Stoelben E, Stephan B, Stehle I, Hamacher J, Huwer H, Lenhof HP, Meese E.
Identification of lung cancer with high sensitivity and specificity by blood testing.
Respir Res. 2010 Feb 10;11:18

 

Fischer U, Leidinger P, Keller A, Folarin A, Ketter R, Graf N, Lenhof HP, Meese E.
Amplicons on chromosome 12q13-21 in glioblastoma recurrences.
Int J Cancer. 2010 Jun 1;126(11):2594-602.

 

Ludwig N, Keller A, Heisel S, Leidinger P, Rheinheimer S, Andres C, Stephan B, Steudel WI, Donauer E, Graf N, Burgeth B, Weickert J, Lenhof HP, Meese E.
Novel immunogenic antigens increase classification accuracy in meningioma to 93.84%. Int J Cancer. 2010 May 20. [Epub ahead of print]

 

Leidinger P, Keller A, Borries A, Reichrath J, Rass K, Jager SU, Lenhof HP, Meese E.
High-throughput miRNA profiling of human melanoma blood samples. BMC Cancer. 2010 Jun 7;10:262.

 

Heisel S, Habel NC, Schuetz N, Ruggieri A, Meese E.
The YEATS family member GAS41 interacts with the general transcription factor TFIIF. BMC Mol Biol. 2010 Jul 12;11:53.

 

Melchior K, Tholey A, Heisel S, Keller A, Lenhof HP, Meese E, Huber CG.
Protein- versus peptide fractionation in the first dimension of two-dimensional high-performance liquid chromatography-matrix-assisted laser desorption/ionization tandem mass spectrometry for qualitative proteome analysis of tissue samples. J Chromatogr A. 2010 Oct 1;1217(40):6159-68. Epub 2010 Jul 21.

 

Meder B, Keller A, Vogel B, Haas J, Sedaghat-Hamedani F, Kayvanpour E, Just S, Borries A, Rudloff J, Leidinger P, Meese E, Katus HA, Rottbauer W.
MicroRNA signatures in total peripheral blood as novel biomarkers for acute myocardial infarction. Basic Res Cardiol. 2010 Oct 1, 106(1): 13-23.

 

 

Shah AA, Leidinger P, Blin N, Meese E.
miRNA: small molecules as potential novel biomarkers in cancer. Curr Med Chem. 2010;17(36):4427-32. Review.

 

Shah AA, Meese E, Blin N.
Profiling of regulatory microRNA transcriptomes in various biological processes: a review. J Appl Genet. 2010;51(4):501-7. Review.

 

Stempfer R, Syed P, Vierlinger K, Pichler R, Meese E, Leidinger P, Ludwig N, Kriegner A, Nöhammer C, Weinhäusel A.
Tumour auto-antibody screening: performance of protein microarrays using SEREX derived antigens. BMC Cancer. 2010 Nov 16;10:627.

2009

Keller A, Leidinger P, Lange J, Borries A, Schroers H, Scheffler M, Lenhof HP, Ruprecht K, Meese E.
Multiple sclerosis: microRNA expression profiles accurately differentiate patients with relapsing-remitting disease from healthy controls. PLoS One. 2009 Oct 13;4(10):e7440.

  

Ludwig N, Keller A, Heisel S, Leidinger P, Klein V, Rheinheimer S, Andres CU, Stephan B, Steudel WI, Graf NM, Burgeth B, Weickert J, Lenhof HP, Meese E.
Improving seroreactivity-based detection of glioma. Neoplasia. 2009;11(12):1383-9.

 

Keller A, Leidinger P, Borries A, Wendschlag A, Wucherpfennig F, Scheffler M, Huwer H,  Lenhof H-P and Meese E.
miRNAs in lung cancer - Studying complex fingerprints in patient's blood cells by microarray experiments. BMC Cancer 2009, 9:353

 

Keller A, Ludwig N, Heisel S, Leidinger P, Andres C, Steudel WI, Huwer H, Burgeth B, Hein M, Weickert J, Meese E,Lenhof HP.
Large-scale antibody profiling of human blood sera: The future of molecular diagnosis. Informatik-Spektrum, 2009, 32(4): 332

 

Keller A, Ludwig N, Comtesse N, Henn W, Steudel WI, Lenhof HP, Meese E.
Combining gene expression signatures and autoantibody profiles in human meningioma.Gene Ther. 2009, 16:184-189

 

Ruggieri A, Maldener E, Sauter M, Müller-Lantzsch N, Meese E, Fackler OT, Mayer J.
Human endogenous retrovirus HERV-K(HML-2) encodes a stable signal peptide with biological properties distinct from Rec. Retrovirology 2009, 6:17

 

Leidinger P, Keller A, Heisel S, Ludwig N, Rheinheimer S, Klein V, Andres C, Hamacher J, Huwer H, Stephan B, Stehle I, Lenhof HP, Meese E.
Novel autoantigens immunpogenic in COPD patients. Respir Res. 2009, 10: 20

 

Melchior K, Tholey A, Heisel S, Keller A, Lenhof HP, Meese E, Huber CG.
Proteomic study of human glioblastoma multiforme tissue employing complementary two-dimensional liquid chromatography-mass spectrometry-based approaches. J Proteome Res. 2009, Aug. 12

 

Keller A, Backes C, Gerasch A, Kaufmann M, Kohlbacher O, Meese E, Lenhof HP.
A novel algorithm for detecting differentially regulated paths based on Gene SEt Enrichment Analysis. Bioinformatics 2009, Aug. 27


2008

Menzel A, Meese E.
Nutzen für Diagnostik und Therapie. Genetische Polymorphismen beim Prostatakarzinom. Uro-News. 2008, 12: 22-24

 

Heisel SM, Ketter R, Keller A, Klein V, Pallasch CP, Lenhof HP, Meese E.
Increased seroreactivity to glioma-expressed antigen 2 in brain tumor patients under radiation. PLoS ONE. 2008 May 14;3(5):e2164.

