Research
Our research laboratory investigates nucleocytoplasmic transport of macromolecules across the nuclear pore complex. We study the import and export of proteins and RNAs in the yeast Saccharomyces cerevisiae as a model organism. Transport is mediated by specific shuttling receptors which belong to the importin β superfamily. The import of proteins containing a classical nuclear localization signal (NLS) is the best understood transport pathway. Several export routes and import pathways independent of classical NLSs have been identified recently. We are especially interested in the role of the various transport receptors, the regulatory function of the Ran GTPase, and the RanGTP-interactor Yrb1p (yeast Ran binding protein 1). We apply a combination of molecular biology, genetics, biochemistry and cell biology techniques.
The picture shows a functional fusion of the green fluorescent protein (GFP) and yeast importin β viewed by fluorescence microscopy. The GFP fusion protein is concentrated at the nuclear envelope
| Projects |
| SFB 530 Räumlich-zeitliche Interaktionen zellulärer Signalmoleküle |
 | Graduiertenkolleg 1326 Calciumsignale und zelluläre Nanodomänen | |
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