 

Leidinger P, Keller A, Ludwig N, Rheinheimer S, Hamacher J, Huwer H, Stehle I, Lenhof HP, Meese E.
Toward an early diagnosis of lung cancer: an autoantibody signature for squamous cell lung carcinoma.Int J Cancer. 2008 Oct 1;123(7):1631-6.

 

Ludwig N, Keller A, Comtesse N, Rheinheimer S, Pallasch C, Fischer U, Fassbender K, Steudel WI, Lenhof HP, Meese E.
Pattern of serum autoantibodies allows accurate distinction between a tumor and pathologies of the same organ.Clin Cancer Res. 2008 Aug 1;14(15):4767-74.

 

Keller A, Ludwig N, Backes C, Romeike BF, Comtesse N, Henn W, Steudel WI, Mawrin C, Lenhof HP, Meese E.
Genome wide expression profiling identifies specific deregulated pathways in meningioma.Int J Cancer. 2008 Nov 11;124(2):346-351

 

Fischer U, Radermacher J, Mayer J, Mehraein Y, Meese E.
Tumor hypoxia: Impact on gene amplification in Glioblastoma. Int. J. Oncol., 2008, 33: 509-515

 

Flockerzi A, Ruggieri A, Frank O, Sauter M, Maldener E, Kopper B, Wullich B, 7, Seifarth W, Müller-Lantzsch N, Leib-Mösch N, Meese E, Mayer J
Expression patterns of transcribed human endogenous retrovirus HERV-K (HML-2) loci in human tissues and the need for a HERV Transcriptome Project. BMC Genomics, 2008, 9: 354

 

Sauter W, Rosenberger A, Beckmann L, Kropp S, Mittelstrass K, Timofeeva M, Wölke G, Steinwachs A, Scheiner D, Meese E, Sybrecht G, Kronenberg F, Dienemann H; The LUCY-Consortium, Chang-Claude J, Illig T, Wichmann HE, Bickeböller H, Risch A.
Matrix Metalloproteinase 1 (MMP1) Is Associated with Early-Onset Lung Cancer. Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1127-1135.

 

Mittelstrass KK, Sauter WW, Rosenberger AA, Illig TT, Timofeeva MM, Klopp NN, Dienemann HH, Meese EE, Sybrecht GG, Woelke GG, Cebulla MM, Degen MM, Morr HH, Drings PP, Groeschel AA, Grosse Kreymborg KK, Haeussinger KK, Hoeffken GG, Schmidt CC, Jilge BB, Schmidt WW, Ko YD, Taeuscher DD, Chang-Claude JJ, Wichmann HE, Bickeboeller HH, Risch AA.
Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene. BMC Cancer. 2008 Apr 23;8(1):113.

 

Fischer U, Keller A, Leidinger P, Deutscher S, Heisel S, Urbschat S, Lenhof HP, Meese E.
A different view on DNA amplifications indicates frequent, highly complex, and stable amplicons on 12q13-21 in glioma. Mol. Cancer Res. 2008 Apr. 6 (4): 576-584

 

Rosenberger A , Illig T , Korb K , Klopp N , Zietemann V , Woelke G , Meese E , Sybrecht G , Kronenberg F , Cebulla M , Degen M , Drings P , Groeschel A , Konietzko N , Grosse Kreymborg K , Haeuszlinger K , Hapffken G , Jilge B , Ko YD , Morr H , Schmidt C , Schmidt EW , Taeuscher D , Bickeboeller H , Wichmann HE .
Do genetic factors protected for early onset lung cancer? A case control study before the age of 50 years. BMC Cancer. 2008 Feb 25; 8 ( 1 ): 60


2007

Fischer U, Meese E.
Glioblastoma multiforme: the role of DSB repair between genotype and phenotype. Oncogene. 2007, 10; 26 ( 56 ): 7809-15 .

 

Flockerzi A, Maydt J, Frank O, Ruggieri A, Maldener E, Seifarth W, Medstrand P, Lengauer T, Meyerhans A, Leib-Mösch C, Meese E, Mayer J.
Expression pattern analysis of transcribed HERV sequences is complicated by ex vivo recombination. Retrovirology. 2007 Jun 6;4:39.

 

Backes C, Keller A, Kuentzer J, Kneissl B, Comtesse N, Elnakady YA, Muller R, Meese E, Lenhof HP.
GeneTrail--advanced gene set enrichment analysis. Nucleic Acids Res . 2007 May 25

 

Keller A, Comtesse N, Ludwig N, Meese E, Lenhof HP.
SePaCS--a web-based application for classification of seroreactivity profiles. Nucleic Acids Res . 2007 May 3

 

Comtesse N, Keller A, Diesinger I, Bauer C, Kayser K, Huwer H, Lenhof HP, Meese E.
Frequent overexpression of the genes FXR1, CLAPM1 and EIF4G located on amplicon 3q26-27 in squamous cell carcinoma of the lung.
Int J Cancer . 2007 Jun 15;120(12):2538-44.

 

Reichrath J, Rech M, Moeini M, Meese E, Tilgen W, Seifert M.
In vitro comparison of the vitamin D endocrine system in 1,25(OH)2D3-responsive and -resistant melanoma cells.
Cancer Biol Ther. 2007 Jan;6(1):48-55.


2006

Brunner E.C., Romeike B.F.M., Jung M., Comtesse N., Meese E.
Altered expression of ß-catenin/E-cadherin in meningiomas. Histopathologie 2006, 49:178-187

 

Mehraein Y, Wagner M, Remberger K, Fuzesi L, Middel P, Kaptur S, Schmitt K, Meese E.
Parvovirus B19 detected in Rosai-Dorfman disease in nodal and extranodal manifestations. J Clin Pathol. 2006 Dec;59(12):1320-6.

 

Radermacher J, Diesel B, Seifert M, Tilgen W, Reichrath J, Fischer U, Meese E.
Expression analysis of CYP27B1 in tumor biopsies and cell cultures. Anticancer Res. 2006 Jul-Aug;26(4A):2683-6.

 

Heubeck B., Wendler O., Bumm K., Schafer R., Muller-Vogt U., Hausler M., Meese E., Iro H., Steinhart H.
Tumor-associated antigenic pattern in squamous cell carcinomas of the head and neck - Analysed by SEREX. Eur. J. Cancer. 2006 Jul 10

 

Keller A., Ludwig N., Comtesse N., Hildebrandt A., Meese E., Lenhof H.P.
A minimally invasive >multiple marker approach allows highly efficient >detection of meningioma tumors. BMC Bioinformatics 2006, 7 :539


2005

Comtesse N., Zippel A., Walle S., Monz D., Backes C. Fischer U., Mayer J., Ludwig N., Hildebrandt, A., Keller A., Steudel W.I., Lenhof H.P., Meese E.
Complex humoral immune response against a benign tumor: Frequent antibody response against specific antigens as diagnostic targets.
Proc. Natl. Acad. Sci USA, 2005, 102: 9601-9606

 

Backes C., Kuentzer J., Lenhof H.P., Comtesse N., Meese E.
GraBCas: a bioinformatics tool for score-based prediction of Caspase- and Granzuyme B-cleavage sites in protein sequences. Nucleic Acid Res. 2005, 1: 33  

 

Lavie L., Kitova M., Maldener E., Meese E., Mayer J.
CpG methylation directly regulates transcriptional activity of the human endogenous retrovirus family HERV-K(HML-2).
Journal of Virology, 2005, 79(2):876-83

Prowald A., Wemmert S., Biehl C., Storck S. Martin T., Henn W., Ketter R., Meese E., Zang K.D., Steudel W.I., Urbschat S.
Interstitial loss and gain of sequences on chromosome 22 in meningiomas with normal karyotype.
International Journal of Oncology, 2005, 26(2): 385-393  

 

Schick, B., Veldung B., Wemmert S., Jung V., Montenarh M., Meese E., Urbschat S.
p53 and Her-2/neu in juvenile angiofibromas.
Oncol. Rep. 2005, 13(3): 453-457  

 

Flockerzi S, Burkhardt S, Schempp W, Meese E, Mayer J
The human endogenous retrovirus HERV-K14 families: status, variants, evolution and mobilization of other cellular sequences.Journal of Virology, 2005, 79(5): 2941-2949  

 

Mayer J., Meese E.
Human endogenous retroviruses in the primate lineage and their influence on host genomes. (Review)
Cytogenetic and Genome Research, 2005, 110: 448-456  

 

Diesel B., Radermacher J., Bureik M., Bernhardt R., Seifert M., Reichrath J., Fischer U., Meese E.
Vitamin D(3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol.Clinical Cancer Research, 2005, 11(15): 5370-5380  

 

Fischer U., Michel A., Meese E.
Expression of the gene for hematopoietic cell specific protein is not restricted to cells of hematopoietic origin.
International Journal of Molecular Medicine, 2005, 15: 611-615  

 

Mayer J., Stuhr T., Reus K., Maldener E., Kitova M., Asmus F., Meese, E.
Haplotype analysis of the human endogenous retrovirus locus HERV-K(HML-2.HOM) and its evolutionary implications.
Journal of Molecular Evolution, 2005, in press

 

Pallasch C., Struss A.-K., Munnia A., König J., Steudel, W.-I., Fischer U., Meese E.
Autoantibodies against GLEA2 and PHF3 in glioblastoma: Tumor-associated autoantibodies correlated with prolonged survival.International Journal of Cancer, 2005, 456-459

 

Wemmert S., Ketter R., Rahnenführer J., Beerenwinkel, N., Strowitzki M., Feiden W., Hartmann C., Lengauer T., Stockhammer F., Zang K.D.,Meese E., Steudel W.-I., von Deimling A., Urbschat S.
Patients with high grade gliomas harboring deletions of chromosomes 9p and 10q benefit from temozolomide treatment.Neoplasia, 2005, accepted

 

Seifert M., Diesel B., Meese E.
Expression of 25-hydroxyvitamin D-3-1 alpha-hydroxylase in malignant melanoma: implications of growth control via local synthesis of 1.25(OH)(2)D-3 and detection of multiple splice variants.
Exp. Dermatol. 2005, 14(2): 153-154


2004

Mayer J., Ehlhardt S. Seifert M., Sauter M., Mller-Lantzsch N., Mehraein Y., Zang K.D., Meese E.
Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.
Virology, 2004, 322(1): 190-198

 

Lavie L., Medstrand P., Schempp W., Meese E., Mayer J.
The human endogenous retrovirus family HERV-K(HML-5) status, evolution and reconstruction of an ancient betaretrovirus in the human genome.
Journal of Virology, 2004, 78(16): 8788-8798

 

Dönnes P., Höglund A., Sturm M., Comtesse N., Backes C., Meese E., Kohlbacher O., Lenhof H-P.
Integrative analysis of cancer-related data using CAP.
FASEB, 2004, Page 1-16

 

Lavie L., Maldener E., Brouha B., Meese, E., Mayer J.
The human L1 promoter: variable transcription initiation sites and a major impact of upstream flanking sequence on promoter activity.
Genome Research, 2004, Nov.; 14(11): 2253-2260

 

Diesel B., Seifert M., Rademacher J., Fischer U., Tilgen W. Reichrath J., Meese E.
Towards a complete picture of splice variants of the gene for 25-Hydroxyvitamin D3-1alpha-hydroxylase in brain and skin cancer.
J Steroid Biochem & Mol Biol, 2004, 89-90: 527-532

 

Klein A., Reichardt W., Jung V., Zang K.D., Meese E., Urbschat S.
Overexpression and amplification of STK15 in human gliomas.
Int. Journal of Oncology, 2004, 25: 1789-1794

 

Mitschele T., Diesel B., Friedrich M., Meineke V., Maas R.M., Gärtner B.C., Kamradt J., Meese E., Tilgen W., Reichrath J.
Analyis of the Vitam D System in Basal Cell Carcinomas (BCCs). Lab Invest, submitted


2003

Diesel B., Fischer U., Meese E.
Gene amplification and splice variants of 25-hydroxyvitamin 1, alpha-hydroxylase (CYP27B1) in glioblastoma multiforme possible role in tumor progression?
Recent Results Cancer Res, 2003, 164: 151-155

 

Mayer J., Meese E.
Presence of dUTPase in human endogenous retrovirus K (HERV-K) families.
J Mol Evol, 2003; 57: 642-649

 

Menges M., Michaeli B., Pueschel W., Zeitz M., Meese E.
The influrence of the suppression of gastrooesophageal reflux on the gene expression pattern in Barrett's esophagus.
Int J Oncology 20: 1323-1329


2002

Diesinger I, Bauer C, Brass N, Schaefers HJ, Comtesse N, Sybrecht G, Meese E.
Toward a more complete recognition of immunoreactive antigens in squamous cell lung carcinoma.
Int J Cancer. 2002 Dec 1;102(4):372-8.

 

Mayer J, Meese EU.
The human endogenous retrovirus family HERV-K(HML-3).
Genomics. 2002 Sep;80(3):331-43.

 

Jung A, Maier R, Vartanian JP, Bocharov G, Jung V, Fischer U, Meese E, Wain-Hobson S, Meyerhans A.
Multiply infected spleen cells in HIV patients.
Nature. 2002 Jul 11;418(6894):144.

 

Armbruester V, Sauter M, Krautkraemer E, Meese E, Kleiman A, Best B, Roemer K, Mueller-Lantzsch N.
A novel gene from the human endogenous retrovirus K expressed in transformed cells.
Clin Cancer Res. 2002 Jun;8(6):1800-7.

 

Menges M, Michaeli B, Pueschel W, Zeitz M, Meese E.
The influence of the suppression of gastrooesophageal reflux on the gene expression pattern in Barrett's oesophagus.
Int J Oncol. 2002 Jun;20(6):1323-9.

 

Bauer C, Brass N, Diesinger I, Kayser K, Grasser FA, Meese E.
Overexpression of the eukaryotic translation initiation factor 4G (eIF4G-1) in squamous cell lung carcinoma.
Int J Cancer. 2002 Mar 10;98(2):181-5.

 

Comtesse N, Niedermayer I, Glass B, Heckel D, Maldener E, Nastainczyk W, Feiden W, Meese E.
MGEA6 is tumor-specific overexpressed and frequently recognized by patient-serum antibodies.
Oncogene. 2002 Jan 10;21(2):239-47.

 

Meese E, Comtesse N.
Cancer genetics and tumor antigens: time for a combined view?
Genes Chromosomes Cancer. 2002 Feb;33(2):107-13. Review.

 

Debernardi S, Bassini A, Jones LK, Chaplin T, Linder B, de Bruijn DR, Meese E, Young BD.
The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex.
Blood. 2002 Jan 1;99(1):275-81.

 

Fischer U, Schutz N, Hemmer D, Meese E.
GAS64, the first amplified and putative non-translated gene.
Int J Oncol. 2002 Jan;20(1):173-6.

 

Diesel A., Meese E.
Functional study on splice variants of the gene encoding the P450 cytochrome 25-hydroxyvitamin D-3, 1, alpha-hydroxylase (CYP 27B1).
Anti Cancer Drugs 2002, 13(5): A18-A18


2001

Steinhart H, Bohlender JE, Constantinidis J, Urbschat S, Fischer U, Iro H, Pahl S, Meese E.
Genetic imbalances in preinvasive tissue of hypopharynx provide evidence for cytogenetic heterogeneity.
Oncol Rep. 2001 Nov-Dec;8(6):1229-31.

 

Reus K, Mayer J, Sauter M, Zischler H, Muller-Lantzsch N, Meese E.
HERV-K(OLD): ancestor sequences of the human endogenous retrovirus family HERV-K(HML-2).
J Virol. 2001 Oct;75(19):8917-26.

 

Fischer U, Struss AK, Hemmer D, Michel A, Henn W, Steudel WI, Meese E.
PHF3 expression is frequently reduced in glioma.
Cytogenet Cell Genet. 2001;94(3-4):131-6.

 

Fischer U, Hemmer D, Heckel D, Michel A, Feiden W, Steudel WI, Hulsebos T, Meese E.
KUB3 amplification and overexpression in human gliomas.
Glia. 2001 Oct;36(1):1-10.

 

Munnia A, Schutz N, Romeike BF, Maldener E, Glass B, Maas R, Nastainczyk W, Feiden W, Fischer U, Meese E.
Expression, cellular distribution and protein binding of the glioma amplified sequence (GAS41), a highly conserved putative transcription factor.
Oncogene. 2001 Aug 9;20(35):4853-63.

 

Bauer C, Diesinger I, Brass N, Steinhart H, Iro H, Meese EU.
Translation initiation factor eIF-4G is immunogenic, overexpressed, and amplified in patients with squamous cell lung carcinoma.
Cancer. 2001 Aug 15;92(4):822-9.

 

Comtesse N, Reus K, Meese E.
The genetic complexity of the MGEA6 multigene familiy with an active locus on 14q and at least nine pseudogenes on different chromosomes.
Genomics. 2001 Jul;75(1-3):43-8

 

Stru�A-K, Romeike B F M, Munnia A, Nastainczyk W, Steudel W-I, K�ig J, Ohgaki H, Feiden W, Fischer U, Meese E.
PHF3-specific antibody responses in over 60% of patients with glioblastoma multiforme
Oncogene. 2001 Jul 12;20(31):4107-14.

 

Reus K, Mayer J, Sauter M, Scherer D, Mueller-Lantzsch N, Meese E.
Genomic organization of the human endogeneous retrovirus HERV-K(HML-2.HOM)
(ERVK6) on chromosome 7
Genomics 2001, 72:314-320.

 

Comtesse N, Maldener E, Meese E.
Identification of a nuclear variant of MGEA6, a cytoplasmic hyaluronidase a beta-N- Acetylglucosaminidase.
Biochem Biophys Res Commun. 2001 May 11; 283(3):634-40

 

Monz D, Munnia A, Comtesse N, Fischer U, Steudel W-I, Feiden W, Glass B, Meese E.
Novel Tankyrase-related gene detected with meningioma specific sera.
Clin Cancer Res 2001 Jan;7(1):113-9

 

Wissenbach U, Niemeyer BA, Fixemer T, Schneidewind A, Trost C, Cavalie A, Reus K, Meese E, Bonkhoff H, Flockerzi V.
Expression of CaT-like, a novel calcium-selective channel, correlates with the malignancy of prostate cancer.
J Biol Chem. 2001 Jun 1;276(22):19461-8. Epub 2001 Feb 02.

 

Maas RM, Reus K, Diesel B, Steudel WI, Feiden W, Fischer U, Meese E
Amplification and expression of splice variants of the gene encoding the p450 cytochrome 25-hydroxyvitamin d(3) 1, alpha-hydroxylase (cyp 27b1) in human malignant glioma.
Clin Cancer Res 2001, Apr; 7(4):868-75.

 

Fischer U., Struss A.K., Hemmer D., Pallach C.P., Steudel W.I., Meese E.
Glioma-expressed antigen 2 (GLEA2):  a novel protein that can elicit immune responses in glioblastoma patients and some controls
Clin Exp. Imm. 2001, 126(2): 206-213


2000

Sattler HP, Lensch R, Rohde V, Zimmer E, Meese E, Bonkhoff H, Retz M, Zwergel T, Bex A, Stoeckle M, Wullich B.
Novel amplification unit at chromosome 3q25-q27 in human prostate cancer.
Prostate. 2000 Nov 1;45(3):207-15.

 

Comtesse N, Heckel D, Maldener E, Glass B, Meese E.
Probing the human natural autoantibody repertoire using an immunoscreening approach.
Clin Exp Immunol. 2000 Sep;121(3):430-6.

 

Racz A, Brass N, Hofer M, Sybrecht GW, Remberger K, Meese EU.
Gene amplification at chromosome 1pter-p33 including the genes PAX7 and ENO1 in squamous cell lung carcinoma.
Int J Oncol. 2000 Jul;17(1):67-73.


1999

Comtesse N, Heckel D, Racz A, Brass N, Glass B, Meese E.
Five novel immunogenic antigens in meningioma: cloning, expression analysis, and chromosomal mapping.
Clin Cancer Res. 1999 Nov;5(11):3560-8.

 

Michel A, Fischer U, Meese E.
A reticulon gene localized on chromosome 2 encodes a protein with increased autoimmunogenic properties in pilocytic astrocytoma patients. Electronic Journal of Pathology and Histology 1999; Vol 5.3, 993-07

 

Racz A., Brass N., Meese E.
Correlation between genetic lesions and immune responses in human tumors demonstrated for the translation initiation factor eIF-4gamma in squamous cell lung carcinoma. Nowotwory, 1999, 49, Suppl. 1: 60-62

 

Racz A, Brass N, Heckel D, Pahl S, Remberger K, Meese E.
Expression analysis of genes at 3q26-q27 involved in frequent amplification in squamous cell lung carcinoma.
Eur J Cancer. 1999 Apr;35(4):641-6.

 

Subke F, Pusch C, Schroder K, Meese E, Blin N.
Assessing chromosome 22 microdeletions in meningioma with new polymorphic DNA markers.
Oncol Rep. 1999 Sep-Oct;6(5):1147-9.

 

Brass N, Racz A, Bauer C, Heckel D, Sybrecht G, Meese E.
Role of amplified genes in the production of autoantibodies.
Blood. 1999 Apr 1;93(7):2158-66.

 

Mayer J, Sauter M, Racz A, Scherer D, Mueller-Lantzsch N, Meese E.
An almost-intact human endogenous retrovirus K on human chromosome 7.
Nat Genet. 1999 Mar;21(3):257-8.


1998

Loetscher M, Loetscher P, Brass N, Meese E, Moser B.
Lymphocyte-specific chemokine receptor CXCR3: regulation, chemokine binding and gene localization.
Eur J Immunol. 1998 Nov;28(11):3696-705.

 

Heckel D, Comtesse N, Brass N, Blin N, Zang KD, Meese E.
Novel immunogenic antigen homologous to hyaluronidase in meningioma.
Hum Mol Genet. 1998 Nov;7(12):1859-72.

 

Mayer J, Meese E, Mueller-Lantzsch N.
Human endogenous retrovirus K homologous sequences and their coding capacity in Old World primates.
J Virol. 1998 Mar;72(3):1870-5.

 

Brass N, Heckel D, Meese E.
Comparative PCR: an improved method to detect gene amplification.
Biotechniques. 1998 Jan;24(1):22-4, 26.


1997

Mayer J, Meese E, Mueller-Lantzsch N.
Chromosomal assignment of human endogenous retrovirus K (HERV-K) env open reading frames.
Cytogenet Cell Genet. 1997;79(1-2):157-61.

 

Mueller HW, Michel A, Heckel D, Fischer U, Tonnes M, Tsui LC, Scherer S, Zang KD, Meese E.
Identification of an amplified gene cluster in glioma including two novel amplified genes isolated by exon trapping.
Hum Genet. 1997 Dec;101(2):190-7.

 

Bouterfa H, Janka M, Meese E, Kerkau S, Roosen K, Tonn JC.
Effect of changes in the CD44 gene on tumour cell invasion in gliomas.
Neuropathol Appl Neurobiol. 1997 Oct;23(5):373-9.

 

Heckel D, Brass N, Fischer U, Blin N, Steudel I, Tureci O, Fackler O, Zang KD, Meese E.
cDNA cloning and chromosomal mapping of a predicted coiled-coil proline-rich protein immunogenic in meningioma patients.
Hum Mol Genet. 1997 Nov;6(12):2031-41.

 

Mayer J, Meese E, Mueller-Lantzsch N.
Multiple human endogenous retrovirus (HERV-K) loci with gag open reading frames in the human genome.
Cytogenet Cell Genet. 1997;78(1):1-5.

 

Fischer U, Heckel D, Michel A, Janka M, Hulsebos T, Meese E.
Cloning of a novel transcription factor-like gene amplified in human glioma including astrocytoma grade I.
Hum Mol Genet. 1997 Oct;6(11):1817-22.

 

Loetscher M, Amara A, Oberlin E, Brass N, Legler D, Loetscher P, D'Apuzzo M, Meese E, Rousset D, Virelizier JL, Baggiolini M, Arenzana-Seisdedos F, Moser B.
TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function.
Curr Biol. 1997 Sep 1;7(9):652-60.

 

Brass N, Racz A, Heckel D, Remberger K, Sybrecht GW, Meese EU.
Amplification of the genes BCHE and SLC2A2 in 40% of squamous cell carcinoma of the lung.
Cancer Res. 1997 Jun 1;57(11):2290-4.

 

Muller HW, Meese EU.
Improved method for the construction of cosmid sublibraries from yeast artificial chromosomes.
Biotechniques. 1997 Feb;22(2):264-6, 268.

 

Brass N, Heckel D, Sahin U, Pfreundschuh M, Sybrecht GW, Meese E.
Translation initiation factor eIF-4gamma is encoded by an amplified gene and induces an immune response in squamous cell lung carcinoma.
Hum Mol Genet. 1997 Jan;6(1):33-9.


1996

Fischer U, Meltzer P, Meese E.
Twelve amplified and expressed genes localized in a single domain in glioma.
Hum Genet. 1996 Nov;98(5):625-8.

 

Janka M, Fischer U, Tonn JC, Kerkau S, Roosen K, Meese E.
Comparative amplification analysis of human glioma tissue and glioma derived fragment spheroids using reverse Chromosome painting (RCP).
Anticancer Res. 1996 Sep-Oct;16(5A):2601-6.

 

Herrmann ME, Lalley PA, Rydstedt LL, Meese E, Lang CH, Abumrad NN, Moll UM, Talpos GB.
Double minutes in the papillary thyroid cancer cell line PTC-1113A.
Cancer Genet Cytogenet. 1996 Aug;90(1):70-4.

 

Budarf ML, Eckman B, Michaud D, McDonald T, Gavigan S, Buetow KH, Tatsumura Y, Liu Z, Hilliard C, Driscoll D, Goldmuntz E,Meese E, Zwarthoff EC, Williams S, McDermid H, Dumanski JP, Biegel J, Bell CJ,Emanuel BS.
Regional localization of over 300 loci on human chromosome 22 using a somatic cell hybrid mapping panel.
Genomics. 1996 Jul 15;35(2):275-88.

 

Brass N, Ukena I, Remberger K, Mack U, Sybrecht GW, Meese EU.
DNA amplification on chromosome 3q26.1-q26.3 in squamous cell carcinoma of the lung detected by reverse chromosome painting.
Eur J Cancer. 1996 Jun;32A(7):1205-8.

 

Wundrack I, Reichert J, Langer HJ, Leicht E, Herrmann M, Subke F, Meese E, Blin N.
Molecular Screening for RET Proto-Oncogene Mutations in a German MEN2A Pedigree.
Endocr Pathol. 1996 Spring;7(1):71-76.

 

Gracia E, Fischer U, elKahloun A, Trent JM, Meese E, Meltzer PS.
Isolation of genes amplified in human cancers by microdissection mediated cDNA capture.
Hum Mol Genet. 1996 May;5(5):595-600.

 

Overmyer K., Gimbel W., Mller H-W., Gottert E., Meese E.
Enrichment of chromosome specific hncDNAs by magnetic beads.
Molecular Biology Reports 1996; 22: 53-57

 

Meese E, Gottert E, Zang KD, Sauter M, Schommer S, Mueller-Lantzsch N.
Human endogenous retroviral element k10 (HERV-K10): chromosomal localization by somatic hybrid mapping and fluorescence in situ hybridization.
Cytogenet Cell Genet. 1996;72(1):40-2.


1995

Overmyer K, Muller HW, Gimbel W, Gottert E, Meese E.
Enrichment of chromosome specific hncDNAs by magnetic bead coupled Alu sequences.
Mol Biol Rep. 1995-96;22(1):53-7.

 

Meese E, Muller HW, Brass N, Trent JM, Blin N.
Assignment of Alu-repetitive sequences to large restriction fragments from human chromosomes 6 and 22.
Mol Biol Rep. 1995;21(2):81-4.

 

Piontek K, Muller HW, Fischer U, Gottert E, Batzer MA, Meltzer PS, Trent JM, Meese E.
Generation and characterization of a human chromosome 6-specific hncDNA library from a somatic cell hybrid.
Cytogenet Cell Genet. 1995;69(3-4):273-8.

 

Blin N, Schneider G, Janka M, Subke F, Zang KD, Meese E.
Lack of isodisomy for chromosome 22 in disomic meningiomas.
Cytogenet Cell Genet. 1995;71(2):139-41.

 

Gimbel W, Klein V, Brass N, Fischer U, Piontek K, Overmyer K, Gottert E, Zang KD, Meese E.
Isolation and localization of transcribed sequences on human chromosome 22.
Cytogenet Cell Genet. 1995;71(1):81-5.

 

Fischer U, Muller HW, Sattler HP, Feiden K, Zang KD, Meese E.
Amplification of the MET gene in glioma.
Genes Chromosomes Cancer. 1995 Jan;12(1):63-5.


1994

Brass N, Fischer U, Mueller HW, Klein V, Meese E.
Strategy for chromosomal assignment of expressed sequences derived from heteronuclear RNA.
Biotechniques. 1994 Jul;17(1):88-90, 92.

 

Fischer U, Wullich B, Sattler HP, Gottert E, Zang KD, Meese E.
Coamplification on chromosomes 7p12-13 and 9q12-13 identified by reverse chromosome painting in a glioblastoma multiforme.
Hum Genet. 1994 Mar;93(3):331-4.

 

Wullich B, Sattler HP, Fischer U, Meese E.
Two independent amplification events on chromosome 7 in glioma: amplification of the epidermal growth factor receptor gene and amplification of the oncogene MET.
Anticancer Res. 1994 Mar-Apr;14(2A):577-9.

 

Lagoda PJ, Trent JM, Meese EU.
Chromosome specific c-DNA libraries: reduction of unspecific priming events by purification of heteronuclear RNA.
Mol Biol Rep. 1994 Mar;19(2):89-92.

 

Wundrack I, Meese E, Mullenbach R, Blin N.
Debrisoquine hydroxylase gene polymorphism in meningioma.
Acta Neuropathol (Berl). 1994;88(5):472-4.

 

Fischer U, Wullich B, Sattler HP, Gottert E, Zang KD, Meese E.
DNA amplifications on chromosomes 7, 9 and 12 in glioblastoma detected by reverse chromosome painting.
Eur J Cancer. 1994;30A(8):1124-7.


1993

Göttert E, Klein V, Piontek K, Overmyer K, Zang KD, Meese E.
Generation of a chromosome-22-specific c-DNA library as confirmed by FISH analysis.
Hum Genet. 1993 Dec;92(6):623-6.

 

Blin N, Mullenbach R, Suijkerbuijk R, Herzog R, Meese E.
Cosmid mapping and locus linkage within the human chromosomal region 22q13.1.
Cancer Genet Cytogenet. 1993 Oct 15;70(2):108-11.

 

Klein V, Piontek K, Brass N, Subke F, Zang KD, Meese E.
Identification of chromosome-specific sequence-tagged sites by Alu-PCR.
Genet Anal Tech Appl. 1993 Feb;10(1):6-9.

 

Corcos IA, Meese EU, Loch-Caruso R.
Human connexin43 gene locus, GJA1, sublocalized to band 6q21-->q23.2.
Cytogenet Cell Genet. 1993;64(1):31-2.

 

Wullich B, Muller HW, Fischer U, Zang KD, Meese E.
Amplified met gene linked to double minutes in human glioblastoma.
Eur J Cancer. 1993;29A(14):1991-5.


1992

Church SL, Grant JW, Meese EU, Trent JM.
Sublocalization of the gene encoding manganese superoxide dismutase (MnSOD/SOD2) to 6q25 by fluorescence in situ hybridization and somatic cell hybrid mapping.
Genomics. 1992 Nov;14(3):823-5.

 

Meese EU, Meltzer PS, Ferguson PW, Trent JM.
Alu-PCR: characterization of a chromosome 6-specific hybrid mapping panel and cloning of chromosome-specific markers.
Genomics. 1992 Mar;12(3):549-54.

 

Meese EU, Witkowski CM, Zoghbi HY, Stanbridge EJ, Meltzer PS, Trent JM.
Development and utilization of a somatic cell hybrid mapping panel to assign NotI linking probes to the long arm of human chromosome 6.
Genomics. 1992 Mar;12(3):542-8.

 

Meese EU, Horwitz SB, Trent JM.
Evidence for linear extrachromosomal elements mediating gene amplification in the multidrugresistant J774.2 murine cell line.
Cancer Genet Cytogenet. 1992 Mar;59(1):20-5.


1991

Millikin D, Meese E, Vogelstein B, Witkowski C, Trent J.
Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma.
Cancer Res. 1991 Oct 15;51(20):5449-53.

 

Herzog R, Gottert E, Henn W, Zang K, Blin N, Trent J, Meese E.
Large-scale physical mapping within the region 22q12.3-13.1 in meningioma.
Genomics. 1991 Aug;10(4):1041-6.


1990

Dieken ES, Meese EU, Miesfeld RL.
Anti glucocorticoid receptor transcripts lack sequences encoding the amino-terminal transcriptional modulatory domain.
Mol Cell Biol. 1990 Sep;10(9):4574-81.

 

Meese E, Olson S, Leis L, Trent J.
Quick method for high yields of lambda bacteriophage DNA.
Nucleic Acids Res. 1990 Apr 11;18(7):1923.

 

Trent JM, Stanbridge EJ, McBride HL, Meese EU, Casey G, Araujo DE, Witkowski CM, Nagle RB.
Tumorigenicity in human melanoma cell lines controlled by introduction of human chromosome 6.
Science. 1990 Feb 2;247(4942):568-71.


1989

Dieken ES, Meese EU, Miesfeld RL.
Anti glucocorticoid receptor transcripts lack sequences encoding the amino-terminal transcriptional modulatory domain.
Mol Cell Biol. 1990 Sep;10(9):4574-81.

 

Meese E, Olson S, Leis L, Trent J.
Quick method for high yields of lambda bacteriophage DNA.
Nucleic Acids Res. 1990 Apr 11;18(7):1923.

 

Trent JM, Stanbridge EJ, McBride HL, Meese EU, Casey G, Araujo DE, Witkowski CM, Nagle RB.
Tumorigenicity in human melanoma cell lines controlled by introduction of human chromosome 6.
Science. 1990 Feb 2;247(4942):568-71.


1988

Pietsch T, Gottert E, Meese E, Blin N, Feickert HJ, Riehm H, Kovacs G.
Characterization of a continuous cell line (MHH-NB-11) derived from advanced neuroblastoma.
Anticancer Res. 1988 Nov-Dec;8(6):1329-33.

 

Welter C, Meese E, Blin N.
Rapid step-gradient purification of mitochondrial DNA.
Mol Biol Rep. 1988;13(2):117-20.


1987

Meese E, Blin N, Zang KD.
Loss of heterozygosity and the origin of meningioma.
Hum Genet. 1987 Dec;77(4):349-51.

 

Meese E, Blin N.
Simultaneous isolation of high molecular weight RNA and DNA from limited amounts of tissues and cells.
Gene Anal Tech. 1987 May-Jun;4(3):45-9.

 

Blin N, Muller-Brechlin R, Carstens C, Meese E, Zang KD.
Enhanced expression of four cellular oncogenes in a human glioblastoma cell line. Cancer Genet Cytogenet. 1987 Apr;25(2):285-92.